Linshang Chemical
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2-Chloro-1,5-Difluoro-3-Nitrobenzene
Linshang Chemical
|
HS Code |
237454 |
| Chemical Formula | C6H2ClF2NO2 |
| Molecular Weight | 193.54 |
| Appearance | Typically a solid |
| Physical State At Room Temperature | Solid |
| Odor | May have a characteristic chemical odor |
| Melting Point | Specific value would require reference data |
| Boiling Point | Specific value would require reference data |
| Solubility In Water | Low solubility, likely insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane |
| Density | Specific value would require reference data |
| Vapor Pressure | Low vapor pressure |
| Stability | Stable under normal conditions but may react with strong oxidants |
As an accredited 2-Chloro-1,5-Difluoro-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 1,5 - difluoro - 3 - nitrobenzene in a sealed chemical - grade bottle. |
| Storage | 2 - chloro - 1,5 - difluoro - 3 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials like stainless steel or certain plastics, to prevent leakage and contamination. |
| Shipping | 2 - chloro - 1,5 - difluoro - 3 - nitrobenzene is a chemical. It should be shipped in well - sealed, corrosion - resistant containers, following strict hazardous material regulations, ensuring safe transit from origin to destination. |
Competitive 2-Chloro-1,5-Difluoro-3-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Chloro-1,5-Difluoro-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 2-chloro-1,5-difluoro-3-nitrobenzene?
2-Chloro-1,5-difluoro-3-nitrobenzene is also an organic compound. It has a wide range of main uses and has important applications in various fields of chemical industry.
First, in the process of pharmaceutical synthesis, this compound is often a key intermediary. With it as the starting material, through a series of delicate chemical reactions, a molecular structure with specific pharmacological activities can be constructed. For example, in the creation process of some antibacterial drugs, the chlorine, fluorine, nitro and other functional groups of 2-chloro-1,5-difluoro-3-nitrobenzene can participate in nucleophilic substitution, reduction and other reactions, helping to construct the target drug molecule and endowing the drug with excellent antibacterial efficacy.
Second, it is also indispensable in the field of pesticide research and development. Due to its structural characteristics, it can be used as an important building block for the synthesis of new pesticides. Through chemical modification, pesticide varieties that have high-efficiency poisoning effects on pests and are relatively friendly to the environment can be derived. For example, the introduction of fluorine atoms in some fluorinated pesticides can improve the stability and biological activity of pesticides. 2-chloro-1,5-difluoro-3-nitrobenzene is an important starting material for the synthesis of such fluorinated pesticides.
Third, it also has its uses in the field of materials science. Can participate in the synthesis of polymer materials with special properties. In the polymerization reaction, its functional groups can react with other monomers, thus giving the polymer material unique electrical, optical or mechanical properties. For example, in the preparation of some functional polymer films, the participation of 2-chloro-1,5-difluoro-3-nitrobenzene can make the film have specific solubility, thermal stability or adsorption properties for specific substances, and then be used in electronic devices, separation membranes and other fields.
Overall, 2-chloro-1,5-difluoro-3-nitrobenzene, with its unique chemical structure, plays a crucial role in many chemical-related fields such as medicine, pesticides, and materials. It has made significant contributions to promoting technological progress and innovation in various fields.
First, in the process of pharmaceutical synthesis, this compound is often a key intermediary. With it as the starting material, through a series of delicate chemical reactions, a molecular structure with specific pharmacological activities can be constructed. For example, in the creation process of some antibacterial drugs, the chlorine, fluorine, nitro and other functional groups of 2-chloro-1,5-difluoro-3-nitrobenzene can participate in nucleophilic substitution, reduction and other reactions, helping to construct the target drug molecule and endowing the drug with excellent antibacterial efficacy.
Second, it is also indispensable in the field of pesticide research and development. Due to its structural characteristics, it can be used as an important building block for the synthesis of new pesticides. Through chemical modification, pesticide varieties that have high-efficiency poisoning effects on pests and are relatively friendly to the environment can be derived. For example, the introduction of fluorine atoms in some fluorinated pesticides can improve the stability and biological activity of pesticides. 2-chloro-1,5-difluoro-3-nitrobenzene is an important starting material for the synthesis of such fluorinated pesticides.
Third, it also has its uses in the field of materials science. Can participate in the synthesis of polymer materials with special properties. In the polymerization reaction, its functional groups can react with other monomers, thus giving the polymer material unique electrical, optical or mechanical properties. For example, in the preparation of some functional polymer films, the participation of 2-chloro-1,5-difluoro-3-nitrobenzene can make the film have specific solubility, thermal stability or adsorption properties for specific substances, and then be used in electronic devices, separation membranes and other fields.
Overall, 2-chloro-1,5-difluoro-3-nitrobenzene, with its unique chemical structure, plays a crucial role in many chemical-related fields such as medicine, pesticides, and materials. It has made significant contributions to promoting technological progress and innovation in various fields.
2-Chloro-1, what are the physical properties of 5-difluoro-3-nitrobenzene
2-Chloro-1,5-difluoro-3-nitrobenzene is also an organic compound. Its physical properties and first properties are mostly solid at room temperature, and the color may be light yellow to light brown. It is fine and has a specific crystal form.
When it comes to the melting point, the melting point of this compound is quite high, usually around [X] ° C. Due to the complex intermolecular forces, higher energy is required to break the lattice and cause the molecules to break away from the solid state. The boiling point is also higher, about [X] ° C. Due to the polarity of the molecule and the relative molecular mass, the gas phase separation requires more energy.
In terms of density, it is heavier than water, and sinks when it is in water. Its solubility is specific and slightly soluble in water. Because its molecular polarity is different from that of water molecules, it is difficult to date with water. However, in organic solvents, such as ether, dichloromethane, acetone, etc., the solubility is quite good, and the intermolecular force of organic solvents is similar to that of 2-chloro-1,5-difluoro-3-nitrobenzene, and it can be miscible with each other.
The smell of 2-chloro-1,5-difluoro-3-nitrobenzene is irritating and uncomfortable to smell. During operation, it should be protected to avoid hurting the respiratory tract. And it has a certain volatility and can spread slowly in the air. Although the volatilization rate is not very fast, it cannot be ignored. Its vapor pressure is low at room temperature, which is related to the strong attractive force between molecules, and it is difficult for molecules to escape from the liquid surface and enter the gas phase.
In summary, the physical properties of 2-chloro-1,5-difluoro-3-nitrobenzene lay the foundation for its application in chemical industry and scientific research.
When it comes to the melting point, the melting point of this compound is quite high, usually around [X] ° C. Due to the complex intermolecular forces, higher energy is required to break the lattice and cause the molecules to break away from the solid state. The boiling point is also higher, about [X] ° C. Due to the polarity of the molecule and the relative molecular mass, the gas phase separation requires more energy.
In terms of density, it is heavier than water, and sinks when it is in water. Its solubility is specific and slightly soluble in water. Because its molecular polarity is different from that of water molecules, it is difficult to date with water. However, in organic solvents, such as ether, dichloromethane, acetone, etc., the solubility is quite good, and the intermolecular force of organic solvents is similar to that of 2-chloro-1,5-difluoro-3-nitrobenzene, and it can be miscible with each other.
The smell of 2-chloro-1,5-difluoro-3-nitrobenzene is irritating and uncomfortable to smell. During operation, it should be protected to avoid hurting the respiratory tract. And it has a certain volatility and can spread slowly in the air. Although the volatilization rate is not very fast, it cannot be ignored. Its vapor pressure is low at room temperature, which is related to the strong attractive force between molecules, and it is difficult for molecules to escape from the liquid surface and enter the gas phase.
In summary, the physical properties of 2-chloro-1,5-difluoro-3-nitrobenzene lay the foundation for its application in chemical industry and scientific research.
What are the chemical synthesis methods of 2-chloro-1,5-difluoro-3-nitrobenzene
The chemical synthesis methods of 2-chloro-1,5-difluoro-3-nitrobenzene have different paths. The following are described in detail.
First, the halogenation reaction begins. First, take an appropriate aromatic compound, such as 1,5-difluoro-3-nitrobenzene, and place it in a suitable reaction vessel. Then, introduce a chlorine-containing reagent, such as thionyl chloride ($SOCl_2 $), and add an appropriate amount of catalyst, such as anhydrous aluminum trichloride ($AlCl_3 $). The reaction needs to be carried out in a certain temperature range, about 60-80 ° C, with continuous stirring. Sulfoxide chloride reacts with the substrate, and chlorine atoms replace hydrogen atoms at specific positions on the benzene ring to obtain 2-chloro-1,5-difluoro-3-nitrobenzene. After the reaction, the product is purified by distillation, extraction and other separation methods.
Second, through the combination of nitrification and halogenation steps. First, 1,5-difluorobenzene is used as the starting material, and it is put into the reaction system. Add a mixed acid (a mixture of nitric acid and sulfuric acid) to carry out the nitrification reaction. This process requires strict control of the temperature and the ratio of mixed acid. Generally, the temperature is maintained at 0-10 ° C, so that the nitro group is selectively introduced into the specific position of the benzene ring to generate 1,5-difluoro-3-nitrobenzene. Then, based on this product, a halogenation reaction is carried out, such as the above halogenation reaction method, the introduction of chlorine atoms, and the final synthesis of the target product. In the meantime, after each step of the reaction, it is necessary to properly separate and purify to ensure the purity of the product, which is conducive to the next reaction.
Third, a halogen exchange reaction is used. First prepare benzene derivatives containing different halogens, such as 2-bromo-1,5-difluoro-3-nitrobenzene. Mix it with a chlorination reagent, such as sodium chloride ($NaCl $), in a suitable solvent, such as N, N-dimethylformamide (DMF). At the same time, add a catalyst, such as cuprous iodide ($CuI $) and a suitable ligand. The reaction is carried out under heating conditions, about 100-120 ℃, bromine atoms are exchanged with chloride ions, resulting in 2-chloro-1,5-difluoro-3-nitrobenzene. After the reaction, the pure product is obtained through filtration, washing, recrystallization and other operations.
All synthesis methods have advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, the ease of control of reaction conditions, and the requirements of product purity, and choose the optimal method.
First, the halogenation reaction begins. First, take an appropriate aromatic compound, such as 1,5-difluoro-3-nitrobenzene, and place it in a suitable reaction vessel. Then, introduce a chlorine-containing reagent, such as thionyl chloride ($SOCl_2 $), and add an appropriate amount of catalyst, such as anhydrous aluminum trichloride ($AlCl_3 $). The reaction needs to be carried out in a certain temperature range, about 60-80 ° C, with continuous stirring. Sulfoxide chloride reacts with the substrate, and chlorine atoms replace hydrogen atoms at specific positions on the benzene ring to obtain 2-chloro-1,5-difluoro-3-nitrobenzene. After the reaction, the product is purified by distillation, extraction and other separation methods.
Second, through the combination of nitrification and halogenation steps. First, 1,5-difluorobenzene is used as the starting material, and it is put into the reaction system. Add a mixed acid (a mixture of nitric acid and sulfuric acid) to carry out the nitrification reaction. This process requires strict control of the temperature and the ratio of mixed acid. Generally, the temperature is maintained at 0-10 ° C, so that the nitro group is selectively introduced into the specific position of the benzene ring to generate 1,5-difluoro-3-nitrobenzene. Then, based on this product, a halogenation reaction is carried out, such as the above halogenation reaction method, the introduction of chlorine atoms, and the final synthesis of the target product. In the meantime, after each step of the reaction, it is necessary to properly separate and purify to ensure the purity of the product, which is conducive to the next reaction.
Third, a halogen exchange reaction is used. First prepare benzene derivatives containing different halogens, such as 2-bromo-1,5-difluoro-3-nitrobenzene. Mix it with a chlorination reagent, such as sodium chloride ($NaCl $), in a suitable solvent, such as N, N-dimethylformamide (DMF). At the same time, add a catalyst, such as cuprous iodide ($CuI $) and a suitable ligand. The reaction is carried out under heating conditions, about 100-120 ℃, bromine atoms are exchanged with chloride ions, resulting in 2-chloro-1,5-difluoro-3-nitrobenzene. After the reaction, the pure product is obtained through filtration, washing, recrystallization and other operations.
All synthesis methods have advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, the ease of control of reaction conditions, and the requirements of product purity, and choose the optimal method.
2-Chloro-1, what are the precautions during storage and transportation of 5-difluoro-3-nitrobenzene
2-Chloro-1,5-difluoro-3-nitrobenzene organic compounds, when storing and transporting, the following matters should be paid attention to:
One is storage. This compound may be more active in nature and sensitive to temperature and humidity. It should be stored in a cool, dry and well-ventilated place to prevent it from decomposing or triggering chemical reactions due to excessive temperature. Due to humidity or affecting its stability, the humidity in the warehouse should be properly controlled. Generally speaking, the relative humidity should be kept at 40% - 60%. And it needs to be stored separately from oxidants, reducing agents, alkalis, etc., to avoid mixed storage. It may react violently with these substances and increase safety risks. The storage place should be equipped with obvious warning signs, marking its hazard characteristics and emergency treatment methods, so that personnel can identify and respond.
The second is related to transportation. Before transportation, it is necessary to ensure that the packaging is complete and sealed to prevent leakage. Packaging materials need to be able to withstand certain external shocks and temperature changes, and are often packaged in special steel drums, plastic drums, etc. During transportation, the transportation temperature should be strictly controlled. Transportation vehicles with temperature control functions can be used to maintain the temperature within a suitable range. At the same time, transportation personnel should be professionally trained to be familiar with the dangerous characteristics of the compound and emergency treatment measures. Transportation vehicles should also be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. In the event of leakage and other accidents, they can be responded to in a timely manner.
In addition, whether it is storage or transportation, it is necessary to strictly follow relevant regulations and standards, and make detailed records, covering the time, quantity, transportation route and other information in and out of the warehouse, so as to trace and manage. In this way, we can ensure the safety of 2-chloro-1,5-difluoro-3-nitrobenzene during storage and transportation, and avoid accidents.
One is storage. This compound may be more active in nature and sensitive to temperature and humidity. It should be stored in a cool, dry and well-ventilated place to prevent it from decomposing or triggering chemical reactions due to excessive temperature. Due to humidity or affecting its stability, the humidity in the warehouse should be properly controlled. Generally speaking, the relative humidity should be kept at 40% - 60%. And it needs to be stored separately from oxidants, reducing agents, alkalis, etc., to avoid mixed storage. It may react violently with these substances and increase safety risks. The storage place should be equipped with obvious warning signs, marking its hazard characteristics and emergency treatment methods, so that personnel can identify and respond.
The second is related to transportation. Before transportation, it is necessary to ensure that the packaging is complete and sealed to prevent leakage. Packaging materials need to be able to withstand certain external shocks and temperature changes, and are often packaged in special steel drums, plastic drums, etc. During transportation, the transportation temperature should be strictly controlled. Transportation vehicles with temperature control functions can be used to maintain the temperature within a suitable range. At the same time, transportation personnel should be professionally trained to be familiar with the dangerous characteristics of the compound and emergency treatment measures. Transportation vehicles should also be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. In the event of leakage and other accidents, they can be responded to in a timely manner.
In addition, whether it is storage or transportation, it is necessary to strictly follow relevant regulations and standards, and make detailed records, covering the time, quantity, transportation route and other information in and out of the warehouse, so as to trace and manage. In this way, we can ensure the safety of 2-chloro-1,5-difluoro-3-nitrobenzene during storage and transportation, and avoid accidents.
What are the effects of 2-chloro-1, 5-difluoro-3-nitrobenzene on the environment and human health?
2-Chloro-1,5-difluoro-3-nitrobenzene is also an organic compound. It has an impact on the environment and human health.
In terms of the environment, if this compound is released in nature, or difficult to degrade, it will accumulate in soil and water bodies. It can spread through water runoff and atmospheric transmission, affecting the surrounding ecology. In aquatic organisms, it may be highly toxic, causing damage to their physiological functions, hindering reproduction, and endangering the ecological balance of water. And because it is fat-soluble, or enriched in the food chain, it is gradually accumulated in higher organisms by lower organisms, endangering the entire ecosystem.
For human health, exposure to this compound can enter the body through the respiratory tract, skin or digestive tract. Respiratory inhalation, or irritation of respiratory mucosa, causing cough, asthma, breathing difficulties and other symptoms. Skin contact, or cause allergies, redness, swelling, itching. If ingested orally, or damage the digestive system, causing nausea, vomiting, abdominal pain, etc. Long-term exposure, or potentially carcinogenic, damage the liver, kidneys and other organs, affecting the normal metabolism and physiological functions of the human body. Especially in occupational exposure, long-term exposure to this compound in the environment, the health risk is higher. Therefore, the production, use and disposal of 2-chloro-1,5-difluoro-3-nitrobenzene should be handled with caution and proper protection and treatment measures should be taken to reduce its harm to the environment and human health.
In terms of the environment, if this compound is released in nature, or difficult to degrade, it will accumulate in soil and water bodies. It can spread through water runoff and atmospheric transmission, affecting the surrounding ecology. In aquatic organisms, it may be highly toxic, causing damage to their physiological functions, hindering reproduction, and endangering the ecological balance of water. And because it is fat-soluble, or enriched in the food chain, it is gradually accumulated in higher organisms by lower organisms, endangering the entire ecosystem.
For human health, exposure to this compound can enter the body through the respiratory tract, skin or digestive tract. Respiratory inhalation, or irritation of respiratory mucosa, causing cough, asthma, breathing difficulties and other symptoms. Skin contact, or cause allergies, redness, swelling, itching. If ingested orally, or damage the digestive system, causing nausea, vomiting, abdominal pain, etc. Long-term exposure, or potentially carcinogenic, damage the liver, kidneys and other organs, affecting the normal metabolism and physiological functions of the human body. Especially in occupational exposure, long-term exposure to this compound in the environment, the health risk is higher. Therefore, the production, use and disposal of 2-chloro-1,5-difluoro-3-nitrobenzene should be handled with caution and proper protection and treatment measures should be taken to reduce its harm to the environment and human health.
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