Linshang Chemical
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2-Chloro-1-Fluoro-4-Isothiocyanato-Benzene
Linshang Chemical
|
HS Code |
951324 |
| Chemical Formula | C7H3ClFNS |
| Molecular Weight | 187.62 |
| Appearance | Typically a liquid (but appearance can vary based on purity and conditions) |
| Boiling Point | Data may vary, but generally in the range relevant to aromatic organic compounds with such substituents |
| Melting Point | Data may vary based on purity and crystal form |
| Solubility | Soluble in common organic solvents like dichloromethane, chloroform, etc., less soluble in water |
| Density | Specific density data would depend on temperature, but typical for aromatic halide - containing compounds |
| Vapor Pressure | Relatively low vapor pressure at standard conditions due to its molecular structure |
| Stability | Stable under normal conditions, but can react with nucleophiles due to the isothiocyanate group |
| Reactivity | Reactive towards amines, alcohols, and other nucleophilic species |
As an accredited 2-Chloro-1-Fluoro-4-Isothiocyanato-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 2 - chloro - 1 - fluoro - 4 - isothiocyanato - benzene in sealed chemical - grade container. |
| Storage | 2 - Chloro - 1 - fluoro - 4 - isothiocyanato - benzene should be stored in a cool, dry, well - ventilated area away from heat and ignition sources. Keep it in a tightly sealed container to prevent leakage and exposure to air or moisture, which could lead to decomposition. Store it separately from incompatible substances like oxidizing agents, bases, and amines to avoid potential reactions. |
| Shipping | 2 - chloro - 1 - fluoro - 4 - isothiocyanato - benzene is a chemical. Shipping should be in well - sealed, appropriate containers, following strict hazardous materials regulations. Ensure proper labeling for safe transportation. |
Competitive 2-Chloro-1-Fluoro-4-Isothiocyanato-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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What is the chemistry of 2-chloro-1-fluoro-4-isothiocyanato-benzene?
The chemical properties of 2-chloro-1-fluoro-4-isothiocyanate benzene are particularly important and should be discussed in detail.
In this compound, the presence of chlorine atoms, fluorine atoms and isothiocyanate endows it with unique reactivity. Chlorine atoms have certain nucleophilic substitution activities, and can undergo substitution reactions with many nucleophilic reagents under appropriate reaction conditions. Fluorine atoms have strong electronegativity, which can affect the electron cloud distribution of molecules, causing their chemical activity to change, and affect the physical properties of molecules such as boiling point and solubility.
And isothiocyanate is a reactive functional group, which can react with a variety of compounds containing active hydrogen, such as alcohols and amines, to form new chemical bonds and construct complex compound structures.
In the field of organic synthesis, 2-chloro-1-fluoro-4-isothiocyanate synbenzene is often an important synthetic intermediate. Due to the characteristics of multifunctional groups, chemists can ingeniously design reaction pathways according to specific synthesis targets, and use the reactivity of each functional group to gradually construct the desired organic molecular structure.
However, its reactivity also needs to be finely regulated, covering the interaction between functional groups. Small changes in reaction conditions can cause changes in reaction selectivity and product distribution. Therefore, when using this compound for chemical synthesis, chemists need to accurately grasp the reaction conditions, such as temperature, solvent, reactant ratio and other factors, in order to achieve the desired reaction effect and obtain the ideal product.
In short, 2-chloro-1-fluoro-4-isothiocyanate benzene has unique chemical properties and is a valuable research object and synthesis tool in the field of organic synthesis chemistry.
In this compound, the presence of chlorine atoms, fluorine atoms and isothiocyanate endows it with unique reactivity. Chlorine atoms have certain nucleophilic substitution activities, and can undergo substitution reactions with many nucleophilic reagents under appropriate reaction conditions. Fluorine atoms have strong electronegativity, which can affect the electron cloud distribution of molecules, causing their chemical activity to change, and affect the physical properties of molecules such as boiling point and solubility.
And isothiocyanate is a reactive functional group, which can react with a variety of compounds containing active hydrogen, such as alcohols and amines, to form new chemical bonds and construct complex compound structures.
In the field of organic synthesis, 2-chloro-1-fluoro-4-isothiocyanate synbenzene is often an important synthetic intermediate. Due to the characteristics of multifunctional groups, chemists can ingeniously design reaction pathways according to specific synthesis targets, and use the reactivity of each functional group to gradually construct the desired organic molecular structure.
However, its reactivity also needs to be finely regulated, covering the interaction between functional groups. Small changes in reaction conditions can cause changes in reaction selectivity and product distribution. Therefore, when using this compound for chemical synthesis, chemists need to accurately grasp the reaction conditions, such as temperature, solvent, reactant ratio and other factors, in order to achieve the desired reaction effect and obtain the ideal product.
In short, 2-chloro-1-fluoro-4-isothiocyanate benzene has unique chemical properties and is a valuable research object and synthesis tool in the field of organic synthesis chemistry.
What are the physical properties of 2-chloro-1-fluoro-4-isothiocyanato-benzene?
2-Chloro-1-fluoro-4-isothiocyanate benzene, the physical properties of this substance are quite critical, and it depends on it for various applications in the chemical industry.
Its appearance is often colorless to light yellow liquid, and it looks clear, slightly shiny, like the quality of glaze, quiet and transparent. Its smell is unique, and it exudes a pungent smell that seems to be nothing. However, it is not as pungent as ordinary strong acids and alkalis, but it should not be ignored. When you smell it, you can feel a strange smell in the air, as if it is a warning that this thing is extraordinary.
When talking about the boiling point, it is about a specific temperature range. When the external pressure reaches the standard atmospheric pressure, the number of its boiling point can make the molecule break free from the liquid phase and rise into the gas phase. The value of this boiling point is not random, but is caused by the interaction of various factors such as the forces between molecules and the characteristics of chemical bonds. Just like a tug-of-war in the microscopic world, the boiling point is where the balance of forces is located.
The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. The melting point of 2-chloro-1-fluoro-4-isothiocyanate benzene makes it a stable solid state at a specific low temperature, like a sleeping crystal, with a regular and orderly structure. When the temperature gradually rises and reaches the melting point, the energy of the lattice is not enough to maintain the shape of the solid state, so it gradually melts into a liquid state.
Its density is also an important property, slightly heavier than water, placed in water, such as a stone sinking abyss, slowly sinking, this is because the molecules are closely arranged and the mass is relatively concentrated. It has good solubility in organic solvents, such as ethanol, ether and other common organic solvents, which can be fused with it, just like water and emulsion, regardless of each other. Due to the polarity of the molecule and the polarity of the solvent, it follows the principle of similar dissolution.
And because its molecular structure contains chlorine, fluorine, isothiocyanate and other groups, it has a certain chemical activity, which also affects the physical properties, such as the change of intermolecular forces, which in turn affects the melting point, boiling point, etc. All kinds of physical properties are interrelated, forming a unique system of physical properties of this substance, which is an element that cannot be ignored in the fields of chemical synthesis and material preparation.
Its appearance is often colorless to light yellow liquid, and it looks clear, slightly shiny, like the quality of glaze, quiet and transparent. Its smell is unique, and it exudes a pungent smell that seems to be nothing. However, it is not as pungent as ordinary strong acids and alkalis, but it should not be ignored. When you smell it, you can feel a strange smell in the air, as if it is a warning that this thing is extraordinary.
When talking about the boiling point, it is about a specific temperature range. When the external pressure reaches the standard atmospheric pressure, the number of its boiling point can make the molecule break free from the liquid phase and rise into the gas phase. The value of this boiling point is not random, but is caused by the interaction of various factors such as the forces between molecules and the characteristics of chemical bonds. Just like a tug-of-war in the microscopic world, the boiling point is where the balance of forces is located.
The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. The melting point of 2-chloro-1-fluoro-4-isothiocyanate benzene makes it a stable solid state at a specific low temperature, like a sleeping crystal, with a regular and orderly structure. When the temperature gradually rises and reaches the melting point, the energy of the lattice is not enough to maintain the shape of the solid state, so it gradually melts into a liquid state.
Its density is also an important property, slightly heavier than water, placed in water, such as a stone sinking abyss, slowly sinking, this is because the molecules are closely arranged and the mass is relatively concentrated. It has good solubility in organic solvents, such as ethanol, ether and other common organic solvents, which can be fused with it, just like water and emulsion, regardless of each other. Due to the polarity of the molecule and the polarity of the solvent, it follows the principle of similar dissolution.
And because its molecular structure contains chlorine, fluorine, isothiocyanate and other groups, it has a certain chemical activity, which also affects the physical properties, such as the change of intermolecular forces, which in turn affects the melting point, boiling point, etc. All kinds of physical properties are interrelated, forming a unique system of physical properties of this substance, which is an element that cannot be ignored in the fields of chemical synthesis and material preparation.
What are the main uses of 2-chloro-1-fluoro-4-isothiocyanato-benzene?
2-Chloro-1-fluoro-4-isothiocyanate benzene has a wide range of uses. In the chemical industry, it is often used as an intermediate in organic synthesis. The delicate nature of organic synthesis, just like a craftsman's carving utensil, this compound can add to the construction of many complex organic molecules.
In pharmaceutical chemistry, it also has important applications. The development of many drugs relies on such compounds as starting materials or key intermediates. Due to the unique chemical properties of isothiocyanate, it can interact with a variety of targets in organisms, thus providing the possibility for the endowment and optimization of drug activity. The development of medicine is related to the well-being of all people, and the value of this compound in this field cannot be underestimated.
In the field of materials science, it may participate in the creation of new materials. The quality of materials is related to the pace of scientific and technological progress. With the characteristics of chlorine, fluorine and other elements, the properties of materials, such as stability and solubility, can be regulated, helping to develop novel materials with special properties to meet the special needs of different industries.
It can also be seen in the field of dye chemistry. Its structure can be modified and adjusted to provide new ways and possibilities for the synthesis of dyes. The color of dyes adds color to life. This compound may contribute to the improvement of the color and fastness of dyes, so that dyes can play a better role in textile, printing and dyeing industries.
All of these demonstrate the important uses of 2-chloro-1-fluoro-4-isothiocyanate benzene in many fields, and it is an indispensable and important substance in the field of chemistry.
In pharmaceutical chemistry, it also has important applications. The development of many drugs relies on such compounds as starting materials or key intermediates. Due to the unique chemical properties of isothiocyanate, it can interact with a variety of targets in organisms, thus providing the possibility for the endowment and optimization of drug activity. The development of medicine is related to the well-being of all people, and the value of this compound in this field cannot be underestimated.
In the field of materials science, it may participate in the creation of new materials. The quality of materials is related to the pace of scientific and technological progress. With the characteristics of chlorine, fluorine and other elements, the properties of materials, such as stability and solubility, can be regulated, helping to develop novel materials with special properties to meet the special needs of different industries.
It can also be seen in the field of dye chemistry. Its structure can be modified and adjusted to provide new ways and possibilities for the synthesis of dyes. The color of dyes adds color to life. This compound may contribute to the improvement of the color and fastness of dyes, so that dyes can play a better role in textile, printing and dyeing industries.
All of these demonstrate the important uses of 2-chloro-1-fluoro-4-isothiocyanate benzene in many fields, and it is an indispensable and important substance in the field of chemistry.
What are 2-chloro-1-fluoro-4-isothiocyanato-benzene synthesis methods?
To prepare 2-chloro-1-fluoro-4-isothiocyanate benzene, the conventional method is used. First, 2-chloro-1-fluoro-4-aminobenzene is used as the starting material and reacts with sulfur phosgene ($CSCl_2 $). This reaction requires an appropriate solvent, such as dichloromethane, in a low temperature environment, and the presence of an acid binding agent (such as triethylamine). During the reaction, the amino group of 2-chloro-1-fluoro-4-aminobenzene is substituted with the chlorine atom of the sulfur phosgene to release hydrogen chloride, and the acid binding agent is combined with it, which prompts the reaction to proceed to the right and finally obtains the target product.
Second, 2-chloro-1-fluoro-4-nitrobenzene can be used as the starting material first, and the nitro group can be converted into an amino group by reduction means, such as iron/hydrochloric acid system or catalytic hydrogenation method, to obtain 2-chloro-1-fluoro-4-aminobenzene. As mentioned above, it is prepared by reacting with sulphosgene. When catalyzing hydrogenation, palladium carbon is often used as a catalyst. Under appropriate pressure and temperature, hydrogen reacts with nitro groups to achieve reduction. In the iron/hydrochloric acid system, iron reacts with hydrochloric acid to produce new hydrogen, which gradually reduces nitro groups to amino groups.
Another way is to react with thiocyanates (such as potassium thiocyanate $KSCN $) as 2-chloro-1-fluoro-4-halobenzene (the halogen atom can be bromine or iodine) to produce 2-chloro-1-fluoro-4-thiocyanate synbenzene. Subsequently, thiocyanate is oxidized with a suitable oxidant, such as hydrogen peroxide or m-chloroperoxybenzoic acid, to convert it to isothiocyanate, resulting in 2-chloro-1-fluoro-4-isothiocyanate synbenzene. In this process, the oxidation step needs to control the reaction conditions to prevent excessive oxidation and damage to the product.
All methods have their own advantages and disadvantages. In practice, when considering the availability of raw materials, cost, product purity and other factors, choose.
Second, 2-chloro-1-fluoro-4-nitrobenzene can be used as the starting material first, and the nitro group can be converted into an amino group by reduction means, such as iron/hydrochloric acid system or catalytic hydrogenation method, to obtain 2-chloro-1-fluoro-4-aminobenzene. As mentioned above, it is prepared by reacting with sulphosgene. When catalyzing hydrogenation, palladium carbon is often used as a catalyst. Under appropriate pressure and temperature, hydrogen reacts with nitro groups to achieve reduction. In the iron/hydrochloric acid system, iron reacts with hydrochloric acid to produce new hydrogen, which gradually reduces nitro groups to amino groups.
Another way is to react with thiocyanates (such as potassium thiocyanate $KSCN $) as 2-chloro-1-fluoro-4-halobenzene (the halogen atom can be bromine or iodine) to produce 2-chloro-1-fluoro-4-thiocyanate synbenzene. Subsequently, thiocyanate is oxidized with a suitable oxidant, such as hydrogen peroxide or m-chloroperoxybenzoic acid, to convert it to isothiocyanate, resulting in 2-chloro-1-fluoro-4-isothiocyanate synbenzene. In this process, the oxidation step needs to control the reaction conditions to prevent excessive oxidation and damage to the product.
All methods have their own advantages and disadvantages. In practice, when considering the availability of raw materials, cost, product purity and other factors, choose.
What are the precautions in storage and transportation of 2-chloro-1-fluoro-4-isothiocyanato-benzene?
For 2-chloro-1-fluoro-4-isothiocyanate benzene, many matters need to be paid attention to during storage and transportation.
This is a chemical substance with specific chemical properties. When storing, the first environment is dry. Due to moisture or chemical reactions, its quality is damaged, or even dangerous. In the warehouse, the humidity should be controlled within a specific range, and moisture-proof measures are essential.
Temperature is also the key. The substance is quite sensitive to temperature, and overheating or overcooling can cause its properties to change. Therefore, it should be stored in a cool place, protected from direct sunlight, and temperature control equipment should be installed to keep the temperature constant.
Furthermore, the storage must be well ventilated. Because it may evaporate harmful gases, good ventilation can reduce the concentration of harmful substances in the air and ensure the safety of the storage environment.
When transporting, the packaging must be solid. Contain it in a special container to prevent it from leaking. The container must be able to resist collision and extrusion, and be tightly sealed.
Transportation tools are also exquisite. Those with corresponding qualifications should be selected, and their internal environment should meet the transportation requirements of the substance, and there should be emergency treatment equipment. During transportation, avoid severe bumps and vibrations to prevent package damage.
At the same time, transportation personnel need to undergo professional training, familiar with the characteristics of the substance and emergency response methods. In the event of an accident such as a leak, effective measures can be taken quickly to minimize the harm.
In addition, transportation and storage must comply with relevant regulations and standards, and records and labels must be made for inspection to ensure the safety and order of the entire process.
This is a chemical substance with specific chemical properties. When storing, the first environment is dry. Due to moisture or chemical reactions, its quality is damaged, or even dangerous. In the warehouse, the humidity should be controlled within a specific range, and moisture-proof measures are essential.
Temperature is also the key. The substance is quite sensitive to temperature, and overheating or overcooling can cause its properties to change. Therefore, it should be stored in a cool place, protected from direct sunlight, and temperature control equipment should be installed to keep the temperature constant.
Furthermore, the storage must be well ventilated. Because it may evaporate harmful gases, good ventilation can reduce the concentration of harmful substances in the air and ensure the safety of the storage environment.
When transporting, the packaging must be solid. Contain it in a special container to prevent it from leaking. The container must be able to resist collision and extrusion, and be tightly sealed.
Transportation tools are also exquisite. Those with corresponding qualifications should be selected, and their internal environment should meet the transportation requirements of the substance, and there should be emergency treatment equipment. During transportation, avoid severe bumps and vibrations to prevent package damage.
At the same time, transportation personnel need to undergo professional training, familiar with the characteristics of the substance and emergency response methods. In the event of an accident such as a leak, effective measures can be taken quickly to minimize the harm.
In addition, transportation and storage must comply with relevant regulations and standards, and records and labels must be made for inspection to ensure the safety and order of the entire process.
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