Linshang Chemical
PRODUCTS
2-(Bromomethyl)-3-Chloro-1,4-Difluorobenzene
Linshang Chemical
|
HS Code |
367739 |
| Chemical Formula | C7H4BrClF2 |
| Molecular Weight | 243.46 |
| Appearance | Solid (Typical description, actual may vary) |
| Solubility In Water | Low (Aromatic halides generally have low water solubility) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Vapor Pressure | Low (Estimated based on similar aromatic halides) |
As an accredited 2-(Bromomethyl)-3-Chloro-1,4-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2-(bromomethyl)-3 -chloro-1,4 -difluorobenzene packaged in air -tight glass bottles. |
| Storage | 2-(Bromomethyl)-3-chloro-1,4 -difluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and reactive chemicals to avoid potential chemical reactions. |
| Shipping | 2-(Bromomethyl)-3 -chloro-1,4 -difluorobenzene is shipped in sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring secure transport to prevent leakage and environmental risks. |
Competitive 2-(Bromomethyl)-3-Chloro-1,4-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-(Bromomethyl)-3-Chloro-1,4-Difluorobenzene in China?
As a trusted 2-(Bromomethyl)-3-Chloro-1,4-Difluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-(Bromomethyl)-3-Chloro-1,4-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2- (bromomethyl) -3-chloro-1,4-difluorobenzene?
2-%28bromomethyl%29-3-chloro-1%2C4-difluorobenzene is 2 - (bromomethyl) - 3 - chloro - 1,4 - difluorobenzene, which is an important raw material in the field of organic synthesis.
In the field of medicinal chemistry, it plays an indispensable role. Because of its unique chemical structure, it can be used as a key intermediate to participate in the construction of many drug molecules. Through carefully designed chemical reactions, it is combined with other specific chemical groups to synthesize compounds with specific pharmacological activities. In the research and development of some antibacterial and antiviral drugs, the reaction steps involved in 2- (bromomethyl) -3-chloro-1,4-difluorobenzene are crucial for generating active ingredients with precise curative effects.
In the field of materials science, it also shows significant value. It can be used to prepare polymer materials with special properties. By polymerizing with other monomers, the resulting materials can impart unique electrical, optical or thermal properties. For example, when preparing functional materials for optoelectronic devices, the introduction of this compound can effectively adjust the electronic transport properties and optical absorption properties of the materials, thereby improving the working efficiency and stability of optoelectronic devices.
In pesticide chemistry, 2- (bromomethyl) -3-chloro-1,4-difluorobenzene is also useful. It can be used as an important starting material for the synthesis of new pesticides. After a series of chemical transformations, pesticide products with high-efficiency insecticidal, bactericidal or herbicidal activities can be synthesized to help agricultural production in pest control and improve crop yield and quality.
In the field of medicinal chemistry, it plays an indispensable role. Because of its unique chemical structure, it can be used as a key intermediate to participate in the construction of many drug molecules. Through carefully designed chemical reactions, it is combined with other specific chemical groups to synthesize compounds with specific pharmacological activities. In the research and development of some antibacterial and antiviral drugs, the reaction steps involved in 2- (bromomethyl) -3-chloro-1,4-difluorobenzene are crucial for generating active ingredients with precise curative effects.
In the field of materials science, it also shows significant value. It can be used to prepare polymer materials with special properties. By polymerizing with other monomers, the resulting materials can impart unique electrical, optical or thermal properties. For example, when preparing functional materials for optoelectronic devices, the introduction of this compound can effectively adjust the electronic transport properties and optical absorption properties of the materials, thereby improving the working efficiency and stability of optoelectronic devices.
In pesticide chemistry, 2- (bromomethyl) -3-chloro-1,4-difluorobenzene is also useful. It can be used as an important starting material for the synthesis of new pesticides. After a series of chemical transformations, pesticide products with high-efficiency insecticidal, bactericidal or herbicidal activities can be synthesized to help agricultural production in pest control and improve crop yield and quality.
What are the physical properties of 2- (bromomethyl) -3-chloro-1,4-difluorobenzene
2 - (bromomethyl) -3 -chloro-1,4 -difluorobenzene is a kind of organic compound. Its physical properties are quite impressive, as follows:
Looking at its properties, under room temperature and pressure, it is mostly colorless to light yellow liquid. The appearance of this color state can be seen and touched, but it is obvious intuitively. Its smell often has a special fragrance, but this fragrance is not pleasant, or slightly irritating, and it can be sensed by smelling, which touches people's sense of smell.
When it comes to the boiling point, due to the intermolecular force, it is about a specific temperature range, usually around [X] ° C. When the temperature reaches this point, it changes from liquid to gaseous state, which is the key node of material state transition. In terms of melting point, it is around [X] ° C, the temperature drops to this, the liquid gradually condenses into a solid state, and the molecular arrangement tends to be ordered from disorder.
Solubility is also one of its important physical properties. In organic solvents, such as ethanol, ether, etc., its solubility is quite good, and it can be miscible with them to form a uniform mixed system. However, in water, due to the difference between molecular polarity and water molecular polarity, the solubility is very small, and the two are difficult to blend.
The density is greater than that of water. Placing it in one place with water shows that it sinks to the bottom of the water, which is a phenomenon due to the difference in density.
In addition, the volatility of this compound also has characteristics. Although it is not very volatile, under appropriate conditions, some molecules will escape from the liquid surface and enter the gas phase.
The above are all the physical properties of 2- (bromomethyl) -3 -chloro-1,4 -difluorobenzene. These properties are of great significance in terms of their identification, separation, and application. Scholars should study them in detail, understand their reasons, and understand their uses.
Looking at its properties, under room temperature and pressure, it is mostly colorless to light yellow liquid. The appearance of this color state can be seen and touched, but it is obvious intuitively. Its smell often has a special fragrance, but this fragrance is not pleasant, or slightly irritating, and it can be sensed by smelling, which touches people's sense of smell.
When it comes to the boiling point, due to the intermolecular force, it is about a specific temperature range, usually around [X] ° C. When the temperature reaches this point, it changes from liquid to gaseous state, which is the key node of material state transition. In terms of melting point, it is around [X] ° C, the temperature drops to this, the liquid gradually condenses into a solid state, and the molecular arrangement tends to be ordered from disorder.
Solubility is also one of its important physical properties. In organic solvents, such as ethanol, ether, etc., its solubility is quite good, and it can be miscible with them to form a uniform mixed system. However, in water, due to the difference between molecular polarity and water molecular polarity, the solubility is very small, and the two are difficult to blend.
The density is greater than that of water. Placing it in one place with water shows that it sinks to the bottom of the water, which is a phenomenon due to the difference in density.
In addition, the volatility of this compound also has characteristics. Although it is not very volatile, under appropriate conditions, some molecules will escape from the liquid surface and enter the gas phase.
The above are all the physical properties of 2- (bromomethyl) -3 -chloro-1,4 -difluorobenzene. These properties are of great significance in terms of their identification, separation, and application. Scholars should study them in detail, understand their reasons, and understand their uses.
What are the chemical properties of 2- (bromomethyl) -3-chloro-1,4-difluorobenzene?
2-%28bromomethyl%29-3-chloro-1%2C4-difluorobenzene is 2- (bromomethyl) -3 -chloro-1,4 -difluorobenzene, this compound has the characteristics of halogenated aromatics. Its benzene ring has chlorine, fluorohalogen atoms and bromomethyl.
From the perspective of nucleophilic substitution, bromomethyl has high bromine activity. Due to the strong electronegativity of bromine in C-Br bonds, the carbon is partially positively charged and is easily attacked by nucleophiles. Nucleophiles such as alkoxides and amines can replace bromine to form new C-O, C-N bonds, etc. For example, when reacted with sodium alcohol, bromine was replaced by alkoxy to obtain ether products; when reacted with ammonia or amine, nitrogen-containing derivatives were formed.
In metal-catalyzed coupling reactions, this compound can participate. Because halogen atoms can undergo oxidative addition under the action of metal catalysts, such as under palladium catalysis, they can be coupled with boron-containing, tin-containing reagents to construct carbon-carbon bonds and synthesize complex aromatic hydrocarbons.
Because of its halogen-containing atoms, elimination reactions can occur under suitable conditions. For example, under the action of strong bases, bromomethyl and ortho-hydrogen atoms eliminate hydrogen bromide to form products containing double bonds. The products are unsaturated and can further participate in addition reactions.
Although the activity of fluorine and chlorine atoms in this compound is inferior to that of bromomethyl bromide, under specific conditions, it can also participate in the reaction. Changing the reaction conditions or selecting special reagents can replace fluorine and chlorine to achieve substituent conversion on the benzene ring. Because it contains multiple halogen atoms, it is an important intermediate in organic synthesis, and can construct different functional group structures through various reactions to obtain various organic compounds.
From the perspective of nucleophilic substitution, bromomethyl has high bromine activity. Due to the strong electronegativity of bromine in C-Br bonds, the carbon is partially positively charged and is easily attacked by nucleophiles. Nucleophiles such as alkoxides and amines can replace bromine to form new C-O, C-N bonds, etc. For example, when reacted with sodium alcohol, bromine was replaced by alkoxy to obtain ether products; when reacted with ammonia or amine, nitrogen-containing derivatives were formed.
In metal-catalyzed coupling reactions, this compound can participate. Because halogen atoms can undergo oxidative addition under the action of metal catalysts, such as under palladium catalysis, they can be coupled with boron-containing, tin-containing reagents to construct carbon-carbon bonds and synthesize complex aromatic hydrocarbons.
Because of its halogen-containing atoms, elimination reactions can occur under suitable conditions. For example, under the action of strong bases, bromomethyl and ortho-hydrogen atoms eliminate hydrogen bromide to form products containing double bonds. The products are unsaturated and can further participate in addition reactions.
Although the activity of fluorine and chlorine atoms in this compound is inferior to that of bromomethyl bromide, under specific conditions, it can also participate in the reaction. Changing the reaction conditions or selecting special reagents can replace fluorine and chlorine to achieve substituent conversion on the benzene ring. Because it contains multiple halogen atoms, it is an important intermediate in organic synthesis, and can construct different functional group structures through various reactions to obtain various organic compounds.
What are the synthesis methods of 2- (bromomethyl) -3-chloro-1,4-difluorobenzene
There are several methods for synthesizing 2- (bromomethyl) -3 -chloro-1,4 -difluorobenzene. First, it can be started from the corresponding benzene derivative. First, take the benzene containing the appropriate substituent, and introduce the chlorine and fluorine atoms at a specific position through the halogenation reaction. This halogenation method often requires appropriate catalysts and reaction conditions. For example, using iron or its salts as catalysts, benzene is reacted with chlorine and fluorine halogenating agents, and chlorine and fluorine atoms are precisely positioned to obtain chlorine and fluorine substituted benzene intermediates.
Second, for the introduction of bromomethyl, halomethylation can be used. A mixture of formaldehyde and hydrobromic acid is used to react with the above-mentioned benzene intermediates containing chlorine and fluorine in the presence of specific catalysts such as zinc salts or other Lewis acids. In this reaction, formaldehyde and hydrobromic acid form active intermediates, attack specific positions of the benzene ring, and successfully introduce bromomethyl to obtain 2- (bromomethyl) -3 -chloro-1,4 -difluorobenzene.
Furthermore, a strategy of gradually constructing the benzene ring can be adopted. First, simple organic fragments containing bromomethyl, chlorine, and fluorine are used as raw materials, and the benzene ring structure is gradually constructed through multi-step reactions, such as nucleophilic substitution, cyclization, etc. This process requires fine control of the reaction conditions at each step to ensure that the reaction proceeds in the expected direction and the product has high purity and yield. Each method has its advantages and disadvantages, and the most suitable synthetic route should be selected according to the actual demand, the availability of raw materials and the feasibility of the reaction conditions.
Second, for the introduction of bromomethyl, halomethylation can be used. A mixture of formaldehyde and hydrobromic acid is used to react with the above-mentioned benzene intermediates containing chlorine and fluorine in the presence of specific catalysts such as zinc salts or other Lewis acids. In this reaction, formaldehyde and hydrobromic acid form active intermediates, attack specific positions of the benzene ring, and successfully introduce bromomethyl to obtain 2- (bromomethyl) -3 -chloro-1,4 -difluorobenzene.
Furthermore, a strategy of gradually constructing the benzene ring can be adopted. First, simple organic fragments containing bromomethyl, chlorine, and fluorine are used as raw materials, and the benzene ring structure is gradually constructed through multi-step reactions, such as nucleophilic substitution, cyclization, etc. This process requires fine control of the reaction conditions at each step to ensure that the reaction proceeds in the expected direction and the product has high purity and yield. Each method has its advantages and disadvantages, and the most suitable synthetic route should be selected according to the actual demand, the availability of raw materials and the feasibility of the reaction conditions.
2- (bromomethyl) -3-chloro-1,4-difluorobenzene What to pay attention to when storing and transporting
2-%28bromomethyl%29-3-chloro-1%2C4-difluorobenzene, it is an organic compound. When storing and transporting it, many matters must not be ignored.
Bear the brunt, the storage place must be cool and dry. This compound is prone to reactions in case of moisture, so it is important to avoid moisture. If placed in a humid place, moisture or interact with the active groups in the compound, causing it to deteriorate and lose its original chemical properties.
Furthermore, it should be kept away from fires and heat sources. Because of its flammability, in case of open flames, hot topics, it is dangerous to burn, or even cause explosions, endangering the safety of the surrounding area. Fireworks are strictly prohibited in the storage place, and fire protection facilities must be complete.
During transportation, the packaging must be firm. Choose appropriate packaging materials to effectively protect the compound from damage during transportation. If the packaging is not good, the transportation will be bumpy and vibrated, or the container will break, and the compound will not only be wasted, but also may pollute the environment and endanger human health.
In addition, this compound may be toxic and irritating to the human body. Those who store and transport must wear appropriate protective equipment, such as gloves, goggles, protective clothing, etc., to prevent the compound from coming into contact with the skin and eyes, inhalation or ingestion.
At the same time, the storage and transportation places should be equipped with emergency treatment equipment and suitable containment materials. In the event of an accident such as leakage, measures can be taken quickly to reduce the harm. For example, inert materials such as sand are used to absorb leaks to prevent their spread.
In short, the above matters should be treated with caution 2-%28bromomethyl%29-3-chloro-1%2C4-difluorobenzene storage and transportation to ensure safety.
Bear the brunt, the storage place must be cool and dry. This compound is prone to reactions in case of moisture, so it is important to avoid moisture. If placed in a humid place, moisture or interact with the active groups in the compound, causing it to deteriorate and lose its original chemical properties.
Furthermore, it should be kept away from fires and heat sources. Because of its flammability, in case of open flames, hot topics, it is dangerous to burn, or even cause explosions, endangering the safety of the surrounding area. Fireworks are strictly prohibited in the storage place, and fire protection facilities must be complete.
During transportation, the packaging must be firm. Choose appropriate packaging materials to effectively protect the compound from damage during transportation. If the packaging is not good, the transportation will be bumpy and vibrated, or the container will break, and the compound will not only be wasted, but also may pollute the environment and endanger human health.
In addition, this compound may be toxic and irritating to the human body. Those who store and transport must wear appropriate protective equipment, such as gloves, goggles, protective clothing, etc., to prevent the compound from coming into contact with the skin and eyes, inhalation or ingestion.
At the same time, the storage and transportation places should be equipped with emergency treatment equipment and suitable containment materials. In the event of an accident such as leakage, measures can be taken quickly to reduce the harm. For example, inert materials such as sand are used to absorb leaks to prevent their spread.
In short, the above matters should be treated with caution 2-%28bromomethyl%29-3-chloro-1%2C4-difluorobenzene storage and transportation to ensure safety.
Scan to WhatsApp
