Linshang Chemical
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2-Bromo-5-Chloronitrobenzene
Linshang Chemical
|
HS Code |
177618 |
| Chemical Formula | C6H3BrClNO2 |
| Molar Mass | 236.45 g/mol |
| Appearance | Yellow solid |
| Boiling Point | Approximately 287 - 289 °C |
| Melting Point | 62 - 66 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Hazard Class | Harmful if swallowed, inhaled or in contact with skin; irritant |
As an accredited 2-Bromo-5-Chloronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 2 - bromo - 5 - chloronitrobenzene packaged in a sealed glass bottle. |
| Storage | 2 - bromo - 5 - chloronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat and ignition sources. Keep it in a tightly - sealed container to prevent vapor leakage. Due to its chemical reactivity, store it separately from reducing agents, acids, and bases. This storage approach helps maintain its stability and reduces risks of unwanted reactions. |
| Shipping | 2 - bromo - 5 - chloronitrobenzene is a chemical. For shipping, it must be properly packaged in corrosion - resistant containers. Label as a hazardous chemical. Ship via approved carriers following strict safety and regulatory protocols. |
Competitive 2-Bromo-5-Chloronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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What are the chemical properties of 2-bromo-5-chloronitrobenzene?
2-Bromo-5-chloronitrobenzene is one of the organic compounds. Its chemical properties are interesting, and I will describe them in detail for you.
This compound contains bromine, chlorine and nitro functional groups. Nitro has strong electron absorption, which can reduce the electron cloud density of the benzene ring and cause the activity of the electrophilic substitution of the benzene ring to decrease. Above the aromatic ring, due to the presence of nitro groups, it is difficult for electrophilic reagents to act, so more severe conditions are required for electrophilic substitution.
Both bromine and chlorine are halogen atoms. Although they also have the induction effect of electron absorption, they also have the conjugation effect of the electron. However, the induction effect is stronger than the conjugation effect, and the overall electron cloud density of the benzene ring is still reduced. In this molecule, the presence of bromine and chlorine also has a significant impact on the reaction check point and activity.
As far as nucleophilic substitution is concerned, due to the electron-absorbing action of nitro groups, the electron cloud density of the adjacent and para-sites of the benzene ring can be reduced more, making the adjacent and para-sites more vulnerable to nucleophilic reagents. If there are nucleophilic reagents, such as hydroxyl negative ions, amino negative ions, etc., under suitable conditions, bromine or chlorine atoms can be replaced.
And because of its halogen-containing atoms, under metal catalysis and other conditions, coupling reactions may occur, such as reacting with metal-containing organic reagents to form new carbon-carbon bonds or carbon-hetero bonds, which have great application potential in the field of organic synthesis.
And the bromine and chlorine atoms in this compound can undergo substitution, elimination and other reactions under specific conditions, and can be converted into other functional groups, providing a variety of possible paths for organic synthesis. Its chemical properties are complex and rich, and it is of great significance to the research and synthesis practice of organic chemistry.
This compound contains bromine, chlorine and nitro functional groups. Nitro has strong electron absorption, which can reduce the electron cloud density of the benzene ring and cause the activity of the electrophilic substitution of the benzene ring to decrease. Above the aromatic ring, due to the presence of nitro groups, it is difficult for electrophilic reagents to act, so more severe conditions are required for electrophilic substitution.
Both bromine and chlorine are halogen atoms. Although they also have the induction effect of electron absorption, they also have the conjugation effect of the electron. However, the induction effect is stronger than the conjugation effect, and the overall electron cloud density of the benzene ring is still reduced. In this molecule, the presence of bromine and chlorine also has a significant impact on the reaction check point and activity.
As far as nucleophilic substitution is concerned, due to the electron-absorbing action of nitro groups, the electron cloud density of the adjacent and para-sites of the benzene ring can be reduced more, making the adjacent and para-sites more vulnerable to nucleophilic reagents. If there are nucleophilic reagents, such as hydroxyl negative ions, amino negative ions, etc., under suitable conditions, bromine or chlorine atoms can be replaced.
And because of its halogen-containing atoms, under metal catalysis and other conditions, coupling reactions may occur, such as reacting with metal-containing organic reagents to form new carbon-carbon bonds or carbon-hetero bonds, which have great application potential in the field of organic synthesis.
And the bromine and chlorine atoms in this compound can undergo substitution, elimination and other reactions under specific conditions, and can be converted into other functional groups, providing a variety of possible paths for organic synthesis. Its chemical properties are complex and rich, and it is of great significance to the research and synthesis practice of organic chemistry.
What is 2-bromo-5-chloronitrobenzene synthesis method?
The method of preparing 2-bromo-5-chloronitrobenzene should follow the conventional route of chemical synthesis. Its starting material can be selected from suitable benzene derivatives.
First, benzene is used as the base for nitrification. Under suitable reaction conditions, a mixed acid of concentrated nitric acid and concentrated sulfuric acid is used as the nitrifying agent to nitrate benzene to obtain nitrobenzene. This step requires careful control of temperature and reagent ratio to prevent excessive nitrification.
Next, a halogenation reaction is carried out for nitrobenzene. To introduce bromine and chlorine atoms, it can be done step by step. The brominated product is first chlorinated with a brominating reagent, such as bromine and an appropriate catalyst (such as iron or iron tribromide), under appropriate conditions to brominate nitrobenzene, and bromine atoms are introduced at specific positions in the benzene ring to obtain bromine-containing nitrobenzene derivatives.
Then, a chlorinating reagent, such as chlorine gas or a suitable chloride, is used to chlorinate the brominated product in the presence of a suitable catalyst to introduce chlorine atoms into the benzene ring and achieve the expected 2-bromo-5-chloronitrobenzene structure. After the reaction is completed, it needs to be separated and purified by methods such as distillation, recrystallization, column chromatography, etc., to obtain pure 2-bromo-5-chloronitrobenzene. Each step of the reaction requires careful consideration of the conditions to ensure that the reaction proceeds smoothly in the expected direction, enhancing the yield and purity of the product.
First, benzene is used as the base for nitrification. Under suitable reaction conditions, a mixed acid of concentrated nitric acid and concentrated sulfuric acid is used as the nitrifying agent to nitrate benzene to obtain nitrobenzene. This step requires careful control of temperature and reagent ratio to prevent excessive nitrification.
Next, a halogenation reaction is carried out for nitrobenzene. To introduce bromine and chlorine atoms, it can be done step by step. The brominated product is first chlorinated with a brominating reagent, such as bromine and an appropriate catalyst (such as iron or iron tribromide), under appropriate conditions to brominate nitrobenzene, and bromine atoms are introduced at specific positions in the benzene ring to obtain bromine-containing nitrobenzene derivatives.
Then, a chlorinating reagent, such as chlorine gas or a suitable chloride, is used to chlorinate the brominated product in the presence of a suitable catalyst to introduce chlorine atoms into the benzene ring and achieve the expected 2-bromo-5-chloronitrobenzene structure. After the reaction is completed, it needs to be separated and purified by methods such as distillation, recrystallization, column chromatography, etc., to obtain pure 2-bromo-5-chloronitrobenzene. Each step of the reaction requires careful consideration of the conditions to ensure that the reaction proceeds smoothly in the expected direction, enhancing the yield and purity of the product.
2-bromo-5-chloronitrobenzene in what areas?
2-Bromo-5-chloronitrobenzene is an organic compound, which has applications in many fields.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. Due to the characteristics of bromine, chlorine and nitro groups in its structure, it can introduce other functional groups through various chemical reactions to construct molecular structures with specific physiological activities. For example, when developing antibacterial drugs, this is used as a starting material to modify its structure or to obtain novel compounds with antibacterial activity.
In the field of materials science, it also has outstanding performance. Can participate in the preparation of functional materials, such as optoelectronic materials. Due to its special electronic structure, it may affect the electrical and optical properties of materials. After appropriate chemical conversion, materials with specific photoelectric responses can be synthesized for the manufacture of organic Light Emitting Diodes, solar cells and other devices.
Furthermore, in the field of pesticide chemistry, it is also indispensable. Based on this, pesticides with insecticidal and weeding effects can be synthesized. By designing and modifying its structure, the activity and selectivity of pesticides can be optimized, and their control effect on specific pests or weeds can be improved, while reducing the impact on the environment.
In addition, in the field of organic synthetic chemistry, 2-bromo-5-chloronitrobenzene, as an important synthetic building block, can construct more complex organic molecular structures through nucleophilic substitution, coupling and other reactions, providing organic synthetic chemists with rich synthesis strategies and possibilities, and assisting in the creation and research of new organic compounds.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. Due to the characteristics of bromine, chlorine and nitro groups in its structure, it can introduce other functional groups through various chemical reactions to construct molecular structures with specific physiological activities. For example, when developing antibacterial drugs, this is used as a starting material to modify its structure or to obtain novel compounds with antibacterial activity.
In the field of materials science, it also has outstanding performance. Can participate in the preparation of functional materials, such as optoelectronic materials. Due to its special electronic structure, it may affect the electrical and optical properties of materials. After appropriate chemical conversion, materials with specific photoelectric responses can be synthesized for the manufacture of organic Light Emitting Diodes, solar cells and other devices.
Furthermore, in the field of pesticide chemistry, it is also indispensable. Based on this, pesticides with insecticidal and weeding effects can be synthesized. By designing and modifying its structure, the activity and selectivity of pesticides can be optimized, and their control effect on specific pests or weeds can be improved, while reducing the impact on the environment.
In addition, in the field of organic synthetic chemistry, 2-bromo-5-chloronitrobenzene, as an important synthetic building block, can construct more complex organic molecular structures through nucleophilic substitution, coupling and other reactions, providing organic synthetic chemists with rich synthesis strategies and possibilities, and assisting in the creation and research of new organic compounds.
What are the physical properties of 2-bromo-5-chloronitrobenzene?
2-Bromo-5-chloronitrobenzene is one of the organic compounds. Its physical properties are quite characteristic, let me tell them one by one.
Looking at its appearance, at room temperature, it is mostly a light yellow crystalline powder, which is delicate and has its quality. This shape is easy to observe and operate, and in many experiments and industrial processes, its shape is conducive to subsequent processing.
When it comes to the melting point, it is between 67 and 71 ° C. The characteristics of the melting point are crucial in the identification, separation and purification of compounds. In this temperature range, the substance gradually melts from a solid state to a liquid state, and this transformation can help identify its purity and characteristics. If the melting point is accurate and the range is narrow, it indicates that the purity of the substance is quite high; conversely, if the melting point is deviated or the range is too wide, it may be contaminated with impurities.
As for the boiling point, it is about 294 ° C. The boiling point characterizes the temperature conditions required for the transformation of a substance from a liquid state to a gaseous state. Such a high boiling point reflects a strong intermolecular force. During the heating process, more energy is required to overcome the intermolecular attractive force before it can be vaporized. This property plays a key guiding role in separation techniques such as distillation, whereby it can be separated from other substances with different boiling points.
In terms of solubility, 2-bromo-5-chloronitrobenzene is slightly soluble in water. Water is a common solvent, but the affinity of this compound with water is weak. Due to the existence of functional groups such as bromine, chlorine and nitro in its molecular structure, the molecular polarity is quite different from that of water, so it is difficult to dissolve in water. However, it is soluble in organic solvents such as ethanol, ether, and benzene. The molecular structure and polarity of organic solvents such as ethanol, ether, and benzene are more compatible with 2-bromo-5-chloronitrobenzene, and the intermolecular force can promote the mutual dissolution of the two. This property is often used in extraction and dissolution processes in organic synthesis and analytical chemistry.
Density is also one of its important physical properties, and its density is higher than that of water. When mixed with water, it will settle at the bottom. This property can be used as a basis for separation in experiments or industrial processes involving liquid-liquid separation.
In conclusion, the physical properties of 2-bromo-5-chloronitrobenzene, such as appearance, melting point, boiling point, solubility, and density, are of great significance in the study of organic chemistry, the practice of organic synthesis, and related industrial production processes, laying the foundation for the understanding, operation, and application of this compound.
Looking at its appearance, at room temperature, it is mostly a light yellow crystalline powder, which is delicate and has its quality. This shape is easy to observe and operate, and in many experiments and industrial processes, its shape is conducive to subsequent processing.
When it comes to the melting point, it is between 67 and 71 ° C. The characteristics of the melting point are crucial in the identification, separation and purification of compounds. In this temperature range, the substance gradually melts from a solid state to a liquid state, and this transformation can help identify its purity and characteristics. If the melting point is accurate and the range is narrow, it indicates that the purity of the substance is quite high; conversely, if the melting point is deviated or the range is too wide, it may be contaminated with impurities.
As for the boiling point, it is about 294 ° C. The boiling point characterizes the temperature conditions required for the transformation of a substance from a liquid state to a gaseous state. Such a high boiling point reflects a strong intermolecular force. During the heating process, more energy is required to overcome the intermolecular attractive force before it can be vaporized. This property plays a key guiding role in separation techniques such as distillation, whereby it can be separated from other substances with different boiling points.
In terms of solubility, 2-bromo-5-chloronitrobenzene is slightly soluble in water. Water is a common solvent, but the affinity of this compound with water is weak. Due to the existence of functional groups such as bromine, chlorine and nitro in its molecular structure, the molecular polarity is quite different from that of water, so it is difficult to dissolve in water. However, it is soluble in organic solvents such as ethanol, ether, and benzene. The molecular structure and polarity of organic solvents such as ethanol, ether, and benzene are more compatible with 2-bromo-5-chloronitrobenzene, and the intermolecular force can promote the mutual dissolution of the two. This property is often used in extraction and dissolution processes in organic synthesis and analytical chemistry.
Density is also one of its important physical properties, and its density is higher than that of water. When mixed with water, it will settle at the bottom. This property can be used as a basis for separation in experiments or industrial processes involving liquid-liquid separation.
In conclusion, the physical properties of 2-bromo-5-chloronitrobenzene, such as appearance, melting point, boiling point, solubility, and density, are of great significance in the study of organic chemistry, the practice of organic synthesis, and related industrial production processes, laying the foundation for the understanding, operation, and application of this compound.
What are the precautions in the preparation of 2-bromo-5-chloronitrobenzene?
When preparing 2-bromo-5-chloronitrobenzene, all matters need to be treated with caution. The selection and disposal of raw materials are particularly important. Bromide, chloride and nitrogenation reagents should be selected with high purity and stored properly to avoid moisture, deterioration and disturbance of the reaction.
The control of reaction conditions is related to success or failure. Temperature must be accurately controlled. Nitrogenation reactions require a specific temperature range. If they are too high, side reactions will occur, and if they are too low, the reaction will be delayed or even stagnant. If concentrated sulfuric acid and concentrated nitric acid are mixed with mixed acid as a nitrifying agent, the reaction temperature may be controlled at low temperature to prevent excessive nitrification of the benzene ring. Stirring should not be neglected. Full stirring can promote the uniform mixing of the reactants, so that the reaction can proceed efficiently and smoothly, and avoid local overheating or uneven reaction.
Furthermore, the choice of reaction solvent is also exquisite. The selected solvent needs to have good solubility to the reactants and does not chemically react with the reactants and products. In this way, a suitable environment can be created for the reaction to ensure a smooth reaction.
The post-treatment stage should not be underestimated. The separation and purification of the product is the key to obtaining pure 2-bromo-5-chloronitrobenzene. According to the characteristics of the product, extraction, distillation, recrystallization and other methods can be selected. During recrystallization, the type, dosage, and cooling rate of solvents can all affect the purity and crystallization of the product.
Safety matters throughout. The reagents used are mostly corrosive and toxic. When operating, strictly follow safety procedures, wear protective equipment, work in good ventilation, and properly dispose of waste to avoid harm to the environment and humans. In this way, it is expected to produce 2-bromo-5-chloronitrobenzene efficiently and safely.
The control of reaction conditions is related to success or failure. Temperature must be accurately controlled. Nitrogenation reactions require a specific temperature range. If they are too high, side reactions will occur, and if they are too low, the reaction will be delayed or even stagnant. If concentrated sulfuric acid and concentrated nitric acid are mixed with mixed acid as a nitrifying agent, the reaction temperature may be controlled at low temperature to prevent excessive nitrification of the benzene ring. Stirring should not be neglected. Full stirring can promote the uniform mixing of the reactants, so that the reaction can proceed efficiently and smoothly, and avoid local overheating or uneven reaction.
Furthermore, the choice of reaction solvent is also exquisite. The selected solvent needs to have good solubility to the reactants and does not chemically react with the reactants and products. In this way, a suitable environment can be created for the reaction to ensure a smooth reaction.
The post-treatment stage should not be underestimated. The separation and purification of the product is the key to obtaining pure 2-bromo-5-chloronitrobenzene. According to the characteristics of the product, extraction, distillation, recrystallization and other methods can be selected. During recrystallization, the type, dosage, and cooling rate of solvents can all affect the purity and crystallization of the product.
Safety matters throughout. The reagents used are mostly corrosive and toxic. When operating, strictly follow safety procedures, wear protective equipment, work in good ventilation, and properly dispose of waste to avoid harm to the environment and humans. In this way, it is expected to produce 2-bromo-5-chloronitrobenzene efficiently and safely.
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