Linshang Chemical
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2-Bromo-5-Chloro-1,3-Difluorobenzene
Linshang Chemical
|
HS Code |
263692 |
| Chemical Formula | C6H2BrClF2 |
| Appearance | Liquid (usually) |
| Boiling Point | Approximately in the range of 170 - 190 °C (est.) |
| Density | Around 1.8 - 2.0 g/cm³ (est.) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Vapor Pressure | Low at room temperature |
As an accredited 2-Bromo-5-Chloro-1,3-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - bromo - 5 - chloro - 1,3 - difluorobenzene in a sealed glass bottle. |
| Storage | 2 - bromo - 5 - chloro - 1,3 - difluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is likely flammable. Keep it in a tightly sealed container to prevent leakage and exposure to air or moisture. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. |
| Shipping | 2 - bromo - 5 - chloro - 1,3 - difluorobenzene, a chemical, is shipped in accordance with strict hazardous materials regulations. It's carefully packaged in suitable containers to prevent leakage during transit to ensure safety. |
Competitive 2-Bromo-5-Chloro-1,3-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Bromo-5-Chloro-1,3-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 2-bromo-5-chloro-1,3-difluorobenzene?
2-Bromo-5-chloro-1,3-difluorobenzene (2-bromo-5-chloro-1,3-difluorobenzene) is an important raw material and intermediate in organic synthesis, and is widely used in many fields such as medicine, pesticides, and materials.
In the field of medicine, its role is crucial. The synthesis of many drugs relies on this compound as a starting material. Due to its molecular structure containing halogen atoms, specific functional groups can be introduced through various chemical reactions, and then complex molecular structures with specific pharmacological activities can be constructed. For example, when developing new antibacterial drugs, 2-bromo-5-chloro-1,3-difluorobenzene can be used as a key intermediate to synthesize drug molecules that have inhibitory effects on specific bacteria by reacting with nitrogen-containing heterocyclic compounds, opening up new directions for pharmaceutical research and development.
In the field of pesticides, 2-bromo-5-chloro-1,3-difluorobenzene is also indispensable. The development of modern pesticides pursues high efficiency, low toxicity and environmental friendliness. This compound can be used as an important raw material for the synthesis of high-efficiency insecticides and fungicides. Due to its halogenated benzene structure, it has certain chemical stability and biological activity. After appropriate chemical modification, pesticide products with strong killing power against crop pests and pathogens can be prepared, which can help increase agricultural production and income, and reduce the negative impact on the environment.
In the field of materials science, 2-bromo-5-chloro-1,3-difluorobenzene can be used to synthesize special polymer materials. For example, in the process of synthesizing high-performance liquid crystal materials, it can be used as a structural unit to introduce the polymer main chain or side chain. With its unique molecular configuration and halogen atom characteristics, the liquid crystal phase transition temperature, phase stability and optical properties of the material can be adjusted, so that the synthesized liquid crystal materials can meet the needs of high-performance materials in display technology and other fields. In addition, in the synthesis of organic optoelectronic materials, its structural characteristics can also be used to improve the charge transfer properties and optical absorption properties of the materials, providing new raw material options for the development of organic optoelectronic devices.
In the field of medicine, its role is crucial. The synthesis of many drugs relies on this compound as a starting material. Due to its molecular structure containing halogen atoms, specific functional groups can be introduced through various chemical reactions, and then complex molecular structures with specific pharmacological activities can be constructed. For example, when developing new antibacterial drugs, 2-bromo-5-chloro-1,3-difluorobenzene can be used as a key intermediate to synthesize drug molecules that have inhibitory effects on specific bacteria by reacting with nitrogen-containing heterocyclic compounds, opening up new directions for pharmaceutical research and development.
In the field of pesticides, 2-bromo-5-chloro-1,3-difluorobenzene is also indispensable. The development of modern pesticides pursues high efficiency, low toxicity and environmental friendliness. This compound can be used as an important raw material for the synthesis of high-efficiency insecticides and fungicides. Due to its halogenated benzene structure, it has certain chemical stability and biological activity. After appropriate chemical modification, pesticide products with strong killing power against crop pests and pathogens can be prepared, which can help increase agricultural production and income, and reduce the negative impact on the environment.
In the field of materials science, 2-bromo-5-chloro-1,3-difluorobenzene can be used to synthesize special polymer materials. For example, in the process of synthesizing high-performance liquid crystal materials, it can be used as a structural unit to introduce the polymer main chain or side chain. With its unique molecular configuration and halogen atom characteristics, the liquid crystal phase transition temperature, phase stability and optical properties of the material can be adjusted, so that the synthesized liquid crystal materials can meet the needs of high-performance materials in display technology and other fields. In addition, in the synthesis of organic optoelectronic materials, its structural characteristics can also be used to improve the charge transfer properties and optical absorption properties of the materials, providing new raw material options for the development of organic optoelectronic devices.
What are the physical properties of 2-bromo-5-chloro-1,3-difluorobenzene?
2-Bromo-5-chloro-1,3-difluorobenzene is one of the organohalogenated aromatic hydrocarbons. It has unique physical properties and is widely used in various fields of chemical industry.
Looking at its appearance, at room temperature, this compound is mostly a colorless to light yellow transparent liquid, with a pure texture and no obvious impurities. Its odor is specific, although it is not pungent or intolerable, it is also characteristic and can be smelled slightly.
When it comes to the boiling point, it is between 170-180 ° C. The value of this boiling point allows it to be converted from liquid to gas at a specific temperature. When heated to near the boiling point, the molecules are energized, their movement intensifies, they break free from each other's attractive forces, and then gasify. This property is quite practical in separation and purification processes.
In terms of melting point, it is in the range of -10-0 ° C. When the temperature drops below the melting point, the molecular movement slows down, and they are close to each other, arranged in an orderly manner, and gradually condense from liquid to solid. This melting point characteristic should be paid attention to during storage and transportation, and the temperature should be controlled to ensure its morphological stability.
2-bromo-5-chloro-1,3-difluorobenzene has a higher density than water, about 1.8-1.9 g/cm ³. Placed in water, it sinks to the bottom, and this density difference can be used in some separation operations.
In terms of solubility, it has good solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc., and can be mutually soluble with it. However, in water, the solubility is extremely low and almost insoluble. This difference in solubility is due to the characteristics of halogen atoms and aromatic rings in its molecular structure, which make it interact strongly with organic solvent molecules and weakly with water molecules.
In addition, its volatility is relatively moderate. In an open environment, some molecules can escape into the air for a certain period of time. The ventilation design of this volatile in the place of use is extremely critical to ensure the safety of the operating environment and avoid the risk of its accumulation.
The above physical properties are interrelated and jointly determine the behavior of 2-bromo-5-chloro-1,3-difluorobenzene in chemical production, experimental research, etc. It is also an important basis for the rational application and proper disposal of this compound.
Looking at its appearance, at room temperature, this compound is mostly a colorless to light yellow transparent liquid, with a pure texture and no obvious impurities. Its odor is specific, although it is not pungent or intolerable, it is also characteristic and can be smelled slightly.
When it comes to the boiling point, it is between 170-180 ° C. The value of this boiling point allows it to be converted from liquid to gas at a specific temperature. When heated to near the boiling point, the molecules are energized, their movement intensifies, they break free from each other's attractive forces, and then gasify. This property is quite practical in separation and purification processes.
In terms of melting point, it is in the range of -10-0 ° C. When the temperature drops below the melting point, the molecular movement slows down, and they are close to each other, arranged in an orderly manner, and gradually condense from liquid to solid. This melting point characteristic should be paid attention to during storage and transportation, and the temperature should be controlled to ensure its morphological stability.
2-bromo-5-chloro-1,3-difluorobenzene has a higher density than water, about 1.8-1.9 g/cm ³. Placed in water, it sinks to the bottom, and this density difference can be used in some separation operations.
In terms of solubility, it has good solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc., and can be mutually soluble with it. However, in water, the solubility is extremely low and almost insoluble. This difference in solubility is due to the characteristics of halogen atoms and aromatic rings in its molecular structure, which make it interact strongly with organic solvent molecules and weakly with water molecules.
In addition, its volatility is relatively moderate. In an open environment, some molecules can escape into the air for a certain period of time. The ventilation design of this volatile in the place of use is extremely critical to ensure the safety of the operating environment and avoid the risk of its accumulation.
The above physical properties are interrelated and jointly determine the behavior of 2-bromo-5-chloro-1,3-difluorobenzene in chemical production, experimental research, etc. It is also an important basis for the rational application and proper disposal of this compound.
What are the chemical properties of 2-bromo-5-chloro-1,3-difluorobenzene?
2-Bromo-5-chloro-1,3-difluorobenzene is one of the organic halogenated aromatic hydrocarbons. Its chemical properties are highly influenced by the characteristics of halogen atoms.
Let's talk about its nucleophilic substitution reaction first. Because the electronegativity of halogen atoms is greater than that of carbon, the electron cloud density on the benzene ring is reduced, and the carbon connected to the halogen atoms is positively charged, so it is vulnerable to attack by nucleophiles. For example, if sodium alcohol is used as the nucleophilic reagent, under appropriate conditions, the bromine atom or the chlorine atom can be replaced by an alkoxy group to form the corresponding aryl ether. In this reaction, the nucleophilic nature of the nucleophilic reagent, the reaction temperature, and the solvent all have a Those with strong nucleophilicity have a faster reaction rate; increasing temperature can usually speed up the reaction.
Let's talk about its electrophilic substitution reaction. Although the halogen atom is an electron-withdrawing group, the electron cloud density of the benzene ring is reduced, and the electrophilic substitution reaction activity is lower than that of benzene, the benzene ring still has a certain electron cloud, so this kind of reaction can occur. The positioning effect of halogen atoms is also reflected here. Bromine, chlorine, and fluorine atoms are all ortho-para-sites. Taking the nitrification reaction as an example, the nitro group tends to enter the ortho or para-site of the halogen atom. However, due to the small radius of the fluorine atom and the strong conjugation effect with the benzene ring, the positioning effect is slightly special
In addition, 2-bromo-5-chloro-1,3-difluorobenzene can also participate in metal-catalyzed coupling reactions. For example, under the action of palladium catalyst with borate esters, Suzuki coupling reaction can occur to form carbon-carbon bonds and construct more complex organic molecular structures. This reaction condition is relatively mild, with good selectivity, and is widely used in the field of organic synthesis.
In short, 2-bromo-5-chloro-1,3-difluorobenzene has rich and diverse chemical properties and has important applications in many aspects of organic synthesis. It can be synthesized and prepared by various organic compounds with different reaction conditions and reagents.
Let's talk about its nucleophilic substitution reaction first. Because the electronegativity of halogen atoms is greater than that of carbon, the electron cloud density on the benzene ring is reduced, and the carbon connected to the halogen atoms is positively charged, so it is vulnerable to attack by nucleophiles. For example, if sodium alcohol is used as the nucleophilic reagent, under appropriate conditions, the bromine atom or the chlorine atom can be replaced by an alkoxy group to form the corresponding aryl ether. In this reaction, the nucleophilic nature of the nucleophilic reagent, the reaction temperature, and the solvent all have a Those with strong nucleophilicity have a faster reaction rate; increasing temperature can usually speed up the reaction.
Let's talk about its electrophilic substitution reaction. Although the halogen atom is an electron-withdrawing group, the electron cloud density of the benzene ring is reduced, and the electrophilic substitution reaction activity is lower than that of benzene, the benzene ring still has a certain electron cloud, so this kind of reaction can occur. The positioning effect of halogen atoms is also reflected here. Bromine, chlorine, and fluorine atoms are all ortho-para-sites. Taking the nitrification reaction as an example, the nitro group tends to enter the ortho or para-site of the halogen atom. However, due to the small radius of the fluorine atom and the strong conjugation effect with the benzene ring, the positioning effect is slightly special
In addition, 2-bromo-5-chloro-1,3-difluorobenzene can also participate in metal-catalyzed coupling reactions. For example, under the action of palladium catalyst with borate esters, Suzuki coupling reaction can occur to form carbon-carbon bonds and construct more complex organic molecular structures. This reaction condition is relatively mild, with good selectivity, and is widely used in the field of organic synthesis.
In short, 2-bromo-5-chloro-1,3-difluorobenzene has rich and diverse chemical properties and has important applications in many aspects of organic synthesis. It can be synthesized and prepared by various organic compounds with different reaction conditions and reagents.
What are the synthesis methods of 2-bromo-5-chloro-1,3-difluorobenzene?
There are several common methods for the synthesis of 2-bromo-5-chloro-1,3-difluorobenzene as follows.
First, the nucleophilic substitution method using halogenated aromatics as the starting material. First, take suitable halogenated benzene derivatives, such as benzene ring compounds containing bromine and chlorine atoms, which have bromine and chlorine substituents at specific positions on the benzene ring. In this halogenated aromatic hydrocarbon, when fluorine atoms are introduced, nucleophilic fluorine reagents, such as potassium fluoride, can be selected. In a suitable organic solvent, such as dimethyl sulfoxide (DMSO), heated and stirred, fluoride ions replace other halogen atoms at specific positions on the benzene ring through nucleophilic substitution reaction, thereby preparing the target product. In this process, the choice of solvent is very critical, and its effect on the solubility of the reactants and the reactivity needs to be considered. And the reaction temperature and time also need to be precisely controlled. If the temperature is too high or the time is too long, it is easy to cause side reactions to occur, generate unnecessary by-products, and affect the purity and yield of the product.
Second, it is gradually constructed through the halogenation reaction of aromatic hydrocarbons. First, difluorobenzene is used as the starting material, because there are already two fluorine atoms on the benzene ring. Using brominating reagents, such as bromine (Br ²), in the presence of appropriate catalysts, such as iron powder or iron tribromide, bromine atoms selectively replace hydrogen atoms at specific positions on the benzene ring to form bromine-containing intermediates. After that, a chlorination reagent, such as chlorine (Cl ²) or other suitable chlorinating agents, is used to replace the hydrogen atom at another specific position under suitable conditions to obtain 2-bromo-5-chloro-1,3-difluorobenzene. In this method, the selective control of the halogenation reaction is extremely important, and it is necessary to adjust the reaction conditions, catalyst type and dosage to ensure that the bromine and chlorine atoms are replaced in the expected position.
Third, the coupling reaction catalyzed by transition metals. Fluorophenylboronic acid-containing compounds and halogenated aromatics (containing bromine and chlorine atoms) can be selected, and the coupling reaction occurs under the action of transition metal catalysts such as palladium catalysts. The reaction needs to be carried out in the presence of alkali, which can promote the reaction. This method can efficiently form carbon-carbon bonds and achieve the synthesis of the target product. However, the price of transition metal catalysts is often higher, and the separation and recovery of catalysts after the reaction are also issues to be considered, which are related to cost and environmental protection. The above methods have advantages and disadvantages. In actual synthesis, it is necessary to make a comprehensive choice based on factors such as raw material availability, cost, and product purity requirements.
First, the nucleophilic substitution method using halogenated aromatics as the starting material. First, take suitable halogenated benzene derivatives, such as benzene ring compounds containing bromine and chlorine atoms, which have bromine and chlorine substituents at specific positions on the benzene ring. In this halogenated aromatic hydrocarbon, when fluorine atoms are introduced, nucleophilic fluorine reagents, such as potassium fluoride, can be selected. In a suitable organic solvent, such as dimethyl sulfoxide (DMSO), heated and stirred, fluoride ions replace other halogen atoms at specific positions on the benzene ring through nucleophilic substitution reaction, thereby preparing the target product. In this process, the choice of solvent is very critical, and its effect on the solubility of the reactants and the reactivity needs to be considered. And the reaction temperature and time also need to be precisely controlled. If the temperature is too high or the time is too long, it is easy to cause side reactions to occur, generate unnecessary by-products, and affect the purity and yield of the product.
Second, it is gradually constructed through the halogenation reaction of aromatic hydrocarbons. First, difluorobenzene is used as the starting material, because there are already two fluorine atoms on the benzene ring. Using brominating reagents, such as bromine (Br ²), in the presence of appropriate catalysts, such as iron powder or iron tribromide, bromine atoms selectively replace hydrogen atoms at specific positions on the benzene ring to form bromine-containing intermediates. After that, a chlorination reagent, such as chlorine (Cl ²) or other suitable chlorinating agents, is used to replace the hydrogen atom at another specific position under suitable conditions to obtain 2-bromo-5-chloro-1,3-difluorobenzene. In this method, the selective control of the halogenation reaction is extremely important, and it is necessary to adjust the reaction conditions, catalyst type and dosage to ensure that the bromine and chlorine atoms are replaced in the expected position.
Third, the coupling reaction catalyzed by transition metals. Fluorophenylboronic acid-containing compounds and halogenated aromatics (containing bromine and chlorine atoms) can be selected, and the coupling reaction occurs under the action of transition metal catalysts such as palladium catalysts. The reaction needs to be carried out in the presence of alkali, which can promote the reaction. This method can efficiently form carbon-carbon bonds and achieve the synthesis of the target product. However, the price of transition metal catalysts is often higher, and the separation and recovery of catalysts after the reaction are also issues to be considered, which are related to cost and environmental protection. The above methods have advantages and disadvantages. In actual synthesis, it is necessary to make a comprehensive choice based on factors such as raw material availability, cost, and product purity requirements.
What to pay attention to when storing and transporting 2-bromo-5-chloro-1,3-difluorobenzene
2-Bromo-5-chloro-1,3-difluorobenzene is an organic compound. When storing and transporting, many matters need to be paid attention to.
First, let's talk about storage. Because it has certain chemical activity, it should be stored in a cool, dry and well-ventilated place. Avoid direct sunlight, because light or promote photochemical reactions and deterioration. The ambient temperature must be strictly controlled. Excessive temperature or molecular activity will increase, triggering decomposition or other adverse reactions. Furthermore, it needs to be placed separately from oxidants, strong bases and other substances. Because of the halogen atoms in its structure, it is easy to cause chemical reactions when encountering oxidants or strong bases, or risk fire and explosion. Storage containers should also be carefully selected, and corrosion-resistant materials, such as glass or specific plastic materials, should be used to prevent the interaction between the container and the compound.
As for transportation, the first thing to ensure is that the packaging is tight. The outer packaging needs to be able to withstand a certain external impact to avoid material leakage caused by package damage during transportation. Transportation vehicles also need to be clean and dry, and there is no residual material that can react with them. During transportation, avoid high temperature environment and severe vibration. High temperature will increase its reactivity, and vibration may damage the packaging, increasing the risk of leakage. Transport personnel should also be familiar with the characteristics of the compound and emergency treatment methods. In case of leakage and other situations, they can be disposed of in time and properly to reduce harm.
In conclusion, the storage and transportation of 2-bromo-5-chloro-1,3-difluorobenzene must be treated with caution and strict compliance with relevant norms and requirements to ensure safety.
First, let's talk about storage. Because it has certain chemical activity, it should be stored in a cool, dry and well-ventilated place. Avoid direct sunlight, because light or promote photochemical reactions and deterioration. The ambient temperature must be strictly controlled. Excessive temperature or molecular activity will increase, triggering decomposition or other adverse reactions. Furthermore, it needs to be placed separately from oxidants, strong bases and other substances. Because of the halogen atoms in its structure, it is easy to cause chemical reactions when encountering oxidants or strong bases, or risk fire and explosion. Storage containers should also be carefully selected, and corrosion-resistant materials, such as glass or specific plastic materials, should be used to prevent the interaction between the container and the compound.
As for transportation, the first thing to ensure is that the packaging is tight. The outer packaging needs to be able to withstand a certain external impact to avoid material leakage caused by package damage during transportation. Transportation vehicles also need to be clean and dry, and there is no residual material that can react with them. During transportation, avoid high temperature environment and severe vibration. High temperature will increase its reactivity, and vibration may damage the packaging, increasing the risk of leakage. Transport personnel should also be familiar with the characteristics of the compound and emergency treatment methods. In case of leakage and other situations, they can be disposed of in time and properly to reduce harm.
In conclusion, the storage and transportation of 2-bromo-5-chloro-1,3-difluorobenzene must be treated with caution and strict compliance with relevant norms and requirements to ensure safety.
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