Linshang Chemical
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2-Chloro-1-Methoxy-4-Methylbenzene
Linshang Chemical
|
HS Code |
744071 |
| Chemical Formula | C8H9ClO |
| Molar Mass | 156.609 g/mol |
| Appearance | Liquid (usually) |
| Odor | Characteristic aromatic odor |
| Density | Data depends on temperature (usually around 1.1 g/cm³) |
| Boiling Point | Around 200 - 205 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Data required from experimental sources |
As an accredited 2-Chloro-1-Methoxy-4-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle of 2 - chloro - 1 - methoxy - 4 - methylbenzene, well - sealed for storage. |
| Storage | 2 - Chloro - 1 - methoxy - 4 - methylbenzene should be stored in a cool, well - ventilated area, away from heat sources and ignition points due to its flammable nature. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances. This helps maintain its chemical stability and reduces risks of fire, explosion, or unwanted reactions. |
| Shipping | 2 - chloro - 1 - methoxy - 4 - methylbenzene is shipped in tightly - sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations, ensuring proper labeling and handling to prevent spills and maintain safety during transit. |
Competitive 2-Chloro-1-Methoxy-4-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 2-chloro-1-methoxy-4-methylbenzene?
2-Chloro-1-methoxy-4-methylbenzene, this is an organic compound. In its molecular structure, the chlorine atom is in the second position above the benzene ring, the methoxy group is in the first position, and the methyl group is in the fourth position. This compound has the following chemical properties:
In terms of electrophilic substitution reaction, the benzene ring is rich in electrons and exhibits electrophilic substitution activity. Because the methoxy group is a strong electron donor group, it produces a + M effect on the benzene ring, which increases the electron cloud density of the benzene ring, especially the electron cloud density of the ortho and para-position. Methyl is also a electron donor group, which has a + I effect and can also increase the electron cloud density of the Therefore, the electrophilic substitution reaction of 2-chloro-1-methoxy-4-methylbenzene mostly occurs in the adjacent and para-position of methoxy group and methyl group. For example, during nitration reaction, nitro (-NO ³) tends to enter the methoxy ortho-position or methyl ortho-position.
In the reaction characteristics of halogen atoms, although chlorine atoms are attached to benzene rings, their activity is lower than that of halogen atoms in halogenated alkanes due to the conjugation effect of benzene rings. However, under certain conditions, such as high temperature, strong base or the presence of catalysts, chlorine atoms can undergo substitution reactions. For example, when interacting with nucleophiles (such as sodium alcohol), chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds.
In terms of methoxy reactivity, the oxygen atoms in the methoxy group have unpaired electron pairs and can participate in the reaction. Under acidic conditions, the methoxy group can be protonated, which reduces the electron cloud density of the benzene ring and changes the reactivity. Moreover, the methoxy group can be broken by some reactions, such as under the action of hydroiodic acid (HI), the methyl group in the methoxy group can be replaced by iodine to form iodomethane and phenolic compounds.
In methyl-related reactions, some reactions can occur in the methyl group on the benzene ring. For example, when the hydrogen atom on the methyl group can be replaced by a halogen atom in the presence of light or a free radical initiator, a free radical substitution reaction occurs. If there is a hydrogen atom on the carbon atom connected to the methyl group, the methyl group can be oxidized to a carboxyl group under the action of a strong oxidant (such
In summary, the interaction of different groups in 2-chloro-1-methoxy-4-methylbenzene molecules exhibits diverse chemical properties and has important applications in organic synthesis and other fields.
In terms of electrophilic substitution reaction, the benzene ring is rich in electrons and exhibits electrophilic substitution activity. Because the methoxy group is a strong electron donor group, it produces a + M effect on the benzene ring, which increases the electron cloud density of the benzene ring, especially the electron cloud density of the ortho and para-position. Methyl is also a electron donor group, which has a + I effect and can also increase the electron cloud density of the Therefore, the electrophilic substitution reaction of 2-chloro-1-methoxy-4-methylbenzene mostly occurs in the adjacent and para-position of methoxy group and methyl group. For example, during nitration reaction, nitro (-NO ³) tends to enter the methoxy ortho-position or methyl ortho-position.
In the reaction characteristics of halogen atoms, although chlorine atoms are attached to benzene rings, their activity is lower than that of halogen atoms in halogenated alkanes due to the conjugation effect of benzene rings. However, under certain conditions, such as high temperature, strong base or the presence of catalysts, chlorine atoms can undergo substitution reactions. For example, when interacting with nucleophiles (such as sodium alcohol), chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds.
In terms of methoxy reactivity, the oxygen atoms in the methoxy group have unpaired electron pairs and can participate in the reaction. Under acidic conditions, the methoxy group can be protonated, which reduces the electron cloud density of the benzene ring and changes the reactivity. Moreover, the methoxy group can be broken by some reactions, such as under the action of hydroiodic acid (HI), the methyl group in the methoxy group can be replaced by iodine to form iodomethane and phenolic compounds.
In methyl-related reactions, some reactions can occur in the methyl group on the benzene ring. For example, when the hydrogen atom on the methyl group can be replaced by a halogen atom in the presence of light or a free radical initiator, a free radical substitution reaction occurs. If there is a hydrogen atom on the carbon atom connected to the methyl group, the methyl group can be oxidized to a carboxyl group under the action of a strong oxidant (such
In summary, the interaction of different groups in 2-chloro-1-methoxy-4-methylbenzene molecules exhibits diverse chemical properties and has important applications in organic synthesis and other fields.
What are the main uses of 2-chloro-1-methoxy-4-methylbenzene?
2-Chloro-1-methoxy-4-methylbenzene, this substance has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique structure, chlorine atoms, methoxy groups and methyl groups give it special activity and reaction characteristics. Chemists can modify and transform its structure through various chemical reactions, and then synthesize many organic compounds with specific functions and uses.
In the field of pharmaceutical research and development, it also plays an important role. After a series of reaction transformations, it can become the core structure part of some drug molecules, laying the foundation for the development of new drugs. For example, by modifying it with functional groups, the resulting compounds can have specific biological activities, such as antibacterial, anti-inflammatory or anti-tumor effects.
In the field of materials science, 2-chloro-1-methoxy-4-methylbenzene is also useful. By appropriate reactions, it can be introduced into the structure of polymer materials to change the properties of materials, such as improving the stability, solubility or endowing it with special optical and electrical properties, to meet the special needs of materials in different fields.
In addition, it also plays an indispensable role in the preparation of fine chemical products. It can be used to synthesize fine chemicals such as fragrances, dyes and surfactants. By ingeniously designing reaction paths, these products are endowed with unique properties and excellent properties. In conclusion, 2-chloro-1-methoxy-4-methylbenzene, as an important organic compound, has shown important value and broad application prospects in many fields.
In the field of pharmaceutical research and development, it also plays an important role. After a series of reaction transformations, it can become the core structure part of some drug molecules, laying the foundation for the development of new drugs. For example, by modifying it with functional groups, the resulting compounds can have specific biological activities, such as antibacterial, anti-inflammatory or anti-tumor effects.
In the field of materials science, 2-chloro-1-methoxy-4-methylbenzene is also useful. By appropriate reactions, it can be introduced into the structure of polymer materials to change the properties of materials, such as improving the stability, solubility or endowing it with special optical and electrical properties, to meet the special needs of materials in different fields.
In addition, it also plays an indispensable role in the preparation of fine chemical products. It can be used to synthesize fine chemicals such as fragrances, dyes and surfactants. By ingeniously designing reaction paths, these products are endowed with unique properties and excellent properties. In conclusion, 2-chloro-1-methoxy-4-methylbenzene, as an important organic compound, has shown important value and broad application prospects in many fields.
What are 2-chloro-1-methoxy-4-methylbenzene synthesis methods?
The synthesis methods of 2-chloro-1-methoxy-4-methylbenzene are quite diverse, each has its own advantages and disadvantages, and is selected according to different needs and conditions.
First, p-methylphenol can be started. First, chloromethane reacts with p-methylphenol under basic conditions, and the phenolic hydroxyl group undergoes nucleophilic substitution with chloromethane to form a methoxy group to obtain 1-methoxy-4-methylbenzene. Then, the product is chlorinated. Chlorine is used as a chlorination agent. In the presence of light or a catalyst such as ferric chloride, chlorine atoms will selectively replace hydrogen atoms on the benzene ring, mainly to obtain 2-chloro-1-methoxy-4-methylbenzene. The starting materials of this path are common and easy to obtain, but the chlorination step may produce by-products, and the reaction conditions need to be carefully adjusted to improve the yield of the target product.
Second, p-chlorotoluene is used as the starting material. First, p-chlorotoluene is made into a Grignard reagent, and magnesium and p-chlorotoluene are reacted in anhydrous ether and other solvents to obtain it. After that, the Grignard reagent is reacted with chloromethyl ether, and 2-chloro-1-methoxy-4-methylbenzene can be obtained through nucleophilic addition and subsequent treatment. The advantage of this approach is that the steps are relatively direct, but the preparation of Grignard reagent requires strict anhydrous and anaerobic conditions, and the operation requirements are high.
Third, start from p-cresol methyl ether. A suitable chlorination reagent, such as N-chlorosuccinimide (NCS), can be used to chlorinate the benzene ring under the action of light or initiator. This method has relatively mild conditions, fewer side reactions, and higher product purity, but the price of NCS is higher, and the cost factor needs to be considered.
Or, using 2-chloro-4-methylaniline as raw material, through diazotization reaction, sodium nitrite reacts with 2-chloro-4-methylaniline under acidic conditions to form diazonium salts, and then treated with methanol. A similar process occurs in Sandmeier reaction. The diazonium group is replaced by a methoxy group to obtain 2-chloro-1-methoxy-4-methylbenzene. This method is a little complicated, and the diazotization reaction requires strict control of temperature and other conditions, but the precise introduction of specific groups can be achieved.
First, p-methylphenol can be started. First, chloromethane reacts with p-methylphenol under basic conditions, and the phenolic hydroxyl group undergoes nucleophilic substitution with chloromethane to form a methoxy group to obtain 1-methoxy-4-methylbenzene. Then, the product is chlorinated. Chlorine is used as a chlorination agent. In the presence of light or a catalyst such as ferric chloride, chlorine atoms will selectively replace hydrogen atoms on the benzene ring, mainly to obtain 2-chloro-1-methoxy-4-methylbenzene. The starting materials of this path are common and easy to obtain, but the chlorination step may produce by-products, and the reaction conditions need to be carefully adjusted to improve the yield of the target product.
Second, p-chlorotoluene is used as the starting material. First, p-chlorotoluene is made into a Grignard reagent, and magnesium and p-chlorotoluene are reacted in anhydrous ether and other solvents to obtain it. After that, the Grignard reagent is reacted with chloromethyl ether, and 2-chloro-1-methoxy-4-methylbenzene can be obtained through nucleophilic addition and subsequent treatment. The advantage of this approach is that the steps are relatively direct, but the preparation of Grignard reagent requires strict anhydrous and anaerobic conditions, and the operation requirements are high.
Third, start from p-cresol methyl ether. A suitable chlorination reagent, such as N-chlorosuccinimide (NCS), can be used to chlorinate the benzene ring under the action of light or initiator. This method has relatively mild conditions, fewer side reactions, and higher product purity, but the price of NCS is higher, and the cost factor needs to be considered.
Or, using 2-chloro-4-methylaniline as raw material, through diazotization reaction, sodium nitrite reacts with 2-chloro-4-methylaniline under acidic conditions to form diazonium salts, and then treated with methanol. A similar process occurs in Sandmeier reaction. The diazonium group is replaced by a methoxy group to obtain 2-chloro-1-methoxy-4-methylbenzene. This method is a little complicated, and the diazotization reaction requires strict control of temperature and other conditions, but the precise introduction of specific groups can be achieved.
What do 2-chloro-1-methoxy-4-methylbenzene need to pay attention to when storing and transporting?
2-Chloro-1-methoxy-4-methylbenzene, this is an organic compound. When storing and transporting, many matters need to be paid attention to.
First of all, storage should be placed in a cool and ventilated warehouse. This compound is prone to danger due to heat, and a cool place can reduce the risk of temperature-induced risks. Good ventilation can prevent it from accumulating in a limited space and reduce hidden dangers such as explosions. Second, keep away from fires and heat sources. Open flames and high temperatures can easily cause it to burn or even explode, so fireworks are strictly prohibited in warehouses, and electrical equipment needs to be explosion-proof. Third, store separately from oxidants, acids, and alkalis, and avoid mixed storage. Because of its active chemical properties, contact with the above substances, or a violent reaction, there is an unpredictable danger. Fourth, the storage area should be equipped with suitable materials to contain leaks. Just in case of leakage, it can be collected in time to prevent its spread from causing greater harm.
As for transportation, the first heavy packaging. Packaging must be tight, firm, in line with relevant standards, can resist vibration, collision and friction, to ensure that no damage and leakage during transportation. During transportation, the vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. During transportation, the speed should not be too fast, to avoid sudden braking, in order to prevent packaging damage due to bumps and collisions. And drive according to the specified route, do not stop in densely populated areas and residential areas. Transport personnel also need to undergo professional training, familiar with the characteristics of the compound and emergency treatment methods, strict monitoring during transportation, if there is any abnormality, prompt measures. In this way, the safety of 2-chloro-1-methoxy-4-methylbenzene storage and transportation can be guaranteed.
First of all, storage should be placed in a cool and ventilated warehouse. This compound is prone to danger due to heat, and a cool place can reduce the risk of temperature-induced risks. Good ventilation can prevent it from accumulating in a limited space and reduce hidden dangers such as explosions. Second, keep away from fires and heat sources. Open flames and high temperatures can easily cause it to burn or even explode, so fireworks are strictly prohibited in warehouses, and electrical equipment needs to be explosion-proof. Third, store separately from oxidants, acids, and alkalis, and avoid mixed storage. Because of its active chemical properties, contact with the above substances, or a violent reaction, there is an unpredictable danger. Fourth, the storage area should be equipped with suitable materials to contain leaks. Just in case of leakage, it can be collected in time to prevent its spread from causing greater harm.
As for transportation, the first heavy packaging. Packaging must be tight, firm, in line with relevant standards, can resist vibration, collision and friction, to ensure that no damage and leakage during transportation. During transportation, the vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. During transportation, the speed should not be too fast, to avoid sudden braking, in order to prevent packaging damage due to bumps and collisions. And drive according to the specified route, do not stop in densely populated areas and residential areas. Transport personnel also need to undergo professional training, familiar with the characteristics of the compound and emergency treatment methods, strict monitoring during transportation, if there is any abnormality, prompt measures. In this way, the safety of 2-chloro-1-methoxy-4-methylbenzene storage and transportation can be guaranteed.
What are the effects of 2-chloro-1-methoxy-4-methylbenzene on the environment and human health?
2-Chloro-1-methoxy-4-methylbenzene, this is an organic compound. In today's world, everyone cares about the environment and health, and the impact of this compound on the environment and human body is also of concern.
First talk about its impact on the environment. If this substance enters the natural environment, it may affect the soil microbial community. Soil microorganisms are extremely important for soil fertility and material circulation, and they may be affected, causing soil ecological imbalance. In water bodies, or toxic to aquatic organisms. For example, aquatic organisms such as fish and shellfish, if exposed for a long time, may cause damage to physiological functions, decrease in fertility, or even death, thereby destroying the balance of aquatic ecosystems. And this substance may have a certain volatility. After entering the atmosphere, it may participate in photochemical reactions, affecting air quality and causing adverse consequences to the atmospheric environment.
Let's talk about the impact on human health. If people inhale the air containing this substance through the respiratory tract, it may irritate the respiratory tract, causing symptoms such as cough and asthma. Long-term inhalation, or cause damage to the lungs, affecting the normal function of the lungs. If it comes into contact with the skin, it may be irritating, causing redness, swelling and itching of the skin. If ingested inadvertently, it may interfere with normal physiological metabolism in the body, produce toxic effects on the liver, kidneys and other organs, and damage the detoxification and excretion functions of the human body.
It can be seen that 2-chloro-1-methoxy-4-methylbenzene poses a potential threat to both the environment and human health. During its production, use and handling, it should be treated with caution and appropriate measures should be taken to reduce its harm to the environment and human health, and to protect the natural environment and human well-being.
First talk about its impact on the environment. If this substance enters the natural environment, it may affect the soil microbial community. Soil microorganisms are extremely important for soil fertility and material circulation, and they may be affected, causing soil ecological imbalance. In water bodies, or toxic to aquatic organisms. For example, aquatic organisms such as fish and shellfish, if exposed for a long time, may cause damage to physiological functions, decrease in fertility, or even death, thereby destroying the balance of aquatic ecosystems. And this substance may have a certain volatility. After entering the atmosphere, it may participate in photochemical reactions, affecting air quality and causing adverse consequences to the atmospheric environment.
Let's talk about the impact on human health. If people inhale the air containing this substance through the respiratory tract, it may irritate the respiratory tract, causing symptoms such as cough and asthma. Long-term inhalation, or cause damage to the lungs, affecting the normal function of the lungs. If it comes into contact with the skin, it may be irritating, causing redness, swelling and itching of the skin. If ingested inadvertently, it may interfere with normal physiological metabolism in the body, produce toxic effects on the liver, kidneys and other organs, and damage the detoxification and excretion functions of the human body.
It can be seen that 2-chloro-1-methoxy-4-methylbenzene poses a potential threat to both the environment and human health. During its production, use and handling, it should be treated with caution and appropriate measures should be taken to reduce its harm to the environment and human health, and to protect the natural environment and human well-being.
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