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2-(Bromomethyl)-1-Chloro-4-Iodobenzene
Linshang Chemical
|
HS Code |
835803 |
| Chemical Formula | C7H5BrClI |
| Molecular Weight | 329.38 |
| Appearance | Solid (Typical for such aromatic halides) |
| Solubility In Water | Insoluble (Aromatic halides are generally hydrophobic) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Stability | Stable under normal conditions, but may react with strong nucleophiles |
As an accredited 2-(Bromomethyl)-1-Chloro-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2-(bromomethyl)-1 -chloro-4-iodobenzene packaged in a sealed glass bottle. |
| Storage | Store 2-(bromomethyl)-1 -chloro-4-iodobenzene in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Since it contains reactive halogens, store it in a tightly - sealed container to prevent moisture ingress and potential decomposition or unwanted reactions. Use appropriate secondary containment in case of leaks. |
| Shipping | 2-(Bromomethyl)-1 -chloro-4-iodobenzene is shipped in sealed, corrosion - resistant containers. It's carefully packaged to prevent leakage. Shipment follows strict chemical transport regulations to ensure safety during transit. |
Competitive 2-(Bromomethyl)-1-Chloro-4-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 2-(Bromomethyl)-1-Chloro-4-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 2- (bromomethyl) -1-chloro-4-iodobenzene?
2-%28bromomethyl%29-1-chloro-4-iodobenzene is 2- (bromomethyl) -1 -chloro-4 -iodobenzene, which is an organohalogenated aromatic hydrocarbon. Its physical properties are as follows:
Viewed at room temperature, it is mostly colorless to light yellow liquid or solid state, but its specific state also changes with the change of ambient temperature and pressure. Its melting boiling point is affected by the intermolecular force. Because the molecule contains halogen atoms such as bromine, chlorine, and iodine, the intermolecular force is enhanced, so the melting boiling point is relatively high. After precise determination, its melting point is about [X] ° C, and the boiling point is about [X] ° C. However, this value will also vary slightly depending on the measurement conditions.
As for solubility, due to the fact that the organic substance contains halogen atoms, which have a certain polarity, but also contains the non-polar structure of benzene ring, according to the principle of similar compatibility, its solubility in water is not good, because water is a strong polar solvent; while in organic solvents, such as ethanol, ether, dichloromethane, etc., the solubility is quite good, because it is similar to the polarity of organic solvents.
In terms of density, the density of bromine, chlorine, and iodine atoms in the molecule is larger than that of water, which is about [X] g/cm ³. This density characteristic is crucial when it comes to the separation and mixing operations of the substance.
In addition, its volatility is weak, due to the strong intermolecular force, it is difficult for molecules to leave the liquid phase and enter the gas phase. However, under high temperature or decompression environment, its volatilization rate will also accelerate.
In addition, the substance has a certain odor, but the odor description of your mileage may vary, and it varies depending on the concentration. It can usually be described as a special odor with irritation.
In summary, the physical properties of 2- (bromomethyl) -1 -chloro-4 -iodobenzene are unique, and these properties need to be carefully considered when applying in chemical industry, scientific research and other fields.
Viewed at room temperature, it is mostly colorless to light yellow liquid or solid state, but its specific state also changes with the change of ambient temperature and pressure. Its melting boiling point is affected by the intermolecular force. Because the molecule contains halogen atoms such as bromine, chlorine, and iodine, the intermolecular force is enhanced, so the melting boiling point is relatively high. After precise determination, its melting point is about [X] ° C, and the boiling point is about [X] ° C. However, this value will also vary slightly depending on the measurement conditions.
As for solubility, due to the fact that the organic substance contains halogen atoms, which have a certain polarity, but also contains the non-polar structure of benzene ring, according to the principle of similar compatibility, its solubility in water is not good, because water is a strong polar solvent; while in organic solvents, such as ethanol, ether, dichloromethane, etc., the solubility is quite good, because it is similar to the polarity of organic solvents.
In terms of density, the density of bromine, chlorine, and iodine atoms in the molecule is larger than that of water, which is about [X] g/cm ³. This density characteristic is crucial when it comes to the separation and mixing operations of the substance.
In addition, its volatility is weak, due to the strong intermolecular force, it is difficult for molecules to leave the liquid phase and enter the gas phase. However, under high temperature or decompression environment, its volatilization rate will also accelerate.
In addition, the substance has a certain odor, but the odor description of your mileage may vary, and it varies depending on the concentration. It can usually be described as a special odor with irritation.
In summary, the physical properties of 2- (bromomethyl) -1 -chloro-4 -iodobenzene are unique, and these properties need to be carefully considered when applying in chemical industry, scientific research and other fields.
What are the chemical properties of 2- (bromomethyl) -1-chloro-4-iodobenzene
2-%28bromomethyl%29-1-chloro-4-iodobenzene is 2- (bromomethyl) -1 -chloro-4 -iodobenzene, which is an organohalogenated aromatic hydrocarbon. Its chemical properties are unique and have the following numbers:
- ** Nucleophilic Substitution Reaction **: The carbon-bromine bond polarity of bromomethyl in its molecule is quite large, and the bromine atom is a good leaving group, which is vulnerable to nucleophilic attack. For example, when heated with an aqueous solution of sodium hydroxide, the hydroxyl negative ion will replace the bromine atom to form 2- (hydroxymethyl) -1 -chloro-4 -iodobenzene; when reacted with sodium alcohol, the alkoxy group will replace the bromine to form the corresponding ether compound. This kind of reaction is caused by the carbon-bromine bond electron cloud biased towards the bromine atom, which makes the carbon atom partially positively charged and vulnerable to the attack of nucleophilic reagents.
- ** Difference in the reactivity of halogen atoms **: The chlorine atom and the iodine atom in the molecule can also participate in the nucleophilic substitution reaction, but the activity is different from that of the bromine atom. Usually, the activity of the iodine atom is higher than that of the chlorine atom, which is due to the fact that the carbon-iodine bond energy is less than that of the carbon-chlorine bond and is more prone to fracture. If under certain conditions, the iodine atom can be preferentially replaced by the nucleophilic reagent, which can selectively introduce different functional groups in organic synthesis However, because chlorine, iodine, and bromomethyl are all electron-withdrawing groups, the electron cloud density of the benzene ring will be reduced, and the reactivity will be weakened compared with that of benzene. For example, when the nitration reaction is carried out, the reaction conditions will be more severe than that of benzene, and the main generation of meta-substituted products will be formed. Due to the electron-withdrawing group, the density of the o-and para-electron cloud will decrease more than that of the meta-position.
- ** Redox Reaction **: Although the compound is mainly halogenated aromatics, bromomethyl can be oxidized under appropriate conditions. In case of strong oxidizing agents, bromomethyl may be oxidized to a car At the same time, the halogen atoms may also be reduced and removed under specific reduction conditions, so that the halogen atoms on the benzene ring are reduced.
- ** Nucleophilic Substitution Reaction **: The carbon-bromine bond polarity of bromomethyl in its molecule is quite large, and the bromine atom is a good leaving group, which is vulnerable to nucleophilic attack. For example, when heated with an aqueous solution of sodium hydroxide, the hydroxyl negative ion will replace the bromine atom to form 2- (hydroxymethyl) -1 -chloro-4 -iodobenzene; when reacted with sodium alcohol, the alkoxy group will replace the bromine to form the corresponding ether compound. This kind of reaction is caused by the carbon-bromine bond electron cloud biased towards the bromine atom, which makes the carbon atom partially positively charged and vulnerable to the attack of nucleophilic reagents.
- ** Difference in the reactivity of halogen atoms **: The chlorine atom and the iodine atom in the molecule can also participate in the nucleophilic substitution reaction, but the activity is different from that of the bromine atom. Usually, the activity of the iodine atom is higher than that of the chlorine atom, which is due to the fact that the carbon-iodine bond energy is less than that of the carbon-chlorine bond and is more prone to fracture. If under certain conditions, the iodine atom can be preferentially replaced by the nucleophilic reagent, which can selectively introduce different functional groups in organic synthesis However, because chlorine, iodine, and bromomethyl are all electron-withdrawing groups, the electron cloud density of the benzene ring will be reduced, and the reactivity will be weakened compared with that of benzene. For example, when the nitration reaction is carried out, the reaction conditions will be more severe than that of benzene, and the main generation of meta-substituted products will be formed. Due to the electron-withdrawing group, the density of the o-and para-electron cloud will decrease more than that of the meta-position.
- ** Redox Reaction **: Although the compound is mainly halogenated aromatics, bromomethyl can be oxidized under appropriate conditions. In case of strong oxidizing agents, bromomethyl may be oxidized to a car At the same time, the halogen atoms may also be reduced and removed under specific reduction conditions, so that the halogen atoms on the benzene ring are reduced.
What is the main synthesis method of 2- (bromomethyl) -1-chloro-4-iodobenzene
2-%28bromomethyl%29-1-chloro-4-iodobenzene is 2- (bromomethyl) -1 -chloro-4 -iodobenzene, and its main synthesis methods are as follows:
First, p-chloroiodobenzene can be started. P-chloroiodobenzene is chloromethylated with polyformaldehyde and hydrobromic acid under the catalysis of Lewis acid (such as ZnCl ²). In this reaction, polyformaldehyde forms an active electrophilic reagent under the action of hydrobromic acid and Lewis acid, attacks the benzene ring of p-chloroiodobenzene, and introduces bromomethyl at the ortho-position of the para-chlorine atom to obtain the target product 2- (bromomethyl) -1 -chloro-4 -iodobenzene Or, p-chlorobenzyl alcohol can be used as a raw material to react with phosphorus tribromide, and the hydroxyl group is replaced by a bromine atom to obtain p-chlorobenzyl bromide. After that, in the presence of a suitable catalyst (such as copper salt, etc.), a halogen exchange reaction occurs with potassium iodide, and iodine atoms are introduced into the chlorine atom counterposition of the benzene ring, and 2 - (bromomethyl) -1 -chloro-4 -iodobenzene can also be obtained.
Furthermore, with 4-iodine-2-nitrotoluene as the starting material, the nitro group is first reduced to an amino group, and then the diazotization and chlorination reactions are carried out to replace the amino group with a chlorine atom to obtain 2-chloromethyl-4-iodotoluene. Finally, under suitable halogenation conditions, the hydrogen atom on the methyl group is replaced by a bromine atom, and the same 2- (bromomethyl) -1-chloro-4-iodobenzene can be synthesized.
The above methods have advantages and disadvantages. In the actual synthesis, the factors such as the availability of raw materials, reaction conditions and product purity need to be comprehensively weighed and selected.
First, p-chloroiodobenzene can be started. P-chloroiodobenzene is chloromethylated with polyformaldehyde and hydrobromic acid under the catalysis of Lewis acid (such as ZnCl ²). In this reaction, polyformaldehyde forms an active electrophilic reagent under the action of hydrobromic acid and Lewis acid, attacks the benzene ring of p-chloroiodobenzene, and introduces bromomethyl at the ortho-position of the para-chlorine atom to obtain the target product 2- (bromomethyl) -1 -chloro-4 -iodobenzene Or, p-chlorobenzyl alcohol can be used as a raw material to react with phosphorus tribromide, and the hydroxyl group is replaced by a bromine atom to obtain p-chlorobenzyl bromide. After that, in the presence of a suitable catalyst (such as copper salt, etc.), a halogen exchange reaction occurs with potassium iodide, and iodine atoms are introduced into the chlorine atom counterposition of the benzene ring, and 2 - (bromomethyl) -1 -chloro-4 -iodobenzene can also be obtained.
Furthermore, with 4-iodine-2-nitrotoluene as the starting material, the nitro group is first reduced to an amino group, and then the diazotization and chlorination reactions are carried out to replace the amino group with a chlorine atom to obtain 2-chloromethyl-4-iodotoluene. Finally, under suitable halogenation conditions, the hydrogen atom on the methyl group is replaced by a bromine atom, and the same 2- (bromomethyl) -1-chloro-4-iodobenzene can be synthesized.
The above methods have advantages and disadvantages. In the actual synthesis, the factors such as the availability of raw materials, reaction conditions and product purity need to be comprehensively weighed and selected.
Where is 2- (bromomethyl) -1-chloro-4-iodobenzene used?
2-%28bromomethyl%29-1-chloro-4-iodobenzene, the Chinese name is 2 - (bromomethyl) -1 - chloro - 4 - iodobenzene. This substance is useful in a wide range of fields.
It can be used as an important medium for synthesis. Due to the high reaction activity of bromine, chlorine and iodine atoms in the molecule, it can be used by general chemical reactions, such as nuclear substitution of anti-molecules, etc., to introduce various functional molecules, and to create chemical molecules with specific biological activities. For example, it can contain nitrogen, oxygen and other nuclear reactions to generate new chemical reactions, and synthesize chemical solutions with antibacterial, anti-cancer and other effects.
In the field of materials science, 2- (bromomethyl) -1 -chloro-4 -iodobenzene also has an outstanding performance. It can be used for its anti-reaction activity, polymerization anti-reaction, and special-purpose polymers. This polymer may have special properties and optical properties, which can be used in the manufacture of high-quality materials. It is used in devices such as optical diodes (OLEDs) and energy pools to improve their performance.
Furthermore, in chemical research, it is special and can be used to explore new types of chemical reactions. Because of its multi-atom characteristics, it can provide a variety of anti-reaction methods, helping researchers to further explore the anti-reaction technology, explore new synthesis methods, and promote the development of synthetic technologies.
Therefore, 2- (bromomethyl) -1 -chloro-4 -iodobenzene, with its unique molecular reaction activity, plays an important role in many fields such as engineering, materials and chemical research, promoting the development of multiphase technology.
It can be used as an important medium for synthesis. Due to the high reaction activity of bromine, chlorine and iodine atoms in the molecule, it can be used by general chemical reactions, such as nuclear substitution of anti-molecules, etc., to introduce various functional molecules, and to create chemical molecules with specific biological activities. For example, it can contain nitrogen, oxygen and other nuclear reactions to generate new chemical reactions, and synthesize chemical solutions with antibacterial, anti-cancer and other effects.
In the field of materials science, 2- (bromomethyl) -1 -chloro-4 -iodobenzene also has an outstanding performance. It can be used for its anti-reaction activity, polymerization anti-reaction, and special-purpose polymers. This polymer may have special properties and optical properties, which can be used in the manufacture of high-quality materials. It is used in devices such as optical diodes (OLEDs) and energy pools to improve their performance.
Furthermore, in chemical research, it is special and can be used to explore new types of chemical reactions. Because of its multi-atom characteristics, it can provide a variety of anti-reaction methods, helping researchers to further explore the anti-reaction technology, explore new synthesis methods, and promote the development of synthetic technologies.
Therefore, 2- (bromomethyl) -1 -chloro-4 -iodobenzene, with its unique molecular reaction activity, plays an important role in many fields such as engineering, materials and chemical research, promoting the development of multiphase technology.
What are the storage conditions for 2- (bromomethyl) -1-chloro-4-iodobenzene
2-%28bromomethyl%29-1-chloro-4-iodobenzene, the Chinese name is 2- (bromomethyl) -1 -chloro-4 -iodobenzene, this is a chemical compound. Its storage parts are very important and need to be properly placed in order to ensure its stability and avoid the risk of chemical change and product decline.
It is suitable to be used in a good place for drying and drying. The environment can inhibit molecular activity and reduce the reaction rate; the dry can avoid reactions such as hydrolysis caused by moisture; it can be discharged and prevented from accumulating and causing danger.
This compound has atoms, sexual activity, and is easy to be reacted. Oxidation isolation is very important because it encounters oxidation or strong reaction, causing ignition and explosion. It also needs to be a source of fire and heat, and there are many flammable compounds, and they are more flammable at high temperatures.
It is appropriate to store in a sealed container to prevent air and moisture from invading. Containers also need to be sealed, such as glass or specific plastic containers. Glass is resistant to multi-chemical corrosion and has good sealing performance; specific plastic materials have good solubility and tolerance, and can be used according to the characteristics of the compound.
The storage should be clear, indicating the name of the product, its properties, and its danger, etc., so that the operator can operate the product and follow the correct procedures. Regularly check and store the product. If the container is broken, the color and smell of the product, etc., take quick measures to prevent leakage and pollution.
Therefore, the storage of 2- (bromomethyl) -1 -chloro-4 -iodobenzene should be sealed, clear, and regularly checked to ensure the safety of its products.
It is suitable to be used in a good place for drying and drying. The environment can inhibit molecular activity and reduce the reaction rate; the dry can avoid reactions such as hydrolysis caused by moisture; it can be discharged and prevented from accumulating and causing danger.
This compound has atoms, sexual activity, and is easy to be reacted. Oxidation isolation is very important because it encounters oxidation or strong reaction, causing ignition and explosion. It also needs to be a source of fire and heat, and there are many flammable compounds, and they are more flammable at high temperatures.
It is appropriate to store in a sealed container to prevent air and moisture from invading. Containers also need to be sealed, such as glass or specific plastic containers. Glass is resistant to multi-chemical corrosion and has good sealing performance; specific plastic materials have good solubility and tolerance, and can be used according to the characteristics of the compound.
The storage should be clear, indicating the name of the product, its properties, and its danger, etc., so that the operator can operate the product and follow the correct procedures. Regularly check and store the product. If the container is broken, the color and smell of the product, etc., take quick measures to prevent leakage and pollution.
Therefore, the storage of 2- (bromomethyl) -1 -chloro-4 -iodobenzene should be sealed, clear, and regularly checked to ensure the safety of its products.
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