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2-(Bromomethyl)-1,3-Dichlorobenzene
Linshang Chemical
|
HS Code |
609710 |
| Chemical Formula | C7H5BrCl2 |
| Molecular Weight | 225.92 |
| Appearance | Solid (likely white or off - white) |
| Boiling Point | Approximately 250 - 260 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, and chloroform |
| Vapor Pressure | Low at room temperature |
| Odor | Typical aromatic and halogen - like odor |
As an accredited 2-(Bromomethyl)-1,3-Dichlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 2-(bromomethyl)-1,3 - dichlorobenzene packaged in a sealed glass bottle. |
| Storage | 2-(Bromomethyl)-1,3 - dichlorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, bases, and reactive chemicals to avoid potential chemical reactions. Follow proper safety regulations during storage. |
| Shipping | 2-(Bromomethyl)-1,3 - dichlorobenzene is shipped in accordance with hazardous chemical regulations. It's packed in secure, tightly - sealed containers, safeguarded from heat and moisture, and transported by carriers trained in handling such substances. |
Competitive 2-(Bromomethyl)-1,3-Dichlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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What is the main use of 2- (bromomethyl) -1,3-dichlorobenzene?
2-%28bromomethyl%29-1%2C3-dichlorobenzene is 2- (bromomethyl) -1,3-dichlorobenzene, which is widely used.
In the field of organic synthesis, it can be used as a key intermediate. Due to the structure of bromomethyl and dichlorobenzene in the molecule, bromine atoms can be replaced by other functional groups through many chemical reactions, such as nucleophilic substitution reactions. This property makes it a cornerstone for the construction of complex organic molecules, which can be used to synthesize compounds with specific structures and functions, such as fine chemicals required in the fields of drugs, pesticides, materials, etc.
In drug research and development, compounds with unique pharmacological activities can be prepared by structural modification and derivatization of 2- (bromomethyl) -1,3-dichlorobenzene. Through nucleophilic substitution reaction, bromine atoms are replaced by nucleophilic reagents containing specific nitrogen, oxygen, sulfur and other atoms, thereby changing the spatial structure and electron cloud distribution of molecules, or potential drug lead compounds with specific targeting and biological activities can be obtained.
In the field of pesticide creation, 2- (bromomethyl) -1,3-dichlorobenzene also has important uses. After reasonable structural modification, pesticide varieties with high control effect on specific pests and pathogens can be prepared. Due to the stability of the benzene ring structure and the reactivity of bromomethyl, pesticide molecules with good biological activity and environmental stability can be designed and synthesized.
In the field of materials science, 2- (bromomethyl) -1,3-dichlorobenzene can participate in the synthesis of polymer materials. By reacting with monomers containing unsaturated bonds or active groups, it can be introduced into the main chain or side chain of the polymer to endow the material with special properties, such as improving the heat resistance and chemical corrosion resistance of the material, so as to meet the needs of high-performance materials in different fields.
In the field of organic synthesis, it can be used as a key intermediate. Due to the structure of bromomethyl and dichlorobenzene in the molecule, bromine atoms can be replaced by other functional groups through many chemical reactions, such as nucleophilic substitution reactions. This property makes it a cornerstone for the construction of complex organic molecules, which can be used to synthesize compounds with specific structures and functions, such as fine chemicals required in the fields of drugs, pesticides, materials, etc.
In drug research and development, compounds with unique pharmacological activities can be prepared by structural modification and derivatization of 2- (bromomethyl) -1,3-dichlorobenzene. Through nucleophilic substitution reaction, bromine atoms are replaced by nucleophilic reagents containing specific nitrogen, oxygen, sulfur and other atoms, thereby changing the spatial structure and electron cloud distribution of molecules, or potential drug lead compounds with specific targeting and biological activities can be obtained.
In the field of pesticide creation, 2- (bromomethyl) -1,3-dichlorobenzene also has important uses. After reasonable structural modification, pesticide varieties with high control effect on specific pests and pathogens can be prepared. Due to the stability of the benzene ring structure and the reactivity of bromomethyl, pesticide molecules with good biological activity and environmental stability can be designed and synthesized.
In the field of materials science, 2- (bromomethyl) -1,3-dichlorobenzene can participate in the synthesis of polymer materials. By reacting with monomers containing unsaturated bonds or active groups, it can be introduced into the main chain or side chain of the polymer to endow the material with special properties, such as improving the heat resistance and chemical corrosion resistance of the material, so as to meet the needs of high-performance materials in different fields.
What are the physical properties of 2- (bromomethyl) -1,3-dichlorobenzene
2-%28bromomethyl%29-1%2C3-dichlorobenzene is 2- (bromomethyl) -1,3-dichlorobenzene. The physical properties of this substance are as follows.
It is mostly liquid at room temperature and pressure. Looking at its color, it is colorless to light yellow and transparent, and has a certain volatility. It can smell a special smell in the air, odor or pungent, which stimulates the sense of smell.
When it comes to density, its density is greater than that of water. If mixed with water, it will sink underwater. In terms of solubility, 2- (bromomethyl) -1,3-dichlorobenzene is difficult to dissolve in water, because the polarity of the organic molecule is weak, and water is a polar molecule, so it is difficult to dissolve according to the principle of "similar miscibility". However, in organic solvents, such as ethanol, ether, benzene, etc., it has better solubility because of the force between the molecules of the organic solvent and it is conducive to mixing with each other.
Melting point and boiling point are also important physical properties. Its melting point is relatively low, making it easy to maintain a liquid state near room temperature. The boiling point is higher, and a certain temperature is required to transform it from a liquid state to a gaseous state. This property indicates that the intermolecular force is strong, and more energy is required to overcome this force to vaporize the substance.
In addition, the refractive index of 2- (bromomethyl) -1,3-dichlorobenzene also has a specific value. The refractive index reflects the degree of change in the direction of light propagation in the substance, which can be used to identify the purity of the substance or distinguish between different substances. Measuring its refractive index under specific conditions can provide a basis for the analysis of this substance. These are the main physical properties of 2- (bromomethyl) -1,3-dichlorobenzene.
It is mostly liquid at room temperature and pressure. Looking at its color, it is colorless to light yellow and transparent, and has a certain volatility. It can smell a special smell in the air, odor or pungent, which stimulates the sense of smell.
When it comes to density, its density is greater than that of water. If mixed with water, it will sink underwater. In terms of solubility, 2- (bromomethyl) -1,3-dichlorobenzene is difficult to dissolve in water, because the polarity of the organic molecule is weak, and water is a polar molecule, so it is difficult to dissolve according to the principle of "similar miscibility". However, in organic solvents, such as ethanol, ether, benzene, etc., it has better solubility because of the force between the molecules of the organic solvent and it is conducive to mixing with each other.
Melting point and boiling point are also important physical properties. Its melting point is relatively low, making it easy to maintain a liquid state near room temperature. The boiling point is higher, and a certain temperature is required to transform it from a liquid state to a gaseous state. This property indicates that the intermolecular force is strong, and more energy is required to overcome this force to vaporize the substance.
In addition, the refractive index of 2- (bromomethyl) -1,3-dichlorobenzene also has a specific value. The refractive index reflects the degree of change in the direction of light propagation in the substance, which can be used to identify the purity of the substance or distinguish between different substances. Measuring its refractive index under specific conditions can provide a basis for the analysis of this substance. These are the main physical properties of 2- (bromomethyl) -1,3-dichlorobenzene.
What are the chemical properties of 2- (bromomethyl) -1,3-dichlorobenzene?
2-%28bromomethyl%29-1%2C3-dichlorobenzene, the Chinese name is 2 - (bromomethyl) -1,3 -dichlorobenzene. The chemical properties of this substance are special, let me mention.
In addition, benzene has dichlorine atoms and monobromomethyl atoms. The presence of the chlorine atom, bromomethyl, makes the compound have a specific chemical activity. As far as substitution is concerned, the bromine atom in bromomethyl is highly active, and it is vulnerable to nuclear attack and nuclear substitution. For example, if it encounters an alkyl nucleus, bromine can be replaced by a alkyl group to form an alcoholic derivative of the phase.
Furthermore, the presence of benzene also gives it its aromaticity. This property makes it highly active, such as alkyl substitution. However, the absorber effect of the chlorine atom affects the density distribution of the benzene sub-cloud, so that the substitution of the benzene is affected by the benzene itself. Usually, the density of the chlorine atom and the sub-cloud is reduced, so it is more difficult to attack the benzene.
In addition, 2 - (bromomethyl) -1,3-dichlorobenzene in the normal state, bromomethyl may eliminate the reaction, debrominate, and form a non-sum.
And because its molecule contains an elastomer atom, in the appropriate state, the elastomer can be intersected and reversed, and the bromine atom or the chlorine atom can be replaced by other elastomer atoms, which can change the properties of the compound.
The chemical properties of this compound are rich, and in the field of chemical synthesis, it can be used as a variety of chemical compounds with special functions by virtue of its various chemical activities. It is an important raw material that cannot be ignored in the synthesis of chemical research.
In addition, benzene has dichlorine atoms and monobromomethyl atoms. The presence of the chlorine atom, bromomethyl, makes the compound have a specific chemical activity. As far as substitution is concerned, the bromine atom in bromomethyl is highly active, and it is vulnerable to nuclear attack and nuclear substitution. For example, if it encounters an alkyl nucleus, bromine can be replaced by a alkyl group to form an alcoholic derivative of the phase.
Furthermore, the presence of benzene also gives it its aromaticity. This property makes it highly active, such as alkyl substitution. However, the absorber effect of the chlorine atom affects the density distribution of the benzene sub-cloud, so that the substitution of the benzene is affected by the benzene itself. Usually, the density of the chlorine atom and the sub-cloud is reduced, so it is more difficult to attack the benzene.
In addition, 2 - (bromomethyl) -1,3-dichlorobenzene in the normal state, bromomethyl may eliminate the reaction, debrominate, and form a non-sum.
And because its molecule contains an elastomer atom, in the appropriate state, the elastomer can be intersected and reversed, and the bromine atom or the chlorine atom can be replaced by other elastomer atoms, which can change the properties of the compound.
The chemical properties of this compound are rich, and in the field of chemical synthesis, it can be used as a variety of chemical compounds with special functions by virtue of its various chemical activities. It is an important raw material that cannot be ignored in the synthesis of chemical research.
What are the synthesis methods of 2- (bromomethyl) -1,3-dichlorobenzene
To prepare 2 - (bromomethyl) -1,3 -dichlorobenzene, there are many methods, and the following common ones can be selected.
One is the halomethylation method. 1,3-dichlorobenzene is used as the starting material, and under the catalysis of Lewis acid (such as anhydrous zinc chloride, etc.), it coreacts with polyformaldehyde and hydrogen bromide. In this process, polyformaldehyde is first hydrolyzed to produce formaldehyde, and formaldehyde and hydrogen bromide are nucleophilically added to obtain bromomethanol, and then electrophilic substitution with 1,3-dichlorobenzene to obtain the target product. This process requires controlling the reaction temperature and the ratio of materials to prevent the formation of polyhalides.
The second is obtained by halogenation of 2-methyl-1,3-dichlorobenzene. Using 2-methyl-1,3-dichlorobenzene as the substrate, select a suitable brominating agent (such as N-bromosuccinimide, or NBS), and in the presence of an initiator (such as benzoyl peroxide, etc.), methyl bromide is reacted by free radical substitution reaction. This reaction condition is mild, with good selectivity, and high purity products can be obtained. However, it is necessary to pay attention to the monitoring of the reaction process, because the reaction activity of free radicals is high, if not properly controlled, it may cause excessive bromination.
Furthermore, 1,3-dichlorobenzene can be chloromethylated with formaldehyde and hydrogen chloride to obtain 2- (chloromethyl) -1,3-dichlorobenzene. After the halogen exchange reaction, chlorine is replaced with bromide with a brominating agent (such as sodium bromide, etc.), and the target product can also be obtained. This path step is slightly complicated, but the reaction conditions of each step are relatively easy to control, and it can be easily selected according to the actual situation and the difficulty of obtaining raw materials.
To produce 2- (bromomethyl) -1,3-dichlorobenzene, the advantages and disadvantages of each method coexist. The factors such as raw material cost, reaction conditions, and product purity need to be comprehensively considered to choose the optimal path.
One is the halomethylation method. 1,3-dichlorobenzene is used as the starting material, and under the catalysis of Lewis acid (such as anhydrous zinc chloride, etc.), it coreacts with polyformaldehyde and hydrogen bromide. In this process, polyformaldehyde is first hydrolyzed to produce formaldehyde, and formaldehyde and hydrogen bromide are nucleophilically added to obtain bromomethanol, and then electrophilic substitution with 1,3-dichlorobenzene to obtain the target product. This process requires controlling the reaction temperature and the ratio of materials to prevent the formation of polyhalides.
The second is obtained by halogenation of 2-methyl-1,3-dichlorobenzene. Using 2-methyl-1,3-dichlorobenzene as the substrate, select a suitable brominating agent (such as N-bromosuccinimide, or NBS), and in the presence of an initiator (such as benzoyl peroxide, etc.), methyl bromide is reacted by free radical substitution reaction. This reaction condition is mild, with good selectivity, and high purity products can be obtained. However, it is necessary to pay attention to the monitoring of the reaction process, because the reaction activity of free radicals is high, if not properly controlled, it may cause excessive bromination.
Furthermore, 1,3-dichlorobenzene can be chloromethylated with formaldehyde and hydrogen chloride to obtain 2- (chloromethyl) -1,3-dichlorobenzene. After the halogen exchange reaction, chlorine is replaced with bromide with a brominating agent (such as sodium bromide, etc.), and the target product can also be obtained. This path step is slightly complicated, but the reaction conditions of each step are relatively easy to control, and it can be easily selected according to the actual situation and the difficulty of obtaining raw materials.
To produce 2- (bromomethyl) -1,3-dichlorobenzene, the advantages and disadvantages of each method coexist. The factors such as raw material cost, reaction conditions, and product purity need to be comprehensively considered to choose the optimal path.
2- (bromomethyl) -1,3-dichlorobenzene What to pay attention to when storing and transporting
2-%28bromomethyl%29-1%2C3-dichlorobenzene, that is, 2- (bromomethyl) -1,3-dichlorobenzene, this material should be paid more attention to the following matters during storage and transportation:
First, it is related to the storage place. This substance is dangerous and should be stored in a cool, dry and well-ventilated place. Because it is more sensitive to heat, if the ambient temperature is too high, it may cause chemical reactions, or even cause safety risks. Therefore, the warehouse temperature must be properly controlled, generally it should be maintained at room temperature and below 30 ° C. Furthermore, the humidity of the air should not be underestimated. If the humidity is too high, it is easy to make the substance damp, which affects its quality and stability. The relative humidity should be controlled below 65%. In addition, the storage place should be kept away from fire and heat sources, and smoking should be strictly prohibited to prevent serious accidents such as combustion and even explosion caused by open flames.
Second, in terms of storage methods. It needs to be stored separately from oxidizing agents, acids, alkalis and other substances, and must not be mixed. Gein 2 - (bromomethyl) -1,3 - dichlorobenzene may react violently with the above-mentioned substances, resulting in dangerous conditions. At the same time, the storage container must be well sealed to prevent the evaporation and leakage of substances. The container material used should also be carefully selected, and it should have good corrosion resistance. Containers such as glass, specific plastics or metal materials (specially treated to prevent corrosion) can be selected.
Third, when transporting, there are also many key points. Transport vehicles must be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. During transportation, ensure that the container does not leak, collapse, fall, or damage. Driving routes should try to avoid densely populated areas and busy traffic areas in case of accidents that cause major casualties and property losses. Moreover, transport personnel need to be professionally trained, familiar with the characteristics of the substance and emergency treatment methods, and strictly abide by relevant transportation regulations during transportation.
All of these are the key points that 2- (bromomethyl) -1,3-dichlorobenzene must pay attention to when storing and transporting. A little carelessness may lead to unimaginable consequences.
First, it is related to the storage place. This substance is dangerous and should be stored in a cool, dry and well-ventilated place. Because it is more sensitive to heat, if the ambient temperature is too high, it may cause chemical reactions, or even cause safety risks. Therefore, the warehouse temperature must be properly controlled, generally it should be maintained at room temperature and below 30 ° C. Furthermore, the humidity of the air should not be underestimated. If the humidity is too high, it is easy to make the substance damp, which affects its quality and stability. The relative humidity should be controlled below 65%. In addition, the storage place should be kept away from fire and heat sources, and smoking should be strictly prohibited to prevent serious accidents such as combustion and even explosion caused by open flames.
Second, in terms of storage methods. It needs to be stored separately from oxidizing agents, acids, alkalis and other substances, and must not be mixed. Gein 2 - (bromomethyl) -1,3 - dichlorobenzene may react violently with the above-mentioned substances, resulting in dangerous conditions. At the same time, the storage container must be well sealed to prevent the evaporation and leakage of substances. The container material used should also be carefully selected, and it should have good corrosion resistance. Containers such as glass, specific plastics or metal materials (specially treated to prevent corrosion) can be selected.
Third, when transporting, there are also many key points. Transport vehicles must be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. During transportation, ensure that the container does not leak, collapse, fall, or damage. Driving routes should try to avoid densely populated areas and busy traffic areas in case of accidents that cause major casualties and property losses. Moreover, transport personnel need to be professionally trained, familiar with the characteristics of the substance and emergency treatment methods, and strictly abide by relevant transportation regulations during transportation.
All of these are the key points that 2- (bromomethyl) -1,3-dichlorobenzene must pay attention to when storing and transporting. A little carelessness may lead to unimaginable consequences.
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