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2-Chloro-1-(Chloromethyl)-4-Fluorobenzene
Linshang Chemical
|
HS Code |
248638 |
| Chemical Formula | C7H5Cl2F |
| Molecular Weight | 181.019 g/mol |
| Appearance | Typically a colorless to light - yellow liquid |
| Boiling Point | Data may vary, around 200 - 220 °C |
| Density | Approx. 1.3 - 1.4 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, etc. |
| Vapor Pressure | Low vapor pressure at room temperature |
| Flash Point | Data may vary, but could be in the range of 80 - 100 °C |
As an accredited 2-Chloro-1-(Chloromethyl)-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram vial packaging for 2 - chloro - 1 - (chloromethyl)-4 - fluorobenzene. |
| Storage | 2 - chloro - 1 - (chloromethyl)-4 - fluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition points. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, bases, and reactive chemicals to prevent potential reactions. |
| Shipping | 2 - chloro - 1 - (chloromethyl)-4 - fluorobenzene is shipped in tightly sealed, corrosion - resistant containers. Special handling precautions are taken due to its chemical nature, and it's transported in accordance with hazardous material shipping regulations. |
Competitive 2-Chloro-1-(Chloromethyl)-4-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 2-Chloro-1-(Chloromethyl)-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 2-chloro-1- (chloromethyl) -4-fluorobenzene?
2-Chloro-1- (chloromethyl) -4-fluorobenzene is also an organic compound. Its chemical properties are unique and worthy of further investigation.
In this compound, chlorine and fluorine atoms are connected to the benzene ring and chloromethyl. The benzene ring has a conjugated system, which is stable in nature but can also undergo specific reactions. Chlorine atoms and fluorine atoms have different electronegativity, which has a great influence on the electron cloud distribution of the benzene ring. Chlorine atoms have a certain electron-withdrawing induction effect, while fluorine atoms have a stronger electron-withdrawing effect. The two reduce the electron cloud density of the benzene ring and weaken the electrophilic substitution activity of the benzene ring
Looking at its electrophilic substitution reaction, due to the positioning effect of chlorine and fluorine atoms, the newly introduced groups enter the specific position of the benzene ring. Taking the nitrification reaction as an example, the nitro group enters more chlorine and fluorine atoms into the interposition, because the two belong to the interposition positioning group, so that the density of the interposition electron cloud is relatively high.
Its halogenated hydrocarbon properties cannot be ignored. Chlorine atoms in chloromethyl groups are active and can undergo nucleophilic substitution reactions. In the case of nucleophilic reagents, such as sodium alcohol, ammonia, etc., chlorine atoms can be replaced and various compounds can be derived. And this compound has certain chemical stability and fat solubility due to its chlorine and fluorine content, and is widely used in the fields of organic synthesis and materials science. It can be used as an intermediate in the synthesis of medicine and pesticides, and is also used to prepare special polymer materials.
In this compound, chlorine and fluorine atoms are connected to the benzene ring and chloromethyl. The benzene ring has a conjugated system, which is stable in nature but can also undergo specific reactions. Chlorine atoms and fluorine atoms have different electronegativity, which has a great influence on the electron cloud distribution of the benzene ring. Chlorine atoms have a certain electron-withdrawing induction effect, while fluorine atoms have a stronger electron-withdrawing effect. The two reduce the electron cloud density of the benzene ring and weaken the electrophilic substitution activity of the benzene ring
Looking at its electrophilic substitution reaction, due to the positioning effect of chlorine and fluorine atoms, the newly introduced groups enter the specific position of the benzene ring. Taking the nitrification reaction as an example, the nitro group enters more chlorine and fluorine atoms into the interposition, because the two belong to the interposition positioning group, so that the density of the interposition electron cloud is relatively high.
Its halogenated hydrocarbon properties cannot be ignored. Chlorine atoms in chloromethyl groups are active and can undergo nucleophilic substitution reactions. In the case of nucleophilic reagents, such as sodium alcohol, ammonia, etc., chlorine atoms can be replaced and various compounds can be derived. And this compound has certain chemical stability and fat solubility due to its chlorine and fluorine content, and is widely used in the fields of organic synthesis and materials science. It can be used as an intermediate in the synthesis of medicine and pesticides, and is also used to prepare special polymer materials.
What are the main uses of 2-chloro-1- (chloromethyl) -4-fluorobenzene?
2-Chloro-1- (chloromethyl) -4-fluorobenzene, an organic compound with a wide range of uses.
In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of drug molecules with specific biological activities. Due to its unique chemical structure, it can impart specific physical and chemical properties to drug molecules, such as improving drug solubility, stability, or enhancing its interaction with biological targets. For example, in the development of some antibacterial and anti-tumor drugs, the structural unit of 2-chloro-1- (chloromethyl) -4-fluorobenzene may participate in the construction of the active center of the drug, helping the drug to act more precisely on pathogens or tumor cells, and improving the efficacy of the drug.
In the field of materials science, this compound also has potential uses. The chlorine and fluorine atoms in its structure can give the material unique properties. For example, the introduction of this structure in the synthesis of special polymer materials can change the surface properties of the material, such as improving the corrosion resistance and wear resistance of the material, or giving the material special optical and electrical properties. These changes in properties make materials useful in high-end fields such as electronic devices and aerospace.
In organic synthesis chemistry, 2-chloro-1- (chloromethyl) -4-fluorobenzene, as a reaction substrate, can participate in many types of organic reactions with its multiple active reaction check points. For example, in nucleophilic substitution reactions, both chlorine atoms and chloromethyl groups can be replaced by different nucleophiles to construct organic compounds with diverse structures, providing organic synthesis chemists with rich structural modification possibilities, helping them to create more complex and unique functional organic molecules.
In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of drug molecules with specific biological activities. Due to its unique chemical structure, it can impart specific physical and chemical properties to drug molecules, such as improving drug solubility, stability, or enhancing its interaction with biological targets. For example, in the development of some antibacterial and anti-tumor drugs, the structural unit of 2-chloro-1- (chloromethyl) -4-fluorobenzene may participate in the construction of the active center of the drug, helping the drug to act more precisely on pathogens or tumor cells, and improving the efficacy of the drug.
In the field of materials science, this compound also has potential uses. The chlorine and fluorine atoms in its structure can give the material unique properties. For example, the introduction of this structure in the synthesis of special polymer materials can change the surface properties of the material, such as improving the corrosion resistance and wear resistance of the material, or giving the material special optical and electrical properties. These changes in properties make materials useful in high-end fields such as electronic devices and aerospace.
In organic synthesis chemistry, 2-chloro-1- (chloromethyl) -4-fluorobenzene, as a reaction substrate, can participate in many types of organic reactions with its multiple active reaction check points. For example, in nucleophilic substitution reactions, both chlorine atoms and chloromethyl groups can be replaced by different nucleophiles to construct organic compounds with diverse structures, providing organic synthesis chemists with rich structural modification possibilities, helping them to create more complex and unique functional organic molecules.
What are the synthesis methods of 2-chloro-1- (chloromethyl) -4-fluorobenzene?
There are several methods for synthesizing 2-chloro-1- (chloromethyl) -4-fluorobenzene as follows.
First, 4-fluorotoluene is used as the starting material. First, 4-fluorotoluene and chlorine are subjected to side-chain chlorination under the action of light or initiator. Because methyl is affected by benzene ring, its α-hydrogen has a certain activity, and chlorine can be replaced with it to generate 4-fluoro-benzyl chloride. This step requires precise control of the reaction conditions, such as chlorine gas intake, light intensity and time, reaction temperature, etc., to avoid excessive chlorination. Subsequently, 4-fluoro-benzyl chloride is chlorinated on the benzene ring with chlorine in an appropriate solvent in the presence of a catalyst. Due to the fact that the fluorine atom is an ortho-site locator and the influence of steric hindrance, chlorine atoms can be introduced at the ortho-site to obtain 2-chloro-1- (chloromethyl) -4-fluorobenzene.
Second, 2-chloro-4-fluorobenzoic acid is used as the starting material. First, 2-chloro-4-fluorobenzoic acid is reduced, and suitable reducing agents, such as lithium aluminum hydride, can be used to reduce the carboxyl group to hydroxymethyl group to obtain 2-chloro-4-fluorobenzyl alcohol. Then, 2-chloro-4-fluorobenzyl alcohol is reacted with chlorination reagents, such as thionyl chloride, phosphorus trichloride, etc., so that the hydroxyl group is replaced by chlorine atoms to generate 2-chloro-1 - (chloromethyl) - 4-fluorobenzene. In this route, the reduction reaction should pay attention to the control of the amount of reducing agent and the reaction conditions to prevent excessive reduction or other side reactions; the chlorination reaction should pay attention to the activity and reaction selectivity of chlorinated reagents.
Third, it is based on the nucleophilic substitution reaction of halogenated aromatics. Select a suitable halogenated aromatic hydrocarbon containing fluorine and react with a nucleophilic reagent containing chloromethyl under appropriate conditions. For example, use a suitable base as a catalyst to react in a polar aprotic solvent. The nucleophilic reagent attacks the position of the halogen atom of the halogenated aromatic hydrocarbon and undergoes a substitution reaction to form 2-chloro-1 - (chloromethyl) - 4-fluorobenzene. The key to this method lies in the selection and preparation of nucleophilic test agents, as well as the optimization of reaction conditions such as temperature, type and dosage of bases, solvent properties, etc., in order to improve the reaction yield and selectivity.
First, 4-fluorotoluene is used as the starting material. First, 4-fluorotoluene and chlorine are subjected to side-chain chlorination under the action of light or initiator. Because methyl is affected by benzene ring, its α-hydrogen has a certain activity, and chlorine can be replaced with it to generate 4-fluoro-benzyl chloride. This step requires precise control of the reaction conditions, such as chlorine gas intake, light intensity and time, reaction temperature, etc., to avoid excessive chlorination. Subsequently, 4-fluoro-benzyl chloride is chlorinated on the benzene ring with chlorine in an appropriate solvent in the presence of a catalyst. Due to the fact that the fluorine atom is an ortho-site locator and the influence of steric hindrance, chlorine atoms can be introduced at the ortho-site to obtain 2-chloro-1- (chloromethyl) -4-fluorobenzene.
Second, 2-chloro-4-fluorobenzoic acid is used as the starting material. First, 2-chloro-4-fluorobenzoic acid is reduced, and suitable reducing agents, such as lithium aluminum hydride, can be used to reduce the carboxyl group to hydroxymethyl group to obtain 2-chloro-4-fluorobenzyl alcohol. Then, 2-chloro-4-fluorobenzyl alcohol is reacted with chlorination reagents, such as thionyl chloride, phosphorus trichloride, etc., so that the hydroxyl group is replaced by chlorine atoms to generate 2-chloro-1 - (chloromethyl) - 4-fluorobenzene. In this route, the reduction reaction should pay attention to the control of the amount of reducing agent and the reaction conditions to prevent excessive reduction or other side reactions; the chlorination reaction should pay attention to the activity and reaction selectivity of chlorinated reagents.
Third, it is based on the nucleophilic substitution reaction of halogenated aromatics. Select a suitable halogenated aromatic hydrocarbon containing fluorine and react with a nucleophilic reagent containing chloromethyl under appropriate conditions. For example, use a suitable base as a catalyst to react in a polar aprotic solvent. The nucleophilic reagent attacks the position of the halogen atom of the halogenated aromatic hydrocarbon and undergoes a substitution reaction to form 2-chloro-1 - (chloromethyl) - 4-fluorobenzene. The key to this method lies in the selection and preparation of nucleophilic test agents, as well as the optimization of reaction conditions such as temperature, type and dosage of bases, solvent properties, etc., in order to improve the reaction yield and selectivity.
What to pay attention to when storing and transporting 2-chloro-1- (chloromethyl) -4-fluorobenzene
2-Chloro-1- (chloromethyl) -4-fluorobenzene is an organic chemical substance. When storing and transporting, care must be taken and must not be taken lightly.
First word storage. This substance should be placed in a cool, dry and well-ventilated place. Because it is quite sensitive to temperature and humidity, it is easy to deteriorate and damage its chemical properties in a high temperature and humid environment. It must be placed separately from oxidizing agents, strong alkalis and other substances. Because of its chemical activity, if it comes into contact with them, it may cause violent chemical reactions and cause fire and explosion. And the place of storage should be clearly marked to make everyone aware of its danger to avoid unintentional touch.
Second talk about transportation. When transporting, be sure to choose suitable packaging materials. Commonly used, have strong metal drums or special plastic containers to ensure good sealing to prevent leakage. Transportation vehicles also need to have corresponding safety equipment, such as fire extinguishers, leakage emergency treatment tools, etc., for emergencies. Transportation personnel should be professionally trained and familiar with the characteristics of this substance and emergency treatment methods. During driving, it is advisable to drive slowly to avoid bumps and vibrations and prevent packaging damage. If a leak unfortunately occurs, emergency measures should be taken immediately, evacuate surrounding personnel, seal the scene, and be properly handled by professionals.
In summary, the storage and transportation of 2-chloro-1- (chloromethyl) -4-fluorobenzene is related to the overall safety situation and must be strictly followed in order to be foolproof.
First word storage. This substance should be placed in a cool, dry and well-ventilated place. Because it is quite sensitive to temperature and humidity, it is easy to deteriorate and damage its chemical properties in a high temperature and humid environment. It must be placed separately from oxidizing agents, strong alkalis and other substances. Because of its chemical activity, if it comes into contact with them, it may cause violent chemical reactions and cause fire and explosion. And the place of storage should be clearly marked to make everyone aware of its danger to avoid unintentional touch.
Second talk about transportation. When transporting, be sure to choose suitable packaging materials. Commonly used, have strong metal drums or special plastic containers to ensure good sealing to prevent leakage. Transportation vehicles also need to have corresponding safety equipment, such as fire extinguishers, leakage emergency treatment tools, etc., for emergencies. Transportation personnel should be professionally trained and familiar with the characteristics of this substance and emergency treatment methods. During driving, it is advisable to drive slowly to avoid bumps and vibrations and prevent packaging damage. If a leak unfortunately occurs, emergency measures should be taken immediately, evacuate surrounding personnel, seal the scene, and be properly handled by professionals.
In summary, the storage and transportation of 2-chloro-1- (chloromethyl) -4-fluorobenzene is related to the overall safety situation and must be strictly followed in order to be foolproof.
What are the effects of 2-chloro-1- (chloromethyl) -4-fluorobenzene on the environment and human health?
2-Chloro-1- (chloromethyl) -4-fluorobenzene is also an organic compound. The impact of this substance on the environment and human health cannot be ignored.
In the environment, 2-chloro-1- (chloromethyl) -4-fluorobenzene has certain stability due to its chemical structure. If released in nature, it is difficult to be rapidly decomposed by microorganisms, or cause it to accumulate in the environment. It may enter the soil, affecting the structure and function of the soil microbial community, hindering the absorption of nutrients by plant roots, and then disturbing the growth and development of plants. And if it flows into the water body, it will also pose a threat to aquatic organisms. Due to its biological toxicity, it can cause abnormal behavior of aquatic organisms, growth retardation, and even death, destroying the balance of aquatic ecosystems.
As for human health, 2-chloro-1- (chloromethyl) -4-fluorobenzene may enter the human body through respiratory tract, skin contact or accidental ingestion. After entering the body, it may have adverse effects on multiple organ systems. The chlorine and fluorine atoms in its chemical structure may interfere with the normal physiological and biochemical processes of the human body. Or damage the function of metabolic organs such as the liver and kidneys, because it needs to metabolize and detoxify the substance, long-term exposure or organ function decline. And this substance may have potential carcinogenicity. Although there is no conclusive conclusion, its chemical properties are similar to some known carcinogens, so it should not be taken lightly. And because it may also affect the nervous system, or cause symptoms such as headache, dizziness, fatigue, etc., it affects people's normal life and work.
In short, 2-chloro-1- (chloromethyl) -4-fluorobenzene has potential harm to the environment and human health. During its production, use and disposal, it must be treated with caution to prevent irreversible damage to the ecological environment and human body.
In the environment, 2-chloro-1- (chloromethyl) -4-fluorobenzene has certain stability due to its chemical structure. If released in nature, it is difficult to be rapidly decomposed by microorganisms, or cause it to accumulate in the environment. It may enter the soil, affecting the structure and function of the soil microbial community, hindering the absorption of nutrients by plant roots, and then disturbing the growth and development of plants. And if it flows into the water body, it will also pose a threat to aquatic organisms. Due to its biological toxicity, it can cause abnormal behavior of aquatic organisms, growth retardation, and even death, destroying the balance of aquatic ecosystems.
As for human health, 2-chloro-1- (chloromethyl) -4-fluorobenzene may enter the human body through respiratory tract, skin contact or accidental ingestion. After entering the body, it may have adverse effects on multiple organ systems. The chlorine and fluorine atoms in its chemical structure may interfere with the normal physiological and biochemical processes of the human body. Or damage the function of metabolic organs such as the liver and kidneys, because it needs to metabolize and detoxify the substance, long-term exposure or organ function decline. And this substance may have potential carcinogenicity. Although there is no conclusive conclusion, its chemical properties are similar to some known carcinogens, so it should not be taken lightly. And because it may also affect the nervous system, or cause symptoms such as headache, dizziness, fatigue, etc., it affects people's normal life and work.
In short, 2-chloro-1- (chloromethyl) -4-fluorobenzene has potential harm to the environment and human health. During its production, use and disposal, it must be treated with caution to prevent irreversible damage to the ecological environment and human body.
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