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2-Bromo-4-Tert-Butyl-1-Chlorobenzene
Linshang Chemical
|
HS Code |
197644 |
| Chemical Formula | C10H12BrCl |
| Molecular Weight | 249.56 g/mol |
| Appearance | Typically a colorless to pale - yellow liquid (assumed based on similar aromatic halogen - substituted compounds) |
| Boiling Point | Estimated around 240 - 260 °C (approximate value for similar aromatic halo - compounds) |
| Density | Estimated around 1.3 - 1.5 g/cm³ (comparable to other halogenated aromatic hydrocarbons) |
| Solubility In Water | Insoluble (aromatic halogenated hydrocarbons are generally hydrophobic) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, and chloroform |
| Flash Point | Estimated around 90 - 110 °C (approx. for similar halogenated aromatic compounds) |
| Vapor Pressure | Low vapor pressure at room temperature (characteristic of relatively high - boiling aromatic halogenated compounds) |
As an accredited 2-Bromo-4-Tert-Butyl-1-Chlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - bromo - 4 - tert - butyl - 1 - chlorobenzene packaged in a sealed glass bottle. |
| Storage | 2 - bromo - 4 - tert - butyl - 1 - chlorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition points. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, bases, and reactive metals to avoid potential chemical reactions. Follow proper safety regulations for storage. |
| Shipping | 2 - bromo - 4 - tert - butyl - 1 - chlorobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict regulations for hazardous chemicals, with proper labeling indicating its nature, to ensure safe transportation. |
Competitive 2-Bromo-4-Tert-Butyl-1-Chlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the Chinese name of 2-bromo-4-tert-butyl-1-chlorobenzene?
2-Bromo-4-tert-butyl-1-chlorobenzene, one of the naming species of organic compounds. Its name comes from the accurate description of the molecular structure of the compound.
Looking at its structure, the phenyl ring is the base, which is the core structure of aromatic hydrocarbons. On the benzene ring, there are three groups: bromine (Br), chlorine (Cl) and tert-butyl (-C (CH).
According to the naming rules of organic compounds, the main chain is first determined, and the benzene ring is the main one. Then the substituent number on the benzene ring. When numbering, the sum of the substituent positions is minimized, and groups with smaller order rules are given priority.
In this compound, the bromine atom is connected to the second position of the benzene ring, the chlorine atom is connected to the first position, and the tert-butyl group is connected to the fourth position. Therefore, it is named "2-bromo-4-tert-butyl-1-chlorobenzene". Such a name can accurately describe the structure of the compound, so that the chemical community can know its molecular composition by seeing its name. It is of great significance in the research, communication and practical application of organic chemistry.
Looking at its structure, the phenyl ring is the base, which is the core structure of aromatic hydrocarbons. On the benzene ring, there are three groups: bromine (Br), chlorine (Cl) and tert-butyl (-C (CH).
According to the naming rules of organic compounds, the main chain is first determined, and the benzene ring is the main one. Then the substituent number on the benzene ring. When numbering, the sum of the substituent positions is minimized, and groups with smaller order rules are given priority.
In this compound, the bromine atom is connected to the second position of the benzene ring, the chlorine atom is connected to the first position, and the tert-butyl group is connected to the fourth position. Therefore, it is named "2-bromo-4-tert-butyl-1-chlorobenzene". Such a name can accurately describe the structure of the compound, so that the chemical community can know its molecular composition by seeing its name. It is of great significance in the research, communication and practical application of organic chemistry.
What is the molecular structure of 2-bromo-4-tert-butyl-1-chlorobenzene?
2-Bromo-4-tert-butyl-1-chlorobenzene is an organic compound with a unique molecular structure. This compound belongs to a halogenated aromatic hydrocarbon, and the benzene ring is its core structure. Above the benzene ring, there is a bromine atom (Br) at position 2, and the characteristics of this bromine atom have a great influence on the chemical activity of the compound. The bromine atom has a high electronegativity, and its existence changes the electron cloud density distribution of the benzene ring, which in turn affects various reactions involved in the benzene ring.
No. 4 is connected with tert-butyl (-C (CH)). Tert-butyl has a large steric resistance, which not only affects the space environment around the benzene ring, but also has a significant spatial effect in chemical reactions. Due to its large size, it will hinder the reactants from approaching a specific position of the benzene ring, thus affecting the reaction path and product selectivity.
1 is connected to a chlorine atom (Cl). Chlorine atoms are also electronegative and have an effect on the electron cloud of the benzene ring. Although both chlorine atoms and bromine atoms are halogen atoms, their electronegativity and atomic radius are slightly different, and their electronic effects on the benzene ring are not the same. In the molecular structure of 2-bromo-4-tert-butyl-1-chlorobenzene, the interaction of benzene ring, bromine atom, tert-butyl group and chlorine atom determines the physical and chemical properties of the compound, which is of great significance in organic synthesis and other fields.
No. 4 is connected with tert-butyl (-C (CH)). Tert-butyl has a large steric resistance, which not only affects the space environment around the benzene ring, but also has a significant spatial effect in chemical reactions. Due to its large size, it will hinder the reactants from approaching a specific position of the benzene ring, thus affecting the reaction path and product selectivity.
1 is connected to a chlorine atom (Cl). Chlorine atoms are also electronegative and have an effect on the electron cloud of the benzene ring. Although both chlorine atoms and bromine atoms are halogen atoms, their electronegativity and atomic radius are slightly different, and their electronic effects on the benzene ring are not the same. In the molecular structure of 2-bromo-4-tert-butyl-1-chlorobenzene, the interaction of benzene ring, bromine atom, tert-butyl group and chlorine atom determines the physical and chemical properties of the compound, which is of great significance in organic synthesis and other fields.
What are the physical properties of 2-bromo-4-tert-butyl-1-chlorobenzene?
2-Bromo-4-tert-butyl-1-chlorobenzene is an organic compound with the following physical properties:
Viewed at room temperature, it is a colorless to light yellow liquid or solid, depending on purity and ambient temperature. It is volatile to a certain extent and can evaporate slowly in the air.
Smell, it has a special odor of organic compounds. Although the odor intensity varies with concentration, it is more pungent and irritating to the olfactory system.
Its melting point and boiling point are also key physical properties. The melting point is about a specific value, which varies slightly due to accurate measurement conditions and the influence of impurities; the boiling point also has a corresponding range, indicating that when heated to this temperature range, the substance changes from liquid to gaseous state.
In terms of solubility, it is an organic halogenated aromatic hydrocarbon, which is insoluble in water. Due to its weak molecular polarity, the force between water molecules is small. However, it is soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. Due to the principle of similar phase dissolution, the intermolecular force between the organic solvent and the compound is suitable and can be miscible.
The density is different from that of water, usually greater than that of water. If mixed with water, it will sink underwater, and the stratification phenomenon is obvious.
In addition, the compound has different light and thermal stability from general phenyl series due to the presence of halogen atoms such as bromine and chlorine. Under light or high temperature, halogen atoms may react, which affects their physical state and properties. In conclusion, the unique physical properties of 2-bromo-4-tert-butyl-1-chlorobenzene are of great significance for its storage, transportation and application.
Viewed at room temperature, it is a colorless to light yellow liquid or solid, depending on purity and ambient temperature. It is volatile to a certain extent and can evaporate slowly in the air.
Smell, it has a special odor of organic compounds. Although the odor intensity varies with concentration, it is more pungent and irritating to the olfactory system.
Its melting point and boiling point are also key physical properties. The melting point is about a specific value, which varies slightly due to accurate measurement conditions and the influence of impurities; the boiling point also has a corresponding range, indicating that when heated to this temperature range, the substance changes from liquid to gaseous state.
In terms of solubility, it is an organic halogenated aromatic hydrocarbon, which is insoluble in water. Due to its weak molecular polarity, the force between water molecules is small. However, it is soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. Due to the principle of similar phase dissolution, the intermolecular force between the organic solvent and the compound is suitable and can be miscible.
The density is different from that of water, usually greater than that of water. If mixed with water, it will sink underwater, and the stratification phenomenon is obvious.
In addition, the compound has different light and thermal stability from general phenyl series due to the presence of halogen atoms such as bromine and chlorine. Under light or high temperature, halogen atoms may react, which affects their physical state and properties. In conclusion, the unique physical properties of 2-bromo-4-tert-butyl-1-chlorobenzene are of great significance for its storage, transportation and application.
What are the main uses of 2-bromo-4-tert-butyl-1-chlorobenzene?
2-Bromo-4-tert-butyl-1-chlorobenzene is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
In the process of drug synthesis, 2-bromo-4-tert-butyl-1-chlorobenzene can be used as a starting material. After many chemical reactions, compounds with specific biological activities can be prepared. The functional groups of this compound, such as bromine and chlorine atoms, can be introduced by nucleophilic substitution and other reactions to construct complex drug molecular structures, thus laying the foundation for the creation of new drugs.
In the field of materials science, it also has important functions. Through chemical modification, it can be integrated into polymer materials, giving the material unique properties. For example, by polymerizing with specific monomers, the material exhibits specific properties in electrical, optical or thermal aspects, suitable for electronic devices, optical materials and other fields.
In addition, in the preparation of fine chemical products, 2-bromo-4-tert-butyl-1-chlorobenzene also plays an important role. It can be used to synthesize special dyes, flavors or additives, etc., providing a rich selection of raw materials for the fine chemical industry, helping to develop diverse and high-performance fine chemical products to meet the needs of different industries.
In the process of drug synthesis, 2-bromo-4-tert-butyl-1-chlorobenzene can be used as a starting material. After many chemical reactions, compounds with specific biological activities can be prepared. The functional groups of this compound, such as bromine and chlorine atoms, can be introduced by nucleophilic substitution and other reactions to construct complex drug molecular structures, thus laying the foundation for the creation of new drugs.
In the field of materials science, it also has important functions. Through chemical modification, it can be integrated into polymer materials, giving the material unique properties. For example, by polymerizing with specific monomers, the material exhibits specific properties in electrical, optical or thermal aspects, suitable for electronic devices, optical materials and other fields.
In addition, in the preparation of fine chemical products, 2-bromo-4-tert-butyl-1-chlorobenzene also plays an important role. It can be used to synthesize special dyes, flavors or additives, etc., providing a rich selection of raw materials for the fine chemical industry, helping to develop diverse and high-performance fine chemical products to meet the needs of different industries.
What are 2-bromo-4-tert-butyl-1-chlorobenzene synthesis methods?
There are several methods for synthesizing 2-bromo-4-tert-butyl-1-chlorobenzene. One is to use benzene as the starting material and perform the tert-butyl reaction first. In this reaction, tert-butyl chloride and benzene are used as raw materials. Under the catalysis of Lewis acid such as aluminum trichloride, tert-butyl can replace the hydrogen on the benzene ring to obtain tert-butyl benzene.
Then, tert-butyl benzene is chlorinated. Using chlorine as chlorination agent, under the action of light or catalyst such as iron trichloride, chlorine atoms can selectively replace tert-butyl o-hydrogen and para-position. Because tert-butyl is an o-para-position group, 4-tert-butyl-1-chlorobenzene can be obtained.
Finally, 4-tert-butyl-1-chlorobenzene is brominated again. With bromine as brominating agent, under the catalysis of iron powder or iron tribromide, bromine atoms can replace hydrogen at the o-position of chlorine atoms to obtain 2-bromo-4-tert-butyl-1-chlorobenzene.
Another way is to first brominate benzene to obtain bromobenzene. Then bromobenzene is tert-butylated and then chlorinated, and this target product is also expected to be obtained. However, in this route, the tert-butylation of bromobenzene requires attention to the position selectivity of tert-butyl introduction. Because bromine is an ortho-para-locator, the reaction conditions need to be controlled so that tert-butyl is mainly introduced into the para-site of bromine, and the target product can be obtained during re-chlorination.
The key to the synthesis lies in the precise control of the reaction conditions at each step, such as the selection of catalysts, the regulation of reaction temperature and time, etc., in order to improve the selectivity and yield of the reaction, and Only in this way can 2-bromo-4-tert-butyl-1-chlorobenzene be effectively synthesized.
Then, tert-butyl benzene is chlorinated. Using chlorine as chlorination agent, under the action of light or catalyst such as iron trichloride, chlorine atoms can selectively replace tert-butyl o-hydrogen and para-position. Because tert-butyl is an o-para-position group, 4-tert-butyl-1-chlorobenzene can be obtained.
Finally, 4-tert-butyl-1-chlorobenzene is brominated again. With bromine as brominating agent, under the catalysis of iron powder or iron tribromide, bromine atoms can replace hydrogen at the o-position of chlorine atoms to obtain 2-bromo-4-tert-butyl-1-chlorobenzene.
Another way is to first brominate benzene to obtain bromobenzene. Then bromobenzene is tert-butylated and then chlorinated, and this target product is also expected to be obtained. However, in this route, the tert-butylation of bromobenzene requires attention to the position selectivity of tert-butyl introduction. Because bromine is an ortho-para-locator, the reaction conditions need to be controlled so that tert-butyl is mainly introduced into the para-site of bromine, and the target product can be obtained during re-chlorination.
The key to the synthesis lies in the precise control of the reaction conditions at each step, such as the selection of catalysts, the regulation of reaction temperature and time, etc., in order to improve the selectivity and yield of the reaction, and Only in this way can 2-bromo-4-tert-butyl-1-chlorobenzene be effectively synthesized.
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