Linshang Chemical
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2-Chloro-1-Fluoro-3-Methylbenzene
|
HS Code |
151000 |
| Chemical Formula | C7H6ClF |
| Molar Mass | 146.573 g/mol |
| Appearance | Liquid |
| Boiling Point | Around 163 - 165 °C |
| Density | Approx. 1.19 g/cm³ |
| Odor | Characteristic aromatic odor |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Around 55 °C |
| Vapor Pressure | Low at room temperature |
| Stability | Stable under normal conditions |
As an accredited 2-Chloro-1-Fluoro-3-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 mL glass bottle with screw - cap for 2 - chloro - 1 - fluoro - 3 - methylbenzene. |
| Storage | 2 - Chloro - 1 - fluoro - 3 - methylbenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, acids, and bases to prevent chemical reactions. Ensure proper labeling for easy identification and compliance with safety regulations. |
| Shipping | 2 - chloro - 1 - fluoro - 3 - methylbenzene is shipped in tightly sealed, corrosion - resistant containers. It must be transported in accordance with hazardous chemical regulations, ensuring proper labeling and handling to prevent leakage and ensure safety during transit. |
Competitive 2-Chloro-1-Fluoro-3-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 2-chloro-1-fluoro-3-methylbenzene?
2-Chloro-1-fluoro-3-methylbenzene is also an organic compound. It has the commonality of aromatic hydrocarbons, and because it contains functional groups such as chlorine, fluorine, and methyl, it presents unique chemical properties.
First, the characteristics of halogenated aromatic hydrocarbons. The presence of chlorine and fluorine atoms changes the electron cloud density of the benzene ring. Chlorine and fluorine atoms have electron-sucking induction effects, which reduce the electron cloud density of the benzene ring, and the activity of electrophilic substitution reactions is slightly lower than that of benzene. However, the electron cloud density of the adjacent and para-position is relatively high, and the electrophilic reagents still tend to attack the adjacent and para-position. For example, during nitrification, more nitro groups are introduced into the
Second, the influence of methyl group. Methyl group is a power supply group, which can increase the electron cloud density of the benzene ring, especially in its adjacent and para-positions. Therefore, in the electrophilic substitution reaction, the adjacent and para-positions of methyl group are more susceptible to attack by electrophilic reagents. Combined with the localization effects of chlorine and fluorine atoms, the selectivity of the check point of the electrophilic substitution reaction of this compound is more complicated. For example, in the halogenation reaction, due to the coexistence of the electron absorption of chlorine and fluorine and the action of the power supply of methyl group, the proportion of products varies according to the reaction conditions.
Third, the reactivity of the halogen atom. Although the halogen atom on the aromatic ring is more stable than the halogen at Such as with strong bases and at high temperatures, chlorine and fluorine atoms can be replaced by nucleophiles such as hydroxyl groups, which is one of the ways to prepare corresponding phenolic compounds.
Fourth, side chain reaction can occur. Methyl can be oxidized, and in case of strong oxidants, it can be converted into carboxyl groups to form 2-chloro-1-fluoro-3-benzoic acid. This reaction is often used in organic synthesis to introduce carboxyl functional groups.
2-chloro-1-fluoro-3-methylbenzene contains functional groups that interact with each other and are rich in chemical properties, which is of great significance in the field of organic synthesis.
First, the characteristics of halogenated aromatic hydrocarbons. The presence of chlorine and fluorine atoms changes the electron cloud density of the benzene ring. Chlorine and fluorine atoms have electron-sucking induction effects, which reduce the electron cloud density of the benzene ring, and the activity of electrophilic substitution reactions is slightly lower than that of benzene. However, the electron cloud density of the adjacent and para-position is relatively high, and the electrophilic reagents still tend to attack the adjacent and para-position. For example, during nitrification, more nitro groups are introduced into the
Second, the influence of methyl group. Methyl group is a power supply group, which can increase the electron cloud density of the benzene ring, especially in its adjacent and para-positions. Therefore, in the electrophilic substitution reaction, the adjacent and para-positions of methyl group are more susceptible to attack by electrophilic reagents. Combined with the localization effects of chlorine and fluorine atoms, the selectivity of the check point of the electrophilic substitution reaction of this compound is more complicated. For example, in the halogenation reaction, due to the coexistence of the electron absorption of chlorine and fluorine and the action of the power supply of methyl group, the proportion of products varies according to the reaction conditions.
Third, the reactivity of the halogen atom. Although the halogen atom on the aromatic ring is more stable than the halogen at Such as with strong bases and at high temperatures, chlorine and fluorine atoms can be replaced by nucleophiles such as hydroxyl groups, which is one of the ways to prepare corresponding phenolic compounds.
Fourth, side chain reaction can occur. Methyl can be oxidized, and in case of strong oxidants, it can be converted into carboxyl groups to form 2-chloro-1-fluoro-3-benzoic acid. This reaction is often used in organic synthesis to introduce carboxyl functional groups.
2-chloro-1-fluoro-3-methylbenzene contains functional groups that interact with each other and are rich in chemical properties, which is of great significance in the field of organic synthesis.
What are the main uses of 2-chloro-1-fluoro-3-methylbenzene?
2-Chloro-1-fluoro-3-methylbenzene is one of the organic compounds. Its main uses are quite extensive, and I will describe them in detail today.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to its functional groups such as chlorine, fluorine and methyl in the molecule, each has unique chemical activities and can participate in a variety of chemical reactions. For example, in nucleophilic substitution reactions, chlorine atoms can be replaced by various nucleophiles, and then new functional groups can be introduced to realize the construction of complex organic molecules. The introduction of fluorine atoms can significantly change the physical and chemical properties of compounds, such as improving their fat solubility and stability, which is of great significance in medicinal chemistry and materials science.
In the field of drug development, derivatives of 2-chloro-1-fluoro-3-methylbenzene exhibit potential biological activities. By modifying and modifying their structures, researchers are expected to create new drugs with specific pharmacological activities. It can be used as an antimicrobial drug, which can combine with key targets in bacteria with its special molecular structure to inhibit the growth and reproduction of bacteria; or it can emerge in the exploration of anti-tumor drugs, by interfering with the metabolic process or signaling pathway of tumor cells, to exert anti-cancer effect.
It is also important in the field of materials science. Using it as the starting material, through polymerization and other means, a polymer material with unique properties can be prepared. The obtained material may have excellent heat resistance and chemical corrosion resistance, and is suitable for high-end fields such as aerospace, electronics and electrical appliances. For example, in electronic packaging materials, its stable chemical properties and good thermal properties can ensure the reliable operation of electronic components.
In addition, in the field of pesticides, 2-chloro-1-fluoro-3-methyl benzene and its derivatives may act as active ingredients for high-efficiency pesticides. It can precisely act on the specific physiological processes of pests, achieve efficient control of pests, and contribute to the sustainable development of agriculture due to its structural characteristics or low environmental toxicity.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to its functional groups such as chlorine, fluorine and methyl in the molecule, each has unique chemical activities and can participate in a variety of chemical reactions. For example, in nucleophilic substitution reactions, chlorine atoms can be replaced by various nucleophiles, and then new functional groups can be introduced to realize the construction of complex organic molecules. The introduction of fluorine atoms can significantly change the physical and chemical properties of compounds, such as improving their fat solubility and stability, which is of great significance in medicinal chemistry and materials science.
In the field of drug development, derivatives of 2-chloro-1-fluoro-3-methylbenzene exhibit potential biological activities. By modifying and modifying their structures, researchers are expected to create new drugs with specific pharmacological activities. It can be used as an antimicrobial drug, which can combine with key targets in bacteria with its special molecular structure to inhibit the growth and reproduction of bacteria; or it can emerge in the exploration of anti-tumor drugs, by interfering with the metabolic process or signaling pathway of tumor cells, to exert anti-cancer effect.
It is also important in the field of materials science. Using it as the starting material, through polymerization and other means, a polymer material with unique properties can be prepared. The obtained material may have excellent heat resistance and chemical corrosion resistance, and is suitable for high-end fields such as aerospace, electronics and electrical appliances. For example, in electronic packaging materials, its stable chemical properties and good thermal properties can ensure the reliable operation of electronic components.
In addition, in the field of pesticides, 2-chloro-1-fluoro-3-methyl benzene and its derivatives may act as active ingredients for high-efficiency pesticides. It can precisely act on the specific physiological processes of pests, achieve efficient control of pests, and contribute to the sustainable development of agriculture due to its structural characteristics or low environmental toxicity.
What are 2-chloro-1-fluoro-3-methylbenzene synthesis methods?
To prepare 2-chloro-1-fluoro-3-methylbenzene, there are several common methods as follows.
First, 3-methylaniline is used as the starting material. First, 3-methylaniline is diazotized, treated with sodium nitrite and hydrochloric acid at low temperature to obtain diazonium salts. After that, fluoroboronic acid is added to the diazonium salt solution to form a fluoroborate precipitation. After separating and drying the precipitation, it is heated and decomposed to obtain 1-fluoro-3-methylbenzene. Then 1-fluoro-3-methylbenzene is chlorinated, and a suitable chlorination reagent, such as chlorine, can be selected. Under the conditions of light or catalyst, chlorine atoms can be introduced into the specific position of the benzene ring to obtain 2-chloro-1-fluoro-3-methylbenzene. In this process, the temperature of the diazotization reaction needs to be strictly controlled to prevent the decomposition of diazonium salts. During the chlorination reaction, attention should be paid to the effect of the reaction conditions on the substitution position.
Second, starting from 3-methylphenol. First, 3-methylphenol is reacted with fluorination reagents, such as potassium fluoride, etc., under the action of suitable solvents and catalysts, the phenolic hydroxyl group is replaced by fluorine atoms to obtain 1-fluoro-3-methylbenzene. Subsequently, according to the above chlorination reaction steps, 1-fluoro-3-methylbenzene is chlorinated to obtain the target product 2-chloro-1-fluoro-3-methylbenzene. In this route, the fluorination reaction conditions of phenolic hydroxyl groups are more critical, and suitable solvents and catalysts need to be selected to improve the reaction efficiency and selectivity.
Third, m-methylanisole is used as the raw material. The halogenation reaction of m-methyl anisole is carried out first. Chlorine gas and a suitable catalyst can be selected. Chlorine atoms are preferentially introduced into the benzene ring to form chlorine-containing m-methyl anisole derivatives. Then, the methoxy group is converted into fluorine atoms, which can be realized by specific reagents and reaction conditions. This process requires fine regulation of the reaction sequence and conditions to ensure that the chlorine atoms and fluorine atoms are in the desired position, and finally 2-chloro-1-fluoro-3-methylbenzene is synthesized. The occurrence of side reactions needs to be paid attention to in each step of the reaction, and the purity and yield of the product can be improved by optimizing the conditions
First, 3-methylaniline is used as the starting material. First, 3-methylaniline is diazotized, treated with sodium nitrite and hydrochloric acid at low temperature to obtain diazonium salts. After that, fluoroboronic acid is added to the diazonium salt solution to form a fluoroborate precipitation. After separating and drying the precipitation, it is heated and decomposed to obtain 1-fluoro-3-methylbenzene. Then 1-fluoro-3-methylbenzene is chlorinated, and a suitable chlorination reagent, such as chlorine, can be selected. Under the conditions of light or catalyst, chlorine atoms can be introduced into the specific position of the benzene ring to obtain 2-chloro-1-fluoro-3-methylbenzene. In this process, the temperature of the diazotization reaction needs to be strictly controlled to prevent the decomposition of diazonium salts. During the chlorination reaction, attention should be paid to the effect of the reaction conditions on the substitution position.
Second, starting from 3-methylphenol. First, 3-methylphenol is reacted with fluorination reagents, such as potassium fluoride, etc., under the action of suitable solvents and catalysts, the phenolic hydroxyl group is replaced by fluorine atoms to obtain 1-fluoro-3-methylbenzene. Subsequently, according to the above chlorination reaction steps, 1-fluoro-3-methylbenzene is chlorinated to obtain the target product 2-chloro-1-fluoro-3-methylbenzene. In this route, the fluorination reaction conditions of phenolic hydroxyl groups are more critical, and suitable solvents and catalysts need to be selected to improve the reaction efficiency and selectivity.
Third, m-methylanisole is used as the raw material. The halogenation reaction of m-methyl anisole is carried out first. Chlorine gas and a suitable catalyst can be selected. Chlorine atoms are preferentially introduced into the benzene ring to form chlorine-containing m-methyl anisole derivatives. Then, the methoxy group is converted into fluorine atoms, which can be realized by specific reagents and reaction conditions. This process requires fine regulation of the reaction sequence and conditions to ensure that the chlorine atoms and fluorine atoms are in the desired position, and finally 2-chloro-1-fluoro-3-methylbenzene is synthesized. The occurrence of side reactions needs to be paid attention to in each step of the reaction, and the purity and yield of the product can be improved by optimizing the conditions
2-chloro-1-fluoro-3-methylbenzene what are the precautions during storage and transportation?
2-Chloro-1-fluoro-3-methylbenzene is an organic compound. During storage and transportation, many key matters need to be paid careful attention.
The first is the storage environment. This compound should be stored in a cool, dry and well-ventilated place. Be sure to keep away from fires and heat sources. Because organic compounds are flammable, they can easily cause combustion or even explosion in case of open flame or high temperature. If the storage environment temperature is too high, the volatility of the compound will be enhanced, and the concentration will accumulate in a limited space, increasing the risk factor; if the humidity is too high, it may cause chemical reactions such as hydrolysis, which will affect the quality and stability.
Secondly, the packaging must be tightly closed. Appropriate packaging materials should be selected to ensure that there is no risk of leakage. Due to its chemical properties, packaging materials that will react with it should be avoided. For example, some metal materials may react with chlorine, fluorine and other elements in the compound, so the choice of packaging materials needs to be carefully considered to ensure safety during storage.
Furthermore, the storage area should be stored separately from oxidants, acids, bases, etc., and mixed storage should not be avoided. 2-Chloro-1-fluoro-3-methylbenzene is in contact with these substances, which is very likely to trigger a violent chemical reaction, resulting in a dangerous situation. Such as oxidizing agents can cause the compound to undergo oxidation reactions, and acids or bases may cause its hydrolysis or other chemical reactions, which will endanger storage safety.
When transporting, there are also many points. Transportation vehicles must have corresponding safety facilities, such as fire prevention and explosion-proof devices, to deal with unexpected situations that may occur during transportation. Transportation personnel need to be professionally trained and familiar with the characteristics of the compound and emergency treatment methods. During handling, light loading and unloading should be carried out. It is strictly forbidden to drop and heavy pressure to prevent leakage caused by damaged packaging.
In addition, the transportation process must strictly follow relevant regulations and standards. Transportation routes should be planned to avoid densely populated areas and environmentally sensitive areas. In case of leakage, the harm can be minimized. At the same time, the status of the goods should be monitored at any time during transportation to ensure safe transportation.
The first is the storage environment. This compound should be stored in a cool, dry and well-ventilated place. Be sure to keep away from fires and heat sources. Because organic compounds are flammable, they can easily cause combustion or even explosion in case of open flame or high temperature. If the storage environment temperature is too high, the volatility of the compound will be enhanced, and the concentration will accumulate in a limited space, increasing the risk factor; if the humidity is too high, it may cause chemical reactions such as hydrolysis, which will affect the quality and stability.
Secondly, the packaging must be tightly closed. Appropriate packaging materials should be selected to ensure that there is no risk of leakage. Due to its chemical properties, packaging materials that will react with it should be avoided. For example, some metal materials may react with chlorine, fluorine and other elements in the compound, so the choice of packaging materials needs to be carefully considered to ensure safety during storage.
Furthermore, the storage area should be stored separately from oxidants, acids, bases, etc., and mixed storage should not be avoided. 2-Chloro-1-fluoro-3-methylbenzene is in contact with these substances, which is very likely to trigger a violent chemical reaction, resulting in a dangerous situation. Such as oxidizing agents can cause the compound to undergo oxidation reactions, and acids or bases may cause its hydrolysis or other chemical reactions, which will endanger storage safety.
When transporting, there are also many points. Transportation vehicles must have corresponding safety facilities, such as fire prevention and explosion-proof devices, to deal with unexpected situations that may occur during transportation. Transportation personnel need to be professionally trained and familiar with the characteristics of the compound and emergency treatment methods. During handling, light loading and unloading should be carried out. It is strictly forbidden to drop and heavy pressure to prevent leakage caused by damaged packaging.
In addition, the transportation process must strictly follow relevant regulations and standards. Transportation routes should be planned to avoid densely populated areas and environmentally sensitive areas. In case of leakage, the harm can be minimized. At the same time, the status of the goods should be monitored at any time during transportation to ensure safe transportation.
What are the effects of 2-chloro-1-fluoro-3-methylbenzene on the environment and human health?
2-Chloro-1-fluoro-3-methylbenzene is one of the organic compounds. The impact of this substance on the environment and human health is quite important in the academic community, as follows.
At the environmental end, it has a certain volatility. If it escapes in the atmosphere or reacts chemically with various substances in the atmosphere, it generates secondary pollutants, which in turn affects air quality. And its solubility in water is limited. If it flows into the water body, or adheres to suspended particles, it settles to the bottom of the water, causing sediment pollution, affecting the balance of aquatic ecosystems, and endangering the survival of aquatic organisms. In addition, it also has certain residues in the soil, or affects the activity and community structure of soil microorganisms, which is unfavorable to soil fertility and plant growth.
As for human health, 2-chloro-1-fluoro-3-methylbenzene can enter the human body through inhalation, skin contact or accidental ingestion. It may damage the nervous system, causing headaches, dizziness, fatigue, drowsiness, etc. Long-term exposure may even affect the development and normal function of the nervous system. In the respiratory system, or irritate the mucosa of the respiratory tract, causing cough, asthma and other discomfort, severe cases or respiratory inflammation. And because of its certain fat solubility, it is easy to accumulate in human adipose tissue, or interfere with the normal function of the endocrine system, and also have adverse effects on reproductive and immune systems.
Therefore, during the production, use and disposal of 2-chloro-1-fluoro-3-methylbenzene, strict protective measures should be taken to reduce its harm to the environment and human health.
At the environmental end, it has a certain volatility. If it escapes in the atmosphere or reacts chemically with various substances in the atmosphere, it generates secondary pollutants, which in turn affects air quality. And its solubility in water is limited. If it flows into the water body, or adheres to suspended particles, it settles to the bottom of the water, causing sediment pollution, affecting the balance of aquatic ecosystems, and endangering the survival of aquatic organisms. In addition, it also has certain residues in the soil, or affects the activity and community structure of soil microorganisms, which is unfavorable to soil fertility and plant growth.
As for human health, 2-chloro-1-fluoro-3-methylbenzene can enter the human body through inhalation, skin contact or accidental ingestion. It may damage the nervous system, causing headaches, dizziness, fatigue, drowsiness, etc. Long-term exposure may even affect the development and normal function of the nervous system. In the respiratory system, or irritate the mucosa of the respiratory tract, causing cough, asthma and other discomfort, severe cases or respiratory inflammation. And because of its certain fat solubility, it is easy to accumulate in human adipose tissue, or interfere with the normal function of the endocrine system, and also have adverse effects on reproductive and immune systems.
Therefore, during the production, use and disposal of 2-chloro-1-fluoro-3-methylbenzene, strict protective measures should be taken to reduce its harm to the environment and human health.
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