Linshang Chemical
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2-Chloro-1-Fluoro-4-Methoxybenzene
Linshang Chemical
|
HS Code |
844980 |
| Chemical Formula | C7H6ClFO |
| Molar Mass | 160.57 g/mol |
| Appearance | Colorless to light yellow liquid (estimated) |
| Solubility In Water | Insoluble (estimated, aromatic ethers with halogen substituents are generally hydrophobic) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, diethyl ether, etc. (estimated, based on similar aromatic compounds) |
As an accredited 2-Chloro-1-Fluoro-4-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 1 - fluoro - 4 - methoxybenzene packaged in a sealed, labeled bottle. |
| Storage | 2 - chloro - 1 - fluoro - 4 - methoxybenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames to prevent ignition. Keep it in a tightly sealed container to avoid leakage and exposure to air and moisture, which could potentially cause decomposition or reaction. Store it separately from oxidizing agents and incompatible substances to ensure safety. |
| Shipping | 2 - chloro - 1 - fluoro - 4 - methoxybenzene is shipped in sealed, corrosion - resistant containers. Compliance with hazardous chemical shipping regulations is ensured, with proper labeling indicating its nature for safe transportation. |
Competitive 2-Chloro-1-Fluoro-4-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What are the chemical properties of 2-chloro-1-fluoro-4-methoxybenzene?
2-Chloro-1-fluoro-4-methoxybenzene, an organic compound with unique chemical properties, is worth studying.
As far as nucleophilic substitution is concerned, the activity of the chlorine atom on the benzene ring changes due to the influence of fluorine and methoxy group. Methoxy groups have electron-giving conjugation effect, which can increase the electron cloud density of the benzene ring. Although fluorine atoms have electron-withdrawing induction effect, their conjugation effect is relatively weak. As a result, the electron cloud density of the chlorine atom is relatively high, and it is more vulnerable to attack by nucleophiles. When encountering strong nucleophilic reagents, such as hydroxide ions, amines, etc., chlorine atoms may be substituted to form corresponding hydroxyl compounds or amine compounds.
In the electrophilic substitution reaction, the electron-giving effect of the methoxy group increases the density of the electron cloud of the benzene ring, and it is more susceptible to the attack of the electrophilic reagent. Electrophilic reagents often attack the neighboring and para-position of the methoxy group, because the electron cloud density at this position is relatively high. For example, in the halogenation reaction catalyzed by iron halide, the electrophilic reagent may be preferentially substituted over the methoxy o-o and para-position to generate the corresponding polysubstituted halobenz
The fluorine atom of 2-chloro-1-fluoro-4-methoxybenzene has a significant electron-withdrawing induction effect due to its high electronegativity. This effect can affect the electron cloud distribution of the benzene ring, and then affect the electron cloud density and reactivity of the atoms connected to it. Although it is relatively difficult for fluorine atoms to participate in nucleophilic substitution reactions, they may also be replaced under specific conditions, such as high temperature, strong alkalinity and the presence of special catalysts.
In addition, the oxygen atom in the methoxy group of the compound contains lone pairs of electrons, which can form coordination bonds with metal ions. This property may be applied to some metal-organic reactions or catalytic systems. In the field of organic synthesis, 2-chloro-1-fluoro-4-methoxybenzene is an important intermediate. Through the above reactions, more complex organic compounds can be constructed, which have important application value in many fields such as medicinal chemistry and materials science.
As far as nucleophilic substitution is concerned, the activity of the chlorine atom on the benzene ring changes due to the influence of fluorine and methoxy group. Methoxy groups have electron-giving conjugation effect, which can increase the electron cloud density of the benzene ring. Although fluorine atoms have electron-withdrawing induction effect, their conjugation effect is relatively weak. As a result, the electron cloud density of the chlorine atom is relatively high, and it is more vulnerable to attack by nucleophiles. When encountering strong nucleophilic reagents, such as hydroxide ions, amines, etc., chlorine atoms may be substituted to form corresponding hydroxyl compounds or amine compounds.
In the electrophilic substitution reaction, the electron-giving effect of the methoxy group increases the density of the electron cloud of the benzene ring, and it is more susceptible to the attack of the electrophilic reagent. Electrophilic reagents often attack the neighboring and para-position of the methoxy group, because the electron cloud density at this position is relatively high. For example, in the halogenation reaction catalyzed by iron halide, the electrophilic reagent may be preferentially substituted over the methoxy o-o and para-position to generate the corresponding polysubstituted halobenz
The fluorine atom of 2-chloro-1-fluoro-4-methoxybenzene has a significant electron-withdrawing induction effect due to its high electronegativity. This effect can affect the electron cloud distribution of the benzene ring, and then affect the electron cloud density and reactivity of the atoms connected to it. Although it is relatively difficult for fluorine atoms to participate in nucleophilic substitution reactions, they may also be replaced under specific conditions, such as high temperature, strong alkalinity and the presence of special catalysts.
In addition, the oxygen atom in the methoxy group of the compound contains lone pairs of electrons, which can form coordination bonds with metal ions. This property may be applied to some metal-organic reactions or catalytic systems. In the field of organic synthesis, 2-chloro-1-fluoro-4-methoxybenzene is an important intermediate. Through the above reactions, more complex organic compounds can be constructed, which have important application value in many fields such as medicinal chemistry and materials science.
What are the common uses of 2-chloro-1-fluoro-4-methoxybenzene?
2-Chloro-1-fluoro-4-methoxybenzene is also an organic compound. The common method for its preparation involves many paths.
First, the halogenation reaction is the beginning. You can first take p-methoxybenzene as the group to make it under specific halogenation conditions. In case of chlorine and fluorine-containing reagents, in a suitable catalyst and reaction environment, chlorine and fluorine atoms gradually replace the hydrogen atoms on the benzene ring to obtain this target. In this process, the choice of catalyst is very critical, such as iron halide, which can promote the smooth progress of the reaction and increase its yield.
Second, the method of nucleophilic substitution can also be obtained. First prepare benzene derivatives containing suitable leaving groups, such as p-methoxy halobenzene, and then use fluorine and chlorine-containing nucleophiles, in the presence of appropriate solvents and bases, nucleophiles attack the benzene ring and replace the leaving groups, thereby synthesizing 2-chloro-1-fluoro-4-methoxylbenzene. In this method, the polarity of the solvent, the strength and dosage of the base have a significant impact on the rate of reaction and the purity of the product.
Furthermore, there is also a method of conversion by diazonium salts. First, p-methoxyaniline is reacted by diazotization to obtain diazonium salts, and then it is reacted with chlorine and fluorine-containing reagents. After a series of conversions, the final target compound is obtained. This process requires careful control of the reaction temperature and the drip acceleration of the reagent to prevent the occurrence of side reactions and ensure the quality of the product.
When synthesizing this compound, many factors must be carefully controlled. If the reaction temperature is too high, it is easy to increase side reactions and damage the purity of the product; if the temperature is too low, the reaction rate will be slow and take a long time. The proportion of reagents is also critical. Improper proportions may cause residual raw materials or increase the amount of by-products. In addition, the material of the reaction vessel and the stirring rate will also affect the reaction process and results. Therefore, the preparation of 2-chloro-1-fluoro-4-methoxybenzene requires careful consideration of all reaction elements and careful operation to obtain ideal results.
First, the halogenation reaction is the beginning. You can first take p-methoxybenzene as the group to make it under specific halogenation conditions. In case of chlorine and fluorine-containing reagents, in a suitable catalyst and reaction environment, chlorine and fluorine atoms gradually replace the hydrogen atoms on the benzene ring to obtain this target. In this process, the choice of catalyst is very critical, such as iron halide, which can promote the smooth progress of the reaction and increase its yield.
Second, the method of nucleophilic substitution can also be obtained. First prepare benzene derivatives containing suitable leaving groups, such as p-methoxy halobenzene, and then use fluorine and chlorine-containing nucleophiles, in the presence of appropriate solvents and bases, nucleophiles attack the benzene ring and replace the leaving groups, thereby synthesizing 2-chloro-1-fluoro-4-methoxylbenzene. In this method, the polarity of the solvent, the strength and dosage of the base have a significant impact on the rate of reaction and the purity of the product.
Furthermore, there is also a method of conversion by diazonium salts. First, p-methoxyaniline is reacted by diazotization to obtain diazonium salts, and then it is reacted with chlorine and fluorine-containing reagents. After a series of conversions, the final target compound is obtained. This process requires careful control of the reaction temperature and the drip acceleration of the reagent to prevent the occurrence of side reactions and ensure the quality of the product.
When synthesizing this compound, many factors must be carefully controlled. If the reaction temperature is too high, it is easy to increase side reactions and damage the purity of the product; if the temperature is too low, the reaction rate will be slow and take a long time. The proportion of reagents is also critical. Improper proportions may cause residual raw materials or increase the amount of by-products. In addition, the material of the reaction vessel and the stirring rate will also affect the reaction process and results. Therefore, the preparation of 2-chloro-1-fluoro-4-methoxybenzene requires careful consideration of all reaction elements and careful operation to obtain ideal results.
What are 2-chloro-1-fluoro-4-methoxybenzene synthesis methods?
The synthesis of 2-chloro-1-fluoro-4-methoxybenzene has attracted much attention in the field of organic synthesis. The following are common synthetic routes.
First, p-methoxyphenol is used as the starting material. First, p-methoxyphenol is combined with a halogenating reagent. If it reacts with a chlorinating reagent under suitable reaction conditions, chlorine atoms can be introduced into the benzene ring to obtain a chlorine-containing intermediate. Subsequently, this intermediate is then nucleophilic substitution with a fluorinating reagent to introduce fluorine atoms, resulting in the final product 2-chloro-1-fluoro-4-methoxybenzene. In this route, the halogenation reaction conditions are very critical, and factors such as temperature and reagent ratio will affect the selectivity and yield of the reaction. When chlorinating, appropriate chlorination reagents, such as phosphorus oxychloride, need to be selected, and the reaction temperature needs to be precisely controlled to prevent side reactions from occurring. The fluorination step also requires the selection of high-efficiency fluorination reagents, such as potassium fluoride, etc., and the selection of suitable solvents to promote the smooth progress of the reaction.
Second, you can start from p-methoxyaniline. First, p-methoxyaniline is diazotized, and sodium nitrite and an appropriate amount of acid are used as reagents to generate diazonium salts. Then, the diazonium salt interacts with copper salts such as cuprous chloride, and a Sandmeier reaction occurs, introducing chlorine atoms. After that, the fluorination step is followed by the introduction of fluorine atoms at another position. In this method, the diazotization reaction needs to be carefully handled at low temperature to prevent the decomposition of diazonium salts. The success of the Sandmaier reaction is closely related to the activity of the copper salt and the pH of the reaction system. Subsequent fluorination steps also require fine regulation of the reaction conditions to achieve the desired yield and purity.
Third, 4-methoxy anisole is used as the raw material. First, chlorine atoms are introduced at specific positions in the benzene ring through a halogenation reaction to form chlorine-containing derivatives. Then, the methoxy group is partially converted by appropriate methods, and then fluorine atoms are introduced. In this process, the localization selectivity of the halogenation reaction is very important, and it needs to be achieved with the help of suitable catalysts and reaction conditions. The subsequent methoxy conversion and fluorine atom introduction steps also need to be carefully designed according to the principles of organic chemistry to ensure the efficient synthesis of the target product.
All these synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to consider the availability of raw materials, cost, difficulty in controlling reaction conditions, and many other factors to weigh and choose the optimal synthesis strategy to achieve the effective synthesis of 2-chloro-1-fluoro-4-methoxylbenzene.
First, p-methoxyphenol is used as the starting material. First, p-methoxyphenol is combined with a halogenating reagent. If it reacts with a chlorinating reagent under suitable reaction conditions, chlorine atoms can be introduced into the benzene ring to obtain a chlorine-containing intermediate. Subsequently, this intermediate is then nucleophilic substitution with a fluorinating reagent to introduce fluorine atoms, resulting in the final product 2-chloro-1-fluoro-4-methoxybenzene. In this route, the halogenation reaction conditions are very critical, and factors such as temperature and reagent ratio will affect the selectivity and yield of the reaction. When chlorinating, appropriate chlorination reagents, such as phosphorus oxychloride, need to be selected, and the reaction temperature needs to be precisely controlled to prevent side reactions from occurring. The fluorination step also requires the selection of high-efficiency fluorination reagents, such as potassium fluoride, etc., and the selection of suitable solvents to promote the smooth progress of the reaction.
Second, you can start from p-methoxyaniline. First, p-methoxyaniline is diazotized, and sodium nitrite and an appropriate amount of acid are used as reagents to generate diazonium salts. Then, the diazonium salt interacts with copper salts such as cuprous chloride, and a Sandmeier reaction occurs, introducing chlorine atoms. After that, the fluorination step is followed by the introduction of fluorine atoms at another position. In this method, the diazotization reaction needs to be carefully handled at low temperature to prevent the decomposition of diazonium salts. The success of the Sandmaier reaction is closely related to the activity of the copper salt and the pH of the reaction system. Subsequent fluorination steps also require fine regulation of the reaction conditions to achieve the desired yield and purity.
Third, 4-methoxy anisole is used as the raw material. First, chlorine atoms are introduced at specific positions in the benzene ring through a halogenation reaction to form chlorine-containing derivatives. Then, the methoxy group is partially converted by appropriate methods, and then fluorine atoms are introduced. In this process, the localization selectivity of the halogenation reaction is very important, and it needs to be achieved with the help of suitable catalysts and reaction conditions. The subsequent methoxy conversion and fluorine atom introduction steps also need to be carefully designed according to the principles of organic chemistry to ensure the efficient synthesis of the target product.
All these synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to consider the availability of raw materials, cost, difficulty in controlling reaction conditions, and many other factors to weigh and choose the optimal synthesis strategy to achieve the effective synthesis of 2-chloro-1-fluoro-4-methoxylbenzene.
2-chloro-1-fluoro-4-methoxybenzene What are the precautions in storage and transportation?
2-Chloro-1-fluoro-4-methoxybenzene is an organic compound. When storing and transporting, there are a number of things that need to be paid attention to.
Let's talk about storage first. This compound must be stored in a cool, dry and well-ventilated place. Because it is easy to change its chemical properties when heated, or even cause danger, it is extremely important to keep away from heat sources and open flames. Like a summer warehouse, if the temperature is too high, this compound may react. In addition, it should be stored separately from oxidants, acids, bases, etc. Because of its chemical activity, it can mix with these substances, or trigger violent chemical reactions. For example, coexistence with strong oxidants, or risk of combustion or explosion. The storage place should also be equipped with suitable materials for containing leaks in case of leakage, which can be handled in time to avoid greater harm.
As for transportation, it is necessary to ensure that the packaging is complete and sealed before transportation. Packaging materials must be able to withstand certain external forces and environmental changes to prevent damage during transportation. During transportation, keep away from fire and heat sources, keep the means of transportation clean, and do not leave other substances that may react with them. Transport personnel also need to be professionally trained to be familiar with their dangerous characteristics and emergency treatment methods. In case of leakage, corresponding measures should be taken quickly to evacuate the crowd, isolate the contaminated area, and collect and dispose of the leakage in the correct way. Do not act blindly, so as not to endanger personal safety and the environment.
In conclusion, the storage and transportation of 2-chloro-1-fluoro-4-methoxybenzene, from environmental control to packaging requirements, from material isolation to personnel professionalism, cannot be ignored, so as to ensure process safety and avoid accidents.
Let's talk about storage first. This compound must be stored in a cool, dry and well-ventilated place. Because it is easy to change its chemical properties when heated, or even cause danger, it is extremely important to keep away from heat sources and open flames. Like a summer warehouse, if the temperature is too high, this compound may react. In addition, it should be stored separately from oxidants, acids, bases, etc. Because of its chemical activity, it can mix with these substances, or trigger violent chemical reactions. For example, coexistence with strong oxidants, or risk of combustion or explosion. The storage place should also be equipped with suitable materials for containing leaks in case of leakage, which can be handled in time to avoid greater harm.
As for transportation, it is necessary to ensure that the packaging is complete and sealed before transportation. Packaging materials must be able to withstand certain external forces and environmental changes to prevent damage during transportation. During transportation, keep away from fire and heat sources, keep the means of transportation clean, and do not leave other substances that may react with them. Transport personnel also need to be professionally trained to be familiar with their dangerous characteristics and emergency treatment methods. In case of leakage, corresponding measures should be taken quickly to evacuate the crowd, isolate the contaminated area, and collect and dispose of the leakage in the correct way. Do not act blindly, so as not to endanger personal safety and the environment.
In conclusion, the storage and transportation of 2-chloro-1-fluoro-4-methoxybenzene, from environmental control to packaging requirements, from material isolation to personnel professionalism, cannot be ignored, so as to ensure process safety and avoid accidents.
What are the effects of 2-chloro-1-fluoro-4-methoxybenzene on the environment and human health?
2-Chloro-1-fluoro-4-methoxybenzene is one of the organic compounds. Its impact on the environment and human health is of great concern to the world.
When it comes to the impact on the environment, if this compound is released in nature, its characteristics make it exist in the environment for a long time. In the soil, it may gradually accumulate, affecting the balance of soil ecology, causing disturbance to the activity of soil microorganisms, and then endangering the growth of plants. In the water body, it may cause water quality deterioration and poison aquatic organisms. Such as plankton, fish, etc., or due to damage to physiological functions, reproduction is blocked, and eventually the structure and function of aquatic ecosystems are destroyed.
As for the impact on human health, it can enter the human body through respiratory tract, skin contact or ingestion. In the body, or interfere with normal physiological and biochemical processes. Or damage the nervous system, cause headaches, dizziness, fatigue, long-term exposure, or cause chronic decline of nerve function. Or involve important organs such as the liver and kidneys, affect their metabolism and detoxification functions, and cause organ diseases. And studies have shown that some of these halogenated aromatic compounds may be potentially carcinogenic, although the carcinogenicity of 2-chloro-1-fluoro-4-methoxybenzene needs more empirical evidence, so it is inevitable. Therefore, when manufacturing and using this compound, it is necessary to exercise caution and take appropriate protective and handling measures to reduce its potential harm to the environment and human health.
When it comes to the impact on the environment, if this compound is released in nature, its characteristics make it exist in the environment for a long time. In the soil, it may gradually accumulate, affecting the balance of soil ecology, causing disturbance to the activity of soil microorganisms, and then endangering the growth of plants. In the water body, it may cause water quality deterioration and poison aquatic organisms. Such as plankton, fish, etc., or due to damage to physiological functions, reproduction is blocked, and eventually the structure and function of aquatic ecosystems are destroyed.
As for the impact on human health, it can enter the human body through respiratory tract, skin contact or ingestion. In the body, or interfere with normal physiological and biochemical processes. Or damage the nervous system, cause headaches, dizziness, fatigue, long-term exposure, or cause chronic decline of nerve function. Or involve important organs such as the liver and kidneys, affect their metabolism and detoxification functions, and cause organ diseases. And studies have shown that some of these halogenated aromatic compounds may be potentially carcinogenic, although the carcinogenicity of 2-chloro-1-fluoro-4-methoxybenzene needs more empirical evidence, so it is inevitable. Therefore, when manufacturing and using this compound, it is necessary to exercise caution and take appropriate protective and handling measures to reduce its potential harm to the environment and human health.
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