Linshang Chemical
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2-Chloro-1,3-Bis(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
454750 |
| Chemical Formula | C8H3ClF6 |
| Molar Mass | 258.55 g/mol |
| Appearance | Liquid |
| Boiling Point | 148 - 150 °C |
| Density | 1.52 g/cm³ |
| Flash Point | 45 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble |
| Odor | Characteristic |
| Vapor Pressure | Low |
| Stability | Stable under normal conditions |
As an accredited 2-Chloro-1,3-Bis(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottle packaging for 2 - chloro - 1,3 - bis(trifluoromethyl)benzene. |
| Storage | 2 - Chloro - 1,3 - bis(trifluoromethyl)benzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances. Ensure the storage place has proper spill - containment measures due to its potential hazards. |
| Shipping | 2 - chloro - 1,3 - bis(trifluoromethyl)benzene should be shipped in tightly sealed, corrosion - resistant containers. It must comply with hazardous chemical shipping regulations, with proper labeling indicating its properties and handling precautions. |
Competitive 2-Chloro-1,3-Bis(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-1,3-Bis(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 2-chloro-1,3-bis (trifluoromethyl) benzene?
2-Chloro-1,3-bis (trifluoromethyl) benzene, this is an organic compound. Its main uses are quite extensive and it plays a key role in the field of organic synthesis.
is often used as a key intermediate in the synthesis of medicine. With its special molecular structure, it can participate in a series of chemical reactions, and it can be cleverly designed and transformed to construct a complex molecular structure with specific pharmacological activities. For example, when developing new antimicrobial drugs, compounds with high inhibitory effect on specific pathogens can be synthesized by modifying and derivatizing their functional groups, paving the way for the creation of new anti-infective drugs.
is also of great value in the field of materials science. Due to the fluorine atoms in the molecule, it is endowed with unique physical and chemical properties, such as excellent thermal stability, chemical stability and low surface energy. Based on this, it can be used to prepare high-performance fluoropolymer materials. Introducing it into the polymer main chain or side chain can significantly improve the weather resistance, corrosion resistance and water and oil resistance of the material. It is widely used in aerospace, automobile manufacturing, construction and other industries, such as the manufacture of aircraft skin coatings, automotive interior materials and building exterior wall protective coatings, etc., to enhance the durability and functionality of the material.
In the field of pesticide synthesis, it is also an important raw material. It can be used to synthesize pesticide products with high insecticidal, bactericidal or herbicidal activities. Its special structure helps to improve the selectivity and affinity of pesticides to target organisms, enhance their efficacy, and reduce the impact on non-target organisms, reducing the risk of environmental pollution, providing an important basis for the development of green and efficient pesticides.
is often used as a key intermediate in the synthesis of medicine. With its special molecular structure, it can participate in a series of chemical reactions, and it can be cleverly designed and transformed to construct a complex molecular structure with specific pharmacological activities. For example, when developing new antimicrobial drugs, compounds with high inhibitory effect on specific pathogens can be synthesized by modifying and derivatizing their functional groups, paving the way for the creation of new anti-infective drugs.
is also of great value in the field of materials science. Due to the fluorine atoms in the molecule, it is endowed with unique physical and chemical properties, such as excellent thermal stability, chemical stability and low surface energy. Based on this, it can be used to prepare high-performance fluoropolymer materials. Introducing it into the polymer main chain or side chain can significantly improve the weather resistance, corrosion resistance and water and oil resistance of the material. It is widely used in aerospace, automobile manufacturing, construction and other industries, such as the manufacture of aircraft skin coatings, automotive interior materials and building exterior wall protective coatings, etc., to enhance the durability and functionality of the material.
In the field of pesticide synthesis, it is also an important raw material. It can be used to synthesize pesticide products with high insecticidal, bactericidal or herbicidal activities. Its special structure helps to improve the selectivity and affinity of pesticides to target organisms, enhance their efficacy, and reduce the impact on non-target organisms, reducing the risk of environmental pollution, providing an important basis for the development of green and efficient pesticides.
What are the physical properties of 2-chloro-1,3-bis (trifluoromethyl) benzene
2-Chloro-1,3-bis (trifluoromethyl) benzene is one of the organic compounds. Its physical properties are quite unique and it has important uses in many fields.
This compound is often in a liquid state at room temperature and pressure. Looking at its appearance, it is mostly a colorless and transparent liquid, like clear water, pure and free of variegated colors. It has a certain volatility, and in the air, it is light and dissipating like a spirit, and can spread quickly.
In terms of solubility, 2-chloro-1,3-bis (trifluoromethyl) benzene exhibits good affinity for organic solvents. Organic solvents such as common ethanol, ether, acetone, etc. can be miscible with each other, just like water emulsion blends. However, it is extremely difficult to blend with water. The two are like two parallel lines that never intersect. Water is itself water, and this compound is itself, with a clear boundary.
As for the density, compared to water, the density of 2-chloro-1,3-bis (trifluoromethyl) benzene is slightly higher. If it is placed in the same container as water, this compound will be like a stable stone, quietly sinking to the bottom, while water is on the upper layer.
Furthermore, its boiling point and melting point are also key physical properties. At the boiling point, the compound will undergo a magical transformation from liquid to gaseous state, just like a chrysalis turning into a butterfly; at the melting point, there will be a transition from solid to liquid state. The specific values of these two are affected by the molecular structure and interaction forces, and can be presented under specific conditions.
The physical properties of 2-chloro-1,3-bis (trifluoromethyl) benzene play an important role in many fields such as organic synthesis and materials science. Due to its unique physical properties, it can be used as an excellent solvent in a specific reaction system to assist in the smooth progress of chemical reactions. During the preparation of materials, it can also optimize and regulate the properties of materials by virtue of its characteristics, which is an indispensable and important compound.
This compound is often in a liquid state at room temperature and pressure. Looking at its appearance, it is mostly a colorless and transparent liquid, like clear water, pure and free of variegated colors. It has a certain volatility, and in the air, it is light and dissipating like a spirit, and can spread quickly.
In terms of solubility, 2-chloro-1,3-bis (trifluoromethyl) benzene exhibits good affinity for organic solvents. Organic solvents such as common ethanol, ether, acetone, etc. can be miscible with each other, just like water emulsion blends. However, it is extremely difficult to blend with water. The two are like two parallel lines that never intersect. Water is itself water, and this compound is itself, with a clear boundary.
As for the density, compared to water, the density of 2-chloro-1,3-bis (trifluoromethyl) benzene is slightly higher. If it is placed in the same container as water, this compound will be like a stable stone, quietly sinking to the bottom, while water is on the upper layer.
Furthermore, its boiling point and melting point are also key physical properties. At the boiling point, the compound will undergo a magical transformation from liquid to gaseous state, just like a chrysalis turning into a butterfly; at the melting point, there will be a transition from solid to liquid state. The specific values of these two are affected by the molecular structure and interaction forces, and can be presented under specific conditions.
The physical properties of 2-chloro-1,3-bis (trifluoromethyl) benzene play an important role in many fields such as organic synthesis and materials science. Due to its unique physical properties, it can be used as an excellent solvent in a specific reaction system to assist in the smooth progress of chemical reactions. During the preparation of materials, it can also optimize and regulate the properties of materials by virtue of its characteristics, which is an indispensable and important compound.
What are the chemical properties of 2-chloro-1,3-bis (trifluoromethyl) benzene
2-Chloro-1,3-bis (trifluoromethyl) benzene is also an organic compound. Its molecule contains a chlorine atom and two trifluoromethyl groups, which are connected to the benzene ring. The chemical properties of this compound are worth exploring.
As far as its stability is concerned, the benzene ring has a conjugated system, which has a certain stability. However, trifluoromethyl has strong electron-withdrawing, and the chlorine atom also has an electron-withdrawing effect. The two are connected to the benzene ring, or the electron cloud density of the benzene ring is reduced, which makes its stability slightly changed. In the electrophilic substitution reaction, due to the existence of electron-withdrawing groups, the reactivity may be different from that of ordinary benzene derivatives. When the electrophilic reagent attacks the benzene ring, Usually, such electron-withdrawing groups reduce the electron cloud density of the ortho-and para-site of the benzene ring even more, so the electrophilic substitution reaction may occur more easily in the meta-site.
Re-discussion on the properties of its halogen atom. The chlorine atom in 2-chloro-1,3-bis (trifluoromethyl) benzene has the general properties of halogenated hydrocarbons. Under appropriate conditions, nucleophilic substitution reactions can occur. Due to the reduction of the electron cloud density of the benzene ring, the positive electricity of the carbon attached to the chlorine atom is enhanced, and it is more vulnerable to attack by nucleophiles. Chlorine ions can be replaced by nucleophiles to form new compounds.
Because of its trifluoromethyl content, this group makes the compound have Compounds containing trifluoromethyl are often used in medicine, pesticides and other fields. This compound may have special performance in biological activity and stability due to the characteristics of trifluoromethyl, and can be used to develop drugs or pesticide products with specific properties.
Its chemical properties are not only affected by the benzene ring conjugation system, but also unique due to the existence of chlorine atoms and trifluoromethyl. It has potential application value and research significance in organic synthesis and related fields.
As far as its stability is concerned, the benzene ring has a conjugated system, which has a certain stability. However, trifluoromethyl has strong electron-withdrawing, and the chlorine atom also has an electron-withdrawing effect. The two are connected to the benzene ring, or the electron cloud density of the benzene ring is reduced, which makes its stability slightly changed. In the electrophilic substitution reaction, due to the existence of electron-withdrawing groups, the reactivity may be different from that of ordinary benzene derivatives. When the electrophilic reagent attacks the benzene ring, Usually, such electron-withdrawing groups reduce the electron cloud density of the ortho-and para-site of the benzene ring even more, so the electrophilic substitution reaction may occur more easily in the meta-site.
Re-discussion on the properties of its halogen atom. The chlorine atom in 2-chloro-1,3-bis (trifluoromethyl) benzene has the general properties of halogenated hydrocarbons. Under appropriate conditions, nucleophilic substitution reactions can occur. Due to the reduction of the electron cloud density of the benzene ring, the positive electricity of the carbon attached to the chlorine atom is enhanced, and it is more vulnerable to attack by nucleophiles. Chlorine ions can be replaced by nucleophiles to form new compounds.
Because of its trifluoromethyl content, this group makes the compound have Compounds containing trifluoromethyl are often used in medicine, pesticides and other fields. This compound may have special performance in biological activity and stability due to the characteristics of trifluoromethyl, and can be used to develop drugs or pesticide products with specific properties.
Its chemical properties are not only affected by the benzene ring conjugation system, but also unique due to the existence of chlorine atoms and trifluoromethyl. It has potential application value and research significance in organic synthesis and related fields.
What is the preparation method of 2-chloro-1,3-bis (trifluoromethyl) benzene?
There are several common methods for preparing 2-chloro-1,3-bis (trifluoromethyl) benzene. One is to use 1,3-bis (trifluoromethyl) benzene as the starting material and make it react with the chlorine source under suitable conditions. Among them, the chlorine source is often chlorine gas. When reacting, a suitable catalyst is required, such as iron powder or ferric chloride and other Lewis acid catalysts. Under the conditions of light or heating, chlorine molecules are excited to produce active chlorine radicals, which attack the benzene ring of 1,3-bis (trifluoromethyl) benzene. Through the radical substitution process, chlorine atoms are introduced at specific positions on the benzene ring, and then 2-chloro-1,3-bis (trifluoromethyl) benzene is generated.
In addition, benzene derivatives containing corresponding substituents can also be prepared by multi-step reaction. For example, first introduce trifluoromethyl into the benzene ring in a suitable method, and then perform a chlorination reaction. When introducing trifluoromethyl, a trifluoromethyl-containing reagent can be selected. Under specific reaction conditions, it interacts with benzene derivatives to connect the benzene ring to the trifluoromethyl group. The subsequent chlorination step is similar to the above chlorination with 1,3-bis (trifluoromethyl) benzene as raw material, and the appropriate chlorine source and reaction conditions are selected to complete the introduction of chlorine atoms.
Or it can be prepared by the reaction of organometallic reagents. For example, the organometallic reagent containing trifluoromethyl is first prepared, and then the coupling reaction is carried out with the chlorine-containing benzene derivative. In this process, the precise control of the activity of the organometallic reagent and the reaction conditions is very critical. According to the characteristics of the reagent used, the reaction temperature, solvent and reaction time must be carefully adjusted to obtain the target product 2-chloro-1,3-bis (trifluoromethyl) benzene. Each method has its advantages and disadvantages. In actual preparation, the choice needs to be weighed according to various factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity requirements of the product.
In addition, benzene derivatives containing corresponding substituents can also be prepared by multi-step reaction. For example, first introduce trifluoromethyl into the benzene ring in a suitable method, and then perform a chlorination reaction. When introducing trifluoromethyl, a trifluoromethyl-containing reagent can be selected. Under specific reaction conditions, it interacts with benzene derivatives to connect the benzene ring to the trifluoromethyl group. The subsequent chlorination step is similar to the above chlorination with 1,3-bis (trifluoromethyl) benzene as raw material, and the appropriate chlorine source and reaction conditions are selected to complete the introduction of chlorine atoms.
Or it can be prepared by the reaction of organometallic reagents. For example, the organometallic reagent containing trifluoromethyl is first prepared, and then the coupling reaction is carried out with the chlorine-containing benzene derivative. In this process, the precise control of the activity of the organometallic reagent and the reaction conditions is very critical. According to the characteristics of the reagent used, the reaction temperature, solvent and reaction time must be carefully adjusted to obtain the target product 2-chloro-1,3-bis (trifluoromethyl) benzene. Each method has its advantages and disadvantages. In actual preparation, the choice needs to be weighed according to various factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity requirements of the product.
Precautions for storage and transportation of 2-chloro-1,3-bis (trifluoromethyl) benzene
2-Chloro-1,3-bis (trifluoromethyl) benzene is an organic chemical substance, and many things should be paid attention to during storage and transportation.
First, storage, because it has a certain chemical activity, needs to be placed in a cool and dry place. When this substance is wet or heated, it may cause chemical reactions, change its properties, or even risk safety. Therefore, the humidity and temperature of the warehouse should be carefully controlled. The humidity is always controlled in a relatively low range, and the temperature should not be too high to prevent accidents.
Furthermore, the storage must be well ventilated. 2-Chloro-1,3-bis (trifluoromethyl) benzene or volatile irritating and potentially harmful gases can be dispersed in time with good ventilation to prevent their accumulation and reduce the threat to personnel and the environment.
And because of its certain toxicity and corrosion, the storage container must be adapted. When using corrosion-resistant materials, such as specific metal or plastic containers, and the container must be well sealed to avoid contact with air, moisture, etc., to ensure the purity and stability of the substance.
As for transportation, the first heavy packaging is stable. Professional and strong packaging materials must be used to ensure that the packaging is not damaged due to bumps and collisions during transportation, and to prevent material leakage.
The means of transportation must also be selected with caution. Do not mix with oxidizing, reducing or acid-alkaline substances, because 2-chloro-1,3-bis (trifluoromethyl) benzene is prone to violent reactions in contact with such substances. During transportation, the temperature and humidity should also be closely monitored, and appropriate control measures should be taken according to the actual situation.
The escort must have professional knowledge and be familiar with the characteristics, hazards and emergency response methods of this substance. If there is an accident such as leakage during transportation, it can be dealt with in a timely and correct manner to minimize the harm.
First, storage, because it has a certain chemical activity, needs to be placed in a cool and dry place. When this substance is wet or heated, it may cause chemical reactions, change its properties, or even risk safety. Therefore, the humidity and temperature of the warehouse should be carefully controlled. The humidity is always controlled in a relatively low range, and the temperature should not be too high to prevent accidents.
Furthermore, the storage must be well ventilated. 2-Chloro-1,3-bis (trifluoromethyl) benzene or volatile irritating and potentially harmful gases can be dispersed in time with good ventilation to prevent their accumulation and reduce the threat to personnel and the environment.
And because of its certain toxicity and corrosion, the storage container must be adapted. When using corrosion-resistant materials, such as specific metal or plastic containers, and the container must be well sealed to avoid contact with air, moisture, etc., to ensure the purity and stability of the substance.
As for transportation, the first heavy packaging is stable. Professional and strong packaging materials must be used to ensure that the packaging is not damaged due to bumps and collisions during transportation, and to prevent material leakage.
The means of transportation must also be selected with caution. Do not mix with oxidizing, reducing or acid-alkaline substances, because 2-chloro-1,3-bis (trifluoromethyl) benzene is prone to violent reactions in contact with such substances. During transportation, the temperature and humidity should also be closely monitored, and appropriate control measures should be taken according to the actual situation.
The escort must have professional knowledge and be familiar with the characteristics, hazards and emergency response methods of this substance. If there is an accident such as leakage during transportation, it can be dealt with in a timely and correct manner to minimize the harm.
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