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2-(Bromomethyl)-1-Chloro-4-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
543523 |
| Chemical Formula | C8H5BrClF3 |
| Molecular Weight | 287.48 |
| Physical State At Room Temperature | Unknown |
| Solubility | Unknown |
| Hazardous Nature | May be harmful if inhaled, swallowed, or in contact with skin (general halogen - containing organic compound hazard assumption) |
As an accredited 2-(Bromomethyl)-1-Chloro-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2-(bromomethyl)-1-chloro-4-(trifluoromethyl)benzene in a sealed, chemical - resistant bottle. |
| Storage | 2-(Bromomethyl)-1-chloro-4-(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, bases, and other reactive substances to avoid potential chemical reactions. |
| Shipping | 2-(Bromomethyl)-1-chloro-4-(trifluoromethyl)benzene is shipped in accordance with chemical regulations. Packed securely in appropriate containers, it's transported by carriers licensed for handling such hazardous chemicals to ensure safe delivery. |
Competitive 2-(Bromomethyl)-1-Chloro-4-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 2- (bromomethyl) -1-chloro-4- (trifluoromethyl) benzene?
2-%28bromomethyl%29-1-chloro-4-%28trifluoromethyl%29benzene is 2- (bromomethyl) -1 -chloro-4- (trifluoromethyl) benzene, which has a wide range of uses. In the field of organic synthesis, it can be regarded as a key intermediate. Because its structure contains active groups such as bromomethyl, chlorine atoms and trifluoromethyl, other organic compounds can be derived through many chemical reactions.
For example, through nucleophilic substitution reactions, bromine atoms in bromomethyl are easily replaced by nucleophiles such as hydroxyl and amino groups, so as to synthesize compounds containing different functional groups, which is of great significance in the field of medicinal chemistry. When drugs are developed, molecular structures with specific physiological activities can be constructed through such reactions, and new drugs may be developed.
In the field of materials science, this compound also has its uses. The existence of trifluoromethyl can endow materials with unique properties, such as improving the chemical stability and thermal stability of materials and reducing surface energy. Polymer materials prepared from this as raw materials may demonstrate excellent performance in high-end fields such as aerospace and electronics, such as special coatings used in the manufacture of aerospace equipment to enhance the corrosion resistance and heat resistance of equipment.
In addition, in the field of pesticide chemistry, it may also participate in the synthesis of new pesticides as an intermediate. With its special structure, the synthesized pesticides may have high efficiency, low toxicity and environmentally friendly characteristics, providing a new way for agricultural pest control. Overall, 2- (bromomethyl) -1- chloro-4- (trifluoromethyl) benzene, with its unique structure, plays an important role in many important fields and is of great significance in promoting the development of related fields.
For example, through nucleophilic substitution reactions, bromine atoms in bromomethyl are easily replaced by nucleophiles such as hydroxyl and amino groups, so as to synthesize compounds containing different functional groups, which is of great significance in the field of medicinal chemistry. When drugs are developed, molecular structures with specific physiological activities can be constructed through such reactions, and new drugs may be developed.
In the field of materials science, this compound also has its uses. The existence of trifluoromethyl can endow materials with unique properties, such as improving the chemical stability and thermal stability of materials and reducing surface energy. Polymer materials prepared from this as raw materials may demonstrate excellent performance in high-end fields such as aerospace and electronics, such as special coatings used in the manufacture of aerospace equipment to enhance the corrosion resistance and heat resistance of equipment.
In addition, in the field of pesticide chemistry, it may also participate in the synthesis of new pesticides as an intermediate. With its special structure, the synthesized pesticides may have high efficiency, low toxicity and environmentally friendly characteristics, providing a new way for agricultural pest control. Overall, 2- (bromomethyl) -1- chloro-4- (trifluoromethyl) benzene, with its unique structure, plays an important role in many important fields and is of great significance in promoting the development of related fields.
What are the physical properties of 2- (bromomethyl) -1-chloro-4- (trifluoromethyl) benzene
2-%28bromomethyl%29-1-chloro-4-%28trifluoromethyl%29benzene, the Chinese name or 2- (bromomethyl) -1 -chloro-4- (trifluoromethyl) benzene. The physical properties of this substance, let me tell you in detail.
Looking at its appearance, it is often colorless to light yellow liquid, its texture is uniform, and there are no impurities visible to the naked eye. This substance has a certain volatility and can slowly disperse in the air under normal temperature and pressure.
Talking about the boiling point, because its molecular structure contains atoms and groups such as bromine, chlorine and trifluoromethyl, the intermolecular forces are more complex. It has been determined by many studies that its boiling point is within a specific range, about a certain temperature. This temperature allows the molecule to obtain enough energy to break free from the attractive forces between molecules and transform from liquid to gaseous.
As for the melting point, it is affected by the regularity of molecular structure and the interaction between atoms. When the temperature drops to a certain value, the thermal motion of the molecules slows down, and the arrangement of each other tends to be orderly, and then solidifies. The melting point of this substance also has a specific value and is in the corresponding temperature range.
In terms of solubility, due to the presence of halogen atoms and trifluoromethyl in the molecule, it has a certain lipophilicity. In organic solvents such as toluene and dichloromethane, it exhibits good solubility and can be miscible with these solvents in a certain proportion to form a uniform solution. However, in water, due to the large difference in force between water molecules and the substance, its solubility is poor and almost insoluble.
Density is also one of its important physical properties. The density of this substance is higher than that of water. If it is placed in the same container as water, it will sink to the bottom of the water. This is because of its large molecular weight and tight structure, resulting in a higher mass per unit volume.
2- (bromomethyl) -1-chloro-4- (trifluoromethyl) benzene has such physical properties because of its unique molecular structure, and these properties also play a key role in applications in organic synthesis, materials science and many other fields.
Looking at its appearance, it is often colorless to light yellow liquid, its texture is uniform, and there are no impurities visible to the naked eye. This substance has a certain volatility and can slowly disperse in the air under normal temperature and pressure.
Talking about the boiling point, because its molecular structure contains atoms and groups such as bromine, chlorine and trifluoromethyl, the intermolecular forces are more complex. It has been determined by many studies that its boiling point is within a specific range, about a certain temperature. This temperature allows the molecule to obtain enough energy to break free from the attractive forces between molecules and transform from liquid to gaseous.
As for the melting point, it is affected by the regularity of molecular structure and the interaction between atoms. When the temperature drops to a certain value, the thermal motion of the molecules slows down, and the arrangement of each other tends to be orderly, and then solidifies. The melting point of this substance also has a specific value and is in the corresponding temperature range.
In terms of solubility, due to the presence of halogen atoms and trifluoromethyl in the molecule, it has a certain lipophilicity. In organic solvents such as toluene and dichloromethane, it exhibits good solubility and can be miscible with these solvents in a certain proportion to form a uniform solution. However, in water, due to the large difference in force between water molecules and the substance, its solubility is poor and almost insoluble.
Density is also one of its important physical properties. The density of this substance is higher than that of water. If it is placed in the same container as water, it will sink to the bottom of the water. This is because of its large molecular weight and tight structure, resulting in a higher mass per unit volume.
2- (bromomethyl) -1-chloro-4- (trifluoromethyl) benzene has such physical properties because of its unique molecular structure, and these properties also play a key role in applications in organic synthesis, materials science and many other fields.
What are the synthesis methods of 2- (bromomethyl) -1-chloro-4- (trifluoromethyl) benzene
To prepare 2 - (bromomethyl) -1 -chloro-4- (trifluoromethyl) benzene, you can do it according to the following methods.
First, use 1-chloro-4- (trifluoromethyl) benzene as the starting material. Shilling it with paraformaldehyde, hydrogen bromide and Lewis acid (such as ZnBr ³) in a suitable organic solvent (such as dichloroethane), and react at a suitable temperature (such as 60-80 ° C). This reaction is a variant of chloromethylation. Lewis acid is used to activate polyformaldehyde, which interacts with hydrogen bromide to form an active intermediate, and then undergoes electrophilic substitution with the aromatic ring, and introduces bromomethyl at a specific position in the benzene ring to obtain the target product.
Second, first dissolve 1-chloro-4- (trifluoromethyl) benzene with N-bromosuccinimide (NBS) and initiator (such as benzoyl peroxide) in an inert solvent (such as carbon tetrachloride). Under light or heating conditions, the initiator decomposes to produce free radicals, which initiate the generation of bromine free radicals in NBS, which attack the side chain methyl of the benzene ring. Through the radical substitution mechanism, the methyl is gradually brominated to obtain 2- (bromomethyl) -1 -chloro-4- (trifluoromethyl) benzene. Pay attention to the control of the amount of NBS and reaction conditions during the reaction to prevent excessive bromination.
Third, it can be started from the corresponding phenolic compounds. First, 2-hydroxy-1-chloro-4- (trifluoromethyl) benzene is prepared, and then it is treated with suitable brominating reagents (such as phosphorus tribromide). The hydroxyl group is replaced by bromine to obtain the target product. In this process, the acquisition of phenolic compounds may require a multi-step reaction, which is obtained by converting functional groups from the corresponding benzene ring derivatives.
All synthesis methods have advantages and disadvantages. The raw materials used in the first method are common and easy to obtain, but the reaction conditions may be harsh. The choice and dosage of Lewis acid have a great influence on the reaction. The selectivity of the secondary radical reaction is difficult to precisely control, and it is easy to produce by-products. Although the final method is multi-step, the functional group conversion of phenolic compounds can be carried out according to mature methods, and the introduction and modification of specific functional groups are more flexible. In actual synthesis, the most suitable method is selected according to the availability of raw materials, the difficulty of reaction operation and the requirements of product purity.
First, use 1-chloro-4- (trifluoromethyl) benzene as the starting material. Shilling it with paraformaldehyde, hydrogen bromide and Lewis acid (such as ZnBr ³) in a suitable organic solvent (such as dichloroethane), and react at a suitable temperature (such as 60-80 ° C). This reaction is a variant of chloromethylation. Lewis acid is used to activate polyformaldehyde, which interacts with hydrogen bromide to form an active intermediate, and then undergoes electrophilic substitution with the aromatic ring, and introduces bromomethyl at a specific position in the benzene ring to obtain the target product.
Second, first dissolve 1-chloro-4- (trifluoromethyl) benzene with N-bromosuccinimide (NBS) and initiator (such as benzoyl peroxide) in an inert solvent (such as carbon tetrachloride). Under light or heating conditions, the initiator decomposes to produce free radicals, which initiate the generation of bromine free radicals in NBS, which attack the side chain methyl of the benzene ring. Through the radical substitution mechanism, the methyl is gradually brominated to obtain 2- (bromomethyl) -1 -chloro-4- (trifluoromethyl) benzene. Pay attention to the control of the amount of NBS and reaction conditions during the reaction to prevent excessive bromination.
Third, it can be started from the corresponding phenolic compounds. First, 2-hydroxy-1-chloro-4- (trifluoromethyl) benzene is prepared, and then it is treated with suitable brominating reagents (such as phosphorus tribromide). The hydroxyl group is replaced by bromine to obtain the target product. In this process, the acquisition of phenolic compounds may require a multi-step reaction, which is obtained by converting functional groups from the corresponding benzene ring derivatives.
All synthesis methods have advantages and disadvantages. The raw materials used in the first method are common and easy to obtain, but the reaction conditions may be harsh. The choice and dosage of Lewis acid have a great influence on the reaction. The selectivity of the secondary radical reaction is difficult to precisely control, and it is easy to produce by-products. Although the final method is multi-step, the functional group conversion of phenolic compounds can be carried out according to mature methods, and the introduction and modification of specific functional groups are more flexible. In actual synthesis, the most suitable method is selected according to the availability of raw materials, the difficulty of reaction operation and the requirements of product purity.
2- (bromomethyl) -1-chloro-4- (trifluoromethyl) benzene What are the precautions in storage and transportation
2 - (bromomethyl) -1 - chloro - 4 - (trifluoromethyl) benzene is an organic compound. When storing and transporting, there are several precautions to be taken.
This compound has the properties of halogenated hydrocarbons. Bromomethyl, chlorine atoms and trifluoromethyl all make the molecules reactive to a certain extent. In case of high temperature, open flame or oxidant, it is afraid of violent chemical reaction and risk of fire or explosion. Therefore, when storing, it should be placed in a cool and ventilated warehouse, away from fire and heat sources, and the storage temperature should not exceed 30 ° C. It should be stored separately from oxidants and food chemicals, and should not be mixed.
When transporting, it should be handled according to the rules for transporting dangerous chemicals. Transportation vehicles should be equipped with the corresponding variety and quantity of fire-fighting equipment and leakage emergency treatment equipment. In summer, it is advisable to transport in the morning and evening to prevent sun exposure. During transportation, ensure that the container does not leak, collapse, fall, or damage. When transporting by road, follow the prescribed route and do not stop in residential areas and densely populated areas. When transporting by rail, it is forbidden to slip.
Because it contains halogen atoms such as bromine, chlorine, and fluorine, it may be toxic and irritating to the human body. The storage place should be prepared with suitable materials to contain leaks. When personnel come into contact, protective measures must be taken, such as wearing a self-priming filter gas mask (full mask), wearing rubber gloves, etc. In the event of a leak, quickly evacuate personnel from the spill-contaminated area to a safe area and isolate them, strictly restricting access. Emergency responders wear self-contained positive pressure breathing apparatus and anti-virus clothing. Do not let the spill come into contact with combustible substances (such as wood, paper, oil, etc.). In the event of a small leak, mix it with sand, dry lime or soda ash and collect it in a dry, clean and covered container. In the event of a large leak, build an embankment or dig a pit for containment, cover it with foam to reduce steam disasters, and transfer it to a tanker or special collector with a pump for recycling or transportation to a waste treatment site for disposal.
This compound has the properties of halogenated hydrocarbons. Bromomethyl, chlorine atoms and trifluoromethyl all make the molecules reactive to a certain extent. In case of high temperature, open flame or oxidant, it is afraid of violent chemical reaction and risk of fire or explosion. Therefore, when storing, it should be placed in a cool and ventilated warehouse, away from fire and heat sources, and the storage temperature should not exceed 30 ° C. It should be stored separately from oxidants and food chemicals, and should not be mixed.
When transporting, it should be handled according to the rules for transporting dangerous chemicals. Transportation vehicles should be equipped with the corresponding variety and quantity of fire-fighting equipment and leakage emergency treatment equipment. In summer, it is advisable to transport in the morning and evening to prevent sun exposure. During transportation, ensure that the container does not leak, collapse, fall, or damage. When transporting by road, follow the prescribed route and do not stop in residential areas and densely populated areas. When transporting by rail, it is forbidden to slip.
Because it contains halogen atoms such as bromine, chlorine, and fluorine, it may be toxic and irritating to the human body. The storage place should be prepared with suitable materials to contain leaks. When personnel come into contact, protective measures must be taken, such as wearing a self-priming filter gas mask (full mask), wearing rubber gloves, etc. In the event of a leak, quickly evacuate personnel from the spill-contaminated area to a safe area and isolate them, strictly restricting access. Emergency responders wear self-contained positive pressure breathing apparatus and anti-virus clothing. Do not let the spill come into contact with combustible substances (such as wood, paper, oil, etc.). In the event of a small leak, mix it with sand, dry lime or soda ash and collect it in a dry, clean and covered container. In the event of a large leak, build an embankment or dig a pit for containment, cover it with foam to reduce steam disasters, and transfer it to a tanker or special collector with a pump for recycling or transportation to a waste treatment site for disposal.
What are the effects of 2- (bromomethyl) -1-chloro-4- (trifluoromethyl) benzene on the environment and human health?
2-%28bromomethyl%29-1-chloro-4-%28trifluoromethyl%29benzene, it is also necessary to observe the impact of human health in the environment.
Because of the environment, this nutrient-containing and substituent-based material may be degraded. Entering the natural environment, or remaining in the soil and water. It may affect the normal physiology of aquatic organisms, causing their reproduction and growth to be hindered. In the case of aquatic organisms, if plankton are harmed by it, it will affect the food base and affect many aquatic organisms. And it will accumulate in the soil, or change the soil properties, preventing the absorption of plant roots and water, causing poor vegetation growth and affecting the balance of life.
To the health of humans, this compound may enter the human body through respiration, skin contact and food. It contains bromine, chlorine, fluorine and other pigment atoms, or is toxic and biologically accumulative. If it enters the human body, or the dry secretion system, it will cause the hormone balance. If it affects the synthesis and secretion of thyroid hormones, it will cause the function of the thyroid gland, involving the new generation, the development of the nervous system, etc. It may also have sudden gene outbursts, which will increase the risk of people suffering from tumors and other diseases. If the pregnancy is exposed to this, it may endanger the normal fertility of the fetus and cause congenital defects and other adverse consequences.
Because of the environment, this nutrient-containing and substituent-based material may be degraded. Entering the natural environment, or remaining in the soil and water. It may affect the normal physiology of aquatic organisms, causing their reproduction and growth to be hindered. In the case of aquatic organisms, if plankton are harmed by it, it will affect the food base and affect many aquatic organisms. And it will accumulate in the soil, or change the soil properties, preventing the absorption of plant roots and water, causing poor vegetation growth and affecting the balance of life.
To the health of humans, this compound may enter the human body through respiration, skin contact and food. It contains bromine, chlorine, fluorine and other pigment atoms, or is toxic and biologically accumulative. If it enters the human body, or the dry secretion system, it will cause the hormone balance. If it affects the synthesis and secretion of thyroid hormones, it will cause the function of the thyroid gland, involving the new generation, the development of the nervous system, etc. It may also have sudden gene outbursts, which will increase the risk of people suffering from tumors and other diseases. If the pregnancy is exposed to this, it may endanger the normal fertility of the fetus and cause congenital defects and other adverse consequences.
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