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2-Chloro-1,5-Dinitro-3-(Trifluoromethyl)-Benzene
Linshang Chemical
|
HS Code |
508901 |
| Chemical Formula | C7H2ClF3N2O4 |
| Molar Mass | 272.55 g/mol |
| Appearance | likely a solid, color may vary (usually yellowish - brownish solids for nitro - containing aromatic compounds) |
| Physical State At Room Temperature | solid |
| Solubility In Water | low solubility, as it is a non - polar aromatic compound with hydrophobic trifluoromethyl and non - water - soluble nitro groups |
| Solubility In Organic Solvents | soluble in common organic solvents like dichloromethane, chloroform, toluene due to its non - polar nature |
| Density | no widely - known standard value, but would be denser than water considering its molecular structure and heavy atoms |
| Odor | may have a pungent, characteristic odor associated with nitro - and chloro - containing aromatic compounds |
| Stability | relatively stable under normal conditions, but can react under strong reducing or oxidizing conditions, and heat can also cause decomposition due to the presence of nitro groups |
| Reactivity | can undergo substitution reactions due to the presence of the chloro group, and nitro groups can participate in reduction reactions |
As an accredited 2-Chloro-1,5-Dinitro-3-(Trifluoromethyl)-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 1,5 - dinitro - 3 - (trifluoromethyl) - benzene in airtight chemical - grade containers. |
| Storage | 2 - chloro - 1,5 - dinitro - 3 - (trifluoromethyl) - benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Separate storage from incompatible substances like oxidizers, reducing agents, and bases to prevent potential reactions. Store at a temperature below 30°C to ensure stability. |
| Shipping | 2 - chloro - 1,5 - dinitro - 3 - (trifluoromethyl) - benzene is a hazardous chemical. It must be shipped in accordance with strict regulations, using appropriate containers to prevent leakage, and labeled clearly for safe transportation. |
Competitive 2-Chloro-1,5-Dinitro-3-(Trifluoromethyl)-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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What are the physical properties of 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene?
2-Chloro-1,5-dinitro-3- (trifluoromethyl) benzene is a kind of organic compound. Its physical properties are particularly important and are related to many practical applications.
First of all, its appearance, under room temperature and pressure, this substance is mostly solid. Its color is usually light yellow to yellow, and the characteristics of this color state can be easily recognized by the naked eye. Looking at its texture, or crystalline, crystalline state, is also one of its appearance characteristics.
As for the melting point, it is about a specific temperature range. This melting point is important for determining the purity of the substance and the change of its state during heating. When the temperature gradually rises to the melting point, 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene gradually melts from the solid state to the liquid state.
The other is the boiling point. However, due to the structure containing chlorine, nitro and trifluoromethyl groups, the intermolecular forces are complex and the boiling point is quite high. This boiling point characteristic is crucial in separation operations such as distillation. To separate it from the mixture, precise temperature control is required to achieve the desired separation effect.
In terms of solubility, 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene exhibits some solubility in most organic solvents. Organic solvents such as common toluene and dichloromethane can dissolve it. However, in water, its solubility is very small. This difference in solubility is due to the difference in the polarity of its molecules and the polarity of water molecules, as well as the difference in the interaction with organic solvent molecules.
In addition, the density of the substance is also one of its physical properties. The value of density affects its location in the liquid-liquid mixture system, as well as the separation and mixing of related substances. Due to the relatively large atomic mass of chlorine and fluorine atoms in the molecule, the density is higher than that of common hydrocarbons.
In conclusion, the physical properties of 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene, such as appearance, melting point, boiling point, solubility and density, are all related and have their own uses. They are all indispensable factors for organic synthesis, chemical production and many other fields.
First of all, its appearance, under room temperature and pressure, this substance is mostly solid. Its color is usually light yellow to yellow, and the characteristics of this color state can be easily recognized by the naked eye. Looking at its texture, or crystalline, crystalline state, is also one of its appearance characteristics.
As for the melting point, it is about a specific temperature range. This melting point is important for determining the purity of the substance and the change of its state during heating. When the temperature gradually rises to the melting point, 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene gradually melts from the solid state to the liquid state.
The other is the boiling point. However, due to the structure containing chlorine, nitro and trifluoromethyl groups, the intermolecular forces are complex and the boiling point is quite high. This boiling point characteristic is crucial in separation operations such as distillation. To separate it from the mixture, precise temperature control is required to achieve the desired separation effect.
In terms of solubility, 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene exhibits some solubility in most organic solvents. Organic solvents such as common toluene and dichloromethane can dissolve it. However, in water, its solubility is very small. This difference in solubility is due to the difference in the polarity of its molecules and the polarity of water molecules, as well as the difference in the interaction with organic solvent molecules.
In addition, the density of the substance is also one of its physical properties. The value of density affects its location in the liquid-liquid mixture system, as well as the separation and mixing of related substances. Due to the relatively large atomic mass of chlorine and fluorine atoms in the molecule, the density is higher than that of common hydrocarbons.
In conclusion, the physical properties of 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene, such as appearance, melting point, boiling point, solubility and density, are all related and have their own uses. They are all indispensable factors for organic synthesis, chemical production and many other fields.
What are the chemical properties of 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene
2-Chloro-1,5-dinitro-3- (trifluoromethyl) benzene is an organic compound with many chemical properties.
First of all, its reactivity is due to the presence of chlorine atoms, nitro groups and trifluoromethyl groups on the benzene ring, and chlorine atoms can undergo nucleophilic substitution reactions. Cover chlorine atoms have certain electronegativity, which makes the carbon-chlorine bond electron cloud biased towards chlorine, causing carbon atoms to be partially positively charged and vulnerable to nucleophilic reagents. In case of nucleophilic reagents, such as sodium alcohol, amines, etc., chlorine atoms can be replaced by corresponding groups to form new organic compounds.
Furthermore, the existence of nitro groups greatly affects the properties of the compound. Nitro is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and reduce the electrophilic substitution activity of the benzene ring. However, under specific conditions, nitro reduction reaction can occur, and nitro can be gradually reduced to amino group. This is an important reaction step in organic synthesis, which can be used to introduce amino functional groups to expand the application scope of compounds.
In addition, trifluoromethyl is also a strong electron-absorbing group, which has a significant impact on the distribution of benzene ring electron cloud, and works synergistically with nitro to further reduce the density of benzene ring electron cloud. And trifluoromethyl has unique chemical stability and hydrophobicity, which endows the compound with special physical and chemical properties, such as affecting its solubility, melting point, boiling point and other physical properties, which may have unique applications in materials science and other fields.
In addition, the compound may participate in redox reactions. Due to the redox activity of the functional groups contained, under the action of appropriate oxidants or reducing agents, corresponding oxidation or reduction changes occur, and products with different structures and properties are derived. This is a key consideration in the design of organic synthesis pathways.
In short, 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene contains a variety of special functional groups, exhibiting rich and diverse chemical properties, which hold potential application value in organic synthesis, materials science and other fields, providing a broad exploration space for chemical research and industrial production.
First of all, its reactivity is due to the presence of chlorine atoms, nitro groups and trifluoromethyl groups on the benzene ring, and chlorine atoms can undergo nucleophilic substitution reactions. Cover chlorine atoms have certain electronegativity, which makes the carbon-chlorine bond electron cloud biased towards chlorine, causing carbon atoms to be partially positively charged and vulnerable to nucleophilic reagents. In case of nucleophilic reagents, such as sodium alcohol, amines, etc., chlorine atoms can be replaced by corresponding groups to form new organic compounds.
Furthermore, the existence of nitro groups greatly affects the properties of the compound. Nitro is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and reduce the electrophilic substitution activity of the benzene ring. However, under specific conditions, nitro reduction reaction can occur, and nitro can be gradually reduced to amino group. This is an important reaction step in organic synthesis, which can be used to introduce amino functional groups to expand the application scope of compounds.
In addition, trifluoromethyl is also a strong electron-absorbing group, which has a significant impact on the distribution of benzene ring electron cloud, and works synergistically with nitro to further reduce the density of benzene ring electron cloud. And trifluoromethyl has unique chemical stability and hydrophobicity, which endows the compound with special physical and chemical properties, such as affecting its solubility, melting point, boiling point and other physical properties, which may have unique applications in materials science and other fields.
In addition, the compound may participate in redox reactions. Due to the redox activity of the functional groups contained, under the action of appropriate oxidants or reducing agents, corresponding oxidation or reduction changes occur, and products with different structures and properties are derived. This is a key consideration in the design of organic synthesis pathways.
In short, 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene contains a variety of special functional groups, exhibiting rich and diverse chemical properties, which hold potential application value in organic synthesis, materials science and other fields, providing a broad exploration space for chemical research and industrial production.
What is the main use of 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene?
2-Chloro-1,5-dinitro-3- (trifluoromethyl) benzene has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique molecular structure, it contains functional groups such as chlorine atoms, nitro groups and trifluoromethyl groups. These functional groups give it a variety of reactive activities, and can be derived from a variety of organic compounds through many chemical reactions, such as nucleophilic substitution and reduction.
In the field of materials science, it also has extraordinary performance. Due to the introduction of trifluoromethyl, the properties of materials can be significantly improved, such as enhancing the chemical stability, thermal stability and corrosion resistance of materials. For example, when preparing high-performance polymer materials, incorporating this compound into the polymer structure can make the polymer material retain good performance in extreme environments, and is suitable for aerospace, electronic equipment and other fields that require strict material properties.
In addition, in the field of medicinal chemistry, the special structure of this compound may be able to interact with specific targets in organisms, so in the process of drug development, it can be used as a lead compound to conduct in-depth research to explore new drugs with specific biological activities and pharmacological effects. However, it should be noted that this compound contains functional groups such as nitro groups, which are toxic and dangerous. During use, it is necessary to strictly follow relevant safety operating procedures to ensure the safety of personnel and the environment.
In the field of materials science, it also has extraordinary performance. Due to the introduction of trifluoromethyl, the properties of materials can be significantly improved, such as enhancing the chemical stability, thermal stability and corrosion resistance of materials. For example, when preparing high-performance polymer materials, incorporating this compound into the polymer structure can make the polymer material retain good performance in extreme environments, and is suitable for aerospace, electronic equipment and other fields that require strict material properties.
In addition, in the field of medicinal chemistry, the special structure of this compound may be able to interact with specific targets in organisms, so in the process of drug development, it can be used as a lead compound to conduct in-depth research to explore new drugs with specific biological activities and pharmacological effects. However, it should be noted that this compound contains functional groups such as nitro groups, which are toxic and dangerous. During use, it is necessary to strictly follow relevant safety operating procedures to ensure the safety of personnel and the environment.
What are the synthesis methods of 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene
To prepare 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene, the conventional number method.
First, an aromatic hydrocarbon containing the corresponding substituent is used as the starting material. If 3- (trifluoromethyl) aniline is used as the starting material, it is first diazotized, and then reacted with a solution of cuprous chloride in hydrochloric acid to introduce chlorine atoms to obtain 3- (trifluoromethyl) chlorobenzene. Then it is heated with a mixed acid (a mixture of nitric acid and sulfuric acid) to carry out nitrification. Because trifluoromethyl is an intermediate locator group, nitro groups can be introduced at the 1,5 position of the benzene ring, so the target product is obtained. In this path, the diazotization reaction needs to be precisely controlled at temperature, usually at low temperature (0-5 ° C) to prevent the decomposition of diazonium salts. During the nitration reaction, the proportion of mixed acids and the reaction temperature are all key factors, and the temperature is too high or causes side reactions such as polynitrogenation.
Second, we can start from 3 - (trifluoromethyl) benzoic acid. First, the carboxyl group is converted into an acyl chloride group to obtain 3 - (trifluoromethyl) benzoyl chloride. Then it reacts with chlorine gas catalyzed by iron powder to introduce chlorine atoms on the benzene ring to form 2-chloro-3 - (trifluoromethyl) benzoyl chloride. After the Hoffman degradation reaction, the acyl group is converted into an amino group to obtain 2-chloro-3- (trifluoromethyl) aniline. The amino group is removed by diazotization and reaction with sodium nitrite and copper powder, and then nitrified with mixed acid, and nitro is introduced at the 1,5 position to obtain 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene. In this process, the Hoffman degradation reaction requires basic conditions, and the separation and purification after each step of the reaction is quite important. Methods such as distillation, recrystallization, and column chromatography are required to remove impurities and obtain pure products.
Third, m (trifluoromethyl) benzaldehyde is used as the starting material. First, chlorine atoms are introduced into the ortho-position of the benzene ring through chlorination reaction to obtain 2-chloro-3- (trifluoromethyl) benzaldehyde. Then a strong oxidant such as potassium permanganate is used to oxidize the aldehyde group to a carboxyl group to obtain 2-chloro-3- (trifluoromethyl) benzoic acid. As mentioned above, the target molecule is synthesized through the steps of acylation, Hoffmann degradation, diazotization, deamination, and nitrification. In this route, it is particularly important to control the conditions of the oxidation reaction, and the adverse consequences such as excessive oxidation or destruction of the benzene ring are caused.
All synthesis methods have their own advantages and disadvantages. In practical application, the optimal way is selected according to the availability of raw materials, cost, yield and product purity.
First, an aromatic hydrocarbon containing the corresponding substituent is used as the starting material. If 3- (trifluoromethyl) aniline is used as the starting material, it is first diazotized, and then reacted with a solution of cuprous chloride in hydrochloric acid to introduce chlorine atoms to obtain 3- (trifluoromethyl) chlorobenzene. Then it is heated with a mixed acid (a mixture of nitric acid and sulfuric acid) to carry out nitrification. Because trifluoromethyl is an intermediate locator group, nitro groups can be introduced at the 1,5 position of the benzene ring, so the target product is obtained. In this path, the diazotization reaction needs to be precisely controlled at temperature, usually at low temperature (0-5 ° C) to prevent the decomposition of diazonium salts. During the nitration reaction, the proportion of mixed acids and the reaction temperature are all key factors, and the temperature is too high or causes side reactions such as polynitrogenation.
Second, we can start from 3 - (trifluoromethyl) benzoic acid. First, the carboxyl group is converted into an acyl chloride group to obtain 3 - (trifluoromethyl) benzoyl chloride. Then it reacts with chlorine gas catalyzed by iron powder to introduce chlorine atoms on the benzene ring to form 2-chloro-3 - (trifluoromethyl) benzoyl chloride. After the Hoffman degradation reaction, the acyl group is converted into an amino group to obtain 2-chloro-3- (trifluoromethyl) aniline. The amino group is removed by diazotization and reaction with sodium nitrite and copper powder, and then nitrified with mixed acid, and nitro is introduced at the 1,5 position to obtain 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene. In this process, the Hoffman degradation reaction requires basic conditions, and the separation and purification after each step of the reaction is quite important. Methods such as distillation, recrystallization, and column chromatography are required to remove impurities and obtain pure products.
Third, m (trifluoromethyl) benzaldehyde is used as the starting material. First, chlorine atoms are introduced into the ortho-position of the benzene ring through chlorination reaction to obtain 2-chloro-3- (trifluoromethyl) benzaldehyde. Then a strong oxidant such as potassium permanganate is used to oxidize the aldehyde group to a carboxyl group to obtain 2-chloro-3- (trifluoromethyl) benzoic acid. As mentioned above, the target molecule is synthesized through the steps of acylation, Hoffmann degradation, diazotization, deamination, and nitrification. In this route, it is particularly important to control the conditions of the oxidation reaction, and the adverse consequences such as excessive oxidation or destruction of the benzene ring are caused.
All synthesis methods have their own advantages and disadvantages. In practical application, the optimal way is selected according to the availability of raw materials, cost, yield and product purity.
What are the precautions for 2-chloro-1,5-dinitro-3- (trifluoromethyl) benzene during storage and transportation?
2-Chloro-1,5-dinitro-3- (trifluoromethyl) benzene is an organic compound, and many matters need to be carefully paid attention to during storage and transportation.
When storing, choose the first environment. When placed in a cool and ventilated warehouse, away from fire and heat sources, the substance is prone to danger due to heat. The temperature of the warehouse should be strictly controlled to prevent its stability from being disturbed due to excessive temperature.
Furthermore, it should be stored separately from oxidizing agents, reducing agents, alkalis, etc., and must not be mixed. Due to its active chemical properties, contact with the above substances is likely to trigger violent chemical reactions, and even cause combustion and explosion.
Packaging is also crucial to ensure that it is well sealed to prevent leakage. Packaging materials should have corresponding corrosion resistance to resist the erosion of the compound and ensure storage safety.
During transportation, transportation vehicles should be equipped with corresponding types and quantities of fire equipment and leakage emergency treatment equipment. Driving routes should avoid passing through densely populated areas and important places to prevent accidents from expanding the harm.
Loading and unloading during transportation also need to be cautious. Operators should wear appropriate protective equipment, pack and unload lightly, and do not subject the container to severe impact or heavy pressure to avoid package damage and leakage.
If a leak occurs during transportation, the leaked contaminated area should be quickly isolated and personnel should be restricted from entering and leaving. Emergency responders must wear gas masks and protective gloves to avoid direct contact with leaks. In the event of a small leak, it can be mixed with sand, dry lime, etc., and collected in a closed container; in the event of a large leak, build a dike or dig a pit to contain it, cover it with foam to reduce volatilization, and then deal with it. In this way, the safety of storage and transportation can be guaranteed.
When storing, choose the first environment. When placed in a cool and ventilated warehouse, away from fire and heat sources, the substance is prone to danger due to heat. The temperature of the warehouse should be strictly controlled to prevent its stability from being disturbed due to excessive temperature.
Furthermore, it should be stored separately from oxidizing agents, reducing agents, alkalis, etc., and must not be mixed. Due to its active chemical properties, contact with the above substances is likely to trigger violent chemical reactions, and even cause combustion and explosion.
Packaging is also crucial to ensure that it is well sealed to prevent leakage. Packaging materials should have corresponding corrosion resistance to resist the erosion of the compound and ensure storage safety.
During transportation, transportation vehicles should be equipped with corresponding types and quantities of fire equipment and leakage emergency treatment equipment. Driving routes should avoid passing through densely populated areas and important places to prevent accidents from expanding the harm.
Loading and unloading during transportation also need to be cautious. Operators should wear appropriate protective equipment, pack and unload lightly, and do not subject the container to severe impact or heavy pressure to avoid package damage and leakage.
If a leak occurs during transportation, the leaked contaminated area should be quickly isolated and personnel should be restricted from entering and leaving. Emergency responders must wear gas masks and protective gloves to avoid direct contact with leaks. In the event of a small leak, it can be mixed with sand, dry lime, etc., and collected in a closed container; in the event of a large leak, build a dike or dig a pit to contain it, cover it with foam to reduce volatilization, and then deal with it. In this way, the safety of storage and transportation can be guaranteed.
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