Linshang Chemical
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2-Chloro-1,3-Difluoro-4-Nitrobenzene
Linshang Chemical
|
HS Code |
158890 |
| Chemical Formula | C6H2ClF2NO2 |
| Molecular Weight | 195.54 |
| Appearance | Solid (usually) |
| Physical State At Room Temp | Solid |
| Odor | Typical aromatic nitro - halogenated odor |
| Melting Point | Specific value would need experimental determination |
| Boiling Point | Specific value would need experimental determination |
| Solubility In Water | Low solubility in water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Density | Specific value would need experimental determination |
| Vapor Pressure | Low vapor pressure |
As an accredited 2-Chloro-1,3-Difluoro-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250 - gram bottle of 2 - chloro - 1,3 - difluoro - 4 - nitrobenzene, well - sealed. |
| Storage | 2 - chloro - 1,3 - difluoro - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames to prevent fire or decomposition. It should be stored separately from oxidizing agents, reducing agents, and bases due to potential reactivity. Keep containers tightly sealed to prevent leakage and vapor release, safeguarding both the chemical and the storage environment. |
| Shipping | 2 - chloro - 1,3 - difluoro - 4 - nitrobenzene is shipped in sealed, corrosion - resistant containers. Shipment follows strict hazardous chemical regulations, ensuring proper labeling, secure packaging to prevent leakage during transit. |
Competitive 2-Chloro-1,3-Difluoro-4-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Chloro-1,3-Difluoro-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
2-Chloro-1, what are the physical properties of 3-difluoro-4-nitrobenzene?
2-Chloro-1,3-difluoro-4-nitrobenzene is a kind of organic compound. Its physical properties, with specific morphology, odor, melting boiling point and solubility, are widely used in various fields of chemical industry.
Looking at its properties, under normal circumstances, 2-chloro-1,3-difluoro-4-nitrobenzene is mostly colorless to light yellow liquid or crystalline solid. Its odor is specific, but the literature describes it in detail, because your mileage may vary and is related to concentration.
When it comes to the melting and boiling point, the melting point is about 35-39 ° C, and the boiling point is in the range of 213-215 ° C. The melting point is relatively low, so that the compound is easy to change from solid to liquid at a slightly warmer temperature. The higher boiling point reflects the strong intermolecular force, and more energy is required to vaporize it.
In terms of solubility, 2-chloro-1,3-difluoro-4-nitrobenzene is insoluble in water. Because water is a very polar solvent, and the polar molecules of this compound are limited, according to the principle of "similar miscibility", the two are not compatible. However, it has good solubility in organic solvents such as ethanol, ether, acetone, etc. This property is crucial in organic synthesis. It can help the reactants to mix thoroughly and improve the reaction rate and yield.
In addition, the density of 2-chloro-1,3-difluoro-4-nitrobenzene is greater than that of water. This property is crucial when it comes to liquid-liquid separation operations. Due to its high density, it will be in the lower layer when delaminated, which is convenient for separation and purification.
In summary, the physical properties of 2-chloro-1, 3-difluoro-4-nitrobenzene have an important impact on its production, storage, transportation and application. Knowing these properties can make good use of them and maximize their effectiveness in organic synthesis, pharmaceutical and chemical industries.
Looking at its properties, under normal circumstances, 2-chloro-1,3-difluoro-4-nitrobenzene is mostly colorless to light yellow liquid or crystalline solid. Its odor is specific, but the literature describes it in detail, because your mileage may vary and is related to concentration.
When it comes to the melting and boiling point, the melting point is about 35-39 ° C, and the boiling point is in the range of 213-215 ° C. The melting point is relatively low, so that the compound is easy to change from solid to liquid at a slightly warmer temperature. The higher boiling point reflects the strong intermolecular force, and more energy is required to vaporize it.
In terms of solubility, 2-chloro-1,3-difluoro-4-nitrobenzene is insoluble in water. Because water is a very polar solvent, and the polar molecules of this compound are limited, according to the principle of "similar miscibility", the two are not compatible. However, it has good solubility in organic solvents such as ethanol, ether, acetone, etc. This property is crucial in organic synthesis. It can help the reactants to mix thoroughly and improve the reaction rate and yield.
In addition, the density of 2-chloro-1,3-difluoro-4-nitrobenzene is greater than that of water. This property is crucial when it comes to liquid-liquid separation operations. Due to its high density, it will be in the lower layer when delaminated, which is convenient for separation and purification.
In summary, the physical properties of 2-chloro-1, 3-difluoro-4-nitrobenzene have an important impact on its production, storage, transportation and application. Knowing these properties can make good use of them and maximize their effectiveness in organic synthesis, pharmaceutical and chemical industries.
What are the main uses of 2-chloro-1, 3-difluoro-4-nitrobenzene?
2-Chloro-1,3-difluoro-4-nitrobenzene is also an organic compound. Its main use is more common in the field of organic synthesis.
In the synthesis of medicine, this compound can be used as a key intermediate. Functional groups such as chlorine, fluorine and nitro on the benzene ring have unique chemical activities. The introduction of fluorine atoms can significantly change the physical and chemical properties of compounds, such as improving fat solubility, which in turn affects the ability of drug molecules to bind to targets and enhance drug efficacy. Nitro can be converted into amino groups through reactions such as reduction, laying the foundation for the construction of diverse drug structures. Chlorine atoms can also participate in nucleophilic substitution reactions, and many novel compounds can be derived, which play an important role in the creation of new pharmaceutical ingredients.
In the field of pesticide synthesis, 2-chloro-1,3-difluoro-4-nitrobenzene also plays an important role. Due to its structural properties, compounds with high insecticidal, bactericidal or herbicidal activities can be derived. For example, through reactions such as nucleophilic substitution, specific organic groups can be connected to create pesticide varieties with high selectivity and high activity to specific pests or weeds, providing powerful tools for agricultural pest control.
In addition, in the field of materials science, special functional materials synthesized from this raw material have also attracted attention. It can participate in polymerization reactions, introduce unique functional groups into the polymer structure, endow the material with special properties such as chemical resistance and optical properties, and display application potential in special coatings, optical materials, etc.
In the synthesis of medicine, this compound can be used as a key intermediate. Functional groups such as chlorine, fluorine and nitro on the benzene ring have unique chemical activities. The introduction of fluorine atoms can significantly change the physical and chemical properties of compounds, such as improving fat solubility, which in turn affects the ability of drug molecules to bind to targets and enhance drug efficacy. Nitro can be converted into amino groups through reactions such as reduction, laying the foundation for the construction of diverse drug structures. Chlorine atoms can also participate in nucleophilic substitution reactions, and many novel compounds can be derived, which play an important role in the creation of new pharmaceutical ingredients.
In the field of pesticide synthesis, 2-chloro-1,3-difluoro-4-nitrobenzene also plays an important role. Due to its structural properties, compounds with high insecticidal, bactericidal or herbicidal activities can be derived. For example, through reactions such as nucleophilic substitution, specific organic groups can be connected to create pesticide varieties with high selectivity and high activity to specific pests or weeds, providing powerful tools for agricultural pest control.
In addition, in the field of materials science, special functional materials synthesized from this raw material have also attracted attention. It can participate in polymerization reactions, introduce unique functional groups into the polymer structure, endow the material with special properties such as chemical resistance and optical properties, and display application potential in special coatings, optical materials, etc.
What are the synthesis methods of 2-chloro-1, 3-difluoro-4-nitrobenzene?
There are several common methods for the synthesis of 2-chloro-1,3-difluoro-4-nitrobenzene.
One is to use 2,6-difluoroaniline as the starting material. First, 2,6-difluoroaniline is reacted with sodium nitrite and hydrochloric acid at low temperature. This process requires strict temperature control to prevent the decomposition of diazonium salts. The resulting diazonium salt reacts with the hydrochloric acid solution of cuprous chloride to undergo a Sandmeier reaction, which can replace the diazonium group with a chlorine atom, resulting in 2-chloro-1,3-difluorobenzene. Subsequently, 2-chloro-1,3-difluorobenzene is nitrified with a mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid). At the right temperature and reaction time, the nitro group selectively enters a specific position on the benzene ring, and finally generates 2-chloro-1,3-difluoro-4-nitrobenzene.
The second is to start with 1,3-difluorobenzene. 1,3-difluorobenzene is first chlorinated with a chlorinated reagent, such as N-chlorosuccinimide (NCS), in the presence of a suitable catalyst such as benzoyl peroxide. The reaction conditions are relatively mild, allowing chlorine atoms to be introduced into the benzene ring to generate 2-chloro-1,3-difluorobenzene. After that, as in the above method, the obtained product is nitrified with mixed acids, and through a series of reaction steps, the target product 2-chloro-1,3-difluoro-4-nitrobenzene can also be obtained.
Furthermore, if 2-chloro-1,3-difluorobenzoic acid is used as a raw material, it can be decarboxylated first. In the presence of catalysts such as copper powder and quinoline, the carboxyl groups are heated to remove in the form of carbon dioxide to obtain 2-chloro-1,3-difluorobenzene. Then, the synthesis of 2-chloro-1,3-difluoro-4-nitrobenzene was also achieved by nitration reaction with mixed acids.
Each method has its advantages and disadvantages. Using 2,6-difluoroaniline as the raw material, the starting material is relatively easy to obtain, but the diazotization and Sandmeier reaction steps are slightly more complicated and require strict reaction conditions. Using 1,3-difluorobenzene as the starting material, the chlorination reaction conditions are mild, but the chlorination positional selectivity should be paid attention to. With 2-chloro-1,3-difluorobenzoic acid as the raw material, the decarboxylation reaction requires a specific catalyst and suitable temperature, but if properly operated, the target product can also be effectively synthesized. In actual synthesis, it is necessary to comprehensively consider factors such as raw material availability, cost and reaction conditions, and choose the appropriate synthesis path.
One is to use 2,6-difluoroaniline as the starting material. First, 2,6-difluoroaniline is reacted with sodium nitrite and hydrochloric acid at low temperature. This process requires strict temperature control to prevent the decomposition of diazonium salts. The resulting diazonium salt reacts with the hydrochloric acid solution of cuprous chloride to undergo a Sandmeier reaction, which can replace the diazonium group with a chlorine atom, resulting in 2-chloro-1,3-difluorobenzene. Subsequently, 2-chloro-1,3-difluorobenzene is nitrified with a mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid). At the right temperature and reaction time, the nitro group selectively enters a specific position on the benzene ring, and finally generates 2-chloro-1,3-difluoro-4-nitrobenzene.
The second is to start with 1,3-difluorobenzene. 1,3-difluorobenzene is first chlorinated with a chlorinated reagent, such as N-chlorosuccinimide (NCS), in the presence of a suitable catalyst such as benzoyl peroxide. The reaction conditions are relatively mild, allowing chlorine atoms to be introduced into the benzene ring to generate 2-chloro-1,3-difluorobenzene. After that, as in the above method, the obtained product is nitrified with mixed acids, and through a series of reaction steps, the target product 2-chloro-1,3-difluoro-4-nitrobenzene can also be obtained.
Furthermore, if 2-chloro-1,3-difluorobenzoic acid is used as a raw material, it can be decarboxylated first. In the presence of catalysts such as copper powder and quinoline, the carboxyl groups are heated to remove in the form of carbon dioxide to obtain 2-chloro-1,3-difluorobenzene. Then, the synthesis of 2-chloro-1,3-difluoro-4-nitrobenzene was also achieved by nitration reaction with mixed acids.
Each method has its advantages and disadvantages. Using 2,6-difluoroaniline as the raw material, the starting material is relatively easy to obtain, but the diazotization and Sandmeier reaction steps are slightly more complicated and require strict reaction conditions. Using 1,3-difluorobenzene as the starting material, the chlorination reaction conditions are mild, but the chlorination positional selectivity should be paid attention to. With 2-chloro-1,3-difluorobenzoic acid as the raw material, the decarboxylation reaction requires a specific catalyst and suitable temperature, but if properly operated, the target product can also be effectively synthesized. In actual synthesis, it is necessary to comprehensively consider factors such as raw material availability, cost and reaction conditions, and choose the appropriate synthesis path.
What are the precautions for storing and transporting 2-chloro-1, 3-difluoro-4-nitrobenzene?
2-Chloro-1,3-difluoro-4-nitrobenzene is an organic compound. When storing and transporting, many matters must be paid attention to.
Let's talk about storage first. This compound has certain chemical activity and potential danger, and the first choice for storage environment. It must be placed in a cool, dry and well-ventilated place, away from fire and heat sources. It is easy to exacerbate chemical reactions due to heat, or it may be dangerous. If the environment is humid, or it may cause reactions such as hydrolysis, it will damage its quality.
Furthermore, storage containers are also crucial. It is advisable to use corrosion-resistant materials, such as glass, certain plastics or metal containers, and ensure that they are tightly sealed. The cover may be corrosive to certain materials. If the container leaks, it will not only lose the material, but also endanger the surrounding environment and personal safety.
As for transportation, the first thing to do is packaging. It is necessary to follow relevant regulations and use suitable packaging materials to ensure that there is no leakage or damage during transportation. Transportation vehicles should also be selected with corresponding safety facilities, and drivers and escorts must undergo professional training to be familiar with their characteristics and emergency disposal methods.
During transportation, avoid mixing with oxidants, reducing agents, alkalis, etc. Gein 2-chloro-1, 3-difluoro-4-nitrobenzene and other such substances are prone to chemical reactions, resulting in serious consequences such as combustion and explosion.
In addition, transportation route planning should not be underestimated. Try to avoid sensitive areas such as densely populated areas and water sources to prevent accidental leakage from causing major harm. And the transportation process should strictly abide by traffic laws and special regulations on the transportation of hazardous chemicals to ensure safe transportation.
Let's talk about storage first. This compound has certain chemical activity and potential danger, and the first choice for storage environment. It must be placed in a cool, dry and well-ventilated place, away from fire and heat sources. It is easy to exacerbate chemical reactions due to heat, or it may be dangerous. If the environment is humid, or it may cause reactions such as hydrolysis, it will damage its quality.
Furthermore, storage containers are also crucial. It is advisable to use corrosion-resistant materials, such as glass, certain plastics or metal containers, and ensure that they are tightly sealed. The cover may be corrosive to certain materials. If the container leaks, it will not only lose the material, but also endanger the surrounding environment and personal safety.
As for transportation, the first thing to do is packaging. It is necessary to follow relevant regulations and use suitable packaging materials to ensure that there is no leakage or damage during transportation. Transportation vehicles should also be selected with corresponding safety facilities, and drivers and escorts must undergo professional training to be familiar with their characteristics and emergency disposal methods.
During transportation, avoid mixing with oxidants, reducing agents, alkalis, etc. Gein 2-chloro-1, 3-difluoro-4-nitrobenzene and other such substances are prone to chemical reactions, resulting in serious consequences such as combustion and explosion.
In addition, transportation route planning should not be underestimated. Try to avoid sensitive areas such as densely populated areas and water sources to prevent accidental leakage from causing major harm. And the transportation process should strictly abide by traffic laws and special regulations on the transportation of hazardous chemicals to ensure safe transportation.
What are the effects of 2-chloro-1, 3-difluoro-4-nitrobenzene on the environment and human health?
2-Chloro-1,3-difluoro-4-nitrobenzene is an organic compound that may be used in chemical and other fields. However, it has many effects on the environment and human health.
At the end of the environment, this compound has certain stability and is not easy to degrade. If released in nature, or stored in soil or water bodies, it will last for a long time. It is in the soil, or it may cause soil quality deterioration, preventing plants from absorbing nutrients and water, which in turn affects plant growth, or causes crop production and quality decline. In water bodies, it may be harmful to aquatic organisms. It can be enriched through the food chain. If small fish and shrimp are contaminated by it and eaten by large fish, more toxins will accumulate in the body of large fish. Ultimately, the entire aquatic ecosystem is unbalanced and biodiversity is damaged.
On the one hand of human health, the harm is also very clear. If people ingest this compound through breathing, skin contact or diet, it can endanger their health. Respiratory inhalation, or cause respiratory irritation, cough, asthma, breathing difficulties, etc. Skin contact, or cause skin allergies, redness, swelling, itching, or even ulceration. If ingested by mistake, or damage the digestive system, nausea, vomiting, abdominal pain, diarrhea or symptoms, and or damage the function of important organs such as liver and kidney. Long-term exposure to this compound environment may increase the risk of cancer, because it may be carcinogenic, can cause cell mutation, leading to tumor formation.
Therefore, the use and disposal of 2-chloro-1,3-difluoro-4-nitrobenzene should be handled with caution and appropriate measures should be taken to reduce its harm to the environment and human health.
At the end of the environment, this compound has certain stability and is not easy to degrade. If released in nature, or stored in soil or water bodies, it will last for a long time. It is in the soil, or it may cause soil quality deterioration, preventing plants from absorbing nutrients and water, which in turn affects plant growth, or causes crop production and quality decline. In water bodies, it may be harmful to aquatic organisms. It can be enriched through the food chain. If small fish and shrimp are contaminated by it and eaten by large fish, more toxins will accumulate in the body of large fish. Ultimately, the entire aquatic ecosystem is unbalanced and biodiversity is damaged.
On the one hand of human health, the harm is also very clear. If people ingest this compound through breathing, skin contact or diet, it can endanger their health. Respiratory inhalation, or cause respiratory irritation, cough, asthma, breathing difficulties, etc. Skin contact, or cause skin allergies, redness, swelling, itching, or even ulceration. If ingested by mistake, or damage the digestive system, nausea, vomiting, abdominal pain, diarrhea or symptoms, and or damage the function of important organs such as liver and kidney. Long-term exposure to this compound environment may increase the risk of cancer, because it may be carcinogenic, can cause cell mutation, leading to tumor formation.
Therefore, the use and disposal of 2-chloro-1,3-difluoro-4-nitrobenzene should be handled with caution and appropriate measures should be taken to reduce its harm to the environment and human health.
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