Linshang Chemical
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2-Chloro-1-Methoxy-4-Nitrobenzene
Linshang Chemical
|
HS Code |
130404 |
| Chemical Formula | C7H6ClNO3 |
| Molar Mass | 187.58 g/mol |
| Appearance | Yellow solid |
| Boiling Point | Approximately 274 - 276 °C |
| Melting Point | 57 - 60 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Density | Approx. 1.384 g/cm³ |
| Odor | Characteristic aromatic odor |
| Stability | Stable under normal conditions, but can react with strong oxidizing agents |
As an accredited 2-Chloro-1-Methoxy-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 1 - methoxy - 4 - nitrobenzene packaged in a sealed plastic bottle. |
| Storage | 2 - Chloro - 1 - methoxy - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and incompatible substances such as strong oxidizers and reducing agents. Store it in tightly closed containers to prevent leakage and exposure to air and moisture, which could potentially lead to chemical degradation or dangerous reactions. |
| Shipping | 2 - chloro - 1 - methoxy - 4 - nitrobenzene should be shipped in tightly sealed containers, protected from heat and light. It must follow hazardous chemical shipping regulations, with proper labeling for safe transportation. |
Competitive 2-Chloro-1-Methoxy-4-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What are the physical properties of 2-chloro-1-methoxy-4-nitrobenzene?
2-Chloro-1-methoxy-4-nitrobenzene is also an organic compound. Its physical properties are quite important and often need to be studied in chemical industry.
Looking at its properties, it is mostly solid at room temperature. Its melting and boiling point is the key physical property. The melting point is about [specific value] ° C, which is caused by the force between molecules. Chlorine, methoxy and nitro groups in the molecule have their own characteristics and interact with each other, resulting in the melting point. The boiling point is about [specific value] ° C. When the temperature reaches this point, the molecule can be energized enough to break free from the liquid phase and escape into the gas phase.
When it comes to solubility, it is quite soluble in organic solvents such as ethanol and ether. This edge of its molecular structure contains non-polar parts such as benzene rings, which can form van der Waals forces with organic solvent molecules, so it can be dissolved. However, in water, due to its weak polarity, it is difficult to form strong interactions with water molecules, so it is slightly soluble in water.
In other words, the density is larger than that of water. Because of its molecular composition, chlorine, nitro and other atoms or groups have a relatively large mass, resulting in their unit volume mass greater than that of water.
Its appearance may be a white to light yellow crystalline powder with a special odor. This odor originates from the chemical structure of the molecule and can also be a characteristic of identification.
The physical properties of 2-chloro-1-methoxy-4-nitrobenzene are determined by its molecular structure, and are important in chemical synthesis, separation and purification.
Looking at its properties, it is mostly solid at room temperature. Its melting and boiling point is the key physical property. The melting point is about [specific value] ° C, which is caused by the force between molecules. Chlorine, methoxy and nitro groups in the molecule have their own characteristics and interact with each other, resulting in the melting point. The boiling point is about [specific value] ° C. When the temperature reaches this point, the molecule can be energized enough to break free from the liquid phase and escape into the gas phase.
When it comes to solubility, it is quite soluble in organic solvents such as ethanol and ether. This edge of its molecular structure contains non-polar parts such as benzene rings, which can form van der Waals forces with organic solvent molecules, so it can be dissolved. However, in water, due to its weak polarity, it is difficult to form strong interactions with water molecules, so it is slightly soluble in water.
In other words, the density is larger than that of water. Because of its molecular composition, chlorine, nitro and other atoms or groups have a relatively large mass, resulting in their unit volume mass greater than that of water.
Its appearance may be a white to light yellow crystalline powder with a special odor. This odor originates from the chemical structure of the molecule and can also be a characteristic of identification.
The physical properties of 2-chloro-1-methoxy-4-nitrobenzene are determined by its molecular structure, and are important in chemical synthesis, separation and purification.
What are the chemical properties of 2-chloro-1-methoxy-4-nitrobenzene?
2-Chloro-1-methoxy-4-nitrobenzene is also an organic compound. Its chemical properties are unique and valuable to explore.
First, the nature of the halogen atom. This compound contains chlorine atoms, which are highly active and can often initiate nucleophilic substitution reactions. Under appropriate conditions, in case of nucleophilic reagents, chlorine atoms are easily replaced by them, and then new compounds can be derived. This is a commonly used method in organic synthesis. It can be used to select different nucleophilic reagents to construct a variety of molecular structures.
Furthermore, the influence of methoxy groups. The electron cloud density of the benzene ring can be increased by the methoxy group as the power supply group, which affects the reactivity and selectivity of the benzene ring to a certain extent. In the electrophilic substitution reaction, it can guide the reaction to occur in adjacent and para-sites, which is helpful for the generation of specific position-substituted products, and is of great significance in the formulation of organic synthesis strategies.
And the properties of nitro groups cannot be underestimated. Nitro is a strong electron-absorbing group, which will reduce the electron cloud density of the benzene ring and make it more difficult for the electrophilic substitution of the benzene ring. However, nitro groups can make the benzene ring connected to it more prone to nucleophilic substitution. And the existence of nitro groups can participate in the reduction reaction under certain conditions and be converted into other functional groups such as amino groups, expanding the path for
In addition, the chlorine atom, methoxy group and nitro group in this compound interact with each other. The electronic and spatial effects of different functional groups are intertwined to jointly determine their chemical behavior. This complex interaction makes 2-chloro-1-methoxy-4-nitrobenzene in the field of organic synthesis. By ingeniously designing the reaction steps, various target products can be prepared, which has potential applications in drug synthesis, materials science and many other fields.
First, the nature of the halogen atom. This compound contains chlorine atoms, which are highly active and can often initiate nucleophilic substitution reactions. Under appropriate conditions, in case of nucleophilic reagents, chlorine atoms are easily replaced by them, and then new compounds can be derived. This is a commonly used method in organic synthesis. It can be used to select different nucleophilic reagents to construct a variety of molecular structures.
Furthermore, the influence of methoxy groups. The electron cloud density of the benzene ring can be increased by the methoxy group as the power supply group, which affects the reactivity and selectivity of the benzene ring to a certain extent. In the electrophilic substitution reaction, it can guide the reaction to occur in adjacent and para-sites, which is helpful for the generation of specific position-substituted products, and is of great significance in the formulation of organic synthesis strategies.
And the properties of nitro groups cannot be underestimated. Nitro is a strong electron-absorbing group, which will reduce the electron cloud density of the benzene ring and make it more difficult for the electrophilic substitution of the benzene ring. However, nitro groups can make the benzene ring connected to it more prone to nucleophilic substitution. And the existence of nitro groups can participate in the reduction reaction under certain conditions and be converted into other functional groups such as amino groups, expanding the path for
In addition, the chlorine atom, methoxy group and nitro group in this compound interact with each other. The electronic and spatial effects of different functional groups are intertwined to jointly determine their chemical behavior. This complex interaction makes 2-chloro-1-methoxy-4-nitrobenzene in the field of organic synthesis. By ingeniously designing the reaction steps, various target products can be prepared, which has potential applications in drug synthesis, materials science and many other fields.
What are the common synthetic methods of 2-chloro-1-methoxy-4-nitrobenzene?
The common synthesis methods of 2-chloro-1-methoxy-4-nitrobenzene have attracted much attention in the field of organic synthesis. Its synthesis often follows the following routes.
One is to use halogenated aromatics as the starting material. A suitable halogenated benzene can be taken first, and under specific reaction conditions, it can be nucleophilized with a methoxylating agent to introduce a methoxy group. This step requires the selection of an appropriate base and solvent to promote the smooth progress of the reaction. For example, potassium carbonate can be used as the base, N, N-dimethylformamide (DMF) can be used as the solvent, and the temperature is heated to a suitable temperature to react the halogenated benzene with sodium methoxide or other methoxy sources. After the methoxy group is successfully introduced, the nitrification reaction is carried out. In the nitrification step, mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid) is usually used as a nitrifying reagent, prepared according to a specific ratio, and slowly added dropwise to the reaction system under low temperature conditions to precisely control the reaction process and achieve the purpose of introducing nitro groups at specific positions in the benzene ring. Finally, through the halogenation reaction, a suitable halogenating reagent, such as N-chlorosuccinimide (NCS) or chlorine gas, is selected, and the target product 2-chloro-1-methoxy-4-nitrobenzene is synthesized under specific reaction conditions in the presence of an appropriate catalyst.
Second, nitroaromatic hydrocarbons are used as starting materials. The nitrobenzene derivative is first methoxylated. Similar to the above, the methoxy group is introduced by the nucleophilic substitution mechanism. Subsequently, a halogenation reaction is carried out. This halogenation step also requires careful selection of halogenation reagents and reaction conditions according to the characteristics of the substrate and the reaction requirements.
Third, methoxyaromatic hydrocarbons are used as the starting material. The methoxybenzene derivative is nitrified first to construct a nitro substituent, and then the halogenation reaction is carried out to obtain 2-chloro-1-methoxy-4-nitrobenzene. In the
synthesis process, the fine regulation of each step of the reaction conditions is crucial, such as reaction temperature, reaction time, reagent dosage and ratio, which will have a significant impact on the reaction yield and selectivity. And after each step of the reaction, it is often necessary to separate and purify the products by means of column chromatography, recrystallization, etc., to ensure the purity of the intermediate and final products, so as to achieve the goal of efficient synthesis of 2-chloro-1-methoxy-4-nitrobenzene.
One is to use halogenated aromatics as the starting material. A suitable halogenated benzene can be taken first, and under specific reaction conditions, it can be nucleophilized with a methoxylating agent to introduce a methoxy group. This step requires the selection of an appropriate base and solvent to promote the smooth progress of the reaction. For example, potassium carbonate can be used as the base, N, N-dimethylformamide (DMF) can be used as the solvent, and the temperature is heated to a suitable temperature to react the halogenated benzene with sodium methoxide or other methoxy sources. After the methoxy group is successfully introduced, the nitrification reaction is carried out. In the nitrification step, mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid) is usually used as a nitrifying reagent, prepared according to a specific ratio, and slowly added dropwise to the reaction system under low temperature conditions to precisely control the reaction process and achieve the purpose of introducing nitro groups at specific positions in the benzene ring. Finally, through the halogenation reaction, a suitable halogenating reagent, such as N-chlorosuccinimide (NCS) or chlorine gas, is selected, and the target product 2-chloro-1-methoxy-4-nitrobenzene is synthesized under specific reaction conditions in the presence of an appropriate catalyst.
Second, nitroaromatic hydrocarbons are used as starting materials. The nitrobenzene derivative is first methoxylated. Similar to the above, the methoxy group is introduced by the nucleophilic substitution mechanism. Subsequently, a halogenation reaction is carried out. This halogenation step also requires careful selection of halogenation reagents and reaction conditions according to the characteristics of the substrate and the reaction requirements.
Third, methoxyaromatic hydrocarbons are used as the starting material. The methoxybenzene derivative is nitrified first to construct a nitro substituent, and then the halogenation reaction is carried out to obtain 2-chloro-1-methoxy-4-nitrobenzene. In the
synthesis process, the fine regulation of each step of the reaction conditions is crucial, such as reaction temperature, reaction time, reagent dosage and ratio, which will have a significant impact on the reaction yield and selectivity. And after each step of the reaction, it is often necessary to separate and purify the products by means of column chromatography, recrystallization, etc., to ensure the purity of the intermediate and final products, so as to achieve the goal of efficient synthesis of 2-chloro-1-methoxy-4-nitrobenzene.
2-chloro-1-methoxy-4-nitrobenzene in what areas?
2-Chloro-1-methoxy-4-nitrobenzene, which is useful in various fields.
In the field of pharmaceutical synthesis, it can be an important intermediate. Due to its unique structure, it can be chemically modified to introduce other functional groups to form compounds with specific pharmacological activities. For example, through clever reactions, it can be converted into key components of antibacterial drugs. With precise molecular structures, it can act on specific bacterial targets to achieve antibacterial effects.
In the field of materials science, it also has its own impact. It can be polymerized and integrated into polymer materials. Because it contains chlorine, nitro and other groups, it can give materials different properties. Such as enhancing the heat resistance of the material, so that it can still maintain a stable structure and performance in high temperature environments; or improving the electrical properties of the material, making it suitable for the manufacture of electronic components, such as insulating materials for printed circuit boards.
Furthermore, in the field of pesticide research and development, 2-chloro-1-methoxy-4-nitrobenzene can also be used. It can be used as a starting material for the synthesis of new pesticides, and through a series of reactions, it can generate substances with high toxic effects on pests. Because its structure is compatible with some key biomolecules in insects, it can interfere with the normal physiological metabolism of insects, so as to achieve the purpose of pest control, and the impact on the environment is relatively small, which is in line with the current trend of green pesticide development. In conclusion, 2-chloro-1-methoxy-4-nitrobenzene, with its unique structure, has important application value in many fields such as medicine, materials, and pesticides, providing key support for the development of various industries.
In the field of pharmaceutical synthesis, it can be an important intermediate. Due to its unique structure, it can be chemically modified to introduce other functional groups to form compounds with specific pharmacological activities. For example, through clever reactions, it can be converted into key components of antibacterial drugs. With precise molecular structures, it can act on specific bacterial targets to achieve antibacterial effects.
In the field of materials science, it also has its own impact. It can be polymerized and integrated into polymer materials. Because it contains chlorine, nitro and other groups, it can give materials different properties. Such as enhancing the heat resistance of the material, so that it can still maintain a stable structure and performance in high temperature environments; or improving the electrical properties of the material, making it suitable for the manufacture of electronic components, such as insulating materials for printed circuit boards.
Furthermore, in the field of pesticide research and development, 2-chloro-1-methoxy-4-nitrobenzene can also be used. It can be used as a starting material for the synthesis of new pesticides, and through a series of reactions, it can generate substances with high toxic effects on pests. Because its structure is compatible with some key biomolecules in insects, it can interfere with the normal physiological metabolism of insects, so as to achieve the purpose of pest control, and the impact on the environment is relatively small, which is in line with the current trend of green pesticide development. In conclusion, 2-chloro-1-methoxy-4-nitrobenzene, with its unique structure, has important application value in many fields such as medicine, materials, and pesticides, providing key support for the development of various industries.
What are the precautions in the preparation of 2-chloro-1-methoxy-4-nitrobenzene?
When preparing 2-chloro-1-methoxy-4-nitrobenzene, many precautions need to be kept in mind.
Be the first to bear the brunt, and the selection of raw materials must be accurate. The purity of the raw materials such as chloroanisole and nitric acid used must be up to standard, and impurities must not be too much. If the raw materials are impure, many side reactions may occur during the reaction process, resulting in poor product purity and greatly reduced yield.
Furthermore, the control of the reaction conditions is crucial. Temperature regulation needs to be just right, and this reaction usually takes place within a specific temperature range. If the temperature is too high, the reaction rate will accelerate, but it is easy to cause side reactions such as excessive nitrification, resulting in unnecessary polynitro products; if the temperature is too low, the reaction rate will be slow and time-consuming, which may also lead to incomplete reactions. In addition, the reaction pressure and time also need to be strictly controlled, and the operation according to the established process can ensure that the reaction is sufficient and the product quality is stable.
The choice of reaction solvent cannot be ignored. The selected solvent must not only have good solubility to the reactants to promote full contact with the reaction molecules and accelerate the reaction process, but also need not chemically react with the reactants and products to avoid interfering with the normal progress of the reaction.
At the same time, during the entire preparation process, safety measures must not be slack. Nitric acid and other raw materials are highly corrosive and oxidizing. When operating, be sure to wear complete protective equipment, such as protective clothing, protective gloves and goggles, to avoid contact with skin and eyes. If harmful gases escape during the reaction process, it is also necessary to operate in a well-ventilated place, or use ventilation equipment to discharge harmful gases in time to ensure the safety of operators.
Furthermore, the separation and purification of the product is extremely important. After the reaction, the product is often mixed with impurities such as unreacted raw materials, by-products and solvents. Appropriate separation and purification methods, such as distillation, recrystallization, column chromatography, etc., need to be used to obtain high-purity target products. The operation process should be rigorous and meticulous to prevent product loss and improve product yield and purity.
Be the first to bear the brunt, and the selection of raw materials must be accurate. The purity of the raw materials such as chloroanisole and nitric acid used must be up to standard, and impurities must not be too much. If the raw materials are impure, many side reactions may occur during the reaction process, resulting in poor product purity and greatly reduced yield.
Furthermore, the control of the reaction conditions is crucial. Temperature regulation needs to be just right, and this reaction usually takes place within a specific temperature range. If the temperature is too high, the reaction rate will accelerate, but it is easy to cause side reactions such as excessive nitrification, resulting in unnecessary polynitro products; if the temperature is too low, the reaction rate will be slow and time-consuming, which may also lead to incomplete reactions. In addition, the reaction pressure and time also need to be strictly controlled, and the operation according to the established process can ensure that the reaction is sufficient and the product quality is stable.
The choice of reaction solvent cannot be ignored. The selected solvent must not only have good solubility to the reactants to promote full contact with the reaction molecules and accelerate the reaction process, but also need not chemically react with the reactants and products to avoid interfering with the normal progress of the reaction.
At the same time, during the entire preparation process, safety measures must not be slack. Nitric acid and other raw materials are highly corrosive and oxidizing. When operating, be sure to wear complete protective equipment, such as protective clothing, protective gloves and goggles, to avoid contact with skin and eyes. If harmful gases escape during the reaction process, it is also necessary to operate in a well-ventilated place, or use ventilation equipment to discharge harmful gases in time to ensure the safety of operators.
Furthermore, the separation and purification of the product is extremely important. After the reaction, the product is often mixed with impurities such as unreacted raw materials, by-products and solvents. Appropriate separation and purification methods, such as distillation, recrystallization, column chromatography, etc., need to be used to obtain high-purity target products. The operation process should be rigorous and meticulous to prevent product loss and improve product yield and purity.
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