Linshang Chemical
PRODUCTS
2-Chloro-1,4-Benzenediol
Linshang Chemical
|
HS Code |
444057 |
| Chemical Formula | C6H5ClO2 |
| Molar Mass | 144.56 g/mol |
| Appearance | Solid |
| Odor | Characteristic |
| Melting Point | 104 - 106 °C |
| Boiling Point | 285 °C |
| Density | 1.499 g/cm³ |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in ethanol, ether |
| Pka | 8.55 (estimated) |
| Stability | Stable under normal conditions |
| Flash Point | 133 °C |
As an accredited 2-Chloro-1,4-Benzenediol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 2 - chloro - 1,4 - benzenediol packaged in a sealed plastic container. |
| Storage | 2 - Chloro - 1,4 - benzenediol should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent moisture absorption and exposure to air, which could potentially lead to decomposition. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions. |
| Shipping | 2 - chloro - 1,4 - benzenediol should be shipped in well - sealed, corrosion - resistant containers. Label containers clearly with hazard warnings. Transport via approved carriers following strict regulations for hazardous chemicals to ensure safety. |
Competitive 2-Chloro-1,4-Benzenediol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Chloro-1,4-Benzenediol in China?
As a trusted 2-Chloro-1,4-Benzenediol manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-1,4-Benzenediol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chloro-1,4-benzenediol?
2-Chloro-1,4-catechol, this is an organic compound. It has a wide range of uses and is important in many fields such as industry, medicine, agriculture, etc.
In the industrial field, it is often used as a dye intermediate. It can be converted into a variety of dyes through specific chemical reactions and used in dyeing processes such as fabrics and leather. Due to its structure containing chlorine atoms and phenolic hydroxyl groups, it is endowed with unique chemical activity and can be cleverly combined with other compounds to produce dyes with bright color and good fastness.
In the field of medicine, it has certain antibacterial properties. Phenol hydroxyl can denature proteins and inhibit the growth and reproduction of some bacteria and fungi, so it can be used as an antimicrobial agent in some drug formulations, such as topical preparations, to help treat skin infections and other diseases.
In the agricultural field, it can be used to synthesize pesticides. With its chemical structure characteristics, it participates in the synthesis of pesticides with insecticidal, bactericidal or herbicidal effects, helping to ensure the healthy growth of crops and improve crop yield and quality.
In addition, in the research of organic synthetic chemistry, 2-chloro-1,4-catechol is also an important intermediate. Chemists can perform various chemical reactions on them, such as substitution reactions, oxidation reactions, etc., to synthesize organic compounds with more complex structures and unique functions, thus promoting the development and progress of the field of organic synthetic chemistry.
In the industrial field, it is often used as a dye intermediate. It can be converted into a variety of dyes through specific chemical reactions and used in dyeing processes such as fabrics and leather. Due to its structure containing chlorine atoms and phenolic hydroxyl groups, it is endowed with unique chemical activity and can be cleverly combined with other compounds to produce dyes with bright color and good fastness.
In the field of medicine, it has certain antibacterial properties. Phenol hydroxyl can denature proteins and inhibit the growth and reproduction of some bacteria and fungi, so it can be used as an antimicrobial agent in some drug formulations, such as topical preparations, to help treat skin infections and other diseases.
In the agricultural field, it can be used to synthesize pesticides. With its chemical structure characteristics, it participates in the synthesis of pesticides with insecticidal, bactericidal or herbicidal effects, helping to ensure the healthy growth of crops and improve crop yield and quality.
In addition, in the research of organic synthetic chemistry, 2-chloro-1,4-catechol is also an important intermediate. Chemists can perform various chemical reactions on them, such as substitution reactions, oxidation reactions, etc., to synthesize organic compounds with more complex structures and unique functions, thus promoting the development and progress of the field of organic synthetic chemistry.
What are the physical properties of 2-chloro-1,4-benzenediol?
The physical properties of 2-chloro-1,4-hydroquinone are as follows. The appearance of this substance is often white to light yellow crystalline powder with fine texture. Looking at its color, it may vary slightly due to impurities or storage environment.
When it comes to the melting point, it is about a specific temperature range. Its melting point is an inherent characteristic of the substance and is an important indicator to measure the purity and stability of this compound. At this temperature, the solid 2-chloro-1,4-hydroquinone begins to transform into a liquid state. This process is accompanied by the absorption of energy and the change of intermolecular forces.
Solubility is also an important physical property. In water, its solubility is limited and slightly soluble in water. Due to its molecular structure, although hydroxyl groups can form hydrogen bonds with water molecules, the presence of chlorine atoms hinders its affinity with water to a certain extent, so the amount of solubility is small. However, in organic solvents, such as ethanol, acetone, etc., its solubility is better. The molecular structure of organic solvents is similar to that of 2-chloro-1,4-catechol. Following the principle of similar compatibility, the molecular forces between the two can interact, so that they can be better dispersed in organic solvents.
Its density is also a specific value, reflecting the mass of the substance per unit volume. This property is of great significance in practical applications, such as storage, transportation, and consideration of the amount of substances used in chemical reactions.
In addition, the smell of 2-chloro-1,4-catechol is weak, and it is almost invisible without close sniffing. Its smell is caused by the volatilization of molecules. Although weak, it is also part of its physical properties. In some application scenarios sensitive to odors, this property needs to be paid attention to.
When it comes to the melting point, it is about a specific temperature range. Its melting point is an inherent characteristic of the substance and is an important indicator to measure the purity and stability of this compound. At this temperature, the solid 2-chloro-1,4-hydroquinone begins to transform into a liquid state. This process is accompanied by the absorption of energy and the change of intermolecular forces.
Solubility is also an important physical property. In water, its solubility is limited and slightly soluble in water. Due to its molecular structure, although hydroxyl groups can form hydrogen bonds with water molecules, the presence of chlorine atoms hinders its affinity with water to a certain extent, so the amount of solubility is small. However, in organic solvents, such as ethanol, acetone, etc., its solubility is better. The molecular structure of organic solvents is similar to that of 2-chloro-1,4-catechol. Following the principle of similar compatibility, the molecular forces between the two can interact, so that they can be better dispersed in organic solvents.
Its density is also a specific value, reflecting the mass of the substance per unit volume. This property is of great significance in practical applications, such as storage, transportation, and consideration of the amount of substances used in chemical reactions.
In addition, the smell of 2-chloro-1,4-catechol is weak, and it is almost invisible without close sniffing. Its smell is caused by the volatilization of molecules. Although weak, it is also part of its physical properties. In some application scenarios sensitive to odors, this property needs to be paid attention to.
What are the chemical properties of 2-chloro-1,4-benzenediol?
2-Chloro-1,4-catechol is a genus of organic compounds. It is active and has multiple chemical characteristics.
In terms of reactivity, the hydroxyl group above the benzene ring is the donator group, which increases the electron cloud density of the benzene ring and enhances its electrophilic substitution activity. Although the chlorine atom is an ortho-para-site group, its electron-absorbing induction effect also exists, which affects the selectivity of the check point of the reaction to a certain extent. For example, in electrophilic substitution reactions such as halogenation and nitrification, the reaction easily occurs in the ortho-site and para-site of the hydroxyl group.
Its phenolic-hydroxyl properties are significant. The solitary pair electrons of the oxygen atom in the hydroxyl group are conjugated with the phenyl ring, which enhances the polarity of the hydrogen-oxygen bond, and the hydrogen atom is easy to leave in the form of protons, so it is weakly acidic. It can react with bases such as sodium hydroxide to form corresponding phenolates. This acidity is weaker than carbonate, but stronger than alcohols. According to this, it can be distinguished from alcohols by reagents such as sodium bicarbonate.
In addition, due to the presence of phenolic hydroxyl groups, 2-chloro-1,4-diphenol is easily oxidized. In the air, it can be gradually oxidized into quinones, and its appearance or color changes. This property is of great significance in some redox reaction systems. In the field of organic synthesis, its oxidizing properties can often be used to construct specific structures, or as a raw material for
At the same time, the chlorine atom of 2-chloro-1,4-catechol is also reactive. Under appropriate nucleophilic reagents and reaction conditions, chlorine atoms can be replaced by nucleophiles, such as reacting with nucleophilic reagents such as sodium alcohol and amines to generate corresponding substitution products, providing an effective path for the synthesis of complex organic compounds.
In terms of reactivity, the hydroxyl group above the benzene ring is the donator group, which increases the electron cloud density of the benzene ring and enhances its electrophilic substitution activity. Although the chlorine atom is an ortho-para-site group, its electron-absorbing induction effect also exists, which affects the selectivity of the check point of the reaction to a certain extent. For example, in electrophilic substitution reactions such as halogenation and nitrification, the reaction easily occurs in the ortho-site and para-site of the hydroxyl group.
Its phenolic-hydroxyl properties are significant. The solitary pair electrons of the oxygen atom in the hydroxyl group are conjugated with the phenyl ring, which enhances the polarity of the hydrogen-oxygen bond, and the hydrogen atom is easy to leave in the form of protons, so it is weakly acidic. It can react with bases such as sodium hydroxide to form corresponding phenolates. This acidity is weaker than carbonate, but stronger than alcohols. According to this, it can be distinguished from alcohols by reagents such as sodium bicarbonate.
In addition, due to the presence of phenolic hydroxyl groups, 2-chloro-1,4-diphenol is easily oxidized. In the air, it can be gradually oxidized into quinones, and its appearance or color changes. This property is of great significance in some redox reaction systems. In the field of organic synthesis, its oxidizing properties can often be used to construct specific structures, or as a raw material for
At the same time, the chlorine atom of 2-chloro-1,4-catechol is also reactive. Under appropriate nucleophilic reagents and reaction conditions, chlorine atoms can be replaced by nucleophiles, such as reacting with nucleophilic reagents such as sodium alcohol and amines to generate corresponding substitution products, providing an effective path for the synthesis of complex organic compounds.
What are the preparation methods of 2-chloro-1,4-benzenediol?
2-Chloro-1,4-hydroquinone, also known as 2-chloro-hydroquinone, its preparation method is difficult to find in ancient records, but according to today's chemical knowledge can be described as follows.
First, the method of preparing hydroquinone as the starting material. Dissolve hydroquinone in an appropriate organic solvent, such as dichloromethane, chloroform, etc. This organic solvent needs to be able to dissolve hydroquinone well and have stable properties without side reactions with subsequent reactants. After stirring, slowly add chlorine-containing reagents, commonly used are sulfoxide chloride or phosphorus trichloride. The dropwise addition process requires strict control of the reaction temperature, which is generally maintained at a low temperature, such as between 0 and 10 degrees Celsius. Because the chlorination reaction is mostly exothermic, low temperature can effectively avoid the reaction being too violent and out of control. After the dropwise addition is completed, heat up to an appropriate temperature, such as 30-50 degrees Celsius, and continue to stir the reaction for several hours. The reaction process can be monitored by thin layer chromatography (TLC). When the raw material point basically disappears, it indicates that the reaction is basically completed. Subsequently, the reaction solution is distilled under reduced pressure to remove the organic solvent, and then recrystallized with an appropriate recrystallization solvent, such as ethanol-water mixed solvent, to obtain pure 2-chloro-1,4-catechol crystals.
Second, prepared from chloroben The chlorobenzene is first introduced into the nitro group through nitration reaction to form p-chloronitrobenzene. This nitration reaction usually uses a mixed acid composed of concentrated sulfuric acid and concentrated nitric acid as the nitrifying agent. The reaction temperature is controlled at 50-60 ° C. This temperature range can not only ensure the reaction rate, but also enable the nitro group to be mainly introduced into the para-position of the chlorine atom. The p-chloronitrobenzene is then reduced by iron powder, hydrochloric acid or catalytic hydrogenation to reduce the nitro group to an amino group to obtain p-chloroaniline. P-chloroaniline reacts with sodium nitrite at low temperature (0-5 ° C) and in the presence of hydrochloric acid to form diazonium salts. The diazonium salts undergo hydrolysis in hot dilute sulfuric acid solution, and the diazonium groups are replaced by 2-Chloro-1,4-catechol can be prepared from p-chlorophenol by selective chlorination of phenolic hydroxyl groups. In this process, the selective chlorination step requires the selection of suitable chlorination reagents and reaction conditions to ensure that the chlorine atom mainly replaces the hydrogen atom at the phenolic hydroxyl ortho-position. For example, N-chlorosuccinimide (NCS) can be used to react in the presence of appropriate organic solvents and catalysts.
The method of preparing 2-chloro-1,4-catechol is clear according to modern chemical knowledge, but the operation of each step is fine and the conditions are strict, so it is necessary to be cautious.
First, the method of preparing hydroquinone as the starting material. Dissolve hydroquinone in an appropriate organic solvent, such as dichloromethane, chloroform, etc. This organic solvent needs to be able to dissolve hydroquinone well and have stable properties without side reactions with subsequent reactants. After stirring, slowly add chlorine-containing reagents, commonly used are sulfoxide chloride or phosphorus trichloride. The dropwise addition process requires strict control of the reaction temperature, which is generally maintained at a low temperature, such as between 0 and 10 degrees Celsius. Because the chlorination reaction is mostly exothermic, low temperature can effectively avoid the reaction being too violent and out of control. After the dropwise addition is completed, heat up to an appropriate temperature, such as 30-50 degrees Celsius, and continue to stir the reaction for several hours. The reaction process can be monitored by thin layer chromatography (TLC). When the raw material point basically disappears, it indicates that the reaction is basically completed. Subsequently, the reaction solution is distilled under reduced pressure to remove the organic solvent, and then recrystallized with an appropriate recrystallization solvent, such as ethanol-water mixed solvent, to obtain pure 2-chloro-1,4-catechol crystals.
Second, prepared from chloroben The chlorobenzene is first introduced into the nitro group through nitration reaction to form p-chloronitrobenzene. This nitration reaction usually uses a mixed acid composed of concentrated sulfuric acid and concentrated nitric acid as the nitrifying agent. The reaction temperature is controlled at 50-60 ° C. This temperature range can not only ensure the reaction rate, but also enable the nitro group to be mainly introduced into the para-position of the chlorine atom. The p-chloronitrobenzene is then reduced by iron powder, hydrochloric acid or catalytic hydrogenation to reduce the nitro group to an amino group to obtain p-chloroaniline. P-chloroaniline reacts with sodium nitrite at low temperature (0-5 ° C) and in the presence of hydrochloric acid to form diazonium salts. The diazonium salts undergo hydrolysis in hot dilute sulfuric acid solution, and the diazonium groups are replaced by 2-Chloro-1,4-catechol can be prepared from p-chlorophenol by selective chlorination of phenolic hydroxyl groups. In this process, the selective chlorination step requires the selection of suitable chlorination reagents and reaction conditions to ensure that the chlorine atom mainly replaces the hydrogen atom at the phenolic hydroxyl ortho-position. For example, N-chlorosuccinimide (NCS) can be used to react in the presence of appropriate organic solvents and catalysts.
The method of preparing 2-chloro-1,4-catechol is clear according to modern chemical knowledge, but the operation of each step is fine and the conditions are strict, so it is necessary to be cautious.
What are the precautions for 2-chloro-1,4-benzenediol during use?
2-Chloro-1,4-hydroquinone is an organic compound. During use, many things must be paid attention to.
Bearing the brunt is related to safety protection. This compound is toxic and irritating, or causes damage to the human body. When using, be sure to wear suitable protective equipment, such as gloves, goggles and protective clothing, to prevent skin contact and splashing into the eyes. If you accidentally come into contact with the skin, you should immediately rinse with plenty of water; if it splashes into the eyes, you need to rinse with plenty of running water quickly and seek medical treatment immediately.
Furthermore, its storage is also exquisite. It should be stored in a cool, well-ventilated place, away from fire and heat sources. It should be stored separately from oxidants, acids, etc., and should not be mixed to prevent dangerous reactions. The storage area should be equipped with materials suitable for containing and handling leaks, so that in the event of accidental leakage, it can be dealt with in time.
When operating, caution is also required. It should be operated in a fume hood to ensure good ventilation conditions and avoid inhaling its dust or vapor. Before and after use, carefully check whether the equipment is in good condition to prevent leakage. During weighing and transfer, the action must be accurate to prevent spilling. At the same time, fireworks should be strictly prohibited in the operating place to avoid danger caused by fire sources.
In addition, waste disposal after use cannot be ignored. Relevant environmental regulations and regulations must be followed and cannot be discarded at will. In general, waste should be collected in a specific container and handed over to a professional organization for treatment to prevent pollution to the environment.
In short, when using 2-chloro-1,4-catechol, whether it is safety protection, storage, operation, or waste disposal, it is necessary to strictly follow the norms, and must not be taken lightly, so as to ensure the safety of personnel and the environment is not endangered.
Bearing the brunt is related to safety protection. This compound is toxic and irritating, or causes damage to the human body. When using, be sure to wear suitable protective equipment, such as gloves, goggles and protective clothing, to prevent skin contact and splashing into the eyes. If you accidentally come into contact with the skin, you should immediately rinse with plenty of water; if it splashes into the eyes, you need to rinse with plenty of running water quickly and seek medical treatment immediately.
Furthermore, its storage is also exquisite. It should be stored in a cool, well-ventilated place, away from fire and heat sources. It should be stored separately from oxidants, acids, etc., and should not be mixed to prevent dangerous reactions. The storage area should be equipped with materials suitable for containing and handling leaks, so that in the event of accidental leakage, it can be dealt with in time.
When operating, caution is also required. It should be operated in a fume hood to ensure good ventilation conditions and avoid inhaling its dust or vapor. Before and after use, carefully check whether the equipment is in good condition to prevent leakage. During weighing and transfer, the action must be accurate to prevent spilling. At the same time, fireworks should be strictly prohibited in the operating place to avoid danger caused by fire sources.
In addition, waste disposal after use cannot be ignored. Relevant environmental regulations and regulations must be followed and cannot be discarded at will. In general, waste should be collected in a specific container and handed over to a professional organization for treatment to prevent pollution to the environment.
In short, when using 2-chloro-1,4-catechol, whether it is safety protection, storage, operation, or waste disposal, it is necessary to strictly follow the norms, and must not be taken lightly, so as to ensure the safety of personnel and the environment is not endangered.
Scan to WhatsApp
