Linshang Chemical
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2-Chloro-1,4-Difluorobenzene
Linshang Chemical
|
HS Code |
144794 |
| Chemical Formula | C6H3ClF2 |
| Molar Mass | 148.54 g/mol |
| Appearance | Colorless liquid |
| Boiling Point | 132 - 134 °C |
| Density | 1.344 g/cm³ |
| Solubility In Water | Insoluble |
| Flash Point | 32 °C |
| Refractive Index | 1.473 (20 °C) |
As an accredited 2-Chloro-1,4-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 1,4 - difluorobenzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 2 - chloro - 1,4 - difluorobenzene should be stored in a cool, well - ventilated area away from heat sources and ignition points. Keep it in a tightly - sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to avoid potential reactions. Follow local regulations for proper storage of hazardous chemicals. |
| Shipping | 2 - chloro - 1,4 - difluorobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported in accordance with hazardous chemical regulations, ensuring proper handling to prevent spills and maintain safety during transit. |
Competitive 2-Chloro-1,4-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-1,4-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chloro-1,4-difluorobenzene?
2-Chloro-1,4-difluorobenzene is a class of organic compounds and is widely used in various fields of chemical industry.
First, it is often a key intermediate in the synthesis of medicine. In the process of pharmaceutical preparation, by applying a specific chemical reaction to 2-chloro-1,4-difluorobenzene, unique structural fragments can be introduced to help build molecules with specific pharmacological activities. For example, when synthesizing some antibacterial and antiviral drugs, the chlorine and fluorine atoms of this compound can adjust the lipophilicity and electron cloud distribution of drug molecules, making it easier for drugs to penetrate biological membranes, act precisely on targets, and improve drug efficacy.
Second, it is also an important raw material in the process of pesticide creation. Pesticides are designed to control crop diseases, pests, weeds, etc., in order to ensure a bumper harvest. 2-Chloro-1,4-difluorobenzene participates in the synthesis of pesticides. With its fluorine and chlorine properties, it can enhance the poisoning effect of pesticides on pests and bacteria, and can improve the stability and durability of pesticides. For example, synthetic fluorine-containing insecticides can rely on the special electronic effect of fluorine atoms to enhance the interference of the nervous system of pests and achieve the purpose of efficient insecticide.
Third, it is also useful in the field of materials science. In the preparation of high-performance polymer materials, 2-chloro-1,4-difluorobenzene is introduced as a monomer or modifier, which can endow the material with unique properties. Due to its low surface energy and chemical stability of fluorine atoms, the material can have the characteristics of weather resistance, chemical corrosion resistance, low friction coefficient, etc., and is used in the manufacture of high-performance materials required by the aerospace and automotive industries.
Furthermore, in the industry of dye synthesis, 2-chloro-1,4-difluorobenzene is also indispensable. It can be used to participate in the construction of the conjugated structure of dye molecules to adjust the color, brightness, light fastness and other properties of dyes. Fluorine and chlorine-containing dyes can improve dyeing effect and color fastness in the textile printing and dyeing industry, meeting people's high requirements for fabric color and quality.
First, it is often a key intermediate in the synthesis of medicine. In the process of pharmaceutical preparation, by applying a specific chemical reaction to 2-chloro-1,4-difluorobenzene, unique structural fragments can be introduced to help build molecules with specific pharmacological activities. For example, when synthesizing some antibacterial and antiviral drugs, the chlorine and fluorine atoms of this compound can adjust the lipophilicity and electron cloud distribution of drug molecules, making it easier for drugs to penetrate biological membranes, act precisely on targets, and improve drug efficacy.
Second, it is also an important raw material in the process of pesticide creation. Pesticides are designed to control crop diseases, pests, weeds, etc., in order to ensure a bumper harvest. 2-Chloro-1,4-difluorobenzene participates in the synthesis of pesticides. With its fluorine and chlorine properties, it can enhance the poisoning effect of pesticides on pests and bacteria, and can improve the stability and durability of pesticides. For example, synthetic fluorine-containing insecticides can rely on the special electronic effect of fluorine atoms to enhance the interference of the nervous system of pests and achieve the purpose of efficient insecticide.
Third, it is also useful in the field of materials science. In the preparation of high-performance polymer materials, 2-chloro-1,4-difluorobenzene is introduced as a monomer or modifier, which can endow the material with unique properties. Due to its low surface energy and chemical stability of fluorine atoms, the material can have the characteristics of weather resistance, chemical corrosion resistance, low friction coefficient, etc., and is used in the manufacture of high-performance materials required by the aerospace and automotive industries.
Furthermore, in the industry of dye synthesis, 2-chloro-1,4-difluorobenzene is also indispensable. It can be used to participate in the construction of the conjugated structure of dye molecules to adjust the color, brightness, light fastness and other properties of dyes. Fluorine and chlorine-containing dyes can improve dyeing effect and color fastness in the textile printing and dyeing industry, meeting people's high requirements for fabric color and quality.
What are the physical properties of 2-chloro-1,4-difluorobenzene?
2-Chloro-1,4-difluorobenzene is also an organic compound. Its physical properties are quite important and are involved in all things in the chemical industry.
Looking at its properties, under normal conditions, 2-chloro-1,4-difluorobenzene is a colorless to light yellow transparent liquid. This color and state are visually identifiable and are a sign of preliminary recognition of this thing. Its smell has a special aromatic smell. Although the taste is different, this special aroma is also one of its signs.
When it comes to boiling point, it is between 130-132 ° C. The boiling point is the critical temperature at which a substance changes from liquid to gaseous state. At this temperature, the molecules are energized enough to break free from the shackles of the liquid phase and escape into the gas phase. Knowing the boiling point is of great significance in chemical operations such as distillation and separation, and can be used to control the temperature to obtain pure things.
In terms of melting point, it is about -44 ° C. The melting point is the temperature at which the solid state changes to liquid state. At this temperature, the molecular activities are bound and arranged in an orderly manner to form a solid state. At this temperature, the molecules are energized and the lattice begins to be disordered, resulting in a liquid state. This melting point characteristic also needs to be considered during storage and transportation to prevent it from changing due to temperature changes.
Density of 2-chloro-1,4-difluorobenzene, about 1.32 g/cm ³. Density, the mass per unit volume, reflects the compactness of the substance. In chemical processes, mixing, metering and other operations are involved. Density is a key parameter, which is related to the proportion of materials and the calculation of container volume.
Its solubility also has characteristics. It is slightly soluble in water, but miscible in organic solvents such as ethanol, ether, and acetone. This difference in solubility is due to molecular polarity. Water is a polar solvent, and the molecular polarity of 2-chloro-1,4-difluorobenzene is weak, so it is difficult to dissolve in water; while organic solvents are mostly weakly polar or non-polar, and are mutually soluble with the intermolecular force of 2-chloro-1,4-difluorobenzene. This solubility is an important basis for extraction, reaction medium selection, etc.
Vapor pressure is also one of its physical properties. At a certain temperature, the vapor pressure of 2-chloro-1,4-difluorobenzene in a closed container when the liquid and gas phases are in equilibrium affects its volatilization degree. The higher the vapor pressure, the easier it is to volatilize, which has an impact on the environment, safety and other aspects. The place of production and storage needs to be prevented from volatilization risk.
In summary, the physical properties of 2-chloro-1,4-difluorobenzene, such as properties, melting point, density, solubility, vapor pressure, etc., are interrelated, and are all indispensable factors in chemical production, storage, transportation, and application. Only by grasping it can we achieve the purpose of chemical industry.
Looking at its properties, under normal conditions, 2-chloro-1,4-difluorobenzene is a colorless to light yellow transparent liquid. This color and state are visually identifiable and are a sign of preliminary recognition of this thing. Its smell has a special aromatic smell. Although the taste is different, this special aroma is also one of its signs.
When it comes to boiling point, it is between 130-132 ° C. The boiling point is the critical temperature at which a substance changes from liquid to gaseous state. At this temperature, the molecules are energized enough to break free from the shackles of the liquid phase and escape into the gas phase. Knowing the boiling point is of great significance in chemical operations such as distillation and separation, and can be used to control the temperature to obtain pure things.
In terms of melting point, it is about -44 ° C. The melting point is the temperature at which the solid state changes to liquid state. At this temperature, the molecular activities are bound and arranged in an orderly manner to form a solid state. At this temperature, the molecules are energized and the lattice begins to be disordered, resulting in a liquid state. This melting point characteristic also needs to be considered during storage and transportation to prevent it from changing due to temperature changes.
Density of 2-chloro-1,4-difluorobenzene, about 1.32 g/cm ³. Density, the mass per unit volume, reflects the compactness of the substance. In chemical processes, mixing, metering and other operations are involved. Density is a key parameter, which is related to the proportion of materials and the calculation of container volume.
Its solubility also has characteristics. It is slightly soluble in water, but miscible in organic solvents such as ethanol, ether, and acetone. This difference in solubility is due to molecular polarity. Water is a polar solvent, and the molecular polarity of 2-chloro-1,4-difluorobenzene is weak, so it is difficult to dissolve in water; while organic solvents are mostly weakly polar or non-polar, and are mutually soluble with the intermolecular force of 2-chloro-1,4-difluorobenzene. This solubility is an important basis for extraction, reaction medium selection, etc.
Vapor pressure is also one of its physical properties. At a certain temperature, the vapor pressure of 2-chloro-1,4-difluorobenzene in a closed container when the liquid and gas phases are in equilibrium affects its volatilization degree. The higher the vapor pressure, the easier it is to volatilize, which has an impact on the environment, safety and other aspects. The place of production and storage needs to be prevented from volatilization risk.
In summary, the physical properties of 2-chloro-1,4-difluorobenzene, such as properties, melting point, density, solubility, vapor pressure, etc., are interrelated, and are all indispensable factors in chemical production, storage, transportation, and application. Only by grasping it can we achieve the purpose of chemical industry.
What are the chemical properties of 2-chloro-1,4-difluorobenzene?
2-Chloro-1,4-difluorobenzene is a kind of organic compound. Its molecule contains a chlorine atom and a difluorine atom, which are connected to the benzene ring. The chemical properties of this substance are of great interest and are also relevant to many chemical studies and industrial applications.
First of all, its stability is discussed. The benzene ring has a conjugated system, which gives the molecule a certain stability. However, the introduction of chlorine and fluorine atoms slightly changes the distribution of its electron cloud. The fluorine atom is extremely electronegative, and the electron-absorbing effect is significant, and the chlorine atom also has a certain electron-absorbing ability. The effect of these two makes the electron cloud density of the benzene ring decrease, resulting in a slight decrease in its electrophilic substitution activity compared with benzene.
In the electrophilic substitution reaction, due to the localization effect of fluorine and chlorine, the new substituent more than enters the specific position of the benzene ring. Fluorine and chlorine are both ortho and para-localization groups, but the localization effect of fluorine is stronger. Therefore, electrophilic reagents often attack the ortho and para-position of fluorine or chlorine atoms on the benzene ring.
Let's talk about its reactivity. Due to the decrease in the electron cloud density of the benzene ring, when reacting with nucleophilic reagents, nucleophilic substitution reactions are more likely to occur. Especially under appropriate conditions, chlorine atoms can be replaced by other nucleophilic groups to form new organic compounds. This property is quite valuable in organic synthesis, and can be used to construct a variety of organic molecular structures.
Its physical properties are also 2-Chloro-1,4-difluorobenzene is mostly liquid at room temperature and has a certain volatility. Due to its polar molecule, it has good solubility in organic solvents, but little solubility in water.
In the field of industry and scientific research, 2-chloro-1,4-difluorobenzene is often used as an intermediate in organic synthesis. With its unique chemical properties, it can be converted into a variety of organic compounds with specific functions through various reactions, and is used in various fields such as medicine, pesticides, and materials.
In conclusion, the chemical properties of 2-chloro-1,4-difluorobenzene, determined by its molecular structure, play an important role in the field of organic chemistry, providing an important starting material and reaction intermediate for the synthesis of various organic compounds.
First of all, its stability is discussed. The benzene ring has a conjugated system, which gives the molecule a certain stability. However, the introduction of chlorine and fluorine atoms slightly changes the distribution of its electron cloud. The fluorine atom is extremely electronegative, and the electron-absorbing effect is significant, and the chlorine atom also has a certain electron-absorbing ability. The effect of these two makes the electron cloud density of the benzene ring decrease, resulting in a slight decrease in its electrophilic substitution activity compared with benzene.
In the electrophilic substitution reaction, due to the localization effect of fluorine and chlorine, the new substituent more than enters the specific position of the benzene ring. Fluorine and chlorine are both ortho and para-localization groups, but the localization effect of fluorine is stronger. Therefore, electrophilic reagents often attack the ortho and para-position of fluorine or chlorine atoms on the benzene ring.
Let's talk about its reactivity. Due to the decrease in the electron cloud density of the benzene ring, when reacting with nucleophilic reagents, nucleophilic substitution reactions are more likely to occur. Especially under appropriate conditions, chlorine atoms can be replaced by other nucleophilic groups to form new organic compounds. This property is quite valuable in organic synthesis, and can be used to construct a variety of organic molecular structures.
Its physical properties are also 2-Chloro-1,4-difluorobenzene is mostly liquid at room temperature and has a certain volatility. Due to its polar molecule, it has good solubility in organic solvents, but little solubility in water.
In the field of industry and scientific research, 2-chloro-1,4-difluorobenzene is often used as an intermediate in organic synthesis. With its unique chemical properties, it can be converted into a variety of organic compounds with specific functions through various reactions, and is used in various fields such as medicine, pesticides, and materials.
In conclusion, the chemical properties of 2-chloro-1,4-difluorobenzene, determined by its molecular structure, play an important role in the field of organic chemistry, providing an important starting material and reaction intermediate for the synthesis of various organic compounds.
What are the synthesis methods of 2-chloro-1,4-difluorobenzene?
The process of preparing 2-chloro-1,4-difluorobenzene involves several methods. First, it can be obtained by chlorination of 1,4-difluorobenzene. In this process, a suitable chlorinating agent, such as chlorine, interacts with 1,4-difluorobenzene under suitable reaction conditions, such as suitable temperature, pressure and catalyst presence. The chlorine gas of the chlorinating agent can be substituted with the benzene ring under light or under the catalysis of a specific catalyst, such as ferric chloride, so that the chlorine atom replaces the hydrogen atom on the benzene ring to obtain 2-chloro-1,4-difluorobenzene.
Furthermore, it can also be synthesized by specific reactions with compounds containing chlorine and fluorine. For example, select a suitable halogenated aromatic hydrocarbon, which has chlorine atoms or groups that can be converted into chlorine atoms on the benzene ring, and has a check point that can introduce fluorine atoms. Using a nucleophilic substitution reaction, using a suitable fluorine source, such as potassium fluoride, etc., in a suitable organic solvent and reaction conditions, the fluorine atom is substituted for the corresponding check point group, and then the synthesis of 2-chloro-1,4-difluorobenzene is achieved. In this reaction, the choice of organic solvent is very critical, and it is necessary to be able to dissolve the reactants without adverse effects on the reaction process. Organic solvents such as dimethyl sulfoxide are often optional.
In addition, there are also methods for constructing target molecules through multi-step reactions starting from other aromatic compounds. First, one of the chlorine atoms and the fluorine atom is introduced into the aromatic ring in a specific reaction, and then another halogen atom is introduced through other reaction steps. Through fine control of the reaction conditions and intermediates, 2-chloro-1,4-difluorobenzene is finally synthesized. This multi-step reaction requires precise control of the conditions of each step, including the proportion of reactants, reaction temperature, reaction time, etc., to ensure that the reaction proceeds in the desired direction, effectively avoid the occurrence of side reactions, and improve the yield and purity of the target product.
Furthermore, it can also be synthesized by specific reactions with compounds containing chlorine and fluorine. For example, select a suitable halogenated aromatic hydrocarbon, which has chlorine atoms or groups that can be converted into chlorine atoms on the benzene ring, and has a check point that can introduce fluorine atoms. Using a nucleophilic substitution reaction, using a suitable fluorine source, such as potassium fluoride, etc., in a suitable organic solvent and reaction conditions, the fluorine atom is substituted for the corresponding check point group, and then the synthesis of 2-chloro-1,4-difluorobenzene is achieved. In this reaction, the choice of organic solvent is very critical, and it is necessary to be able to dissolve the reactants without adverse effects on the reaction process. Organic solvents such as dimethyl sulfoxide are often optional.
In addition, there are also methods for constructing target molecules through multi-step reactions starting from other aromatic compounds. First, one of the chlorine atoms and the fluorine atom is introduced into the aromatic ring in a specific reaction, and then another halogen atom is introduced through other reaction steps. Through fine control of the reaction conditions and intermediates, 2-chloro-1,4-difluorobenzene is finally synthesized. This multi-step reaction requires precise control of the conditions of each step, including the proportion of reactants, reaction temperature, reaction time, etc., to ensure that the reaction proceeds in the desired direction, effectively avoid the occurrence of side reactions, and improve the yield and purity of the target product.
What are the precautions for using 2-chloro-1,4-difluorobenzene?
2-Chloro-1,4-difluorobenzene is an organic chemical. During use, many matters should be paid attention to when acting in accordance with ancient laws.
First safety protection. This compound is toxic and irritating, and can endanger health if it touches the skin, inhales or is taken by mistake. Therefore, when using it, be sure to wear complete protective equipment, such as gas masks, protective gloves and goggles, to prevent direct contact with it. And the operation should be carried out in a well-ventilated place, preferably in a fume hood, to promote the timely discharge of volatile gaseous substances, reduce the concentration in the air, and avoid the risk of inhalation.
Second words storage requirements. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. Because it is flammable, it can cause combustion and explosion in case of open flame or hot topic. It needs to be stored separately from oxidants and alkalis, and must not be mixed to prevent chemical reactions. The storage area should be equipped with suitable materials to contain leaks so that they can be dealt with in time when accidents occur.
Furthermore, it is the operating specification. When taking it, the action should be precise and gentle to avoid spillage. If heating, stirring and other operations are required, the reaction conditions should be strictly controlled and carried out according to the established process and parameters. For example, when heating, a suitable heating method and temperature should be selected to prevent the decomposition of compounds or other dangerous reactions due to excessive temperature.
And leak disposal. If there is a leak, don't panic. Quickly evacuate personnel from the contaminated area of the spill to a safe area and isolate them, strictly restricting access. Emergency responders need to wear self-contained positive pressure breathing apparatus and anti-virus clothing. Cut off the source of the leak as much as possible to prevent it from flowing into the restricted space such as sewers and flood drains. In the case of small leaks, you can mix sand, dry lime or soda ash and collect it in a dry, clean and covered container. In the event of a large number of leaks, you should build a dike or dig a pit for containment, cover it with foam to reduce steam disasters, and then transfer it to a tanker or a special collector for recycling or transportation to a waste treatment site for disposal.
In short, the use of 2-chloro-1,4-difluorobenzene requires a cautious attitude at all times and strict adherence to operating and safety guidelines to ensure the safety of personnel and the smooth progress of experiments and production.
First safety protection. This compound is toxic and irritating, and can endanger health if it touches the skin, inhales or is taken by mistake. Therefore, when using it, be sure to wear complete protective equipment, such as gas masks, protective gloves and goggles, to prevent direct contact with it. And the operation should be carried out in a well-ventilated place, preferably in a fume hood, to promote the timely discharge of volatile gaseous substances, reduce the concentration in the air, and avoid the risk of inhalation.
Second words storage requirements. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. Because it is flammable, it can cause combustion and explosion in case of open flame or hot topic. It needs to be stored separately from oxidants and alkalis, and must not be mixed to prevent chemical reactions. The storage area should be equipped with suitable materials to contain leaks so that they can be dealt with in time when accidents occur.
Furthermore, it is the operating specification. When taking it, the action should be precise and gentle to avoid spillage. If heating, stirring and other operations are required, the reaction conditions should be strictly controlled and carried out according to the established process and parameters. For example, when heating, a suitable heating method and temperature should be selected to prevent the decomposition of compounds or other dangerous reactions due to excessive temperature.
And leak disposal. If there is a leak, don't panic. Quickly evacuate personnel from the contaminated area of the spill to a safe area and isolate them, strictly restricting access. Emergency responders need to wear self-contained positive pressure breathing apparatus and anti-virus clothing. Cut off the source of the leak as much as possible to prevent it from flowing into the restricted space such as sewers and flood drains. In the case of small leaks, you can mix sand, dry lime or soda ash and collect it in a dry, clean and covered container. In the event of a large number of leaks, you should build a dike or dig a pit for containment, cover it with foam to reduce steam disasters, and then transfer it to a tanker or a special collector for recycling or transportation to a waste treatment site for disposal.
In short, the use of 2-chloro-1,4-difluorobenzene requires a cautious attitude at all times and strict adherence to operating and safety guidelines to ensure the safety of personnel and the smooth progress of experiments and production.
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