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2-Bromo-4-(Chloromethyl)-1-Methoxybenzene
Linshang Chemical
|
HS Code |
909302 |
| Chemical Formula | C8H8BrClO |
| Molecular Weight | 235.505 g/mol |
| Appearance | Typically a colorless to light - colored liquid or solid |
| Boiling Point | Estimated around 280 - 300 °C (decomposes in some cases) |
| Density | Approximately 1.5 - 1.7 g/cm³ |
| Solubility In Water | Insoluble in water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate |
| Flash Point | Relatively high, around 120 - 140 °C |
| Hazard Class | Irritant, potentially harmful if swallowed, inhaled or in contact with skin |
As an accredited 2-Bromo-4-(Chloromethyl)-1-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - bromo - 4 - (chloromethyl)-1 - methoxybenzene in a sealed, labeled chemical bottle. |
| Storage | 2 - bromo - 4 - (chloromethyl)-1 - methoxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition points. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, bases, and reactive chemicals to prevent potential reactions. Label the storage container clearly for easy identification. |
| Shipping | 2 - bromo - 4 - (chloromethyl)-1 - methoxybenzene is shipped in sealed, corrosion - resistant containers. They are carefully packed to prevent breakage during transit, following strict chemical shipping regulations for safe transportation. |
Competitive 2-Bromo-4-(Chloromethyl)-1-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 2-bromo-4- (chloromethyl) -1-methoxybenzene?
2-Bromo-4- (chloromethyl) -1-methoxybenzene, this is an organic compound with many unique chemical properties.
Its halogenated hydrocarbon properties are remarkable. Both bromine atoms and chloromethyl groups are halogenated groups, giving the compound active reactivity. In case of nucleophiles, halogen atoms are easily replaced. In case of hydroxyl negative ions, bromine atoms or chloromethyl groups can be replaced by hydroxyl groups to form new compounds containing hydroxyl groups. This reaction is often used in organic synthesis to introduce specific functional groups.
Because of its methoxy group, this compound has the characteristics of ethers. Methoxy groups are relatively stable and do not react easily under normal conditions. However, under strong acidic or special catalytic conditions, methoxy groups can break, participate in the reaction, and derive different products.
In addition, the benzene ring structure makes the compound aromatic and can undergo aromatic electrophilic substitution. Because there are substituents such as bromine, chloromethyl and methoxy on the benzene ring, these substituents will affect the electron cloud density of the benzene ring, the reactivity and the substitution position. For example, methoxy group is the power supply group, which can increase the electron cloud density of the benzene ring ortho and para-site, and the electrophilic reagent is more likely to attack the ortho and para-site; while bromine and chloromethyl are electron-absorbing groups, which have the opposite effect on the electron cloud density of the benzene ring. The combined effect determines the reaction check point
At the same time, the chlorine atom on the chloromethyl group in this compound has high activity. In addition to nucleophilic substitution, it can also participate in elimination reactions, etc., to generate products containing unsaturated bonds, which further expands its application in the field of organic synthesis. In short, the diverse chemical properties of 2-bromo-4- (chloromethyl) -1-methoxybenzene make it widely used in organic synthesis, pharmaceutical chemistry and other fields.
Its halogenated hydrocarbon properties are remarkable. Both bromine atoms and chloromethyl groups are halogenated groups, giving the compound active reactivity. In case of nucleophiles, halogen atoms are easily replaced. In case of hydroxyl negative ions, bromine atoms or chloromethyl groups can be replaced by hydroxyl groups to form new compounds containing hydroxyl groups. This reaction is often used in organic synthesis to introduce specific functional groups.
Because of its methoxy group, this compound has the characteristics of ethers. Methoxy groups are relatively stable and do not react easily under normal conditions. However, under strong acidic or special catalytic conditions, methoxy groups can break, participate in the reaction, and derive different products.
In addition, the benzene ring structure makes the compound aromatic and can undergo aromatic electrophilic substitution. Because there are substituents such as bromine, chloromethyl and methoxy on the benzene ring, these substituents will affect the electron cloud density of the benzene ring, the reactivity and the substitution position. For example, methoxy group is the power supply group, which can increase the electron cloud density of the benzene ring ortho and para-site, and the electrophilic reagent is more likely to attack the ortho and para-site; while bromine and chloromethyl are electron-absorbing groups, which have the opposite effect on the electron cloud density of the benzene ring. The combined effect determines the reaction check point
At the same time, the chlorine atom on the chloromethyl group in this compound has high activity. In addition to nucleophilic substitution, it can also participate in elimination reactions, etc., to generate products containing unsaturated bonds, which further expands its application in the field of organic synthesis. In short, the diverse chemical properties of 2-bromo-4- (chloromethyl) -1-methoxybenzene make it widely used in organic synthesis, pharmaceutical chemistry and other fields.
What is the synthesis method of 2-bromo-4- (chloromethyl) -1-methoxybenzene?
To prepare 2-bromo-4- (chloromethyl) -1-methoxybenzene, the following method can be followed.
Take 1-methoxybenzene as the starting material, because the methoxy group is the ortho-para locator, which is very important for the guidance of the subsequent reaction check point. The bromination reaction is carried out with a brominating agent, such as liquid bromine, in the presence of a suitable catalyst, such as iron powder or iron tribromide. Under this reaction condition, the bromine atom will be mainly substituted in the ortho and para-positions of the methoxy group. By separation means, 2-bromo-1-methoxybenzene can be obtained.
After 2-bromo-1-methoxybenzene is obtained, chloromethylation reaction is carried out. Chloromethylation reagents, such as triformaldehyde and hydrogen chloride gas, can be selected in suitable solvents, such as dichloroethane, and reacted in Lewis acid catalysts, such as anhydrous zinc chloride. In the reaction, chloromethyl (-CH ² Cl) will replace the hydrogen atom at a specific position on the benzene ring. After fine control of the reaction conditions and process, the target product 2-bromo-4 - (chloromethyl) -1-methoxybenzene can be obtained. The reaction conditions at each step of this synthesis path need to be precisely controlled, and the separation and purification cannot be ignored in order to obtain a product with higher yield and purity.
Take 1-methoxybenzene as the starting material, because the methoxy group is the ortho-para locator, which is very important for the guidance of the subsequent reaction check point. The bromination reaction is carried out with a brominating agent, such as liquid bromine, in the presence of a suitable catalyst, such as iron powder or iron tribromide. Under this reaction condition, the bromine atom will be mainly substituted in the ortho and para-positions of the methoxy group. By separation means, 2-bromo-1-methoxybenzene can be obtained.
After 2-bromo-1-methoxybenzene is obtained, chloromethylation reaction is carried out. Chloromethylation reagents, such as triformaldehyde and hydrogen chloride gas, can be selected in suitable solvents, such as dichloroethane, and reacted in Lewis acid catalysts, such as anhydrous zinc chloride. In the reaction, chloromethyl (-CH ² Cl) will replace the hydrogen atom at a specific position on the benzene ring. After fine control of the reaction conditions and process, the target product 2-bromo-4 - (chloromethyl) -1-methoxybenzene can be obtained. The reaction conditions at each step of this synthesis path need to be precisely controlled, and the separation and purification cannot be ignored in order to obtain a product with higher yield and purity.
In what fields is 2-bromo-4- (chloromethyl) -1-methoxybenzene used?
2 - bromo - 4- (chloromethyl) - 1 - methoxybenzene, Chinese name 2 - bromo - 4 - chloromethyl - 1 - methoxybenzene, this substance is used in medicine, pesticides, materials and other fields.
In the field of medicine, because its structure contains active groups such as halogen atoms and methoxy groups, it can be used as an intermediate in organic synthesis. After specific chemical reactions, it can construct complex drug molecular structures or modify drug molecules to optimize their pharmacokinetic properties, such as enhancing solubility, enhancing stability, and regulating biological activity. In the research and development of some anti-cancer and anti-infective drugs, this is used as a starting material to introduce key pharmacophore through multi-step reaction to build drug molecules with precise pharmacological effects.
In the field of pesticides, halogen atoms and methoxy groups give the compound specific chemical and physical properties, and have biological activity against insects, pathogens and other harmful organisms. Pesticide products such as insecticides and fungicides can be chemically modified. For example, by adjusting its structure, changing the ability to bind to target proteins in pests or pathogens, the insecticidal and bactericidal effects of pesticides can be enhanced, while reducing the impact on the environment and non-target organisms.
In the field of materials science, 2-bromo-4-chloromethyl-1-methoxybenzene can participate in polymer synthesis. Because it contains reactive functional groups, it can be used as a monomer or crosslinking agent to polymerize with other compounds to form functional polymer materials. For example, the synthesis of polymers with special optical and electrical properties is used in optoelectronic devices, sensors, etc. In the preparation of photosensitive polymers, the compounds can introduce specific structures to enable the polymers to have photoresponsive properties, and react such as crosslinking or degradation when exposed to light, which can be used in materials such as photoresists.
In the field of medicine, because its structure contains active groups such as halogen atoms and methoxy groups, it can be used as an intermediate in organic synthesis. After specific chemical reactions, it can construct complex drug molecular structures or modify drug molecules to optimize their pharmacokinetic properties, such as enhancing solubility, enhancing stability, and regulating biological activity. In the research and development of some anti-cancer and anti-infective drugs, this is used as a starting material to introduce key pharmacophore through multi-step reaction to build drug molecules with precise pharmacological effects.
In the field of pesticides, halogen atoms and methoxy groups give the compound specific chemical and physical properties, and have biological activity against insects, pathogens and other harmful organisms. Pesticide products such as insecticides and fungicides can be chemically modified. For example, by adjusting its structure, changing the ability to bind to target proteins in pests or pathogens, the insecticidal and bactericidal effects of pesticides can be enhanced, while reducing the impact on the environment and non-target organisms.
In the field of materials science, 2-bromo-4-chloromethyl-1-methoxybenzene can participate in polymer synthesis. Because it contains reactive functional groups, it can be used as a monomer or crosslinking agent to polymerize with other compounds to form functional polymer materials. For example, the synthesis of polymers with special optical and electrical properties is used in optoelectronic devices, sensors, etc. In the preparation of photosensitive polymers, the compounds can introduce specific structures to enable the polymers to have photoresponsive properties, and react such as crosslinking or degradation when exposed to light, which can be used in materials such as photoresists.
What are the physical properties of 2-bromo-4- (chloromethyl) -1-methoxybenzene?
2-Bromo-4- (chloromethyl) -1 -methoxybenzene, this is an organic compound. Its physical properties are very important and are related to many chemical applications.
Under normal temperature and pressure, it can be a colorless to pale yellow liquid or a crystalline solid, depending on the specific environmental conditions. Its color and morphology may suggest physical effects caused by molecular structure.
As for the melting point, the melting point of this compound may be in a specific range. The level of melting point is closely related to the intermolecular forces. The presence of bromine, chloromethyl and methoxy groups in the molecule affects the close arrangement and interaction of molecules, which in turn determines the melting point value.
Boiling point is also a key physical property. Its boiling point reflects the energy required for the compound to change from a liquid state to a gaseous state. Due to the interaction between atoms and functional groups in the molecule, the intermolecular force is complex, so the boiling point also has a specific value.
In terms of solubility, the compound may have certain solubility in organic solvents such as ethanol and ether. Due to the principle of similarity and miscibility, its organic structure makes it have good interaction with organic solvent molecules. However, in water, its solubility is poor, because its non-polar part accounts for a large proportion, and the interaction with water molecules is weak.
Density is also a consideration factor. Density reflects the mass of the substance per unit volume and is related to the molecular weight and the way of intermolecular accumulation. The density of this compound may be within a certain range. In chemical experiments and industrial applications, density data are of great significance for operations such as substance separation and metrology.
In summary, the physical properties of 2-bromo-4- (chloromethyl) -1-methoxybenzene are determined by its molecular structure and play a key role in various chemical processes, helping scientists and engineers to better understand and control related chemical reactions and material processing processes.
Under normal temperature and pressure, it can be a colorless to pale yellow liquid or a crystalline solid, depending on the specific environmental conditions. Its color and morphology may suggest physical effects caused by molecular structure.
As for the melting point, the melting point of this compound may be in a specific range. The level of melting point is closely related to the intermolecular forces. The presence of bromine, chloromethyl and methoxy groups in the molecule affects the close arrangement and interaction of molecules, which in turn determines the melting point value.
Boiling point is also a key physical property. Its boiling point reflects the energy required for the compound to change from a liquid state to a gaseous state. Due to the interaction between atoms and functional groups in the molecule, the intermolecular force is complex, so the boiling point also has a specific value.
In terms of solubility, the compound may have certain solubility in organic solvents such as ethanol and ether. Due to the principle of similarity and miscibility, its organic structure makes it have good interaction with organic solvent molecules. However, in water, its solubility is poor, because its non-polar part accounts for a large proportion, and the interaction with water molecules is weak.
Density is also a consideration factor. Density reflects the mass of the substance per unit volume and is related to the molecular weight and the way of intermolecular accumulation. The density of this compound may be within a certain range. In chemical experiments and industrial applications, density data are of great significance for operations such as substance separation and metrology.
In summary, the physical properties of 2-bromo-4- (chloromethyl) -1-methoxybenzene are determined by its molecular structure and play a key role in various chemical processes, helping scientists and engineers to better understand and control related chemical reactions and material processing processes.
What is the market outlook for 2-bromo-4- (chloromethyl) -1-methoxybenzene?
2-Bromo-4- (chloromethyl) -1-methoxybenzene, this substance is worthy of careful investigation in the current market prospect.
Looking at its properties and uses, it is a key intermediate in the field of organic synthesis. The field of organic synthesis is widely used in the fields of medicine, pesticides and materials. In medicine, it may participate in the construction of many drug molecules through specific reaction paths, which is greatly helpful for the development of new drugs. Due to the constant demand for special new drugs in the pharmaceutical industry, and with the increasing emphasis on health, the investment in the research and development of new drugs continues to increase. Therefore, if 2-bromo-4- (chloromethyl) -1-methoxybenzene has unique efficacy in pharmaceutical synthesis, its market demand will gradually increase with the progress of new drug research and development.
The field of pesticides cannot be ignored. With the advancement of agricultural modernization, the demand for high-efficiency, low-toxicity and environmentally friendly pesticides is on the rise. If this compound can be used as a key raw material for the synthesis of such pesticides, the market prospect will also be broad. Because it provides a new path for the creation of pesticides, it is in line with the current concept of sustainable agricultural development.
Looking at the materials industry, the research and development of new materials is in the ascendant. 2-Bromo-4- (chloromethyl) -1-methoxybenzene may contribute to the synthesis of materials with special properties, such as materials with unique optical and electrical properties. The materials industry pursues innovation and replacement of high-performance materials, and this compound may be able to take advantage of this trend to find a place in the market.
However, the market prospect is not completely smooth. The complexity of the synthesis process may be a major challenge. If the synthesis process requires harsh conditions, expensive reagents, or produces a lot of pollutants, it must limit its large-scale production and application. And market competition cannot be ignored. The same kind may replace intermediates or have occupied part of the market share. To stand out, it is necessary to make efforts in cost control, product quality and supply stability.
Overall, the market prospect of 2-bromo-4- (chloromethyl) -1-methoxybenzene contains opportunities due to its potential applications in multiple industries. However, it is necessary to overcome the challenges of synthesis process and competition in order to fully exploit its market value.
Looking at its properties and uses, it is a key intermediate in the field of organic synthesis. The field of organic synthesis is widely used in the fields of medicine, pesticides and materials. In medicine, it may participate in the construction of many drug molecules through specific reaction paths, which is greatly helpful for the development of new drugs. Due to the constant demand for special new drugs in the pharmaceutical industry, and with the increasing emphasis on health, the investment in the research and development of new drugs continues to increase. Therefore, if 2-bromo-4- (chloromethyl) -1-methoxybenzene has unique efficacy in pharmaceutical synthesis, its market demand will gradually increase with the progress of new drug research and development.
The field of pesticides cannot be ignored. With the advancement of agricultural modernization, the demand for high-efficiency, low-toxicity and environmentally friendly pesticides is on the rise. If this compound can be used as a key raw material for the synthesis of such pesticides, the market prospect will also be broad. Because it provides a new path for the creation of pesticides, it is in line with the current concept of sustainable agricultural development.
Looking at the materials industry, the research and development of new materials is in the ascendant. 2-Bromo-4- (chloromethyl) -1-methoxybenzene may contribute to the synthesis of materials with special properties, such as materials with unique optical and electrical properties. The materials industry pursues innovation and replacement of high-performance materials, and this compound may be able to take advantage of this trend to find a place in the market.
However, the market prospect is not completely smooth. The complexity of the synthesis process may be a major challenge. If the synthesis process requires harsh conditions, expensive reagents, or produces a lot of pollutants, it must limit its large-scale production and application. And market competition cannot be ignored. The same kind may replace intermediates or have occupied part of the market share. To stand out, it is necessary to make efforts in cost control, product quality and supply stability.
Overall, the market prospect of 2-bromo-4- (chloromethyl) -1-methoxybenzene contains opportunities due to its potential applications in multiple industries. However, it is necessary to overcome the challenges of synthesis process and competition in order to fully exploit its market value.
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