Linshang Chemical
PRODUCTS
2-Chloro-1-Fluoro-4-Isocyanatobenzene
Linshang Chemical
|
HS Code |
550797 |
| Chemical Formula | C7H3ClFNO |
| Molecular Weight | 171.56 |
| Appearance | Typically a colorless to light - colored liquid |
| Boiling Point | Data may vary, but generally in a certain range depending on pressure |
| Melting Point | Specific value depends on purity and measurement conditions |
| Density | A characteristic density value related to its mass - volume ratio |
| Vapor Pressure | Varies with temperature, gives an indication of volatility |
| Solubility | Solubility in common organic solvents like dichloromethane, etc., and limited solubility in water |
| Flash Point | A value indicating the temperature at which it can form a flammable vapor - air mixture |
| Stability | Stable under normal conditions, but may react with certain substances |
As an accredited 2-Chloro-1-Fluoro-4-Isocyanatobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250 - gram bottle of 2 - chloro - 1 - fluoro - 4 - isocyanatobenzene, well - sealed for safety. |
| Storage | 2 - chloro - 1 - fluoro - 4 - isocyanatobenzene should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and moisture. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances like amines, alcohols, and strong acids to prevent chemical reactions. |
| Shipping | 2 - chloro - 1 - fluoro - 4 - isocyanatobenzene is a chemical that may require special shipping. It should be packaged in accordance with regulations for hazardous chemicals, using proper containers to prevent leakage during transport. |
Competitive 2-Chloro-1-Fluoro-4-Isocyanatobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemistry of 2-chloro-1-fluoro-4-isocyanatobenzene?
2-Chloro-1-fluoro-4-isocyanate benzene, an organic compound whose molecules contain chlorine, fluorine, isocyanate and benzene ring. Its chemical properties are unique, due to the interaction of different functional groups it contains.
Let's talk about the benzene ring first, which is aromatic and relatively stable, giving the compound a certain degree of stability. However, this stability is not absolute. Under certain conditions, the benzene ring can also participate in the reaction.
Chlorine atoms in compounds can cause the electron cloud density of the benzene ring to change due to their electronegativity, which can reduce the density of the ortho and para-electron clouds. Under this influence, when the compound undergoes electrophilic substitution reaction, the chlorine atom is an meta-localization group, and the reaction check point tends to the meta-position. At the same time, the chlorine atom itself can undergo a substitution reaction. If it encounters a nucleophilic reagent, the chlorine atom can be replaced, such as reacting with sodium alcohol, the chlorine atom may be replaced by an alkoxy group.
The fluorine atom also has high electronegativity, which has a significant impact on the electron cloud density of the benzene ring. Although it is a halogen atom like the chlorine atom, the fluorine atom has a small radius and a strong electron-withdrawing induction effect, which reduces the electron cloud density of the benzene ring This not only affects the activity and check point of the electrophilic substitution reaction of benzene ring, but also when the fluorine atom itself participates in the reaction, due to the large bond energy of C-F, the reactivity is different from that of the chlorine atom substitution reaction, and the substitution reaction conditions are often more harsh.
And isocyanate (-NCO) is active. The nitrogen atom is partially positively charged and the carbon atom is partially negatively charged, which is easy to react with compounds containing active hydrogen atoms, such as reacting with alcohol to form carbamate and reacting with amine to form urea. This reaction mechanism is based on the nucleophilic addition of active hydrogen by the carbon-nitrogen double bond in isocyanate, followed by proton transfer to complete the reaction.
In summary, the chemical properties of 2-chloro-1-fluoro-4-isocyanate benzene are determined by benzene ring, chlorine atom, fluorine atom and isocyanate, and each functional group affects each other, resulting in diverse chemical behaviors under different reaction conditions.
Let's talk about the benzene ring first, which is aromatic and relatively stable, giving the compound a certain degree of stability. However, this stability is not absolute. Under certain conditions, the benzene ring can also participate in the reaction.
Chlorine atoms in compounds can cause the electron cloud density of the benzene ring to change due to their electronegativity, which can reduce the density of the ortho and para-electron clouds. Under this influence, when the compound undergoes electrophilic substitution reaction, the chlorine atom is an meta-localization group, and the reaction check point tends to the meta-position. At the same time, the chlorine atom itself can undergo a substitution reaction. If it encounters a nucleophilic reagent, the chlorine atom can be replaced, such as reacting with sodium alcohol, the chlorine atom may be replaced by an alkoxy group.
The fluorine atom also has high electronegativity, which has a significant impact on the electron cloud density of the benzene ring. Although it is a halogen atom like the chlorine atom, the fluorine atom has a small radius and a strong electron-withdrawing induction effect, which reduces the electron cloud density of the benzene ring This not only affects the activity and check point of the electrophilic substitution reaction of benzene ring, but also when the fluorine atom itself participates in the reaction, due to the large bond energy of C-F, the reactivity is different from that of the chlorine atom substitution reaction, and the substitution reaction conditions are often more harsh.
And isocyanate (-NCO) is active. The nitrogen atom is partially positively charged and the carbon atom is partially negatively charged, which is easy to react with compounds containing active hydrogen atoms, such as reacting with alcohol to form carbamate and reacting with amine to form urea. This reaction mechanism is based on the nucleophilic addition of active hydrogen by the carbon-nitrogen double bond in isocyanate, followed by proton transfer to complete the reaction.
In summary, the chemical properties of 2-chloro-1-fluoro-4-isocyanate benzene are determined by benzene ring, chlorine atom, fluorine atom and isocyanate, and each functional group affects each other, resulting in diverse chemical behaviors under different reaction conditions.
What are the main uses of 2-chloro-1-fluoro-4-isocyanatobenzene?
2-Chloro-1-fluoro-4-isocyanate benzene has a wide range of uses. In the field of organic synthesis, it is often a key raw material. Because its molecular structure contains special functional groups, it can participate in many chemical reactions and build complex organic compound structures.
First, in the field of pharmaceutical chemistry, it can be introduced into drug molecules through specific reaction paths to give drugs unique properties and activities. For example, by reacting with other compounds containing active groups, new compounds with specific pharmacological activities can be generated, or it can lay the foundation for the development of new drugs to help fight various diseases.
Second, in the field of materials science, it can be used as a monomer for the synthesis of special polymer materials. After polymerization, its structural units are introduced into the polymer chain, so that the resulting material has special properties, such as unique solubility, thermal stability or mechanical properties. These materials may be used in fields such as electronics and aerospace that require strict material properties.
Third, in pesticide chemistry, new pesticides are created by reacting with other organic compounds. Its special structure may endow pesticides with unique insecticidal, bactericidal or herbicidal activities, and can improve the environmental compatibility and biological activity of pesticides, providing more efficient and safe protection means for agricultural production.
In conclusion, 2-chloro-1-fluoro-4-isocyanate benzene plays an indispensable role in many important fields due to its unique structure, providing a key material basis and technical support for the development of many industries.
First, in the field of pharmaceutical chemistry, it can be introduced into drug molecules through specific reaction paths to give drugs unique properties and activities. For example, by reacting with other compounds containing active groups, new compounds with specific pharmacological activities can be generated, or it can lay the foundation for the development of new drugs to help fight various diseases.
Second, in the field of materials science, it can be used as a monomer for the synthesis of special polymer materials. After polymerization, its structural units are introduced into the polymer chain, so that the resulting material has special properties, such as unique solubility, thermal stability or mechanical properties. These materials may be used in fields such as electronics and aerospace that require strict material properties.
Third, in pesticide chemistry, new pesticides are created by reacting with other organic compounds. Its special structure may endow pesticides with unique insecticidal, bactericidal or herbicidal activities, and can improve the environmental compatibility and biological activity of pesticides, providing more efficient and safe protection means for agricultural production.
In conclusion, 2-chloro-1-fluoro-4-isocyanate benzene plays an indispensable role in many important fields due to its unique structure, providing a key material basis and technical support for the development of many industries.
What is 2-chloro-1-fluoro-4-isocyanatobenzene synthesis method?
To prepare 2-chloro-1-fluoro-4-isocyanate benzene, an organic synthesis method can be followed. Usually, it can be started from the corresponding aromatic hydrocarbon.
First, p-chlorofluorobenzene is used as the raw material, because the structure of p-chlorofluorobenzene is similar to the target benzene ring part. P-chlorofluorobenzene acts with phosgene ($COCl_2 $) and a suitable catalyst. Phosgene is often a reagent for introducing isocyanates in organic synthesis. In the
reaction system, the carbonyl group of phosgene ($C = O $) is electrophilic, while the electron cloud density of the benzene ring of p-chlorofluorobenzene is relatively high. Under the promotion of the catalyst, the hydrogen atom at a specific position on the benzene ring is replaced by a phosgene-derived group. Careful selection of catalysts is required, such as some metal salts or organic bases, which can effectively promote the reaction and improve the reaction selectivity, so that the reaction mainly occurs at a specific position with chlorine and fluorine on the benzene ring, so as to guide the introduction of isocyanate at the 4-position.
The reaction process requires strict control of the reaction conditions, and temperature is very critical. If the temperature is too low, the reaction rate is slow and time-consuming; if the temperature is too high, it may trigger side reactions and reduce the purity of the product. Generally speaking, the appropriate temperature range or in a specific range needs to be carefully explored through experiments.
The pH of the reaction environment also affects, and it is often necessary to maintain a certain acid-base condition to ensure that the reaction occurs according to the expected path. After the reaction, the product mixture needs to be separated and purified. Distillation can be used to separate the target product 2-chloro-1-fluoro-4-isocyanate synbenzene by taking advantage of the difference in boiling points of each component. If a small amount of impurities are mixed in the product, recrystallization can be supplemented to further improve the purity of the product. In this way, 2-chloro-1-fluoro-4-isocyanate benzene can be obtained through raw material selection, reaction control, separation and purification.
First, p-chlorofluorobenzene is used as the raw material, because the structure of p-chlorofluorobenzene is similar to the target benzene ring part. P-chlorofluorobenzene acts with phosgene ($COCl_2 $) and a suitable catalyst. Phosgene is often a reagent for introducing isocyanates in organic synthesis. In the
reaction system, the carbonyl group of phosgene ($C = O $) is electrophilic, while the electron cloud density of the benzene ring of p-chlorofluorobenzene is relatively high. Under the promotion of the catalyst, the hydrogen atom at a specific position on the benzene ring is replaced by a phosgene-derived group. Careful selection of catalysts is required, such as some metal salts or organic bases, which can effectively promote the reaction and improve the reaction selectivity, so that the reaction mainly occurs at a specific position with chlorine and fluorine on the benzene ring, so as to guide the introduction of isocyanate at the 4-position.
The reaction process requires strict control of the reaction conditions, and temperature is very critical. If the temperature is too low, the reaction rate is slow and time-consuming; if the temperature is too high, it may trigger side reactions and reduce the purity of the product. Generally speaking, the appropriate temperature range or in a specific range needs to be carefully explored through experiments.
The pH of the reaction environment also affects, and it is often necessary to maintain a certain acid-base condition to ensure that the reaction occurs according to the expected path. After the reaction, the product mixture needs to be separated and purified. Distillation can be used to separate the target product 2-chloro-1-fluoro-4-isocyanate synbenzene by taking advantage of the difference in boiling points of each component. If a small amount of impurities are mixed in the product, recrystallization can be supplemented to further improve the purity of the product. In this way, 2-chloro-1-fluoro-4-isocyanate benzene can be obtained through raw material selection, reaction control, separation and purification.
What are the precautions in storage and transportation of 2-chloro-1-fluoro-4-isocyanatobenzene?
For 2-chloro-1-fluoro-4-isocyanate benzene, there are several points to pay attention to during storage and transportation.
The first is about its chemical properties. This is a reactive compound, isocyanate is very easy to react with water, alcohol, amine and other active hydrogen-containing substances. Therefore, when storing, it is necessary to ensure that the environment is dry and away from water sources. The container used must also be dry and well sealed to prevent moisture intrusion and deterioration. During transportation, also beware of package damage and water vapor infiltration.
The second is related to its toxicity. This substance may be toxic and irritating to a certain extent, and may be potentially harmful to human health. The storage place should be well ventilated to avoid long-term exposure of personnel to its volatile gas environment. When transporting, relevant personnel must be equipped with suitable protective equipment, such as gas masks, protective gloves and protective clothing, to prevent contact or inhalation and injury to the body.
Furthermore, in terms of its stability. Although it is relatively stable at room temperature and pressure, it may cause reactions such as decomposition or polymerization when exposed to heat, light or specific catalysts. Storage should be placed in a cool, dark place, away from heat and fire sources. During transportation, high temperature environments and direct sunlight should also be avoided to maintain suitable temperature and humidity conditions.
In addition, packaging is also key. The packaging materials used must be able to withstand the corrosion of the substance, and have good sealing and compression resistance. When storing, pay attention to whether the package is damaged or leaked. If so, deal with it in time. During transportation, be careful with loading and unloading to avoid packaging damage caused by collisions and drops.
In addition, following regulations and standards is also indispensable. Storage and transportation must comply with relevant national and local regulations on the management of hazardous chemicals, strictly implement operating procedures and safety regulations, and prepare for emergency measures to prevent accidents.
The first is about its chemical properties. This is a reactive compound, isocyanate is very easy to react with water, alcohol, amine and other active hydrogen-containing substances. Therefore, when storing, it is necessary to ensure that the environment is dry and away from water sources. The container used must also be dry and well sealed to prevent moisture intrusion and deterioration. During transportation, also beware of package damage and water vapor infiltration.
The second is related to its toxicity. This substance may be toxic and irritating to a certain extent, and may be potentially harmful to human health. The storage place should be well ventilated to avoid long-term exposure of personnel to its volatile gas environment. When transporting, relevant personnel must be equipped with suitable protective equipment, such as gas masks, protective gloves and protective clothing, to prevent contact or inhalation and injury to the body.
Furthermore, in terms of its stability. Although it is relatively stable at room temperature and pressure, it may cause reactions such as decomposition or polymerization when exposed to heat, light or specific catalysts. Storage should be placed in a cool, dark place, away from heat and fire sources. During transportation, high temperature environments and direct sunlight should also be avoided to maintain suitable temperature and humidity conditions.
In addition, packaging is also key. The packaging materials used must be able to withstand the corrosion of the substance, and have good sealing and compression resistance. When storing, pay attention to whether the package is damaged or leaked. If so, deal with it in time. During transportation, be careful with loading and unloading to avoid packaging damage caused by collisions and drops.
In addition, following regulations and standards is also indispensable. Storage and transportation must comply with relevant national and local regulations on the management of hazardous chemicals, strictly implement operating procedures and safety regulations, and prepare for emergency measures to prevent accidents.
2-chloro-1-fluoro-4-isocyanatobenzene impact on the environment and human health
2-Chloro-1-fluoro-4-isocyanate benzene has a particularly important impact on the environment and human health. This chemical substance has special chemical properties and can cause disturbance to both the environment and the human body.
In the environment, 2-chloro-1-fluoro-4-isocyanate benzene can be released in the outside world, or can be dispersed through multiple channels. It can be transported in the atmosphere with air flow, causing a wider range of pollution; if it enters the water body, it can cause deterioration of water quality and endanger aquatic life. Aquatic fish, shellfish, etc., may be impaired due to their physiological functions, and their growth and reproduction are hindered by them, or even cause a sharp decrease in the population. And it may accumulate in the soil, affecting the activity of soil microorganisms, causing soil ecological imbalance, and then hindering the growth and development of plants.
As for human health, 2-chloro-1-fluoro-4-isocyanate synbenzene is quite harmful. If inhaled by breathing or exposed to the skin, it can cause damage to the body. It may irritate the respiratory tract, causing coughing, asthma, and even causing more serious respiratory diseases; it also irritates and sensitizes the skin, causing skin redness, swelling, itching, and even ulceration. Long-term exposure to this substance may damage the human body's immune system, nervous system, etc., resulting in weakened immunity, headache, dizziness, fatigue, etc. What's more, it may be carcinogenic and seriously threaten human life and health.
Therefore, 2-chloro-1-fluoro-4-isocyanate benzene, when handled with caution, should be strictly controlled in production, use and other links to prevent its escape, in order to ensure the environment and human health.
In the environment, 2-chloro-1-fluoro-4-isocyanate benzene can be released in the outside world, or can be dispersed through multiple channels. It can be transported in the atmosphere with air flow, causing a wider range of pollution; if it enters the water body, it can cause deterioration of water quality and endanger aquatic life. Aquatic fish, shellfish, etc., may be impaired due to their physiological functions, and their growth and reproduction are hindered by them, or even cause a sharp decrease in the population. And it may accumulate in the soil, affecting the activity of soil microorganisms, causing soil ecological imbalance, and then hindering the growth and development of plants.
As for human health, 2-chloro-1-fluoro-4-isocyanate synbenzene is quite harmful. If inhaled by breathing or exposed to the skin, it can cause damage to the body. It may irritate the respiratory tract, causing coughing, asthma, and even causing more serious respiratory diseases; it also irritates and sensitizes the skin, causing skin redness, swelling, itching, and even ulceration. Long-term exposure to this substance may damage the human body's immune system, nervous system, etc., resulting in weakened immunity, headache, dizziness, fatigue, etc. What's more, it may be carcinogenic and seriously threaten human life and health.
Therefore, 2-chloro-1-fluoro-4-isocyanate benzene, when handled with caution, should be strictly controlled in production, use and other links to prevent its escape, in order to ensure the environment and human health.
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