Linshang Chemical
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2-Chloro-1-Iodo-4-Methylbenzene
Linshang Chemical
|
HS Code |
165710 |
| Chemical Formula | C7H6ClI |
| Molecular Weight | 252.48 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approximately 225 - 227 °C |
| Density | Around 1.80 - 1.90 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
| Odor | Characteristic aromatic odor |
As an accredited 2-Chloro-1-Iodo-4-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 1 - iodo - 4 - methylbenzene in a sealed, labeled glass bottle. |
| Storage | 2 - Chloro - 1 - iodo - 4 - methylbenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames as it is potentially flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances. Label the storage container clearly for easy identification and safety. |
| Shipping | 2 - chloro - 1 - iodo - 4 - methylbenzene is shipped in sealed, corrosion - resistant containers. It must be labeled as a hazardous chemical. Transport follows strict regulations to ensure safety during transit. |
Competitive 2-Chloro-1-Iodo-4-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What are the chemical properties of 2-chloro-1-iodo-4-methylbenzene?
2-Chloro-1-iodine-4-methylbenzene, this is an organic compound. Its chemical properties are unique and valuable for investigation.
Let's talk about its halogen atom properties first. The chlorine atom and the iodine atom are on the benzene ring, giving the compound active reactivity. Due to the high electronegativity of the halogen atom, the electron cloud density of the benzene ring will change. For example, in electrophilic substitution reactions, the presence of chlorine and iodine affects the reaction check point and reaction rate. Usually, the halogen atom is an ortho-para-locator, which will make the electrophilic reagent more inclined to attack the position adjacent to or opposite the halogen atom on the benzene ring.
Let's talk about The methyl group on the benzene ring belongs to the power supply group, which can increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution reaction. The interaction with the halogen atom is intertwined, and together affect the reactivity and selectivity of the compound. For example, in the nitrification reaction, the positioning effect of the methyl group and the halogen atom comprehensively affects the substitution position of the nitro group.
In addition, the chlorine atom and iodine atom in 2-chloro-1-iodine-4-methylbenzene can participate in the nucleophilic substitution reaction. Under suitable nucleophilic reagents and reaction conditions, chlorine or iodine atoms can be replaced by nucleophilic reagents, and then various new organic compounds can be derived, This compound has significant applications in the field of organic synthesis, and can be used as a key intermediate for the preparation of many organic materials, drugs, and other substances with specific functions and structures, promoting the development and innovation of organic chemistry.
Let's talk about its halogen atom properties first. The chlorine atom and the iodine atom are on the benzene ring, giving the compound active reactivity. Due to the high electronegativity of the halogen atom, the electron cloud density of the benzene ring will change. For example, in electrophilic substitution reactions, the presence of chlorine and iodine affects the reaction check point and reaction rate. Usually, the halogen atom is an ortho-para-locator, which will make the electrophilic reagent more inclined to attack the position adjacent to or opposite the halogen atom on the benzene ring.
Let's talk about The methyl group on the benzene ring belongs to the power supply group, which can increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution reaction. The interaction with the halogen atom is intertwined, and together affect the reactivity and selectivity of the compound. For example, in the nitrification reaction, the positioning effect of the methyl group and the halogen atom comprehensively affects the substitution position of the nitro group.
In addition, the chlorine atom and iodine atom in 2-chloro-1-iodine-4-methylbenzene can participate in the nucleophilic substitution reaction. Under suitable nucleophilic reagents and reaction conditions, chlorine or iodine atoms can be replaced by nucleophilic reagents, and then various new organic compounds can be derived, This compound has significant applications in the field of organic synthesis, and can be used as a key intermediate for the preparation of many organic materials, drugs, and other substances with specific functions and structures, promoting the development and innovation of organic chemistry.
What are the physical properties of 2-chloro-1-iodo-4-methylbenzene?
2-Chloro-1-iodine-4-methylbenzene is one of the organic compounds. Its physical properties are particularly important, and it is related to many chemical processes and practical applications.
Looking at its physical state, under normal temperature and pressure, 2-chloro-1-iodine-4-methylbenzene is probably in a liquid state. This state is derived from the force between molecules, and the attractive force and repulsion between molecules are balanced, so it forms a liquid state. Its color may be nearly colorless or slightly light, and the pure ones are mostly colorless and transparent. However, the existence of trace impurities may cause slight changes in color.
When it comes to odor, 2-chloro-1-iodine-4-methylbenzene has a special aromatic odor. This odor is derived from the structural properties of the benzene ring, and the conjugate system of the benzene ring gives it unique volatility and odor characteristics. Although this aromatic odor is not as rich as some fragrances, it is clearly recognizable and can be heard in chemical experiments or industrial sites.
As for the boiling point, the boiling point of 2-chloro-1-iodine-4-methylbenzene is quite high. Due to the presence of chlorine and iodine atoms in addition to van der Waals forces between molecules, the polarity of molecules is enhanced, and the intermolecular forces are increased. To make molecules break free from the liquid phase and turn into the gas phase, higher energy is required, so the boiling point is higher. This property is of great significance in the operation of separation and purification. 2-chloro-1-iodine-4-methylbenzene can be separated from the mixture by distillation according to the difference in boiling point. The melting point of
also varies depending on the molecular structure and interactions. The degree of regularity of molecular arrangement and the interaction between atoms determine the melting point. The melting point of 2-chloro-1-iodine-4-methylbenzene is moderate. At a specific temperature, solid and liquid states transform into each other. This temperature limit is crucial for setting its storage and use conditions.
In terms of solubility, 2-chloro-1-iodine-4-methylbenzene is insoluble in water. Water is a polar molecule, while the non-polar structure of the 2-chloro-1-iodine-4-methylbenzene ring and the influence of chlorine and iodine atoms have weak overall polarity. According to the principle of "similar miscibility", its solubility in water is very small. However, it is easily soluble in organic solvents, such as ethanol, ether, acetone, etc. The non-polar or weak polar of organic solvents is compatible with 2-chloro-1-iodine-4-methylbenzene, and the intermolecular force can promote its mutual dissolution. This solubility is widely used in organic synthesis, extraction and other fields.
Density is also an important physical property. 2-chloro-1-iodine-4-methylbenzene has a higher density than water. When placed in water, it will sink to the bottom of the water. This characteristic can help to determine its position in the system in operations involving liquid-liquid separation, and then select a suitable method for separation.
In summary, the physical properties of 2-chloro-1-iodine-4-methylbenzene, such as physical state, color, odor, boiling point, melting point, solubility, and density, are the key to understanding and applying this compound, and are of great value in chemical research, industrial production, and many other aspects.
Looking at its physical state, under normal temperature and pressure, 2-chloro-1-iodine-4-methylbenzene is probably in a liquid state. This state is derived from the force between molecules, and the attractive force and repulsion between molecules are balanced, so it forms a liquid state. Its color may be nearly colorless or slightly light, and the pure ones are mostly colorless and transparent. However, the existence of trace impurities may cause slight changes in color.
When it comes to odor, 2-chloro-1-iodine-4-methylbenzene has a special aromatic odor. This odor is derived from the structural properties of the benzene ring, and the conjugate system of the benzene ring gives it unique volatility and odor characteristics. Although this aromatic odor is not as rich as some fragrances, it is clearly recognizable and can be heard in chemical experiments or industrial sites.
As for the boiling point, the boiling point of 2-chloro-1-iodine-4-methylbenzene is quite high. Due to the presence of chlorine and iodine atoms in addition to van der Waals forces between molecules, the polarity of molecules is enhanced, and the intermolecular forces are increased. To make molecules break free from the liquid phase and turn into the gas phase, higher energy is required, so the boiling point is higher. This property is of great significance in the operation of separation and purification. 2-chloro-1-iodine-4-methylbenzene can be separated from the mixture by distillation according to the difference in boiling point. The melting point of
also varies depending on the molecular structure and interactions. The degree of regularity of molecular arrangement and the interaction between atoms determine the melting point. The melting point of 2-chloro-1-iodine-4-methylbenzene is moderate. At a specific temperature, solid and liquid states transform into each other. This temperature limit is crucial for setting its storage and use conditions.
In terms of solubility, 2-chloro-1-iodine-4-methylbenzene is insoluble in water. Water is a polar molecule, while the non-polar structure of the 2-chloro-1-iodine-4-methylbenzene ring and the influence of chlorine and iodine atoms have weak overall polarity. According to the principle of "similar miscibility", its solubility in water is very small. However, it is easily soluble in organic solvents, such as ethanol, ether, acetone, etc. The non-polar or weak polar of organic solvents is compatible with 2-chloro-1-iodine-4-methylbenzene, and the intermolecular force can promote its mutual dissolution. This solubility is widely used in organic synthesis, extraction and other fields.
Density is also an important physical property. 2-chloro-1-iodine-4-methylbenzene has a higher density than water. When placed in water, it will sink to the bottom of the water. This characteristic can help to determine its position in the system in operations involving liquid-liquid separation, and then select a suitable method for separation.
In summary, the physical properties of 2-chloro-1-iodine-4-methylbenzene, such as physical state, color, odor, boiling point, melting point, solubility, and density, are the key to understanding and applying this compound, and are of great value in chemical research, industrial production, and many other aspects.
What are the main uses of 2-chloro-1-iodo-4-methylbenzene?
2-Chloro-1-iodine-4-methylbenzene, this is an organic compound with a wide range of uses.
In the field of organic synthesis, it is often used as a key intermediate. Other types of organic compounds can be derived through many chemical reactions. For example, through nucleophilic substitution, chlorine atoms or iodine atoms can be replaced by other functional groups, such as hydroxyl groups, amino groups, etc., to synthesize compounds with different properties and functions, which can be used to create drugs, pesticides and materials.
In the field of pharmaceutical chemistry, it can be used as a part of the structure of the lead compound. Due to the benzene ring structure and the existence of chlorine, iodine and methyl groups, the compound is endowed with specific physicochemical properties and biological activities, laying the foundation for the development of new drugs. Pharmaceutical chemists can modify and optimize its structure to enhance the efficacy of drugs and reduce toxic and side effects.
In the field of materials science, the organic materials synthesized by it may have unique optical and electrical properties. For example, polymer materials containing this structure may show potential application value in the field of optoelectronics, such as organic Light Emitting Diode (OLED), solar cells, etc.
The field of pesticides also has its own shadow. As an intermediate for synthetic pesticides, it can participate in the construction of molecular structures with insecticidal, bactericidal or herbicidal activities. After rational design and modification, new pesticides with high efficiency, low toxicity and environmental friendliness can be developed.
To sum up, 2-chloro-1-iodine-4-methylbenzene plays an important role in many fields such as organic synthesis, medicinal chemistry, materials science, and pesticides, and is of great significance in promoting the development of related fields.
In the field of organic synthesis, it is often used as a key intermediate. Other types of organic compounds can be derived through many chemical reactions. For example, through nucleophilic substitution, chlorine atoms or iodine atoms can be replaced by other functional groups, such as hydroxyl groups, amino groups, etc., to synthesize compounds with different properties and functions, which can be used to create drugs, pesticides and materials.
In the field of pharmaceutical chemistry, it can be used as a part of the structure of the lead compound. Due to the benzene ring structure and the existence of chlorine, iodine and methyl groups, the compound is endowed with specific physicochemical properties and biological activities, laying the foundation for the development of new drugs. Pharmaceutical chemists can modify and optimize its structure to enhance the efficacy of drugs and reduce toxic and side effects.
In the field of materials science, the organic materials synthesized by it may have unique optical and electrical properties. For example, polymer materials containing this structure may show potential application value in the field of optoelectronics, such as organic Light Emitting Diode (OLED), solar cells, etc.
The field of pesticides also has its own shadow. As an intermediate for synthetic pesticides, it can participate in the construction of molecular structures with insecticidal, bactericidal or herbicidal activities. After rational design and modification, new pesticides with high efficiency, low toxicity and environmental friendliness can be developed.
To sum up, 2-chloro-1-iodine-4-methylbenzene plays an important role in many fields such as organic synthesis, medicinal chemistry, materials science, and pesticides, and is of great significance in promoting the development of related fields.
What is 2-chloro-1-iodo-4-methylbenzene synthesis method?
The preparation of 2-chloro-1-iodine-4-methylbenzene can be started from p-methylchlorobenzene.
First, p-methylchlorobenzene reacts with iodine under appropriate catalysts and conditions. The commonly used catalysts can be copper powder or copper chloride. In a certain temperature and solvent environment, the two substitution reactions occur. Because the chlorine atom on the benzene ring is an ortho-para-site group, and the methyl group is also an ortho-site group, and the positioning effect of the two is synergistic, the iodine atom will mainly replace the hydrogen atom at the ortho-site of the chlorine atom (on the side near the methyl group) to generate 2-chloro This reaction requires attention to control the reaction temperature. Excessive temperature may trigger side reactions to form polyiodide products.
Another way is to nitrate p-methyl chlorobenzene first. The mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as the nitrifying reagent. At a suitable temperature, a nitro group is introduced into the benzene ring. Due to the influence of methyl and chlorine atoms, the nitro group mainly enters the ortho-para-position of the methyl and chlorine atoms. After separation, the main product 2-chloro-4-methyl nitrobenzene can be obtained. Subsequently, the nitro group is reduced to an amino group. The commonly used reducing agents are iron and hydrochloric acid systems. After obtaining 2-chloro-4-methylaniline, it is reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt through diazotization Finally, the diazonium salt reacts with potassium iodide, and the diazonium group is replaced by the iodine atom to obtain 2-chloro-1-iodine-4-methylbenzene. There are many steps in this route, but the selectivity of each step is relatively good, which helps to improve the purity of the target product. During the operation, the diazotization reaction needs to strictly control the low temperature conditions, otherwise the diazonium salt is easy to decompose and affect the yield.
First, p-methylchlorobenzene reacts with iodine under appropriate catalysts and conditions. The commonly used catalysts can be copper powder or copper chloride. In a certain temperature and solvent environment, the two substitution reactions occur. Because the chlorine atom on the benzene ring is an ortho-para-site group, and the methyl group is also an ortho-site group, and the positioning effect of the two is synergistic, the iodine atom will mainly replace the hydrogen atom at the ortho-site of the chlorine atom (on the side near the methyl group) to generate 2-chloro This reaction requires attention to control the reaction temperature. Excessive temperature may trigger side reactions to form polyiodide products.
Another way is to nitrate p-methyl chlorobenzene first. The mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as the nitrifying reagent. At a suitable temperature, a nitro group is introduced into the benzene ring. Due to the influence of methyl and chlorine atoms, the nitro group mainly enters the ortho-para-position of the methyl and chlorine atoms. After separation, the main product 2-chloro-4-methyl nitrobenzene can be obtained. Subsequently, the nitro group is reduced to an amino group. The commonly used reducing agents are iron and hydrochloric acid systems. After obtaining 2-chloro-4-methylaniline, it is reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt through diazotization Finally, the diazonium salt reacts with potassium iodide, and the diazonium group is replaced by the iodine atom to obtain 2-chloro-1-iodine-4-methylbenzene. There are many steps in this route, but the selectivity of each step is relatively good, which helps to improve the purity of the target product. During the operation, the diazotization reaction needs to strictly control the low temperature conditions, otherwise the diazonium salt is easy to decompose and affect the yield.
2-chloro-1-iodo-4-methylbenzene what are the precautions during storage and transportation?
2-Chloro-1-iodine-4-methylbenzene is also an organic compound. When storing and transporting, it is necessary to pay attention to many matters to prevent accidents.
One is related to storage. This compound should be stored in a cool, dry and well-ventilated place. Cover because of its nature or sensitive to temperature and humidity, high temperature and humid places may cause it to deteriorate or cause chemical reactions. It is advisable to keep away from fire and heat sources. High temperature of open flames can cause it to be unstable, and even cause the risk of combustion and explosion. And it needs to be stored separately from oxidants, strong alkalis and other substances to avoid mixed storage. Due to its active chemical properties, it is easy to react violently when in contact with them.
Second, as for transportation. Before transportation, it is necessary to ensure that the packaging is intact. Packaging materials must have good sealing and corrosion resistance to prevent leakage. During transportation, the driving should be stable to avoid violent vibration and collision to prevent package rupture. The escort personnel should also be familiar with its characteristics and emergency treatment methods. In case of leakage and other conditions, they can be properly disposed of in time.
Furthermore, whether it is storage or transportation, it is necessary to strictly follow relevant regulations and operating procedures. Operators should also receive professional training and be familiar with its dangerous characteristics and safety precautions to ensure the safety of the whole process. Therefore, it is necessary to properly store and transport 2-chloro-1-iodine-4-methylbenzene to avoid disasters and ensure the safety of personnel and the environment.
One is related to storage. This compound should be stored in a cool, dry and well-ventilated place. Cover because of its nature or sensitive to temperature and humidity, high temperature and humid places may cause it to deteriorate or cause chemical reactions. It is advisable to keep away from fire and heat sources. High temperature of open flames can cause it to be unstable, and even cause the risk of combustion and explosion. And it needs to be stored separately from oxidants, strong alkalis and other substances to avoid mixed storage. Due to its active chemical properties, it is easy to react violently when in contact with them.
Second, as for transportation. Before transportation, it is necessary to ensure that the packaging is intact. Packaging materials must have good sealing and corrosion resistance to prevent leakage. During transportation, the driving should be stable to avoid violent vibration and collision to prevent package rupture. The escort personnel should also be familiar with its characteristics and emergency treatment methods. In case of leakage and other conditions, they can be properly disposed of in time.
Furthermore, whether it is storage or transportation, it is necessary to strictly follow relevant regulations and operating procedures. Operators should also receive professional training and be familiar with its dangerous characteristics and safety precautions to ensure the safety of the whole process. Therefore, it is necessary to properly store and transport 2-chloro-1-iodine-4-methylbenzene to avoid disasters and ensure the safety of personnel and the environment.
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