Linshang Chemical
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(2-Bromomethyl)-4-Chloro-1-Nitrobenzene
Linshang Chemical
|
HS Code |
667136 |
| Chemical Formula | C7H5BrClNO2 |
| Molar Mass | 250.48 g/mol |
| Appearance | Solid (usually a yellowish solid) |
| Melting Point | Data varies, around 90 - 100°C (approximate, experimental values may differ) |
| Solubility In Water | Insoluble (organic nitro - halide compounds are typically hydrophobic) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate |
| Hazard Class | Irritant (can cause irritation to skin, eyes and respiratory tract), potential mutagen (due to nitro group), harmful if swallowed or inhaled |
As an accredited (2-Bromomethyl)-4-Chloro-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of (2 - bromomethyl)-4 - chloro - 1 - nitrobenzene in a sealed, labeled bottle. |
| Storage | (2 - Bromomethyl)-4 - chloro - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat and ignition sources. Keep it in a tightly - sealed container to prevent leakage and exposure to air and moisture. Store it separately from incompatible substances like oxidizing agents and bases to avoid potential chemical reactions. |
| Shipping | (2 - Bromomethyl)-4 - chloro - 1 - nitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It follows strict hazardous chemical regulations, with proper labeling for safe transportation to prevent leakage and ensure safety. |
Competitive (2-Bromomethyl)-4-Chloro-1-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the physical properties of (2-bromomethyl) -4-chloro-1-nitrobenzene?
(2-Hydroxymethyl) -4-chloro-1-naphthyl ether, this is an organic compound. Its physical properties are quite critical and have a profound impact on its application in various scenarios.
Looking at its properties, under normal temperature and pressure, it is mostly white to pale yellow crystalline solid. This form is conducive to storage and transportation. Because of its relatively stable physical structure, it is not easy to change significantly under conventional conditions.
When it comes to the melting point, it is about a specific temperature range. This value provides an important basis for the identification and purification of this compound. Accurate determination of the melting point can help to distinguish its purity. The mixing of impurities usually causes the melting point range to change.
As for the boiling point, in a specific pressure environment, the compound will boil at the corresponding temperature. The boiling point information is of great significance in the separation and purification process. With the help of distillation and other means, the target compound can be accurately separated from the mixture according to the difference in boiling point.
Its solubility cannot be ignored, and it has a certain solubility in common organic solvents, such as ethanol and ether. This property is convenient for use as a solvent for reactants or products in chemical reactions, and helps the smooth development of the reaction. In water, its solubility is poor, which requires special attention in some operations or application scenarios involving the aqueous phase.
In addition, the compound may have a specific odor. Although odor intensity and characteristics are not the most critical physical properties, odor perception can be used as an auxiliary judgment basis during operation and use, and it is also related to the comfort and safety of the operating environment. In short, these physical properties of (2-hydroxymethyl) -4-chloro-1-naphthyl ether together build its unique "identity" in the field of chemistry, laying a solid foundation for its research and application.
Looking at its properties, under normal temperature and pressure, it is mostly white to pale yellow crystalline solid. This form is conducive to storage and transportation. Because of its relatively stable physical structure, it is not easy to change significantly under conventional conditions.
When it comes to the melting point, it is about a specific temperature range. This value provides an important basis for the identification and purification of this compound. Accurate determination of the melting point can help to distinguish its purity. The mixing of impurities usually causes the melting point range to change.
As for the boiling point, in a specific pressure environment, the compound will boil at the corresponding temperature. The boiling point information is of great significance in the separation and purification process. With the help of distillation and other means, the target compound can be accurately separated from the mixture according to the difference in boiling point.
Its solubility cannot be ignored, and it has a certain solubility in common organic solvents, such as ethanol and ether. This property is convenient for use as a solvent for reactants or products in chemical reactions, and helps the smooth development of the reaction. In water, its solubility is poor, which requires special attention in some operations or application scenarios involving the aqueous phase.
In addition, the compound may have a specific odor. Although odor intensity and characteristics are not the most critical physical properties, odor perception can be used as an auxiliary judgment basis during operation and use, and it is also related to the comfort and safety of the operating environment. In short, these physical properties of (2-hydroxymethyl) -4-chloro-1-naphthyl ether together build its unique "identity" in the field of chemistry, laying a solid foundation for its research and application.
What are the chemical properties of (2-bromomethyl) -4-chloro-1-nitrobenzene?
(2-Hydroxymethyl) -4-chloro-1-naphthyl ether, this is an organic compound. Its chemical properties are unique and important in the field of organic synthesis.
First of all, its physical properties are mostly solid at room temperature, and the melting point is affected by factors such as intermolecular forces. Because its molecular structure contains chlorine atoms, naphthyl groups and ether bonds connected by hydroxymethyl groups, it has a certain polarity, but the existence of naphthyl groups makes it hydrophobic.
In terms of chemical properties, chlorine atoms are highly active and can participate in nucleophilic substitution reactions. Nucleophiles such as sodium alcohols and amines can be substituted with chlorine atoms to form new compounds. This reaction is commonly used in the construction of carbon-heteroatomic bonds. For example, by reacting with sodium alcohols, new ether compounds can be formed.
Hydroxymethyl hydroxyl groups are also reactive. Under acidic or basic conditions, dehydration reactions can occur. When acidic, the hydroxyl groups are easily protonated, and then dehydrated to form carbon positive ions. This carbon positive ion can react with other nucleophiles in the system; under alkaline conditions, although the hydroxyl group is weakly acidic, under the action of a specific strong base, it can also remove protons and participate in the reaction in the form of oxygen negative ions, such as nucleophilic substitution with halogenated hydrocarbons to form ethers.
The naphthalene group is relatively stable, but under the action of strong oxidants, the naphthalene ring can be oxidized to change its conjugate structure. At the same time, the conjugated system of the naphthalene gene can undergo electrophilic substitution reaction. Under appropriate catalyst and reaction conditions, electrophilic agents such as halogenating agents and nitrifiers can attack the naphthalene ring and introduce substituents at specific positions.
The chemical properties of this compound make it have potential applications in drug synthesis, materials science and other fields. It can be used as an intermediate to construct more complex functional molecules through a series of reactions.
First of all, its physical properties are mostly solid at room temperature, and the melting point is affected by factors such as intermolecular forces. Because its molecular structure contains chlorine atoms, naphthyl groups and ether bonds connected by hydroxymethyl groups, it has a certain polarity, but the existence of naphthyl groups makes it hydrophobic.
In terms of chemical properties, chlorine atoms are highly active and can participate in nucleophilic substitution reactions. Nucleophiles such as sodium alcohols and amines can be substituted with chlorine atoms to form new compounds. This reaction is commonly used in the construction of carbon-heteroatomic bonds. For example, by reacting with sodium alcohols, new ether compounds can be formed.
Hydroxymethyl hydroxyl groups are also reactive. Under acidic or basic conditions, dehydration reactions can occur. When acidic, the hydroxyl groups are easily protonated, and then dehydrated to form carbon positive ions. This carbon positive ion can react with other nucleophiles in the system; under alkaline conditions, although the hydroxyl group is weakly acidic, under the action of a specific strong base, it can also remove protons and participate in the reaction in the form of oxygen negative ions, such as nucleophilic substitution with halogenated hydrocarbons to form ethers.
The naphthalene group is relatively stable, but under the action of strong oxidants, the naphthalene ring can be oxidized to change its conjugate structure. At the same time, the conjugated system of the naphthalene gene can undergo electrophilic substitution reaction. Under appropriate catalyst and reaction conditions, electrophilic agents such as halogenating agents and nitrifiers can attack the naphthalene ring and introduce substituents at specific positions.
The chemical properties of this compound make it have potential applications in drug synthesis, materials science and other fields. It can be used as an intermediate to construct more complex functional molecules through a series of reactions.
What are the main uses of (2-bromomethyl) -4-chloro-1-nitrobenzene?
(2-Hydroxymethyl) -4-methoxy-1-naphthyl acetic acid is a key intermediate in the field of organic synthesis. It has important uses in pharmaceutical chemistry, materials science and many other aspects.
In the field of pharmaceutical chemistry, it can be used as a key starting material to construct drug molecular structures with specific biological activities. Many drug research and development projects have focused on using its unique chemical structure, chemically modified and derived means to prepare drugs with high affinity and selectivity for specific disease targets. For example, in the study of anti-tumor drugs, researchers try to combine (2-hydroxymethyl) -4-methoxy-1-naphthyl acetic acid with other active groups, hoping to develop new anti-cancer drugs that can effectively inhibit tumor cell proliferation and induce tumor cell apoptosis.
In the field of materials science, it also plays an important role. With its special structure and properties, it can be used to synthesize functional materials with specific optical and electrical properties. For example, when preparing organic Light Emitting Diode (OLED) materials, it can be introduced as a structural unit to adjust the luminous properties of the materials, improve the luminous efficiency and stability, and thus improve the performance of OLED devices.
In addition, in the synthesis of fine chemical products, (2-hydroxymethyl) -4-methoxy-1-naphthyl acetic acid can be used to prepare fine chemicals such as high-end fragrances and cosmetic additives. Because of its unique chemical structure, it can endow products with unique aroma or special skin care and beauty effects, so it has also received extensive attention and application in the fine chemical industry.
In the field of pharmaceutical chemistry, it can be used as a key starting material to construct drug molecular structures with specific biological activities. Many drug research and development projects have focused on using its unique chemical structure, chemically modified and derived means to prepare drugs with high affinity and selectivity for specific disease targets. For example, in the study of anti-tumor drugs, researchers try to combine (2-hydroxymethyl) -4-methoxy-1-naphthyl acetic acid with other active groups, hoping to develop new anti-cancer drugs that can effectively inhibit tumor cell proliferation and induce tumor cell apoptosis.
In the field of materials science, it also plays an important role. With its special structure and properties, it can be used to synthesize functional materials with specific optical and electrical properties. For example, when preparing organic Light Emitting Diode (OLED) materials, it can be introduced as a structural unit to adjust the luminous properties of the materials, improve the luminous efficiency and stability, and thus improve the performance of OLED devices.
In addition, in the synthesis of fine chemical products, (2-hydroxymethyl) -4-methoxy-1-naphthyl acetic acid can be used to prepare fine chemicals such as high-end fragrances and cosmetic additives. Because of its unique chemical structure, it can endow products with unique aroma or special skin care and beauty effects, so it has also received extensive attention and application in the fine chemical industry.
What are the synthesis methods of (2-bromomethyl) -4-chloro-1-nitrobenzene?
The synthesis method of (2-hydroxymethyl) -4-fluoro-1-piperidinyl benzene has been known for a long time. There are many methods, so I will describe them here.
First, it can be obtained by nucleophilic substitution reaction of a halogenated benzene with a reagent containing (2-hydroxymethyl) -4-fluoro-1-piperidinyl with a suitable catalyst at a specific temperature and pressure. At that time, the conditions of the reaction need to be carefully regulated to ensure that the activity check point of the halogenated benzene is accurately combined with the reagent, and the occurrence of side reactions should be paid attention to to to prevent the product from being impure.
Second, benzene derivatives are also used as starting materials. Fluorine atoms are first introduced, and then (2-hydroxymethyl) and 1-piperidinyl groups are gradually constructed by ingenious reaction steps. This process needs to follow the laws of organic reactions and grasp the order of each step of the reaction. For example, the benzene cyclofluoride is first fluorinated with a specific fluorinating agent, and then an aldehyde compound and a suitable nitrogen-containing compound are used to form a piperidine structure through multi-step reactions, and then hydroxymethyl is introduced.
Third, a certain type of heterocyclic compound is used as a precursor, and a series of complex reactions such as ring opening and rearrangement are used to finally synthesize the target product. This approach requires strict conditions for the reaction, and the reagents used need to be carefully selected. During the reaction process, strict monitoring is required to ensure the smooth progress of each step of the reaction in order to obtain this (2-hydroxymethyl) -4-fluoro-1-piperidinylbenzene.
Although there are many methods for synthesis, they all need to be in line with chemical reasons, and the appropriate method should be carefully selected according to the actual required purity, yield and other factors.
First, it can be obtained by nucleophilic substitution reaction of a halogenated benzene with a reagent containing (2-hydroxymethyl) -4-fluoro-1-piperidinyl with a suitable catalyst at a specific temperature and pressure. At that time, the conditions of the reaction need to be carefully regulated to ensure that the activity check point of the halogenated benzene is accurately combined with the reagent, and the occurrence of side reactions should be paid attention to to to prevent the product from being impure.
Second, benzene derivatives are also used as starting materials. Fluorine atoms are first introduced, and then (2-hydroxymethyl) and 1-piperidinyl groups are gradually constructed by ingenious reaction steps. This process needs to follow the laws of organic reactions and grasp the order of each step of the reaction. For example, the benzene cyclofluoride is first fluorinated with a specific fluorinating agent, and then an aldehyde compound and a suitable nitrogen-containing compound are used to form a piperidine structure through multi-step reactions, and then hydroxymethyl is introduced.
Third, a certain type of heterocyclic compound is used as a precursor, and a series of complex reactions such as ring opening and rearrangement are used to finally synthesize the target product. This approach requires strict conditions for the reaction, and the reagents used need to be carefully selected. During the reaction process, strict monitoring is required to ensure the smooth progress of each step of the reaction in order to obtain this (2-hydroxymethyl) -4-fluoro-1-piperidinylbenzene.
Although there are many methods for synthesis, they all need to be in line with chemical reasons, and the appropriate method should be carefully selected according to the actual required purity, yield and other factors.
What are the precautions for (2-bromomethyl) -4-chloro-1-nitrobenzene in storage and transportation?
(Dimethyl) -4-chloro-1-naphthyl ether needs to pay attention to many key matters during storage and transportation.
When storing, choose the first environment. Find a cool, dry and well-ventilated place to avoid direct sunlight. The heat of sunlight and ultraviolet rays may cause this compound to chemically react, which will damage its quality. If stored in a high temperature and humid place, it may deliquescent and deteriorate, so the control of temperature and humidity is very important. The ideal temperature may be between 5 ° C and 25 ° C, and the relative humidity should be lower than 60%.
Furthermore, the choice of storage containers should not be underestimated. It is necessary to use corrosion-resistant materials, such as glass or containers made of certain plastics. Due to its structure containing chlorine, naphthyl, or reacting with certain metals, such as iron, copper, etc., the container will corrode and also affect the purity of the compound.
As for transportation, safety protection is the first priority. This material may be toxic and irritating, and the handler must wear appropriate protective equipment, such as protective clothing, gloves and goggles, to prevent it from contacting the skin and eyes. Transport vehicles should also be airtight to prevent leakage. If there is a leak during transportation, it should be dealt with immediately according to the emergency plan, evacuate the surrounding people, and cover it with sand and other materials to avoid spread.
Transportation route planning is also critical, to avoid densely populated areas and water source reserves. Once it leaks, it can reduce the harm to the public and the environment. And the transportation should be carried at a steady speed to prevent the container from being damaged due to bumps and collisions. In this way, the (dimethyl) -4-chloro-1-naphthyl ether can be stored and transported safely.
When storing, choose the first environment. Find a cool, dry and well-ventilated place to avoid direct sunlight. The heat of sunlight and ultraviolet rays may cause this compound to chemically react, which will damage its quality. If stored in a high temperature and humid place, it may deliquescent and deteriorate, so the control of temperature and humidity is very important. The ideal temperature may be between 5 ° C and 25 ° C, and the relative humidity should be lower than 60%.
Furthermore, the choice of storage containers should not be underestimated. It is necessary to use corrosion-resistant materials, such as glass or containers made of certain plastics. Due to its structure containing chlorine, naphthyl, or reacting with certain metals, such as iron, copper, etc., the container will corrode and also affect the purity of the compound.
As for transportation, safety protection is the first priority. This material may be toxic and irritating, and the handler must wear appropriate protective equipment, such as protective clothing, gloves and goggles, to prevent it from contacting the skin and eyes. Transport vehicles should also be airtight to prevent leakage. If there is a leak during transportation, it should be dealt with immediately according to the emergency plan, evacuate the surrounding people, and cover it with sand and other materials to avoid spread.
Transportation route planning is also critical, to avoid densely populated areas and water source reserves. Once it leaks, it can reduce the harm to the public and the environment. And the transportation should be carried at a steady speed to prevent the container from being damaged due to bumps and collisions. In this way, the (dimethyl) -4-chloro-1-naphthyl ether can be stored and transported safely.
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