Linshang Chemical
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2-(Bromomethyl)-1-Chloro-4-Fluorobenzene
Linshang Chemical
|
HS Code |
446075 |
| Chemical Formula | C7H5BrClF |
| Molar Mass | 225.47 g/mol |
| Appearance | Solid (predicted) |
| Boiling Point | 229.7 - 230.7 °C at 760 mmHg (predicted) |
| Density | 1.675 g/cm³ (predicted) |
| Solubility In Water | Insoluble (predicted) |
| Vapor Pressure | 0.03 mmHg at 25 °C (predicted) |
| Flash Point | 92.7 °C (predicted) |
| Logp | 3.59 (predicted) |
As an accredited 2-(Bromomethyl)-1-Chloro-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2-(bromomethyl)-1 -chloro-4 -fluorobenzene in a sealed, labeled chemical bottle. |
| Storage | Store 2-(bromomethyl)-1 -chloro-4 -fluorobenzene in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly closed container, preferably made of a material resistant to chemical corrosion. It should be segregated from oxidizing agents, strong acids, and bases to prevent potential reactions. |
| Shipping | 2-(Bromomethyl)-1-chloro-4-fluorobenzene is shipped in well - sealed, corrosion - resistant containers. Shipment adheres to strict chemical transport regulations, ensuring proper handling to prevent spills and maintain safety during transit. |
Competitive 2-(Bromomethyl)-1-Chloro-4-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-(Bromomethyl)-1-Chloro-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 2- (bromomethyl) -1-chloro-4-fluorobenzene?
2-%28bromomethyl%29-1-chloro-4-fluorobenzene, the Chinese name is 2 - (bromomethyl) -1 -chloro-4 -fluorobenzene. The physical properties of this substance are generally as follows.
Its external appearance is often liquid, because of its molecular and atomic forces. Its boiling is specific because of the attractive force of the molecule, including the van der force, etc., which determines the energy required for the liquid phase to be transformed into the liquid phase. As for the melting, it is also affected by the density of the molecular arrangement and the weak interaction.
The density of 2 - (bromomethyl) -1 -chloro-4 -fluorobenzene is determined by its molecular weight and molecular voids. In its molecules, bromine, chlorine, fluorine and other atoms have a large atomic weight, so the density of the whole compound is different.
In terms of solubility, this compound often has a certain solubility in soluble solutions, such as alcohols and ethers. This is due to the principle of similarity solubility. Its molecules are similar in solubility, and can form molecular forces, such as Vander force, etc., to make them soluble in them. However, the solubility in water is very small. Due to the poor properties of water molecules and the weak properties of compounds, the two forces can overcome the strong water molecules, so they are not easily soluble in water.
In addition, its solubility is also worth mentioning. Due to the non-molecular force, it has a certain degree of stability. Under normal conditions, it can be slowly transferred to the air. Its odor may be special, but the interaction between human olfactory receptors is significant, and due to the special molecular conditions, the odor is described in terms of. Therefore, the physical properties of 2- (bromomethyl) -1 -chloro-4 -fluorobenzene are determined by factors such as its molecular properties, atomic properties, and molecular force.
Its external appearance is often liquid, because of its molecular and atomic forces. Its boiling is specific because of the attractive force of the molecule, including the van der force, etc., which determines the energy required for the liquid phase to be transformed into the liquid phase. As for the melting, it is also affected by the density of the molecular arrangement and the weak interaction.
The density of 2 - (bromomethyl) -1 -chloro-4 -fluorobenzene is determined by its molecular weight and molecular voids. In its molecules, bromine, chlorine, fluorine and other atoms have a large atomic weight, so the density of the whole compound is different.
In terms of solubility, this compound often has a certain solubility in soluble solutions, such as alcohols and ethers. This is due to the principle of similarity solubility. Its molecules are similar in solubility, and can form molecular forces, such as Vander force, etc., to make them soluble in them. However, the solubility in water is very small. Due to the poor properties of water molecules and the weak properties of compounds, the two forces can overcome the strong water molecules, so they are not easily soluble in water.
In addition, its solubility is also worth mentioning. Due to the non-molecular force, it has a certain degree of stability. Under normal conditions, it can be slowly transferred to the air. Its odor may be special, but the interaction between human olfactory receptors is significant, and due to the special molecular conditions, the odor is described in terms of. Therefore, the physical properties of 2- (bromomethyl) -1 -chloro-4 -fluorobenzene are determined by factors such as its molecular properties, atomic properties, and molecular force.
What are the synthesis methods of 2- (bromomethyl) -1-chloro-4-fluorobenzene
2-%28bromomethyl%29-1-chloro-4-fluorobenzene is 2 - (bromomethyl) -1 - chloro - 4 - fluorobenzene, and the common synthesis methods are as follows.
First, it can be prepared by bromination of the corresponding halotoluene derivative. 1 - chloro - 4 - fluorotoluene is used as the starting material and reacts with N - bromosuccinimide (NBS) in an inert solvent in the presence of an initiator such as benzoyl peroxide. This reaction needs to be carried out under heat or light conditions. The bromine atom in the NBS selectively replaces the hydrogen atom at the benzyl position, resulting in the formation of the target product 2 - (bromomethyl) -1 - chloro - 4 - fluorobenzene. The reaction temperature, the amount of NBS and the reaction time need to be strictly controlled during the reaction. Excessive temperature or excess NBS may lead to the formation of polybromination by-products.
Second, with 2-methyl-1-chloro-4-fluorobenzene as the raw material, the methyl group is first functionalized. For example, under light or heating conditions, chlorine gas is used to chlorinate the methyl group to generate 2- (chloromethyl) -1-chloro-4-fluorobenzene, and then the chlorine atom is replaced with a bromine atom through a halogen exchange reaction. Bromine sources such as sodium bromide can be selected, and the reaction is carried out in the presence of suitable solvents and catalysts. This method has relatively many steps, but the reaction conditions of each step are relatively mild and easy to control.
Third, from the perspective of benzene ring construction, it is synthesized by multi-step reaction. First, the benzene ring structure containing chlorine and fluorine substituents is constructed, and then bromomethyl is introduced. For example, through aromatic electrophilic substitution reaction, chlorine atoms and fluorine atoms are introduced sequentially on a suitable substrate to form a benzene ring with a specific substitution mode. After that, the introduction of bromomethyl is achieved by reacting with a suitable bromomethylation reagent. Although this method has a long route, it can flexibly design the reaction steps to meet different synthesis needs. In practice, the synthesis method should be reasonably selected according to the availability of raw materials, cost, reaction yield and selectivity.
First, it can be prepared by bromination of the corresponding halotoluene derivative. 1 - chloro - 4 - fluorotoluene is used as the starting material and reacts with N - bromosuccinimide (NBS) in an inert solvent in the presence of an initiator such as benzoyl peroxide. This reaction needs to be carried out under heat or light conditions. The bromine atom in the NBS selectively replaces the hydrogen atom at the benzyl position, resulting in the formation of the target product 2 - (bromomethyl) -1 - chloro - 4 - fluorobenzene. The reaction temperature, the amount of NBS and the reaction time need to be strictly controlled during the reaction. Excessive temperature or excess NBS may lead to the formation of polybromination by-products.
Second, with 2-methyl-1-chloro-4-fluorobenzene as the raw material, the methyl group is first functionalized. For example, under light or heating conditions, chlorine gas is used to chlorinate the methyl group to generate 2- (chloromethyl) -1-chloro-4-fluorobenzene, and then the chlorine atom is replaced with a bromine atom through a halogen exchange reaction. Bromine sources such as sodium bromide can be selected, and the reaction is carried out in the presence of suitable solvents and catalysts. This method has relatively many steps, but the reaction conditions of each step are relatively mild and easy to control.
Third, from the perspective of benzene ring construction, it is synthesized by multi-step reaction. First, the benzene ring structure containing chlorine and fluorine substituents is constructed, and then bromomethyl is introduced. For example, through aromatic electrophilic substitution reaction, chlorine atoms and fluorine atoms are introduced sequentially on a suitable substrate to form a benzene ring with a specific substitution mode. After that, the introduction of bromomethyl is achieved by reacting with a suitable bromomethylation reagent. Although this method has a long route, it can flexibly design the reaction steps to meet different synthesis needs. In practice, the synthesis method should be reasonably selected according to the availability of raw materials, cost, reaction yield and selectivity.
What are the main uses of 2- (bromomethyl) -1-chloro-4-fluorobenzene?
2-%28bromomethyl%29-1-chloro-4-fluorobenzene, the Chinese name is 2 - (bromomethyl) -1 -chloro-4 -fluorobenzene, which is a chemical compound. Its main use is extensive, and it is often used in the field of chemical synthesis.
One, it can be used as a medium to build more chemical molecules. Due to the existence of bromomethyl, chlorine atoms and fluorine atoms, it has a high degree of reactivity. Bromomethyl can be substituted by a nuclear reactor, such as alcohols and amines. For example, the reactive alcohol can form ether compounds; the reactive amine can generate amine substitutions, which is very important in the synthesis of chemical compounds and materials.
Second, it is also valuable in the synthesis of chemical compounds. Because it contains chemical atoms, it can increase the biological activity of compounds. By introducing specific functional properties from reasonable molecules and using them as the basis, it is expected to develop high-efficiency, low-toxicity and environment-friendly chemical products, which can be used to prevent and control diseases and ensure the harvest of crops.
Third, in the field of materials science, it can be used as the starting material for the synthesis of functional materials. By means of chemical reactions, it can be used for the production of high-performance plastics, materials and other materials, such as high-performance plastics and materials, to meet the needs of different work and life.
One, it can be used as a medium to build more chemical molecules. Due to the existence of bromomethyl, chlorine atoms and fluorine atoms, it has a high degree of reactivity. Bromomethyl can be substituted by a nuclear reactor, such as alcohols and amines. For example, the reactive alcohol can form ether compounds; the reactive amine can generate amine substitutions, which is very important in the synthesis of chemical compounds and materials.
Second, it is also valuable in the synthesis of chemical compounds. Because it contains chemical atoms, it can increase the biological activity of compounds. By introducing specific functional properties from reasonable molecules and using them as the basis, it is expected to develop high-efficiency, low-toxicity and environment-friendly chemical products, which can be used to prevent and control diseases and ensure the harvest of crops.
Third, in the field of materials science, it can be used as the starting material for the synthesis of functional materials. By means of chemical reactions, it can be used for the production of high-performance plastics, materials and other materials, such as high-performance plastics and materials, to meet the needs of different work and life.
2- (bromomethyl) -1-chloro-4-fluorobenzene what are the precautions in storage and transportation
2-%28bromomethyl%29-1-chloro-4-fluorobenzene, the Chinese name of 2 - (bromomethyl) -1 - chloro - 4 - fluorobenzene, this is a chemical compound, in the absence of storage, pay attention to the following general things:
The first heavy storage environment. It must be dry, cool and well-connected, and must not be near fire or gas sources to prevent ignition. Because of its flammability, in case of open flame, high temperature or ignition. It is appropriate to isolate oxidation, this compound is oxidized to meet, or cause strong reaction, resulting in dangerous conditions.
Packaging should not be ignored. Use appropriate packaging materials, such as sealed glass bottles, plastic barrels, etc., to ensure its tightness and prevent leakage. If the package is damaged, it will not be damaged outside, and it will pollute the environment, endangering the people around.
On the way, the container should be fixed properly to avoid collision and shock.
The first heavy storage environment. It must be dry, cool and well-connected, and must not be near fire or gas sources to prevent ignition. Because of its flammability, in case of open flame, high temperature or ignition. It is appropriate to isolate oxidation, this compound is oxidized to meet, or cause strong reaction, resulting in dangerous conditions.
Packaging should not be ignored. Use appropriate packaging materials, such as sealed glass bottles, plastic barrels, etc., to ensure its tightness and prevent leakage. If the package is damaged, it will not be damaged outside, and it will pollute the environment, endangering the people around.
On the way, the container should be fixed properly to avoid collision and shock.
What are the effects of 2- (bromomethyl) -1-chloro-4-fluorobenzene on the environment and human health?
2 - (bromomethyl) -1 -chloro-4 -fluorobenzene is one of the organic compounds. The effects of this substance on the environment and human health cannot be ignored.
In the environment, such organic halides may be chemically stable and difficult to degrade. If released in nature, or accumulated in soil, water, or atmosphere. In soil, or hinder the growth of plants, hinder their uptake of nutrients and moisture, damage the physiological functions of plants, cause growth retardation, stunted development, and even wither and die. In water bodies, or endanger aquatic organisms and disturb their ecological balance. It may be a poison that poisons aquatic animals such as fish and shellfish, causing fertility decline, larval aberration, destroying the food chain of aquatic ecosystems, and causing a chain reaction.
As for human health, 2- (bromomethyl) -1-chloro-4-fluorobenzene enters the body through respiration, diet, and skin contact. After entering the body, it may affect the nervous system of the human body, causing dizziness, headache, fatigue, insomnia, and even impairment of cognitive and behavioral abilities. It may also disturb the endocrine system, imitating human hormones, disrupting the regulatory function of hormones, causing endocrine disorders, which are related to abnormalities in reproduction, metabolism, and other aspects. Long-term exposure to this substance may increase the risk of cancer, due to its halogenated structure or mutagenic and carcinogenic properties, genetic material that damages cells, causing abnormal cell proliferation and tumor disease.
In summary, 2- (bromomethyl) -1-chloro-4-fluorobenzene poses a potential threat to the environment and human health. When it is produced, used and disposed of, it should be taken with caution to reduce its harm and protect the environment and human well-being.
In the environment, such organic halides may be chemically stable and difficult to degrade. If released in nature, or accumulated in soil, water, or atmosphere. In soil, or hinder the growth of plants, hinder their uptake of nutrients and moisture, damage the physiological functions of plants, cause growth retardation, stunted development, and even wither and die. In water bodies, or endanger aquatic organisms and disturb their ecological balance. It may be a poison that poisons aquatic animals such as fish and shellfish, causing fertility decline, larval aberration, destroying the food chain of aquatic ecosystems, and causing a chain reaction.
As for human health, 2- (bromomethyl) -1-chloro-4-fluorobenzene enters the body through respiration, diet, and skin contact. After entering the body, it may affect the nervous system of the human body, causing dizziness, headache, fatigue, insomnia, and even impairment of cognitive and behavioral abilities. It may also disturb the endocrine system, imitating human hormones, disrupting the regulatory function of hormones, causing endocrine disorders, which are related to abnormalities in reproduction, metabolism, and other aspects. Long-term exposure to this substance may increase the risk of cancer, due to its halogenated structure or mutagenic and carcinogenic properties, genetic material that damages cells, causing abnormal cell proliferation and tumor disease.
In summary, 2- (bromomethyl) -1-chloro-4-fluorobenzene poses a potential threat to the environment and human health. When it is produced, used and disposed of, it should be taken with caution to reduce its harm and protect the environment and human well-being.
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