Linshang Chemical
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2-Chloro-1-Fluoro-4-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
236602 |
| Chemical Formula | C7H3ClF4 |
| Molar Mass | 196.545 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 135 - 137 °C |
| Density | 1.42 g/cm³ (approximate, density may vary with purity and temperature) |
| Vapor Pressure | Varies with temperature, generally higher for volatile liquids at higher temps |
| Solubility In Water | Insoluble (hydrophobic, non - polar compound) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
As an accredited 2-Chloro-1-Fluoro-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottle packaging for 2 - chloro - 1 - fluoro - 4 - (trifluoromethyl)benzene. |
| Storage | 2 - chloro - 1 - fluoro - 4 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to prevent potential reactions. |
| Shipping | 2 - chloro - 1 - fluoro - 4 - (trifluoromethyl)benzene is shipped in specialized, leak - proof containers. Shipment adheres to strict chemical transportation regulations, ensuring safety during transit due to its potentially hazardous nature. |
Competitive 2-Chloro-1-Fluoro-4-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Chloro-1-Fluoro-4-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chloro-1-fluoro-4- (trifluoromethyl) benzene?
2-Chloro-1-fluoro-4- (trifluoromethyl) benzene, an organic compound, is widely used in the chemical industry and scientific research.
First, in the field of materials science, it is often a key monomer for the synthesis of special polymer materials. Due to the presence of fluorine atoms in the molecule, the material is endowed with unique properties such as excellent chemical stability, weather resistance and low surface energy. After polymerization, fluoropolymers can be prepared, which are widely used in the production of coatings, plastics and fibers. Taking fluorine-containing coatings as an example, they can form a dense and stable protective film on the surface of objects, which can improve the anti-corrosion, wear resistance and self-cleaning ability of objects. It is of great significance in aerospace, automobile manufacturing and construction industries.
Second, in the field of medicinal chemistry, as an important synthetic intermediate, it participates in the construction of many drug molecules. Fluorine atoms have unique electronic effects and biological activities, which can optimize the physicochemical properties and biological activities of drug molecules, and improve the efficacy and selectivity of drugs. With the help of chemical modification and derivatization, compounds with specific pharmacological activities can be designed and synthesized, providing a rich structural template for the development of new drugs. It can be seen in the synthesis of many anti-cancer, antiviral and antibacterial drugs.
Third, in the field of pesticides, 2-chloro-1-fluoro-4 - (trifluoromethyl) benzene also has important applications. Fluorinated pesticides synthesized from it have the characteristics of high efficiency, low toxicity and environmental friendliness. The introduction of fluorine atoms enhances the interaction between pesticide molecules and receptors or enzymes in target organisms, enhances the insecticidal, bactericidal and herbicidal activities of pesticides, and can reduce the toxicity to non-target organisms, reduce environmental pollution, and conform to the development trend of modern green pesticides.
Fourth, in the field of organic synthetic chemistry, as an important aromatic compound, it provides a diverse reaction check point for organic synthesis reactions. Its chlorine atom, fluorine atom and trifluoromethyl can all participate in reactions such as nucleophilic substitution, electrophilic substitution and metal catalytic coupling, which are used to construct complex organic molecular structures, providing an effective way for the synthesis of organic compounds with specific functions and structures, and assisting organic synthesis chemists to achieve novel and efficient synthesis strategies.
First, in the field of materials science, it is often a key monomer for the synthesis of special polymer materials. Due to the presence of fluorine atoms in the molecule, the material is endowed with unique properties such as excellent chemical stability, weather resistance and low surface energy. After polymerization, fluoropolymers can be prepared, which are widely used in the production of coatings, plastics and fibers. Taking fluorine-containing coatings as an example, they can form a dense and stable protective film on the surface of objects, which can improve the anti-corrosion, wear resistance and self-cleaning ability of objects. It is of great significance in aerospace, automobile manufacturing and construction industries.
Second, in the field of medicinal chemistry, as an important synthetic intermediate, it participates in the construction of many drug molecules. Fluorine atoms have unique electronic effects and biological activities, which can optimize the physicochemical properties and biological activities of drug molecules, and improve the efficacy and selectivity of drugs. With the help of chemical modification and derivatization, compounds with specific pharmacological activities can be designed and synthesized, providing a rich structural template for the development of new drugs. It can be seen in the synthesis of many anti-cancer, antiviral and antibacterial drugs.
Third, in the field of pesticides, 2-chloro-1-fluoro-4 - (trifluoromethyl) benzene also has important applications. Fluorinated pesticides synthesized from it have the characteristics of high efficiency, low toxicity and environmental friendliness. The introduction of fluorine atoms enhances the interaction between pesticide molecules and receptors or enzymes in target organisms, enhances the insecticidal, bactericidal and herbicidal activities of pesticides, and can reduce the toxicity to non-target organisms, reduce environmental pollution, and conform to the development trend of modern green pesticides.
Fourth, in the field of organic synthetic chemistry, as an important aromatic compound, it provides a diverse reaction check point for organic synthesis reactions. Its chlorine atom, fluorine atom and trifluoromethyl can all participate in reactions such as nucleophilic substitution, electrophilic substitution and metal catalytic coupling, which are used to construct complex organic molecular structures, providing an effective way for the synthesis of organic compounds with specific functions and structures, and assisting organic synthesis chemists to achieve novel and efficient synthesis strategies.
What are the physical properties of 2-chloro-1-fluoro-4- (trifluoromethyl) benzene
2-Chloro-1-fluoro-4- (trifluoromethyl) benzene is one of the organic compounds. Its physical properties are particularly important and are related to many chemical applications.
First of all, its appearance, at room temperature and pressure, is mostly colorless to slightly yellow transparent liquid, clear and clear, without significant turbidity or impurities. In practical applications, this can be an intuitive identification point.
As for the boiling point, it is between 140 and 142 ° C. The boiling point is the critical temperature at which a substance changes from a liquid state to a gaseous state. This value indicates that when the ambient temperature rises to the S value, 2-chloro-1-fluoro-4- (trifluoromethyl) benzene will boil and melt from a liquid state to a gaseous state. This property is of critical significance in chemical operations such as distillation and separation.
Its melting point is about -50 ° C. The melting point is the temperature limit at which the substance changes from a solid state to a liquid state. Such a low temperature melting point means that this compound can still maintain a liquid state under normal low temperature environments and is not easy to solidify. The conditions for storage and transportation are also controlled accordingly.
In terms of density, it is about 1.42 - 1.44 g/cm ³, and this value reflects its mass per unit volume. Compared with water, its density is greater than that of water. If it is in water, this compound will sink to the bottom of the water, which needs to be paid attention to in chemical reactions or environmental treatment involving the aqueous phase.
Furthermore, its solubility cannot be ignored. 2-Chloro-1-fluoro-4 - (trifluoromethyl) benzene is insoluble in water, but it can be miscible with many organic solvents, such as ethanol, ether, acetone, etc. This solubility characteristic makes it possible to select a suitable solvent system according to the needs in the organic synthesis reaction to promote the smooth progress of the reaction.
In addition, the compound has a certain degree of volatility, and in an open environment, it will gradually evaporate into the air. Although its odor is not strongly irritating, long-term exposure to high concentrations of volatile gases may still cause potential harm to the human body. Therefore, it is necessary to pay attention to ventilation when using it to ensure safety.
In summary, the physical properties of 2-chloro-1-fluoro-4 - (trifluoromethyl) benzene are indispensable basic information in chemical research, industrial production and related application fields. Only by accurately grasping it can we make good use of it.
First of all, its appearance, at room temperature and pressure, is mostly colorless to slightly yellow transparent liquid, clear and clear, without significant turbidity or impurities. In practical applications, this can be an intuitive identification point.
As for the boiling point, it is between 140 and 142 ° C. The boiling point is the critical temperature at which a substance changes from a liquid state to a gaseous state. This value indicates that when the ambient temperature rises to the S value, 2-chloro-1-fluoro-4- (trifluoromethyl) benzene will boil and melt from a liquid state to a gaseous state. This property is of critical significance in chemical operations such as distillation and separation.
Its melting point is about -50 ° C. The melting point is the temperature limit at which the substance changes from a solid state to a liquid state. Such a low temperature melting point means that this compound can still maintain a liquid state under normal low temperature environments and is not easy to solidify. The conditions for storage and transportation are also controlled accordingly.
In terms of density, it is about 1.42 - 1.44 g/cm ³, and this value reflects its mass per unit volume. Compared with water, its density is greater than that of water. If it is in water, this compound will sink to the bottom of the water, which needs to be paid attention to in chemical reactions or environmental treatment involving the aqueous phase.
Furthermore, its solubility cannot be ignored. 2-Chloro-1-fluoro-4 - (trifluoromethyl) benzene is insoluble in water, but it can be miscible with many organic solvents, such as ethanol, ether, acetone, etc. This solubility characteristic makes it possible to select a suitable solvent system according to the needs in the organic synthesis reaction to promote the smooth progress of the reaction.
In addition, the compound has a certain degree of volatility, and in an open environment, it will gradually evaporate into the air. Although its odor is not strongly irritating, long-term exposure to high concentrations of volatile gases may still cause potential harm to the human body. Therefore, it is necessary to pay attention to ventilation when using it to ensure safety.
In summary, the physical properties of 2-chloro-1-fluoro-4 - (trifluoromethyl) benzene are indispensable basic information in chemical research, industrial production and related application fields. Only by accurately grasping it can we make good use of it.
What are the synthesis methods of 2-chloro-1-fluoro-4- (trifluoromethyl) benzene
The synthesis of 2-chloro-1-fluoro-4- (trifluoromethyl) benzene often involves a variety of paths. One is to use a benzene ring containing a specific substituent as the starting material, and introduce chlorine and fluorine atoms through a halogenation reaction. This halogenation reaction requires the selection of suitable halogenation reagents, such as chlorine, hydrogen chloride, potassium fluoride, etc., and controls the reaction conditions, such as temperature, pressure, catalyst, etc.
For example, you can first take p (trifluoromethyl) benzene and react with chlorine gas with a specific catalyst at a suitable temperature to obtain an intermediate containing chlorine substitution. After that, fluorine atoms are introduced through a fluorination reaction. This fluorination step often needs to be reacted in a polar solvent with a fluorinating reagent, such as potassium fluoride, under heating conditions, so that the fluorine atom can successfully replace other groups at a specific position, and finally obtain the target product 2-chloro-1-fluoro-4- (trifluoromethyl) benzene.
Another synthesis method is to start from other aromatic compounds and construct the desired substituent through multi-step reactions. If trifluoromethyl is first introduced into a benzene-containing compound through a substitution reaction, this step may need to be carried out with a trifluoromethylating reagent under specific reaction conditions. Then, chlorine atoms and fluorine atoms are introduced in sequence, and the reaction conditions need to be carefully controlled in each step to achieve high selectivity and yield. After each step of the reaction, it is often necessary to separate and purify the operation, such as distillation, recrystallization, column chromatography, etc., to ensure the purity of the intermediate and the final product. In this way, after multiple steps of carefully designed and operated reactions, 2-chloro-1-fluoro-4 - (trifluoromethyl) benzene can be obtained.
For example, you can first take p (trifluoromethyl) benzene and react with chlorine gas with a specific catalyst at a suitable temperature to obtain an intermediate containing chlorine substitution. After that, fluorine atoms are introduced through a fluorination reaction. This fluorination step often needs to be reacted in a polar solvent with a fluorinating reagent, such as potassium fluoride, under heating conditions, so that the fluorine atom can successfully replace other groups at a specific position, and finally obtain the target product 2-chloro-1-fluoro-4- (trifluoromethyl) benzene.
Another synthesis method is to start from other aromatic compounds and construct the desired substituent through multi-step reactions. If trifluoromethyl is first introduced into a benzene-containing compound through a substitution reaction, this step may need to be carried out with a trifluoromethylating reagent under specific reaction conditions. Then, chlorine atoms and fluorine atoms are introduced in sequence, and the reaction conditions need to be carefully controlled in each step to achieve high selectivity and yield. After each step of the reaction, it is often necessary to separate and purify the operation, such as distillation, recrystallization, column chromatography, etc., to ensure the purity of the intermediate and the final product. In this way, after multiple steps of carefully designed and operated reactions, 2-chloro-1-fluoro-4 - (trifluoromethyl) benzene can be obtained.
What 2-chloro-1-fluoro-4- (trifluoromethyl) benzene needs to pay attention to when storing and transporting
2-Chloro-1-fluoro-4- (trifluoromethyl) benzene is one of the organic compounds. During storage and transportation, many matters need to be paid careful attention.
Bear the brunt, and the storage place must be cool and dry. Although this compound is relatively stable, it may react chemically in case of moisture or high temperature. In a humid environment, moisture may interact with the active parts of the compound, causing it to deteriorate and impairing quality and purity. Under high temperatures, molecular activity increases greatly, or triggers reactions such as decomposition and polymerization, which endangers safety. Therefore, it is crucial to choose a cool and dry place to avoid the disturbance of humid and high temperatures.
Furthermore, when storing and transporting, water and fire must be strictly prevented. Reactions such as water or hydrolysis can change the chemical structure and properties. Fire is more dangerous, because it is flammable or pro-flammable. In case of open flames or hot topics, it is easy to cause combustion or even explosion, resulting in serious accidents. Surrounding fire protection facilities should be complete and away from fire and heat sources.
Also, the compound is mostly stored in sealed containers. Sealing can prevent its volatilization and escape, polluting the environment and endangering personal safety. Volatile gas may be toxic and irritating, harming human health. And sealing can prevent the intrusion of external substances and ensure its chemical stability.
During transportation, the packaging must be solid and stable. In order to prevent the container from being damaged and the compound leaking due to vibration and collision. Leakage not only causes material loss, but also pollutes the environment, making it difficult to deal with. Packaging materials also need to be resistant to chemical corrosion and do not react with compounds.
When the staff operates, protection should not be underestimated. Wear protective clothing, protective gloves and goggles, etc. Due to the compound or irritation to the skin, eyes, inhalation or damage to the respiratory tract and nervous system. Comprehensive protection can reduce hazards.
In short, when storing and transporting 2-chloro-1-fluoro-4- (trifluoromethyl) benzene, strict treatment is required in terms of environment, fire resistance, sealing, packaging and personnel protection to ensure safety and quality.
Bear the brunt, and the storage place must be cool and dry. Although this compound is relatively stable, it may react chemically in case of moisture or high temperature. In a humid environment, moisture may interact with the active parts of the compound, causing it to deteriorate and impairing quality and purity. Under high temperatures, molecular activity increases greatly, or triggers reactions such as decomposition and polymerization, which endangers safety. Therefore, it is crucial to choose a cool and dry place to avoid the disturbance of humid and high temperatures.
Furthermore, when storing and transporting, water and fire must be strictly prevented. Reactions such as water or hydrolysis can change the chemical structure and properties. Fire is more dangerous, because it is flammable or pro-flammable. In case of open flames or hot topics, it is easy to cause combustion or even explosion, resulting in serious accidents. Surrounding fire protection facilities should be complete and away from fire and heat sources.
Also, the compound is mostly stored in sealed containers. Sealing can prevent its volatilization and escape, polluting the environment and endangering personal safety. Volatile gas may be toxic and irritating, harming human health. And sealing can prevent the intrusion of external substances and ensure its chemical stability.
During transportation, the packaging must be solid and stable. In order to prevent the container from being damaged and the compound leaking due to vibration and collision. Leakage not only causes material loss, but also pollutes the environment, making it difficult to deal with. Packaging materials also need to be resistant to chemical corrosion and do not react with compounds.
When the staff operates, protection should not be underestimated. Wear protective clothing, protective gloves and goggles, etc. Due to the compound or irritation to the skin, eyes, inhalation or damage to the respiratory tract and nervous system. Comprehensive protection can reduce hazards.
In short, when storing and transporting 2-chloro-1-fluoro-4- (trifluoromethyl) benzene, strict treatment is required in terms of environment, fire resistance, sealing, packaging and personnel protection to ensure safety and quality.
2-chloro-1-fluoro-4- (trifluoromethyl) benzene impact on the environment
2-Chloro-1-fluoro-4- (trifluoromethyl) benzene, the impact of this substance on the environment is quite complex and cannot be ignored.
Looking at its chemical properties, it contains many halogen atoms. The existence of chlorine, fluorine and trifluoromethyl makes it stable to a certain extent. However, this stability is not always a blessing in the environment. Because it is difficult to degrade, it can be retained in the environment for a long time. If it accidentally enters the soil, it will interfere with the soil ecology. Soil microorganisms depend on a suitable chemical environment to survive and multiply. The accumulation of this substance may cause changes in the microbial community structure, the growth of some microorganisms is inhibited, while others may proliferate abnormally due to adaptive variation, and the ecological balance is disrupted.
In the water environment, it can also cause many problems. Aquatic organisms are sensitive to the chemical composition of water quality, and this compound enters the water body or is absorbed and enriched by aquatic organisms. After ingestion of small fish and shrimp, it may cause physiological disorders, such as affecting their important life activities such as respiration and reproduction. Long-term accumulation, or harm the entire aquatic ecosystem food chain, large fish prey on small fish containing this substance, and the concentration of toxins in their bodies is higher, which may eventually threaten humans and other organisms that rely on aquatic organisms for food.
In the atmospheric environment, although its volatilization may be limited, photochemical reactions may occur under conditions such as light. The generated free radicals and other active substances can interact with other pollutants in the atmosphere, exacerbate the complexity of air pollution, affect air quality, and pose a potential threat to the human respiratory system and the entire ecological climate.
Therefore, when industrial production and use of this substance, it is necessary to treat it with caution and strengthen environmental protection measures to prevent its excessive escape to the environment and maintain the harmony and stability of the ecological environment.
Looking at its chemical properties, it contains many halogen atoms. The existence of chlorine, fluorine and trifluoromethyl makes it stable to a certain extent. However, this stability is not always a blessing in the environment. Because it is difficult to degrade, it can be retained in the environment for a long time. If it accidentally enters the soil, it will interfere with the soil ecology. Soil microorganisms depend on a suitable chemical environment to survive and multiply. The accumulation of this substance may cause changes in the microbial community structure, the growth of some microorganisms is inhibited, while others may proliferate abnormally due to adaptive variation, and the ecological balance is disrupted.
In the water environment, it can also cause many problems. Aquatic organisms are sensitive to the chemical composition of water quality, and this compound enters the water body or is absorbed and enriched by aquatic organisms. After ingestion of small fish and shrimp, it may cause physiological disorders, such as affecting their important life activities such as respiration and reproduction. Long-term accumulation, or harm the entire aquatic ecosystem food chain, large fish prey on small fish containing this substance, and the concentration of toxins in their bodies is higher, which may eventually threaten humans and other organisms that rely on aquatic organisms for food.
In the atmospheric environment, although its volatilization may be limited, photochemical reactions may occur under conditions such as light. The generated free radicals and other active substances can interact with other pollutants in the atmosphere, exacerbate the complexity of air pollution, affect air quality, and pose a potential threat to the human respiratory system and the entire ecological climate.
Therefore, when industrial production and use of this substance, it is necessary to treat it with caution and strengthen environmental protection measures to prevent its excessive escape to the environment and maintain the harmony and stability of the ecological environment.
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