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2-(Bromomethyl)-1-Chloro-3-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
587064 |
| Chemical Formula | C8H5BrClF3 |
| Molar Mass | 287.48 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approximately 210 - 215 °C |
| Density | Around 1.7 - 1.8 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Odor | Pungent, characteristic aromatic odor |
As an accredited 2-(Bromomethyl)-1-Chloro-3-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2-(bromomethyl)-1 -chloro-3-(trifluoromethyl)benzene in a sealed glass bottle. |
| Storage | 2-(Bromomethyl)-1-chloro-3-(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, bases, and other reactive chemicals to avoid potential reactions. |
| Shipping | 2-(Bromomethyl)-1-chloro-3-(trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper handling during transit to prevent leaks and ensure safety. |
Competitive 2-(Bromomethyl)-1-Chloro-3-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 2- (bromomethyl) -1-chloro-3- (trifluoromethyl) benzene?
2-%28bromomethyl%29-1-chloro-3-%28trifluoromethyl%29benzene is 2- (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene, which has a wide range of uses and is described here.
In the field of pharmaceutical chemistry, it is often the key intermediate for the synthesis of drugs. Because of the characteristics of halogen atoms and trifluoromethyl atoms in its structure, it can endow the synthesized drugs with special physicochemical properties and biological activities. For example, trifluoromethyl can improve the lipophilicity of drugs and enhance their ability to cross biofilms to facilitate drug absorption and distribution; bromomethyl and chlorine atoms can participate in various chemical reactions, helping to construct complex drug molecular structures, providing the possibility for the development of new specific drugs.
In the field of materials science, it can be used to prepare polymer materials with special functions. Using it as a raw material, by means of polymerization and other means, unique structures can be introduced into the polymer chain, giving the material excellent properties such as chemical resistance and thermal stability. For example, in some situations where it is necessary to resist harsh chemical environments, polymer materials containing such structures can exhibit excellent properties and prolong the service life of the material.
In the field of organic synthetic chemistry, 2 - (bromomethyl) -1 - chloro - 3 - (trifluoromethyl) benzene is an extremely important synthetic building block. The active chemical properties of methyl bromide and chlorine atoms can trigger many reactions such as nucleophilic substitution and coupling, providing an effective path for the construction of complex organic molecular structures. Organic chemists can create organic compounds with diverse structures, enrich the types of organic compounds, and promote the development of organic synthetic chemistry.
In the field of pharmaceutical chemistry, it is often the key intermediate for the synthesis of drugs. Because of the characteristics of halogen atoms and trifluoromethyl atoms in its structure, it can endow the synthesized drugs with special physicochemical properties and biological activities. For example, trifluoromethyl can improve the lipophilicity of drugs and enhance their ability to cross biofilms to facilitate drug absorption and distribution; bromomethyl and chlorine atoms can participate in various chemical reactions, helping to construct complex drug molecular structures, providing the possibility for the development of new specific drugs.
In the field of materials science, it can be used to prepare polymer materials with special functions. Using it as a raw material, by means of polymerization and other means, unique structures can be introduced into the polymer chain, giving the material excellent properties such as chemical resistance and thermal stability. For example, in some situations where it is necessary to resist harsh chemical environments, polymer materials containing such structures can exhibit excellent properties and prolong the service life of the material.
In the field of organic synthetic chemistry, 2 - (bromomethyl) -1 - chloro - 3 - (trifluoromethyl) benzene is an extremely important synthetic building block. The active chemical properties of methyl bromide and chlorine atoms can trigger many reactions such as nucleophilic substitution and coupling, providing an effective path for the construction of complex organic molecular structures. Organic chemists can create organic compounds with diverse structures, enrich the types of organic compounds, and promote the development of organic synthetic chemistry.
What are the synthesis methods of 2- (bromomethyl) -1-chloro-3- (trifluoromethyl) benzene
The preparation of 2 - (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene can be achieved by various paths.
First, 1-chloro-3- (trifluoromethyl) benzene is used as the starting material. First, N-bromosuccinimide (NBS) is used as the bromination reagent, azobisisobutyronitrile (AIBN) is used as the initiator, and it is reacted in an inert solvent such as carbon tetrachloride under heating or light conditions. In this process, NBS provides bromomethyl radicals to attack α-hydrogen of methyl groups on the benzene ring. After the radical substitution reaction, the target product 2 - (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene The advantage of this path is that the reaction conditions are mild and the selectivity is good. NBS can accurately bromide α-hydrogen, and there are relatively few side reactions.
Second, the corresponding alcohol is used as the precursor. First prepare 2- (hydroxymethyl) -1 -chloro-3- (trifluoromethyl) benzene, and then react with halogenated reagents such as hydrobromic acid or phosphorus tribromide. For example, when reacting with hydrobromic acid, the hydroxyl group of the alcohol is replaced by a bromine atom to form the target product. If phosphorus tribromide is used, it reacts with alcohol to form an intermediate. After rearrangement and other processes, the final product is obtained. In this path, the source of the alcohol can be obtained by the reduction of the corresponding aldehyde, and the raw materials are relatively easy to obtain, but it involves a multi-step reaction, and attention should be paid to the control of the reaction conditions of each step and the separation and purification of the intermediate.
Third, the Grignard reagent method is used. The Grignard reagent containing the corresponding group is first prepared, and then reacts with a suitable halogenated hydrocarbon. However, this method requires strict anhydrous and anaerobic conditions, high operation requirements, and the Grignard reagent has high activity and is prone to side reactions. Therefore, the reaction conditions need to be carefully controlled to ensure that the reaction proceeds in the direction of generating the target product.
In short, when synthesizing 2- (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene, it is necessary to consider the actual situation, such as the availability of raw materials, reaction equipment conditions, product purity requirements, etc., and choose the appropriate synthesis method.
First, 1-chloro-3- (trifluoromethyl) benzene is used as the starting material. First, N-bromosuccinimide (NBS) is used as the bromination reagent, azobisisobutyronitrile (AIBN) is used as the initiator, and it is reacted in an inert solvent such as carbon tetrachloride under heating or light conditions. In this process, NBS provides bromomethyl radicals to attack α-hydrogen of methyl groups on the benzene ring. After the radical substitution reaction, the target product 2 - (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene The advantage of this path is that the reaction conditions are mild and the selectivity is good. NBS can accurately bromide α-hydrogen, and there are relatively few side reactions.
Second, the corresponding alcohol is used as the precursor. First prepare 2- (hydroxymethyl) -1 -chloro-3- (trifluoromethyl) benzene, and then react with halogenated reagents such as hydrobromic acid or phosphorus tribromide. For example, when reacting with hydrobromic acid, the hydroxyl group of the alcohol is replaced by a bromine atom to form the target product. If phosphorus tribromide is used, it reacts with alcohol to form an intermediate. After rearrangement and other processes, the final product is obtained. In this path, the source of the alcohol can be obtained by the reduction of the corresponding aldehyde, and the raw materials are relatively easy to obtain, but it involves a multi-step reaction, and attention should be paid to the control of the reaction conditions of each step and the separation and purification of the intermediate.
Third, the Grignard reagent method is used. The Grignard reagent containing the corresponding group is first prepared, and then reacts with a suitable halogenated hydrocarbon. However, this method requires strict anhydrous and anaerobic conditions, high operation requirements, and the Grignard reagent has high activity and is prone to side reactions. Therefore, the reaction conditions need to be carefully controlled to ensure that the reaction proceeds in the direction of generating the target product.
In short, when synthesizing 2- (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene, it is necessary to consider the actual situation, such as the availability of raw materials, reaction equipment conditions, product purity requirements, etc., and choose the appropriate synthesis method.
What are the physical properties of 2- (bromomethyl) -1-chloro-3- (trifluoromethyl) benzene
2-%28bromomethyl%29-1-chloro-3-%28trifluoromethyl%29benzene is 2- (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene. This compound is an organic compound with unique physical properties.
Looking at its properties, it may be in a liquid state at room temperature, due to its molecular structure and interaction force. Organic halides are mostly in a liquid state. This compound contains halogen atoms such as bromine, chlorine, and fluorine, which affect the intermolecular force and then the state of matter.
Discuss the boiling point, or within a certain range. Due to the large electronegativity of halogen atoms in the molecule, there is a strong dipole-dipole force between the molecules. Compared with hydrocarbons without such atoms, the boiling point is higher. However, the exact value needs to be accurately determined experimentally. Due to the complex structure and interaction of molecules, it is difficult to accurately deduce theoretically.
Its density may be greater than that of water. The relative atomic weight of halogen atoms is large, resulting in an increase in molecular weight, and the molecular structure is tight. The spatial arrangement increases the mass per unit volume, so the density is greater than that of water. It may have applications in chemical separation operations.
In terms of solubility, because it is an organic compound, it has a certain hydrophobicity and has a small solubility in water. However, it can be soluble in some organic solvents, such as halogenated hydrocarbon solvents such as dichloromethane and chloroform, or it can be soluble in aromatic hydrocarbon solvents such as benzene and toluene. Due to the principle of "similar miscibility", the molecular structure is similar to the polarity.
< br Although the intermolecular force is enhanced due to the presence of halogen atoms, and the volatility is inferior to that of ordinary hydrocarbons, some molecules will still escape to the gas phase under suitable temperatures and environments.
2- (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene The physical properties of benzene are comprehensively affected by factors such as halogen atoms and benzene rings in the molecular structure, and its applications in organic synthesis, chemical production and other fields are closely related to its physical properties.
Looking at its properties, it may be in a liquid state at room temperature, due to its molecular structure and interaction force. Organic halides are mostly in a liquid state. This compound contains halogen atoms such as bromine, chlorine, and fluorine, which affect the intermolecular force and then the state of matter.
Discuss the boiling point, or within a certain range. Due to the large electronegativity of halogen atoms in the molecule, there is a strong dipole-dipole force between the molecules. Compared with hydrocarbons without such atoms, the boiling point is higher. However, the exact value needs to be accurately determined experimentally. Due to the complex structure and interaction of molecules, it is difficult to accurately deduce theoretically.
Its density may be greater than that of water. The relative atomic weight of halogen atoms is large, resulting in an increase in molecular weight, and the molecular structure is tight. The spatial arrangement increases the mass per unit volume, so the density is greater than that of water. It may have applications in chemical separation operations.
In terms of solubility, because it is an organic compound, it has a certain hydrophobicity and has a small solubility in water. However, it can be soluble in some organic solvents, such as halogenated hydrocarbon solvents such as dichloromethane and chloroform, or it can be soluble in aromatic hydrocarbon solvents such as benzene and toluene. Due to the principle of "similar miscibility", the molecular structure is similar to the polarity.
< br Although the intermolecular force is enhanced due to the presence of halogen atoms, and the volatility is inferior to that of ordinary hydrocarbons, some molecules will still escape to the gas phase under suitable temperatures and environments.
2- (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene The physical properties of benzene are comprehensively affected by factors such as halogen atoms and benzene rings in the molecular structure, and its applications in organic synthesis, chemical production and other fields are closely related to its physical properties.
What are the chemical properties of 2- (bromomethyl) -1-chloro-3- (trifluoromethyl) benzene
2 - (bromomethyl) -1 - chloro - 3- (trifluoromethyl) benzene, an organic compound. It has the properties of halogenated hydrocarbons, because it contains bromomethyl, chlorine atoms and trifluoromethyl functional groups, so it has unique chemical properties.
Its bromomethyl is active and can be involved in nucleophilic substitution reactions. In case of nucleophilic reagents, bromine ions are easy to leave, and nucleophilic reagents replace them. React with sodium alcohol, or ether compounds; react with sodium cyanide, the cyanyl group replaces bromomethyl to obtain a product containing cyanide groups, which can be hydrolyzed into carboxylic acids or reduced to amines, and has a wide range of uses.
Although the activity of chlorine atom is inferior to that of bromomethyl, it can also participate in specific reactions. Under suitable conditions, or replaced by other groups, it can be used as an intermediate for the construction of complex molecules.
Trifluoromethyl has strong electron absorption, which can affect the electron cloud density of benzene ring, reduce the electron cloud density of benzene ring ortho and para-site, and change the activity of electrophilic substitution reaction. Usually, electrophilic reagents are more likely to attack the intermediate sites. And the existence of trifluoromethyl can increase the lipid solubility of molecules, which has an impact on the physical properties of compounds such as boiling point, melting point, solubility, etc.
This compound is rich in chemical properties due to the interaction of functional groups. It is an important raw material in the field of organic synthesis and can be used to produce a variety of fine chemicals such as
Its bromomethyl is active and can be involved in nucleophilic substitution reactions. In case of nucleophilic reagents, bromine ions are easy to leave, and nucleophilic reagents replace them. React with sodium alcohol, or ether compounds; react with sodium cyanide, the cyanyl group replaces bromomethyl to obtain a product containing cyanide groups, which can be hydrolyzed into carboxylic acids or reduced to amines, and has a wide range of uses.
Although the activity of chlorine atom is inferior to that of bromomethyl, it can also participate in specific reactions. Under suitable conditions, or replaced by other groups, it can be used as an intermediate for the construction of complex molecules.
Trifluoromethyl has strong electron absorption, which can affect the electron cloud density of benzene ring, reduce the electron cloud density of benzene ring ortho and para-site, and change the activity of electrophilic substitution reaction. Usually, electrophilic reagents are more likely to attack the intermediate sites. And the existence of trifluoromethyl can increase the lipid solubility of molecules, which has an impact on the physical properties of compounds such as boiling point, melting point, solubility, etc.
This compound is rich in chemical properties due to the interaction of functional groups. It is an important raw material in the field of organic synthesis and can be used to produce a variety of fine chemicals such as
2- (bromomethyl) -1-chloro-3- (trifluoromethyl) benzene during storage and transportation
2-%28bromomethyl%29-1-chloro-3-%28trifluoromethyl%29benzene are organic compounds, and many things need to be paid attention to when storing and transporting.
The first thing to pay attention to is its chemical properties. This compound contains bromomethyl, chlorine atoms and trifluoromethyl, and has high chemical activity. When storing, be sure to keep away from fire sources, heat sources and strong oxidants, as it may cause violent reactions and even lead to the risk of combustion or explosion.
Second, the storage environment is very critical. It should be placed in a cool, dry and well-ventilated place. Humidity and temperature have a great impact on its stability. High temperature and humidity may cause the compound to deteriorate. The temperature should be controlled within a specific range to prevent it from evaporating or decomposing.
Furthermore, the packaging cannot be ignored. Packaging materials with good sealing performance should be used to prevent leakage. During transportation, ensure that the packaging is intact and free from vibration and collision, so as to avoid compound leakage due to package rupture.
Fourth, in view of the toxicity and irritation of this compound, storage and transportation sites should be equipped with corresponding protective facilities and emergency treatment equipment. Staff need to wear protective clothing, protective gloves and goggles to ensure safety. In the event of leakage, emergency measures should be taken quickly, evacuate personnel, seal the site, and select appropriate methods for cleaning according to the characteristics of the compound.
In addition, relevant regulations and standards must be strictly followed. Whether it is storage or transportation, it should comply with national and local safety regulations, and handle necessary permits and procedures to ensure legal compliance throughout the process. Only in this way can we effectively avoid risks and ensure the safety of personnel and the environment from damage.
The first thing to pay attention to is its chemical properties. This compound contains bromomethyl, chlorine atoms and trifluoromethyl, and has high chemical activity. When storing, be sure to keep away from fire sources, heat sources and strong oxidants, as it may cause violent reactions and even lead to the risk of combustion or explosion.
Second, the storage environment is very critical. It should be placed in a cool, dry and well-ventilated place. Humidity and temperature have a great impact on its stability. High temperature and humidity may cause the compound to deteriorate. The temperature should be controlled within a specific range to prevent it from evaporating or decomposing.
Furthermore, the packaging cannot be ignored. Packaging materials with good sealing performance should be used to prevent leakage. During transportation, ensure that the packaging is intact and free from vibration and collision, so as to avoid compound leakage due to package rupture.
Fourth, in view of the toxicity and irritation of this compound, storage and transportation sites should be equipped with corresponding protective facilities and emergency treatment equipment. Staff need to wear protective clothing, protective gloves and goggles to ensure safety. In the event of leakage, emergency measures should be taken quickly, evacuate personnel, seal the site, and select appropriate methods for cleaning according to the characteristics of the compound.
In addition, relevant regulations and standards must be strictly followed. Whether it is storage or transportation, it should comply with national and local safety regulations, and handle necessary permits and procedures to ensure legal compliance throughout the process. Only in this way can we effectively avoid risks and ensure the safety of personnel and the environment from damage.
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