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2-(Bromomethyl)-1-Chloro-3-Fluorobenzene
Linshang Chemical
|
HS Code |
895195 |
| Chemical Formula | C7H5BrClF |
| Molecular Weight | 225.47 |
| Appearance | Typically a colorless to light - yellow liquid |
| Boiling Point | Data may vary, around 220 - 240°C |
| Density | Approx. 1.6 - 1.8 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Stability | Stable under normal conditions, but reactive to strong bases and reducing agents |
As an accredited 2-(Bromomethyl)-1-Chloro-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2-(bromomethyl)-1-chloro-3-fluorobenzene packaged in a sealed, labeled bottle. |
| Storage | 2-(Bromomethyl)-1-chloro-3-fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, bases, and reactive materials to avoid potential chemical reactions. |
| Shipping | 2-(Bromomethyl)-1 -chloro-3 -fluorobenzene is shipped in well - sealed, corrosion - resistant containers. Strict adherence to hazardous chemical shipping regulations ensures safe transportation, with proper labeling and handling to prevent any spills or incidents. |
Competitive 2-(Bromomethyl)-1-Chloro-3-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 2- (bromomethyl) -1-chloro-3-fluorobenzene
2 - (bromomethyl) -1 -chloro-3 -fluorobenzene, this is an organic compound with unique chemical properties. In its structure, above the benzene ring, bromomethyl, chlorine and fluorine atoms are located in specific positions, and this structural feature has a profound impact on its chemical behavior.
Let's talk about its reactivity first. Due to the high polarity of the carbon-bromine bond in bromomethyl, the activity of this part is significant. Bromine atoms, as a good leaving group, are easily replaced by nucleophiles in nucleophilic substitution reactions. For example, if they meet nucleophiles such as sodium oxide, bromine ions leave, and anion alcohol and oxygen attack the carbon site to form ether compounds. This reaction follows a typical nucleophilic substitution mechanism. Whether the reaction conditions are mild or not depends on the activity of the nucleophilic reagent and the properties of the solvent.
Although the activity of chlorine atoms and fluorine atoms is not as high as that of bromomethyl, it also affects the distribution of molecular electron clouds. Fluorine atoms are extremely electronegative, and have an electron-absorbing induction effect on the benzene ring electron cloud, which reduces the electron cloud density of the benzene ring. This effect decreases the activity of the benzene ring electrophilic substitution reaction, and the position of the substituent entering the benzene ring is restricted by its localization effect. Similarly, chlorine atoms also have an electron-absorbing induction effect, but they are weaker than fluorine atoms. The two halogen atoms work together to change the
2- (bromomethyl) -1-chloro-3-fluorobenzene may also participate in free radical reactions. Under specific conditions, such as light or initiators, the carbon-bromine bonds in bromomethyl are homogenized, generating free radicals, which in turn trigger a series of free radical reactions and participate in the construction of complex organic molecular structures.
In terms of physical properties, due to its halogen-containing atoms, the relative molecular weight is large, and the intermolecular force is enhanced, resulting in a slightly higher boiling point than benzene. At the same time, the electronegativity of halogen atoms is different, so that the molecules have a certain polarity and have a certain solubility in polar solvents.
Let's talk about its reactivity first. Due to the high polarity of the carbon-bromine bond in bromomethyl, the activity of this part is significant. Bromine atoms, as a good leaving group, are easily replaced by nucleophiles in nucleophilic substitution reactions. For example, if they meet nucleophiles such as sodium oxide, bromine ions leave, and anion alcohol and oxygen attack the carbon site to form ether compounds. This reaction follows a typical nucleophilic substitution mechanism. Whether the reaction conditions are mild or not depends on the activity of the nucleophilic reagent and the properties of the solvent.
Although the activity of chlorine atoms and fluorine atoms is not as high as that of bromomethyl, it also affects the distribution of molecular electron clouds. Fluorine atoms are extremely electronegative, and have an electron-absorbing induction effect on the benzene ring electron cloud, which reduces the electron cloud density of the benzene ring. This effect decreases the activity of the benzene ring electrophilic substitution reaction, and the position of the substituent entering the benzene ring is restricted by its localization effect. Similarly, chlorine atoms also have an electron-absorbing induction effect, but they are weaker than fluorine atoms. The two halogen atoms work together to change the
2- (bromomethyl) -1-chloro-3-fluorobenzene may also participate in free radical reactions. Under specific conditions, such as light or initiators, the carbon-bromine bonds in bromomethyl are homogenized, generating free radicals, which in turn trigger a series of free radical reactions and participate in the construction of complex organic molecular structures.
In terms of physical properties, due to its halogen-containing atoms, the relative molecular weight is large, and the intermolecular force is enhanced, resulting in a slightly higher boiling point than benzene. At the same time, the electronegativity of halogen atoms is different, so that the molecules have a certain polarity and have a certain solubility in polar solvents.
What are the main uses of 2- (bromomethyl) -1-chloro-3-fluorobenzene
2 - (bromomethyl) -1 -chloro-3 -fluorobenzene, this substance has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique structure, the halogen atoms can be converted into other functional groups through various chemical reactions, thereby constructing complex organic molecules.
For example, in the nucleophilic substitution reaction, the bromine atom of bromomethyl is quite active and is easily attacked by nucleophilic reagents, such as alcohols and amines, which can react with it to generate ethers and amine derivatives. This is a common strategy for creating new drug molecules in pharmaceutical chemistry. In the field of materials science, this can be used as a raw material for polymerization, etc., or can prepare polymer materials with special properties, such as polymers containing fluorochlorine, or have excellent weather resistance and chemical stability, and may have outstanding performance in coatings, plastics and other industries.
In addition, in the field of pesticide chemistry, it also has important uses. After introducing specific functional group modification, it may be able to develop high-efficiency, low-toxicity and unique mechanism of action pesticide products. Because it contains halogen atoms, or gives compounds a certain biological activity, it shows inhibitory or killing effects on pests, bacteria, etc.
For example, in the nucleophilic substitution reaction, the bromine atom of bromomethyl is quite active and is easily attacked by nucleophilic reagents, such as alcohols and amines, which can react with it to generate ethers and amine derivatives. This is a common strategy for creating new drug molecules in pharmaceutical chemistry. In the field of materials science, this can be used as a raw material for polymerization, etc., or can prepare polymer materials with special properties, such as polymers containing fluorochlorine, or have excellent weather resistance and chemical stability, and may have outstanding performance in coatings, plastics and other industries.
In addition, in the field of pesticide chemistry, it also has important uses. After introducing specific functional group modification, it may be able to develop high-efficiency, low-toxicity and unique mechanism of action pesticide products. Because it contains halogen atoms, or gives compounds a certain biological activity, it shows inhibitory or killing effects on pests, bacteria, etc.
What is the synthesis method of 2- (bromomethyl) -1-chloro-3-fluorobenzene
To prepare 2 - (bromomethyl) -1 - chloro - 3 - fluorobenzene, the following method can be used.
First take 1 - chloro - 3 - fluorobenzene as the starting material. First blend it with polyformaldehyde, concentrated hydrochloric acid and zinc salts (such as zinc chloride) to achieve the purpose of chloromethylation. This step needs to be carried out at an appropriate temperature and time, so that chloromethyl is introduced into the benzene ring of 1 - chloro - 3 - fluoro - 2 - (chloromethyl) benzene.
Then, take 1-chloro-3-fluoro-2- (chloromethyl) benzene and place it in an organic solvent (such as acetonitrile) with sodium bromide and a phase transfer catalyst (such as tetrabutylammonium bromide). When heated to a suitable temperature, the chlorine atom on the chloromethyl group is replaced by the bromine atom. This reaction uses the principle of halogen atom exchange to obtain 2- (bromomethyl) -1-chloro-3-fluorobenzene.
During the reaction process, the proportion of starting materials, reaction temperature, reaction time and catalyst dosage are all key factors and need to be carefully controlled. After each step of the reaction, the product should be purified by distillation, extraction, column chromatography, etc. to ensure the purity, and then increase the yield of the target product 2- (bromomethyl) -1-chloro-3-fluorobenzene.
First take 1 - chloro - 3 - fluorobenzene as the starting material. First blend it with polyformaldehyde, concentrated hydrochloric acid and zinc salts (such as zinc chloride) to achieve the purpose of chloromethylation. This step needs to be carried out at an appropriate temperature and time, so that chloromethyl is introduced into the benzene ring of 1 - chloro - 3 - fluoro - 2 - (chloromethyl) benzene.
Then, take 1-chloro-3-fluoro-2- (chloromethyl) benzene and place it in an organic solvent (such as acetonitrile) with sodium bromide and a phase transfer catalyst (such as tetrabutylammonium bromide). When heated to a suitable temperature, the chlorine atom on the chloromethyl group is replaced by the bromine atom. This reaction uses the principle of halogen atom exchange to obtain 2- (bromomethyl) -1-chloro-3-fluorobenzene.
During the reaction process, the proportion of starting materials, reaction temperature, reaction time and catalyst dosage are all key factors and need to be carefully controlled. After each step of the reaction, the product should be purified by distillation, extraction, column chromatography, etc. to ensure the purity, and then increase the yield of the target product 2- (bromomethyl) -1-chloro-3-fluorobenzene.
2- (bromomethyl) -1-chloro-3-fluorobenzene during storage and transportation
2-%28bromomethyl%29-1-chloro-3-fluorobenzene is 2- (bromomethyl) -1 -chloro-3 -fluorobenzene. This substance is an important raw material for organic synthesis. However, it has certain toxicity and danger. When storing and transporting, special attention should be paid to the following things:
First, the storage environment should be cool and dry. Because this substance is sensitive to heat, high temperature can easily cause it to chemically react or even decompose. If it is placed in a humid place or reacts with water, it will deteriorate, affecting the quality and use effect. Therefore, it should be stored in a well-ventilated and cool warehouse, away from fire and heat sources.
Second, it must be sealed and stored. 2 - (bromomethyl) -1 -chloro-3 -fluorobenzene is volatile and may react with oxygen, moisture and other components in the air. Sealed storage can effectively avoid volatilization losses, and can also prevent reactions with air components to maintain their chemical stability. After taking it, the container should be sealed in time to prevent leakage.
Third, the packaging must be intact during transportation. Packaging materials should have good compression resistance, collision resistance and leak resistance to avoid package damage due to bumps and collisions, causing leakage. Once leakage occurs, it will not only cause material loss, but also may pose a threat to the environment and personal safety.
Fourth, it should be stored and transported separately from oxidants, strong alkalis and other substances. 2 - (bromomethyl) -1 -chloro-3 -fluorobenzene is active in nature, comes into contact with oxidants, or triggers violent oxidation reactions; encounters with strong alkalis, or chemical reactions occur, which may lead to dangerous situations, such as combustion, explosion, etc.
Fifth, storage and transportation sites should be equipped with corresponding emergency treatment equipment and protective equipment. Such as fire extinguishers, adsorption materials, protective gloves, goggles, etc. In the event of leakage or other accidents, effective measures can be taken in time to reduce losses and hazards. At the same time, relevant personnel should be familiar with emergency treatment methods to deal with emergencies.
First, the storage environment should be cool and dry. Because this substance is sensitive to heat, high temperature can easily cause it to chemically react or even decompose. If it is placed in a humid place or reacts with water, it will deteriorate, affecting the quality and use effect. Therefore, it should be stored in a well-ventilated and cool warehouse, away from fire and heat sources.
Second, it must be sealed and stored. 2 - (bromomethyl) -1 -chloro-3 -fluorobenzene is volatile and may react with oxygen, moisture and other components in the air. Sealed storage can effectively avoid volatilization losses, and can also prevent reactions with air components to maintain their chemical stability. After taking it, the container should be sealed in time to prevent leakage.
Third, the packaging must be intact during transportation. Packaging materials should have good compression resistance, collision resistance and leak resistance to avoid package damage due to bumps and collisions, causing leakage. Once leakage occurs, it will not only cause material loss, but also may pose a threat to the environment and personal safety.
Fourth, it should be stored and transported separately from oxidants, strong alkalis and other substances. 2 - (bromomethyl) -1 -chloro-3 -fluorobenzene is active in nature, comes into contact with oxidants, or triggers violent oxidation reactions; encounters with strong alkalis, or chemical reactions occur, which may lead to dangerous situations, such as combustion, explosion, etc.
Fifth, storage and transportation sites should be equipped with corresponding emergency treatment equipment and protective equipment. Such as fire extinguishers, adsorption materials, protective gloves, goggles, etc. In the event of leakage or other accidents, effective measures can be taken in time to reduce losses and hazards. At the same time, relevant personnel should be familiar with emergency treatment methods to deal with emergencies.
What are the effects of 2- (bromomethyl) -1-chloro-3-fluorobenzene on the environment and human health?
2-%28bromomethyl%29-1-chloro-3-fluorobenzene, this is an organic compound, which does have an impact on the environment and human health.
At the environmental level, if it is released into the environment, it has the characteristics of halogenated aromatics, and its chemical properties are relatively stable, making it difficult to degrade rapidly in the natural environment. It may accumulate in environmental media such as soil and water, affecting the structure and function of soil microbial communities, thereby interfering with the material cycle and energy flow of soil ecosystems. In water, it may pose a hazard to aquatic organisms, such as inhibiting algae growth, affecting the physiological functions of aquatic animals such as fish, and destroying the balance of aquatic ecosystems. In addition, it can enter the atmosphere through volatilization and participate in atmospheric photochemical reactions, causing adverse effects on atmospheric environmental quality.
It is related to human health. If the substance enters the human body through respiratory tract, skin contact or accidental ingestion, bromine, chlorine, fluorine and other halogen atoms may cause damage to human organs and cells. It may have certain neurotoxicity, interfere with the normal function of the nervous system, and cause symptoms such as headache, dizziness, and fatigue. Long-term exposure may also cause damage to important organs such as the liver and kidneys, affecting their metabolism and detoxification functions. And some halogenated aromatic hydrocarbons have potential carcinogenicity, long-term exposure to them may increase the risk of cancer. In addition, they have certain irritation. Contact with skin and mucous membranes can cause skin redness, itching, and damage to respiratory mucosa, causing symptoms such as cough and breathing difficulties.
At the environmental level, if it is released into the environment, it has the characteristics of halogenated aromatics, and its chemical properties are relatively stable, making it difficult to degrade rapidly in the natural environment. It may accumulate in environmental media such as soil and water, affecting the structure and function of soil microbial communities, thereby interfering with the material cycle and energy flow of soil ecosystems. In water, it may pose a hazard to aquatic organisms, such as inhibiting algae growth, affecting the physiological functions of aquatic animals such as fish, and destroying the balance of aquatic ecosystems. In addition, it can enter the atmosphere through volatilization and participate in atmospheric photochemical reactions, causing adverse effects on atmospheric environmental quality.
It is related to human health. If the substance enters the human body through respiratory tract, skin contact or accidental ingestion, bromine, chlorine, fluorine and other halogen atoms may cause damage to human organs and cells. It may have certain neurotoxicity, interfere with the normal function of the nervous system, and cause symptoms such as headache, dizziness, and fatigue. Long-term exposure may also cause damage to important organs such as the liver and kidneys, affecting their metabolism and detoxification functions. And some halogenated aromatic hydrocarbons have potential carcinogenicity, long-term exposure to them may increase the risk of cancer. In addition, they have certain irritation. Contact with skin and mucous membranes can cause skin redness, itching, and damage to respiratory mucosa, causing symptoms such as cough and breathing difficulties.
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