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2-Bromomethyl-4-Chloro-1-Trifluoromethyl-Benzene
Linshang Chemical
|
HS Code |
431399 |
| Chemical Formula | C8H5BrClF3 |
| Molecular Weight | 273.48 |
| Appearance | Solid (usually) |
| Color | Off - white to pale yellow |
| Odor | Typical organic compound odor |
| Melting Point | Data needed |
| Boiling Point | Data needed |
| Density | Data needed |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Flash Point | Data needed |
| Stability | Stable under normal conditions, but reactive with strong oxidizing agents |
As an accredited 2-Bromomethyl-4-Chloro-1-Trifluoromethyl-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - bromomethyl - 4 - chloro - 1 - trifluoromethyl - benzene in sealed, chemical - resistant bottle. |
| Storage | 2 - bromomethyl - 4 - chloro - 1 - trifluoromethyl - benzene should be stored in a cool, dry, well - ventilated area, away from direct sunlight. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, bases, and reactive substances to avoid potential chemical reactions. Use appropriate storage cabinets designated for hazardous chemicals. |
| Shipping | 2 - bromomethyl - 4 - chloro - 1 - trifluoromethyl - benzene is shipped in sealed, corrosion - resistant containers. Adequate cushioning and secure packaging are used to prevent breakage during transit, following strict chemical transportation regulations. |
Competitive 2-Bromomethyl-4-Chloro-1-Trifluoromethyl-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 2-bromomethyl-4-chloro-1-trifluoromethyl-benzene?
2-Bromomethyl-4-chloro-1-trifluoromethylbenzene is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, in pharmaceutical chemistry, this is used as a starting material. After various reactions, complex molecular structures with specific pharmacological activities can be constructed. Because of its halogen atom and trifluoromethyl, it can significantly change the physical and chemical properties of the compound, such as lipophilicity and stability, and then affect its biological activity and pharmacokinetic properties.
Second, it also has important functions in the field of materials science. Through appropriate chemical reactions, it can be introduced into the structure of polymer materials, giving them special properties. For example, the presence of trifluoromethyl can improve the weather resistance, chemical stability and surface properties of materials, making them suitable for high-end fields such as aerospace and electronics.
Furthermore, in pesticide chemistry, compounds synthesized on this basis may have excellent biological activities such as insecticidal, bactericidal, and weeding. Its special structure helps to enhance the interaction with targets in vivo, improve the efficacy and selectivity of pesticides, and reduce the impact on the environment.
Overall, 2-bromomethyl-4-chloro-1-trifluoromethylbenzene plays an indispensable role in many fields such as organic synthesis, drug research and development, materials science, and pesticide preparation, and is of great significance in promoting the development of related industries.
First, in pharmaceutical chemistry, this is used as a starting material. After various reactions, complex molecular structures with specific pharmacological activities can be constructed. Because of its halogen atom and trifluoromethyl, it can significantly change the physical and chemical properties of the compound, such as lipophilicity and stability, and then affect its biological activity and pharmacokinetic properties.
Second, it also has important functions in the field of materials science. Through appropriate chemical reactions, it can be introduced into the structure of polymer materials, giving them special properties. For example, the presence of trifluoromethyl can improve the weather resistance, chemical stability and surface properties of materials, making them suitable for high-end fields such as aerospace and electronics.
Furthermore, in pesticide chemistry, compounds synthesized on this basis may have excellent biological activities such as insecticidal, bactericidal, and weeding. Its special structure helps to enhance the interaction with targets in vivo, improve the efficacy and selectivity of pesticides, and reduce the impact on the environment.
Overall, 2-bromomethyl-4-chloro-1-trifluoromethylbenzene plays an indispensable role in many fields such as organic synthesis, drug research and development, materials science, and pesticide preparation, and is of great significance in promoting the development of related industries.
What are the physical properties of 2-bromomethyl-4-chloro-1-trifluoromethyl-benzene?
2-Bromomethyl-4-chloro-1-trifluoromethylbenzene is an organic compound with unique physical properties. It is liquid at room temperature and pressure, and its color is almost colorless and transparent. However, due to the influence of impurities, it may appear slightly yellow. The substance has a pungent odor and a pungent smell. It should be used with caution to prevent irritation of the respiratory tract and skin.
Its melting point is about -20 ° C, its boiling point is between 190-200 ° C, and its relative density is greater than 1, about 1.6 g/cm ³. Due to the molecular structure containing halogen atoms such as bromine, chlorine, and fluorine, it has unique solubility. The solubility in water is extremely low, because it is a non-polar or weakly polar organic substance, and the force between it and water molecules is weak. However, in organic solvents, such as common ether, chloroform, dichloromethane, etc., the solubility is quite good, which makes it widely used in organic synthesis and extraction operations.
In addition, the compound has certain volatility. Although the volatility is not strong, in a poorly ventilated environment, its vapor will accumulate in the air, causing safety hazards. And because it contains halogen atoms, it may produce toxic halogenated hydrogen gas during combustion. When handling and using, attention should be paid to fire prevention, and an effective exhaust gas treatment device should be equipped to protect the environment and personnel safety. In practical application and research, clarifying the physical properties of 2-bromomethyl-4-chloro-1-trifluoromethylbenzene is of key significance for optimizing the synthesis process, selecting appropriate separation and purification methods, and ensuring the safety of use.
Its melting point is about -20 ° C, its boiling point is between 190-200 ° C, and its relative density is greater than 1, about 1.6 g/cm ³. Due to the molecular structure containing halogen atoms such as bromine, chlorine, and fluorine, it has unique solubility. The solubility in water is extremely low, because it is a non-polar or weakly polar organic substance, and the force between it and water molecules is weak. However, in organic solvents, such as common ether, chloroform, dichloromethane, etc., the solubility is quite good, which makes it widely used in organic synthesis and extraction operations.
In addition, the compound has certain volatility. Although the volatility is not strong, in a poorly ventilated environment, its vapor will accumulate in the air, causing safety hazards. And because it contains halogen atoms, it may produce toxic halogenated hydrogen gas during combustion. When handling and using, attention should be paid to fire prevention, and an effective exhaust gas treatment device should be equipped to protect the environment and personnel safety. In practical application and research, clarifying the physical properties of 2-bromomethyl-4-chloro-1-trifluoromethylbenzene is of key significance for optimizing the synthesis process, selecting appropriate separation and purification methods, and ensuring the safety of use.
What is 2-bromomethyl-4-chloro-1-trifluoromethyl-benzene synthesis method?
To prepare 2-bromomethyl-4-chloro-1-trifluoromethyl-benzene, the following method can be used.
Take 4-chloro-1-trifluoromethyl-benzene as the starting material, and there are specific substituents on the aromatic ring of this substance. Because trifluoromethyl is the meta-site locator and chlorine is the o-para-site locator, combined with the positioning effect of the two, the subsequent reaction check point is mainly in the ortho-site of chlorine.
4-chloro-1-trifluoromethyl-benzene is chloromethylated with formaldehyde and hydrogen bromide in the presence of a specific catalyst. In this reaction, formaldehyde interacts with hydrogen bromide to form an active intermediate, attacking the benzene ring, and introducing bromomethyl at the ortho-position of chlorine to obtain the target product 2-bromomethyl-4-chloro-1-trifluoromethyl-benzene. The reaction conditions need to be carefully regulated, such as temperature, catalyst dosage, etc. If the temperature is too high, it may cause the formation of multiple substitution by-products; if the temperature is too low, the reaction rate will be slow and the yield will decrease. Catalyst selection is also critical. Different catalyst activities and selectivity vary, which will affect the reaction process and product purity.
Or 4-chloro-1-trifluoromethyl-benzene can be methylated first, and methyl can be introduced into the benzene ring at a specific position with a suitable methylating agent under appropriate conditions. Then the obtained methylation product is brominated with a brominating agent, substituted by free radicals or electrophilic substitution, etc., to obtain the target product. However, this route step is slightly complicated, and the control of reaction conditions and product separation and purification at each step needs to be handled with caution to ensure high yield and purity. During operation, attention should be paid to the safety of each step of the reaction. Many reagents are corrosive, toxic or flammable and explosive, and should be properly disposed of according to specifications.
Take 4-chloro-1-trifluoromethyl-benzene as the starting material, and there are specific substituents on the aromatic ring of this substance. Because trifluoromethyl is the meta-site locator and chlorine is the o-para-site locator, combined with the positioning effect of the two, the subsequent reaction check point is mainly in the ortho-site of chlorine.
4-chloro-1-trifluoromethyl-benzene is chloromethylated with formaldehyde and hydrogen bromide in the presence of a specific catalyst. In this reaction, formaldehyde interacts with hydrogen bromide to form an active intermediate, attacking the benzene ring, and introducing bromomethyl at the ortho-position of chlorine to obtain the target product 2-bromomethyl-4-chloro-1-trifluoromethyl-benzene. The reaction conditions need to be carefully regulated, such as temperature, catalyst dosage, etc. If the temperature is too high, it may cause the formation of multiple substitution by-products; if the temperature is too low, the reaction rate will be slow and the yield will decrease. Catalyst selection is also critical. Different catalyst activities and selectivity vary, which will affect the reaction process and product purity.
Or 4-chloro-1-trifluoromethyl-benzene can be methylated first, and methyl can be introduced into the benzene ring at a specific position with a suitable methylating agent under appropriate conditions. Then the obtained methylation product is brominated with a brominating agent, substituted by free radicals or electrophilic substitution, etc., to obtain the target product. However, this route step is slightly complicated, and the control of reaction conditions and product separation and purification at each step needs to be handled with caution to ensure high yield and purity. During operation, attention should be paid to the safety of each step of the reaction. Many reagents are corrosive, toxic or flammable and explosive, and should be properly disposed of according to specifications.
2-bromomethyl-4-chloro-1-trifluoromethyl-benzene What are the precautions during storage and transportation?
2-Bromomethyl-4-chloro-1-trifluoromethylbenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First storage, this compound should be placed in a cool, dry and well-ventilated place. Because it may have certain chemical activity, it is heated, damp or deteriorated, which affects its quality and performance. Therefore, the temperature of the warehouse must be strictly controlled to prevent high temperature from triggering chemical reactions, causing decomposition or other accidents. And a dry environment can prevent it from reacting with water vapor and maintain its chemical stability.
Furthermore, when storing, it must be isolated from oxidants, strong bases and other substances. The chemical structure of this compound determines that it encounters a specific substance, which is prone to violent chemical reactions, or even the risk of fire and explosion. Therefore, in terms of warehouse layout, careful planning should be made, and various chemicals should be stored in categories, and mixed storage is strictly prohibited.
As for transportation, the packaging must be tight and stable. Because it is a chemical, slight leakage is extremely harmful. The transportation container needs to be made of suitable materials, which can withstand the corrosion of this compound, and has good sealing performance to ensure that there is no risk of leakage during transportation.
During transportation, severe vibration and collision should also be avoided. Violent vibration or collision may cause damage to the packaging and chemical leakage. The route of transportation vehicles should also be carefully planned to avoid densely populated areas and environmentally sensitive areas to prevent accidental leakage from causing serious harm to the public and the environment.
At the same time, transportation personnel must be professionally trained to be familiar with the characteristics, hazards and emergency treatment methods of this compound. In case of emergencies during transportation, they can respond quickly and properly to reduce the harm. In this way, 2-bromomethyl-4-chloro-1-trifluoromethylbenzene is safe during storage and transportation.
First storage, this compound should be placed in a cool, dry and well-ventilated place. Because it may have certain chemical activity, it is heated, damp or deteriorated, which affects its quality and performance. Therefore, the temperature of the warehouse must be strictly controlled to prevent high temperature from triggering chemical reactions, causing decomposition or other accidents. And a dry environment can prevent it from reacting with water vapor and maintain its chemical stability.
Furthermore, when storing, it must be isolated from oxidants, strong bases and other substances. The chemical structure of this compound determines that it encounters a specific substance, which is prone to violent chemical reactions, or even the risk of fire and explosion. Therefore, in terms of warehouse layout, careful planning should be made, and various chemicals should be stored in categories, and mixed storage is strictly prohibited.
As for transportation, the packaging must be tight and stable. Because it is a chemical, slight leakage is extremely harmful. The transportation container needs to be made of suitable materials, which can withstand the corrosion of this compound, and has good sealing performance to ensure that there is no risk of leakage during transportation.
During transportation, severe vibration and collision should also be avoided. Violent vibration or collision may cause damage to the packaging and chemical leakage. The route of transportation vehicles should also be carefully planned to avoid densely populated areas and environmentally sensitive areas to prevent accidental leakage from causing serious harm to the public and the environment.
At the same time, transportation personnel must be professionally trained to be familiar with the characteristics, hazards and emergency treatment methods of this compound. In case of emergencies during transportation, they can respond quickly and properly to reduce the harm. In this way, 2-bromomethyl-4-chloro-1-trifluoromethylbenzene is safe during storage and transportation.
2-bromomethyl-4-chloro-1-trifluoromethyl-benzene impact on the environment
2-Bromomethyl-4-chloro-1-trifluoromethylbenzene is one of the organic compounds. The effects of this substance in the environment are quite complex, and it will be described in detail today.
First of all, its chemical properties are active, because it contains functional groups such as bromomethyl, chlorine and trifluoromethyl. In bromomethyl, the carbon-bromide bond is relatively fragile and prone to substitution reactions. Once released into the environment, this part may react with other substances in the environment to form new compounds, or have effects on molecules in organisms, affecting the normal physiological functions of organisms.
Furthermore, trifluoromethyl has strong electron-absorbing properties, which affect the distribution of electron clouds in the benzene ring and enhance the hydrophobicity of the whole molecule. This property makes it unique in its migration behavior in the environment, and it is easy to accumulate in areas with high lipid content, such as the adipose tissue of organisms. In aquatic environments, its hydrophobicity makes it easy to adsorb on suspended particles, settle to the bottom sediment, and persist for a long time, posing a potential threat to benthic organisms.
Regarding toxicity, although there is no exact comprehensive study, it is speculated that it may have certain biological toxicity by analogy with similar compounds. Trifluoromethyl compounds often interfere with the enzyme system and endocrine system of organisms. The substance may be transmitted and amplified through the food chain, causing greater harm to high trophic organisms.
In addition, this compound has high chemical stability and is difficult to degrade in the natural environment. The metabolic mechanism of ordinary microorganisms may not be effectively decomposed. It exists in the environment for a long time, accumulates continuously, and gradually changes the local ecological and chemical composition, which affects the balance of the ecosystem.
2-Bromomethyl-4-chloro-1-trifluoromethylbenzene in the environment has many potential and complex effects on the ecological environment from the aspects of chemical reactivity, migration characteristics, potential toxicity and refractory degradation. It is necessary to study in depth to understand its exact harm and seek a good solution.
First of all, its chemical properties are active, because it contains functional groups such as bromomethyl, chlorine and trifluoromethyl. In bromomethyl, the carbon-bromide bond is relatively fragile and prone to substitution reactions. Once released into the environment, this part may react with other substances in the environment to form new compounds, or have effects on molecules in organisms, affecting the normal physiological functions of organisms.
Furthermore, trifluoromethyl has strong electron-absorbing properties, which affect the distribution of electron clouds in the benzene ring and enhance the hydrophobicity of the whole molecule. This property makes it unique in its migration behavior in the environment, and it is easy to accumulate in areas with high lipid content, such as the adipose tissue of organisms. In aquatic environments, its hydrophobicity makes it easy to adsorb on suspended particles, settle to the bottom sediment, and persist for a long time, posing a potential threat to benthic organisms.
Regarding toxicity, although there is no exact comprehensive study, it is speculated that it may have certain biological toxicity by analogy with similar compounds. Trifluoromethyl compounds often interfere with the enzyme system and endocrine system of organisms. The substance may be transmitted and amplified through the food chain, causing greater harm to high trophic organisms.
In addition, this compound has high chemical stability and is difficult to degrade in the natural environment. The metabolic mechanism of ordinary microorganisms may not be effectively decomposed. It exists in the environment for a long time, accumulates continuously, and gradually changes the local ecological and chemical composition, which affects the balance of the ecosystem.
2-Bromomethyl-4-chloro-1-trifluoromethylbenzene in the environment has many potential and complex effects on the ecological environment from the aspects of chemical reactivity, migration characteristics, potential toxicity and refractory degradation. It is necessary to study in depth to understand its exact harm and seek a good solution.
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