Linshang Chemical
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2-Chloro-1,5-Dibromo-3-Fluorobenzene
Linshang Chemical
|
HS Code |
898440 |
| Chemical Formula | C6H2Br2ClF |
| Molecular Weight | 298.34 |
| Appearance | Solid (Typical appearance, actual may vary) |
| Melting Point | Data may vary depending on purity |
| Boiling Point | Data may vary depending on purity |
| Density | Data may vary depending on conditions |
| Solubility In Water | Low solubility (Aromatic halides generally have low water solubility) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Flash Point | Data may vary depending on purity |
| Vapor Pressure | Low vapor pressure (due to its relatively high molecular weight and solid nature at room temperature) |
As an accredited 2-Chloro-1,5-Dibromo-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 1,5 - dibromo - 3 - fluorobenzene in a sealed chemical - grade bottle. |
| Storage | Store 2 - chloro - 1,5 - dibromo - 3 - fluorobenzene in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials. Separate it from oxidizing agents, reducing agents, and other reactive chemicals to prevent potential reactions. |
| Shipping | 2 - chloro - 1,5 - dibromo - 3 - fluorobenzene, a hazardous chemical, must be shipped in well - sealed, specialized containers compliant with regulations. Ensure proper labeling indicating its nature and handle with care during transit to prevent spills and ensure safety. |
Competitive 2-Chloro-1,5-Dibromo-3-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 2-chloro-1,5-dibromo-3-fluorobenzene
2-Chloro-1,5-dibromo-3-fluorobenzene is also an organic compound. Its chemical properties are unique and have the commonality of halogenated aromatics.
As far as nucleophilic substitution is concerned, the halogen atoms on the benzene ring are more electronegative than carbon due to fluorine, chlorine and bromine, resulting in a decrease in the electron cloud density of the benzene ring, making them more vulnerable to nucleophilic reagents. However, the activity of halogen atoms is different. Fluorine atoms have a small tendency to leave due to their high C-F bond energy; the carbon-halogen bond energy of bromine and chlorine is relatively small. Under appropriate conditions, nucleophilic reagents can interact with them and replace halogen atoms.
In the electrophilic substitution reaction, the benzene ring of this compound because the halogen atom is an ortho-para-localization group, although the electron cloud density of the benzene ring is reduced, the reactive activity is weaker than that of benzene, but the electrophilic reagents still tend to attack the ortho-para-position of the halogen atom.
And because it contains a variety of halogen atoms, it can undergo metallization reactions with active metals such as magnesium to form organometallic compounds. This compound is an important intermediate in organic synthesis and can participate in the construction of carbon-carbon bonds and other reactions.
When heated or illuminated, the carbon-halogen bonds in the molecule may be homogenized, generating free radicals, which in turn trigger free radical reactions and participate in many complex chemical transformation processes. This compound has diverse chemical properties and is widely used in the field of organic synthesis.
As far as nucleophilic substitution is concerned, the halogen atoms on the benzene ring are more electronegative than carbon due to fluorine, chlorine and bromine, resulting in a decrease in the electron cloud density of the benzene ring, making them more vulnerable to nucleophilic reagents. However, the activity of halogen atoms is different. Fluorine atoms have a small tendency to leave due to their high C-F bond energy; the carbon-halogen bond energy of bromine and chlorine is relatively small. Under appropriate conditions, nucleophilic reagents can interact with them and replace halogen atoms.
In the electrophilic substitution reaction, the benzene ring of this compound because the halogen atom is an ortho-para-localization group, although the electron cloud density of the benzene ring is reduced, the reactive activity is weaker than that of benzene, but the electrophilic reagents still tend to attack the ortho-para-position of the halogen atom.
And because it contains a variety of halogen atoms, it can undergo metallization reactions with active metals such as magnesium to form organometallic compounds. This compound is an important intermediate in organic synthesis and can participate in the construction of carbon-carbon bonds and other reactions.
When heated or illuminated, the carbon-halogen bonds in the molecule may be homogenized, generating free radicals, which in turn trigger free radical reactions and participate in many complex chemical transformation processes. This compound has diverse chemical properties and is widely used in the field of organic synthesis.
What are the synthesis methods of 2-chloro-1,5-dibromo-3-fluorobenzene
To prepare 2-chloro-1,5-dibromo-3-fluorobenzene, the following ancient method can be used.
First, benzene is used as the starting material, and the bromination reaction between benzene and bromine is first carried out under the catalysis of iron bromide. This is an electrophilic substitution, and the bromine atom is preferably entered into the benzene ring to obtain bromobenzene. The reaction formula is:\ (C_ {6} H_ {6} + Br_ {2}\ xrightarrow [] {FeBr_ {3}} C_ {6} H_ {5} Br + HBr\).
Then, the bromobenzene and chlorine are exposed to light or high temperature, and free radical substitution is performed. Because the benzyl hydrogen of bromobenzene is active, the chlorine atom is replaced to obtain 1-bromo-2-chlorobenzene. The reaction formula:\ (C_ {6} H_ {5} Br + Cl_ {2}\ xrightarrow [] {light} C_ {6} H_ {4} BrCl + HCl\).
Then let 1-bromo-2-chlorobenzene react with a fluorine reagent such as potassium fluoride in a suitable solvent (such as dimethyl sulfoxide) at high temperature. This is a halogen exchange reaction. The fluoride ion replaces a halogen atom on the benzene ring to obtain 1-chloro-2-fluoro-5-bromobenzene.
Finally, take 1-chloro-2-fluoro-5-bromobenzene, combine it with bromine and an appropriate catalyst, such as iron powder, and then perform bromination reaction. According to the law of benzene ring substitution, the bromine atom enters a specific position to obtain 2-chloro-1,5-dibromo-3-fluorobenzene.
Each step of the reaction needs to pay attention to the precise control of the reaction conditions, such as temperature, catalyst dosage, reactant ratio, etc., and the product of each step should be purified to achieve the expected purity of the final product.
First, benzene is used as the starting material, and the bromination reaction between benzene and bromine is first carried out under the catalysis of iron bromide. This is an electrophilic substitution, and the bromine atom is preferably entered into the benzene ring to obtain bromobenzene. The reaction formula is:\ (C_ {6} H_ {6} + Br_ {2}\ xrightarrow [] {FeBr_ {3}} C_ {6} H_ {5} Br + HBr\).
Then, the bromobenzene and chlorine are exposed to light or high temperature, and free radical substitution is performed. Because the benzyl hydrogen of bromobenzene is active, the chlorine atom is replaced to obtain 1-bromo-2-chlorobenzene. The reaction formula:\ (C_ {6} H_ {5} Br + Cl_ {2}\ xrightarrow [] {light} C_ {6} H_ {4} BrCl + HCl\).
Then let 1-bromo-2-chlorobenzene react with a fluorine reagent such as potassium fluoride in a suitable solvent (such as dimethyl sulfoxide) at high temperature. This is a halogen exchange reaction. The fluoride ion replaces a halogen atom on the benzene ring to obtain 1-chloro-2-fluoro-5-bromobenzene.
Finally, take 1-chloro-2-fluoro-5-bromobenzene, combine it with bromine and an appropriate catalyst, such as iron powder, and then perform bromination reaction. According to the law of benzene ring substitution, the bromine atom enters a specific position to obtain 2-chloro-1,5-dibromo-3-fluorobenzene.
Each step of the reaction needs to pay attention to the precise control of the reaction conditions, such as temperature, catalyst dosage, reactant ratio, etc., and the product of each step should be purified to achieve the expected purity of the final product.
2-Chloro-1, 5-dibromo-3-fluorobenzene in which areas
2-Chloro-1,5-dibromo-3-fluorobenzene is an organohalogenated aromatic hydrocarbon. It is widely used in many fields such as chemical industry, medicine, materials, etc.
In the field of chemical synthesis, it is often used as a key intermediate. With the activity of the halogen atom on the benzene ring, it can interact with many nucleophiles by means of nucleophilic substitution reactions to form a wide variety of organic compounds. For example, by reacting with alkoxides, corresponding aryl ethers can be formed; by reacting with amines, nitrogen-containing aromatic compounds can be prepared, providing rich raw materials and pathways for the development of organic synthesis chemistry.
In the field of pharmaceutical research and development, this compound is also of great value. Due to its unique structure, it is endowed with certain biological activity. Researchers can design and optimize drug molecules based on this structure. Or through structural modification, the affinity and selectivity of drugs to specific targets can be improved, and then new therapeutic drugs can be developed for the treatment and prevention of diseases.
In the field of materials science, 2-chloro-1,5-dibromo-3-fluorobenzene can participate in the preparation of high-performance materials. Introducing it into the structure of polymer can change the physical and chemical properties of materials. For example, enhancing the thermal stability and chemical resistance of materials, or endowing materials with special optical and electrical properties, to meet the needs of high-performance materials in different fields, such as electronic devices, aerospace and other fields.
In summary, although 2-chloro-1,5-dibromo-3-fluorobenzene is an organic compound, it plays an indispensable role in the fields of chemical engineering, medicine, and materials, and is of vital significance to promote technological progress and innovation in various fields.
In the field of chemical synthesis, it is often used as a key intermediate. With the activity of the halogen atom on the benzene ring, it can interact with many nucleophiles by means of nucleophilic substitution reactions to form a wide variety of organic compounds. For example, by reacting with alkoxides, corresponding aryl ethers can be formed; by reacting with amines, nitrogen-containing aromatic compounds can be prepared, providing rich raw materials and pathways for the development of organic synthesis chemistry.
In the field of pharmaceutical research and development, this compound is also of great value. Due to its unique structure, it is endowed with certain biological activity. Researchers can design and optimize drug molecules based on this structure. Or through structural modification, the affinity and selectivity of drugs to specific targets can be improved, and then new therapeutic drugs can be developed for the treatment and prevention of diseases.
In the field of materials science, 2-chloro-1,5-dibromo-3-fluorobenzene can participate in the preparation of high-performance materials. Introducing it into the structure of polymer can change the physical and chemical properties of materials. For example, enhancing the thermal stability and chemical resistance of materials, or endowing materials with special optical and electrical properties, to meet the needs of high-performance materials in different fields, such as electronic devices, aerospace and other fields.
In summary, although 2-chloro-1,5-dibromo-3-fluorobenzene is an organic compound, it plays an indispensable role in the fields of chemical engineering, medicine, and materials, and is of vital significance to promote technological progress and innovation in various fields.
2-Chloro-1, what are the physical properties of 5-dibromo-3-fluorobenzene
2-Chloro-1,5-dibromo-3-fluorobenzene is one of the organohalogenated aromatic hydrocarbons. Its physical properties are quite important and are detailed as follows:
When it comes to appearance, it is often a colorless to light yellow liquid or solid, but the exact situation may vary depending on purity and environment. Under normal temperature and pressure, if the intermolecular force is moderate, it can be a flowing liquid; if the force is strong, it is a solid state.
It is related to the melting point. Due to the introduction of halogen atoms, the intermolecular force changes. The electronegativity of chlorine, bromine and fluorine atoms is different, which changes the polarity of the molecule, which in turn affects the melting point. After theoretical speculation and reference to related analogs, its melting point may be in a relatively low range. Although the halogen atom enhances the intermolecular force, the planar structure of the benzene ring also plays a role, causing the molecular accumulation to not be tight, so the melting point is not very high.
In terms of boiling point, in view of the increase of halogen atoms, the intermolecular dispersion force and induction force are enhanced, the boiling point should be significantly higher than that of benzene. The boiling point of polyhalogenated benzene is often higher than that of monohalogenated benzene. This compound contains dibromine, monochlorine, and monofluorine. The boiling point may be in a higher range, but the exact value needs to be determined experimentally and accurately.
In terms of solubility, because it is an aromatic hydrocarbon derivative, it has a certain hydrophobicity and has little solubility in polar solv However, it is soluble in many organic solvents, such as ether, dichloromethane, carbon tetrachloride, etc. Due to the principle of similar phase dissolution, organic solvents are similar in structure and polarity to the compound, and can effectively disperse molecules and achieve dissolution.
In the case of density, the relative atomic weight of halogen atoms is larger, which increases the molecular weight and causes the density to be higher than that of water. Its density may vary with the type and quantity of halogen atoms. This compound contains bromine, chlorine, and fluorine, and the density may be between common halogenated aromatics.
In addition, 2-chloro-1,5-dibromo-3-fluorobenzene may be volatile, but the volatility of halogen atoms is weaker than that of benzene. And the electronegativity of the halogen atom may make the compound stable, but under certain conditions, it can still participate in the chemical reaction.
When it comes to appearance, it is often a colorless to light yellow liquid or solid, but the exact situation may vary depending on purity and environment. Under normal temperature and pressure, if the intermolecular force is moderate, it can be a flowing liquid; if the force is strong, it is a solid state.
It is related to the melting point. Due to the introduction of halogen atoms, the intermolecular force changes. The electronegativity of chlorine, bromine and fluorine atoms is different, which changes the polarity of the molecule, which in turn affects the melting point. After theoretical speculation and reference to related analogs, its melting point may be in a relatively low range. Although the halogen atom enhances the intermolecular force, the planar structure of the benzene ring also plays a role, causing the molecular accumulation to not be tight, so the melting point is not very high.
In terms of boiling point, in view of the increase of halogen atoms, the intermolecular dispersion force and induction force are enhanced, the boiling point should be significantly higher than that of benzene. The boiling point of polyhalogenated benzene is often higher than that of monohalogenated benzene. This compound contains dibromine, monochlorine, and monofluorine. The boiling point may be in a higher range, but the exact value needs to be determined experimentally and accurately.
In terms of solubility, because it is an aromatic hydrocarbon derivative, it has a certain hydrophobicity and has little solubility in polar solv However, it is soluble in many organic solvents, such as ether, dichloromethane, carbon tetrachloride, etc. Due to the principle of similar phase dissolution, organic solvents are similar in structure and polarity to the compound, and can effectively disperse molecules and achieve dissolution.
In the case of density, the relative atomic weight of halogen atoms is larger, which increases the molecular weight and causes the density to be higher than that of water. Its density may vary with the type and quantity of halogen atoms. This compound contains bromine, chlorine, and fluorine, and the density may be between common halogenated aromatics.
In addition, 2-chloro-1,5-dibromo-3-fluorobenzene may be volatile, but the volatility of halogen atoms is weaker than that of benzene. And the electronegativity of the halogen atom may make the compound stable, but under certain conditions, it can still participate in the chemical reaction.
What is the market outlook for 2-chloro-1,5-dibromo-3-fluorobenzene?
Today, there are 2-chloro-1,5-dibromo-3-fluorobenzene, and its market prospects are related to many parties. This compound has a unique position in the field of organic synthesis. Due to its special atomic substitution mode, it can be used as a key intermediate to participate in the construction of many complex organic molecules.
In the field of pharmaceutical research and development, it may lay the foundation for the creation of new drugs. Today, the demand for specific drugs is increasing day by day, and many pharmaceutical companies and scientific research teams are committed to exploring novel active ingredients. The structural characteristics of 2-chloro-1,5-dibromo-3-fluorobenzene make it very likely to be properly derived to obtain compounds with specific pharmacological activities, which in turn provide new ways for the treatment of difficult diseases.
In the field of materials science, with the vigorous development of high-tech industries, the demand for special performance materials is also increasing. This compound may be able to participate in the preparation of materials with unique optical and electrical properties. For example, in the field of organic optoelectronic materials, through rational design and synthesis, high-efficiency luminescent materials or semiconductor materials can be prepared to meet the development needs of display technology, optoelectronic devices and other industries.
However, looking at its market prospects, there are also challenges. The process of synthesizing this compound may need to be optimized to increase yield and reduce costs. And the market competition is fierce, in order to gain a place in the market, a balance needs to be found between technological innovation and cost control. However, overall, with its potential applications in organic synthesis, medicine, materials and other fields, the market prospect of 2-chloro-1,5-dibromo-3-fluorobenzene is quite promising, and it is expected to attract the attention and investment of many scientific research and industrial forces, generating new development opportunities.
In the field of pharmaceutical research and development, it may lay the foundation for the creation of new drugs. Today, the demand for specific drugs is increasing day by day, and many pharmaceutical companies and scientific research teams are committed to exploring novel active ingredients. The structural characteristics of 2-chloro-1,5-dibromo-3-fluorobenzene make it very likely to be properly derived to obtain compounds with specific pharmacological activities, which in turn provide new ways for the treatment of difficult diseases.
In the field of materials science, with the vigorous development of high-tech industries, the demand for special performance materials is also increasing. This compound may be able to participate in the preparation of materials with unique optical and electrical properties. For example, in the field of organic optoelectronic materials, through rational design and synthesis, high-efficiency luminescent materials or semiconductor materials can be prepared to meet the development needs of display technology, optoelectronic devices and other industries.
However, looking at its market prospects, there are also challenges. The process of synthesizing this compound may need to be optimized to increase yield and reduce costs. And the market competition is fierce, in order to gain a place in the market, a balance needs to be found between technological innovation and cost control. However, overall, with its potential applications in organic synthesis, medicine, materials and other fields, the market prospect of 2-chloro-1,5-dibromo-3-fluorobenzene is quite promising, and it is expected to attract the attention and investment of many scientific research and industrial forces, generating new development opportunities.
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