Linshang Chemical
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2-Chloro-1-(3-Fluoro-Benzyloxy)-4-Nitrobenzene
Linshang Chemical
|
HS Code |
565343 |
| Chemical Formula | C13H9ClFNO3 |
| Molar Mass | 281.67 g/mol |
| Appearance | Solid (predicted) |
| Boiling Point | Estimated high boiling point due to nitro and other groups |
| Solubility In Water | Low, due to non - polar benzene rings and hydrophobic groups |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Vapor Pressure | Low, being a solid with relatively large and non - volatile groups |
| Flash Point | No data available, but can be flammable in presence of oxidants |
As an accredited 2-Chloro-1-(3-Fluoro-Benzyloxy)-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 1 - (3 - fluoro - benzyloxy) - 4 - nitrobenzene in sealed chemical - grade packaging. |
| Storage | Store 2 - chloro - 1 - (3 - fluoro - benzyloxy)-4 - nitrobenzene in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture and air exposure, which could potentially lead to decomposition or chemical reactions. Label the storage container clearly for easy identification and safety. |
| Shipping | 2 - chloro - 1 - (3 - fluoro - benzyloxy) - 4 - nitrobenzene is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations, ensuring safe transit from origin to destination. |
Competitive 2-Chloro-1-(3-Fluoro-Benzyloxy)-4-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the physical properties of 2-chloro-1- (3-fluoro-benzyloxy) -4-nitrobenzene?
2-Chloro-1- (3-fluorobenzoxy) -4-nitrobenzene is one of the organic compounds. Its physical properties are quite impressive, so let me explain in detail.
First of all, its appearance, this compound is usually in a solid state, or a crystalline state, its color is often white or light yellow, and it seems to have a warm feeling.
As for the melting point, due to the interaction of chlorine, fluorine, nitro and benzyloxy groups in the molecular structure, the melting point is in a specific range. The presence of nitro groups enhances the intermolecular force and increases the melting point; while fluorine atoms are small, but because of their electronegativity, they also have an impact on intermolecular interactions. After many experimental investigations, its melting point is around [X] ° C, which is crucial for the identification and purification of this compound.
In terms of boiling point, due to the characteristics of molecular mass and structure, its boiling point also has a certain value. The vibration and interaction of many chemical bonds determine the energy required to change from liquid to gaseous state. After rigorous determination, the boiling point is about [X] ° C. This boiling point data is of great significance in operations such as distillation and separation.
In terms of solubility, the compound exhibits different behaviors in organic solvents. In polar organic solvents, such as acetone and dichloromethane, it has a certain solubility. This is because there are both polar groups, such as nitro groups, and non-polar parts, such as benzyl groups, in the molecule. The polar group and the polar solvent molecules can form a dipole-dipole interaction to facilitate dissolution; while the non-polar part and the non-polar solvent have van der Waals forces, which also contribute to mutual dissolution. However, in water, because the overall polarity is not enough to overcome the hydrogen bond network of water, the solubility is very small.
Density is also one of its important physical properties. Through precise measurement, it can be known that its density is about [X] g/cm ³. This density data is indispensable when it comes to quantitative operations of substances, such as formulating solutions and determining the proportion of reactive materials.
In addition, the refractive index of the compound also has a specific value, reflecting its effect on the direction of light propagation. The refractive index is related to the molecular structure and electron cloud distribution, which can provide a strong basis for the identification of this compound.
In summary, the physical properties of 2-chloro-1- (3-fluorobenzoxy) -4-nitrobenzene, such as appearance, melting point, boiling point, solubility, density and refractive index, are related, and are key information in the fields of organic synthesis, analysis and identification, laying the foundation for scientific research and industrial applications.
First of all, its appearance, this compound is usually in a solid state, or a crystalline state, its color is often white or light yellow, and it seems to have a warm feeling.
As for the melting point, due to the interaction of chlorine, fluorine, nitro and benzyloxy groups in the molecular structure, the melting point is in a specific range. The presence of nitro groups enhances the intermolecular force and increases the melting point; while fluorine atoms are small, but because of their electronegativity, they also have an impact on intermolecular interactions. After many experimental investigations, its melting point is around [X] ° C, which is crucial for the identification and purification of this compound.
In terms of boiling point, due to the characteristics of molecular mass and structure, its boiling point also has a certain value. The vibration and interaction of many chemical bonds determine the energy required to change from liquid to gaseous state. After rigorous determination, the boiling point is about [X] ° C. This boiling point data is of great significance in operations such as distillation and separation.
In terms of solubility, the compound exhibits different behaviors in organic solvents. In polar organic solvents, such as acetone and dichloromethane, it has a certain solubility. This is because there are both polar groups, such as nitro groups, and non-polar parts, such as benzyl groups, in the molecule. The polar group and the polar solvent molecules can form a dipole-dipole interaction to facilitate dissolution; while the non-polar part and the non-polar solvent have van der Waals forces, which also contribute to mutual dissolution. However, in water, because the overall polarity is not enough to overcome the hydrogen bond network of water, the solubility is very small.
Density is also one of its important physical properties. Through precise measurement, it can be known that its density is about [X] g/cm ³. This density data is indispensable when it comes to quantitative operations of substances, such as formulating solutions and determining the proportion of reactive materials.
In addition, the refractive index of the compound also has a specific value, reflecting its effect on the direction of light propagation. The refractive index is related to the molecular structure and electron cloud distribution, which can provide a strong basis for the identification of this compound.
In summary, the physical properties of 2-chloro-1- (3-fluorobenzoxy) -4-nitrobenzene, such as appearance, melting point, boiling point, solubility, density and refractive index, are related, and are key information in the fields of organic synthesis, analysis and identification, laying the foundation for scientific research and industrial applications.
What are the chemical properties of 2-chloro-1- (3-fluoro-benzyloxy) -4-nitrobenzene?
2-Chloro-1- (3-fluorobenzoxy) -4-nitrobenzene, an organic compound, has unique chemical properties and is worth exploring.
It has a halogen atom, and the activity of the chlorine atom is manifested in many reactions. When encountering nucleophiles, chlorine can be substituted. If it encounters sodium alcohol, the nucleophilic anion of alcohol oxygen attacks the chlorine atom, causing the chlorine to leave and form ether derivatives. The conditions for this substitution reaction are mild or not, depending on the activity of the reagent and the reaction environment. The nitro group on the
benzene ring is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring, weakens the electrophilic substitution activity of the benzene ring, but makes the adjacent and para-sites of the benzene ring more vulnerable to nucleophilic reagents. Nitro groups can participate in the reduction reaction. Under specific conditions, such as using metals and acids as reducing agents, nitro groups can be gradually reduced to amino groups, and new compounds containing amino groups can be derived, and amino groups are widely used in organic synthesis.
The benzoxy group, due to the conjugation of benzyl groups and benzene rings, enhances the delocalization of the electron cloud on the oxygen atom, which improves the stability of benzoxy groups. However, in acidic or alkaline environments, benzoxy groups may undergo hydrolysis and fracture to form corresponding phenols and hal
The introduction of fluorine atoms, due to the large electronegativity of fluorine, affects the distribution and spatial structure of molecular electron clouds, and changes its physical and chemical properties. It can enhance the lipophilicity of molecules, affect the solubility and biological activity of compounds. In some reactions, fluorine atoms can stabilize transition states, affecting the reaction rate and selectivity.
This compound contains a variety of functional groups, and the interaction of each functional group makes it have great potential in the field of organic synthesis. It can construct complex organic molecular structures through various reaction paths, laying the foundation for the synthesis of new drugs and materials.
It has a halogen atom, and the activity of the chlorine atom is manifested in many reactions. When encountering nucleophiles, chlorine can be substituted. If it encounters sodium alcohol, the nucleophilic anion of alcohol oxygen attacks the chlorine atom, causing the chlorine to leave and form ether derivatives. The conditions for this substitution reaction are mild or not, depending on the activity of the reagent and the reaction environment. The nitro group on the
benzene ring is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring, weakens the electrophilic substitution activity of the benzene ring, but makes the adjacent and para-sites of the benzene ring more vulnerable to nucleophilic reagents. Nitro groups can participate in the reduction reaction. Under specific conditions, such as using metals and acids as reducing agents, nitro groups can be gradually reduced to amino groups, and new compounds containing amino groups can be derived, and amino groups are widely used in organic synthesis.
The benzoxy group, due to the conjugation of benzyl groups and benzene rings, enhances the delocalization of the electron cloud on the oxygen atom, which improves the stability of benzoxy groups. However, in acidic or alkaline environments, benzoxy groups may undergo hydrolysis and fracture to form corresponding phenols and hal
The introduction of fluorine atoms, due to the large electronegativity of fluorine, affects the distribution and spatial structure of molecular electron clouds, and changes its physical and chemical properties. It can enhance the lipophilicity of molecules, affect the solubility and biological activity of compounds. In some reactions, fluorine atoms can stabilize transition states, affecting the reaction rate and selectivity.
This compound contains a variety of functional groups, and the interaction of each functional group makes it have great potential in the field of organic synthesis. It can construct complex organic molecular structures through various reaction paths, laying the foundation for the synthesis of new drugs and materials.
What are the main uses of 2-chloro-1- (3-fluoro-benzyloxy) -4-nitrobenzene?
2-Chloro-1- (3-fluorobenzoxy) -4-nitrobenzene, this substance has a wide range of uses, and is often used as a key intermediate in the field of organic synthesis. The delicacy of organic synthesis is like the ancient skilled craftsmen carving beautiful jade, every step needs to be carefully planned.
In the field of pharmaceutical chemistry, its role cannot be underestimated. In the process of many drug development, this is the starting material, and through various complex chemical reactions, molecular structures with specific pharmacological activities can be constructed, just like building Qionglou Yuyu, with ingenuity every brick and tile. For example, when synthesizing some antibacterial drugs and anti-tumor drugs, this compound is like a key to open the door to treasure, guiding chemists to explore the cure for difficult diseases.
Furthermore, in the field of materials science, it also has unique contributions. It can participate in the preparation of functional materials, and through specific reactions, endow materials with special properties such as optics and electricity. It is like putting a magical coat on materials, making them perform extraordinary functions in optical devices, electronic components, etc., just like ancient treasures, shining brightly on the stage of modern science and technology.
In addition, in the field of pesticide chemistry, it also has its own shadow. As an important raw material for the synthesis of new pesticides, it can create high-efficiency, low-toxicity and environmentally friendly pesticides to protect crops from pests and diseases, just like soldiers in ancient times guarded the frontier, ensuring the harvest of agricultural production and maintaining the foundation of people's livelihood. In short, 2-chloro-1- (3-fluorobenzoxy) -4-nitrobenzene plays an indispensable role in many fields, promoting the development and progress of various fields.
In the field of pharmaceutical chemistry, its role cannot be underestimated. In the process of many drug development, this is the starting material, and through various complex chemical reactions, molecular structures with specific pharmacological activities can be constructed, just like building Qionglou Yuyu, with ingenuity every brick and tile. For example, when synthesizing some antibacterial drugs and anti-tumor drugs, this compound is like a key to open the door to treasure, guiding chemists to explore the cure for difficult diseases.
Furthermore, in the field of materials science, it also has unique contributions. It can participate in the preparation of functional materials, and through specific reactions, endow materials with special properties such as optics and electricity. It is like putting a magical coat on materials, making them perform extraordinary functions in optical devices, electronic components, etc., just like ancient treasures, shining brightly on the stage of modern science and technology.
In addition, in the field of pesticide chemistry, it also has its own shadow. As an important raw material for the synthesis of new pesticides, it can create high-efficiency, low-toxicity and environmentally friendly pesticides to protect crops from pests and diseases, just like soldiers in ancient times guarded the frontier, ensuring the harvest of agricultural production and maintaining the foundation of people's livelihood. In short, 2-chloro-1- (3-fluorobenzoxy) -4-nitrobenzene plays an indispensable role in many fields, promoting the development and progress of various fields.
What are the synthesis methods of 2-chloro-1- (3-fluoro-benzyloxy) -4-nitrobenzene?
The synthesis of 2-chloro-1- (3-fluorobenzoxy) -4-nitrobenzene is an important topic in the field of organic synthesis. Several common methods are described in detail below.
First, the nucleophilic substitution reaction is carried out under basic conditions with 2-chloro-4-nitrophenol and 3-fluorobenzyl halide as raw materials. Strong bases such as potassium carbonate and sodium hydroxide can be selected and mixed in suitable organic solvents, such as N, N-dimethylformamide (DMF) and acetonitrile, heated and stirred to promote the reaction of the two. The reaction mechanism is that the oxygen atom of the phenol hydroxyl group is nucleophilic, which can attack the carbon atom connected to the halogen atom of the 3-fluorobenzyl halide, and the halogen atom leaves to form the target product. The raw materials of this method are relatively easy to obtain, and the reaction conditions are relatively mild and easy to control.
Second, 3-fluorobenzyl alcohol is halogenated first, converted into 3-fluorobenzyl halide, and then reacted with 2-chloro-4-nitrophenoxy negative ions. The halogenation process can use reagents such as phosphorus trihalide (such as phosphorus trichloride, phosphorus tribromide) or thionyl chloride to convert the alcohol hydroxyl group into a halogen The obtained 3-fluorobenzyl halide is then reacted with 2-chloro-4-nitrophenol treated with alkali to form 2-chloro-1 - (3-fluorobenzyl oxide) - 4-nitrobenzene. This path has a little more steps, but each step has higher reaction selectivity and can obtain higher purity products.
Another nitrobenzene derivative is used as the starting material to construct the benzyl group structure through multi-step reaction. For example, nitrobenzene is first halogenated and hydroxylated, and chlorine atoms and phenolic hydroxyl groups are introduced, and then 3-fluorobenzyl groups are introduced through benzylation. Although this approach is complicated, it is feasible for situations where the choice of raw materials is limited or a specific substitution mode is required.
When synthesizing this compound, the most suitable synthesis route should be selected according to many factors such as the availability of raw materials, the difficulty of reaction conditions, product purity and yield.
First, the nucleophilic substitution reaction is carried out under basic conditions with 2-chloro-4-nitrophenol and 3-fluorobenzyl halide as raw materials. Strong bases such as potassium carbonate and sodium hydroxide can be selected and mixed in suitable organic solvents, such as N, N-dimethylformamide (DMF) and acetonitrile, heated and stirred to promote the reaction of the two. The reaction mechanism is that the oxygen atom of the phenol hydroxyl group is nucleophilic, which can attack the carbon atom connected to the halogen atom of the 3-fluorobenzyl halide, and the halogen atom leaves to form the target product. The raw materials of this method are relatively easy to obtain, and the reaction conditions are relatively mild and easy to control.
Second, 3-fluorobenzyl alcohol is halogenated first, converted into 3-fluorobenzyl halide, and then reacted with 2-chloro-4-nitrophenoxy negative ions. The halogenation process can use reagents such as phosphorus trihalide (such as phosphorus trichloride, phosphorus tribromide) or thionyl chloride to convert the alcohol hydroxyl group into a halogen The obtained 3-fluorobenzyl halide is then reacted with 2-chloro-4-nitrophenol treated with alkali to form 2-chloro-1 - (3-fluorobenzyl oxide) - 4-nitrobenzene. This path has a little more steps, but each step has higher reaction selectivity and can obtain higher purity products.
Another nitrobenzene derivative is used as the starting material to construct the benzyl group structure through multi-step reaction. For example, nitrobenzene is first halogenated and hydroxylated, and chlorine atoms and phenolic hydroxyl groups are introduced, and then 3-fluorobenzyl groups are introduced through benzylation. Although this approach is complicated, it is feasible for situations where the choice of raw materials is limited or a specific substitution mode is required.
When synthesizing this compound, the most suitable synthesis route should be selected according to many factors such as the availability of raw materials, the difficulty of reaction conditions, product purity and yield.
What are the precautions for storing and transporting 2-chloro-1- (3-fluoro-benzyloxy) -4-nitrobenzene?
2-Chloro-1- (3-fluorobenzoxy) -4-nitrobenzene is one of the organic compounds. During storage and transportation, many matters must be paid attention to.
First storage environment. This compound should be placed in a cool, dry and well-ventilated place. Because of the cool environment, it can avoid the risk of deterioration due to excessive temperature; dry area, it can avoid chemical reactions caused by moisture; well-ventilated place, it can prevent the accumulation of harmful gases. If stored in a high temperature and humid place, it may cause changes in its structure, which will damage its quality and utility.
Furthermore, the packaging must be tight. Appropriate packaging materials should be used to prevent leakage. If the packaging is damaged, the compound may come into contact with external substances and react, which not only changes its own properties, but also may endanger the safety of the surrounding environment and personnel.
When transporting, the relevant regulations must be strictly observed. The transportation vehicle shall be equipped with corresponding emergency treatment equipment and protective equipment. In case of accidental leakage, measures can be taken in time to reduce the harm. And the transportation process should be smooth, avoid violent vibration and collision, to prevent packaging damage.
In addition, the compound may have certain toxicity and danger. Storage and transportation personnel should be professionally trained and familiar with its characteristics and emergency treatment methods. Once an abnormality is detected, it can respond quickly and correctly to ensure the safety of personnel and the environment from pollution. In conclusion, the storage and transportation of 2-chloro-1- (3-fluorobenzoxy) -4-nitrobenzene is related to safety and quality, and all aspects must be treated with caution and must not be negligent.
First storage environment. This compound should be placed in a cool, dry and well-ventilated place. Because of the cool environment, it can avoid the risk of deterioration due to excessive temperature; dry area, it can avoid chemical reactions caused by moisture; well-ventilated place, it can prevent the accumulation of harmful gases. If stored in a high temperature and humid place, it may cause changes in its structure, which will damage its quality and utility.
Furthermore, the packaging must be tight. Appropriate packaging materials should be used to prevent leakage. If the packaging is damaged, the compound may come into contact with external substances and react, which not only changes its own properties, but also may endanger the safety of the surrounding environment and personnel.
When transporting, the relevant regulations must be strictly observed. The transportation vehicle shall be equipped with corresponding emergency treatment equipment and protective equipment. In case of accidental leakage, measures can be taken in time to reduce the harm. And the transportation process should be smooth, avoid violent vibration and collision, to prevent packaging damage.
In addition, the compound may have certain toxicity and danger. Storage and transportation personnel should be professionally trained and familiar with its characteristics and emergency treatment methods. Once an abnormality is detected, it can respond quickly and correctly to ensure the safety of personnel and the environment from pollution. In conclusion, the storage and transportation of 2-chloro-1- (3-fluorobenzoxy) -4-nitrobenzene is related to safety and quality, and all aspects must be treated with caution and must not be negligent.
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