Linshang Chemical
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2-Chloro-1-Methyl-4-(Methylsulfonyl)Benzene
Linshang Chemical
|
HS Code |
275315 |
| Chemical Formula | C8H9ClO2S |
| Molecular Weight | 204.67 |
As an accredited 2-Chloro-1-Methyl-4-(Methylsulfonyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250 - gram bottle of 2 - chloro - 1 - methyl - 4 - (methylsulfonyl)benzene, well - sealed. |
| Storage | 2 - chloro - 1 - methyl - 4 - (methylsulfonyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly closed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to avoid potential chemical reactions. |
| Shipping | 2 - chloro - 1 - methyl - 4 - (methylsulfonyl)benzene is shipped in properly labeled, corrosion - resistant containers. They are secured to prevent movement. Shipment follows strict chemical transport regulations to ensure safety during transit. |
Competitive 2-Chloro-1-Methyl-4-(Methylsulfonyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 2-chloro-1-methyl-4- (methylsulfonyl) benzene
2-Chloro-1-methyl-4- (methylsulfonyl) benzene, this is an organic compound. Its chemical properties are unique, let me explain in detail.
First, the halogen atom chlorine is above the benzene ring, and the chlorine atom has an electron-absorbing induction effect. This effect reduces the electron cloud density of the benzene ring and weakens the electrophilic substitution activity of the benzene ring. Moreover, the electron cloud density of the ortho and para-sites of the chlorine atom is relatively higher than that of the meta-site, and the electrophilic reagents are prone to attack the ortho and para-sites. For example, in the case of electrophilic reagents, the reaction may occur preferentially over the ortho and para-sites of the chlorine atom.
Furthermore, methyl is attached to the benzene ring, and methyl presents a donor electron induction effect and a superconjugation effect, which can increase the electron cloud density of the benzene ring and enhance the electrophilic substitution activity of the benzene ring. However, methyl has a greater impact on the density of ortho and para-potential electron clouds. Therefore, in the electrophilic substitution reaction, the products are mainly ortho and para-sites.
And the methyl sulfonyl group is also connected to the benzene ring. This group has strong electron-absorbing ability, which significantly reduces the electron cloud density of the benzene ring and greatly weakens the electrophilic substitution activity of the benzene ring. It has a wide influence on the electron cloud density of the benzene ring, which changes the overall reactivity of the benzene ring.
From the perspective However, under the action of specific strong oxidants, methyl or methyl sulfonyl groups may be partially oxidized. In case of strong oxidizing substances, the valence state of sulfur atoms in methyl sulfonyl groups may change and an oxidation reaction occurs.
Under basic conditions, chlorine atoms may undergo nucleophilic substitution reactions. In basic reagents, nucleophilic groups attack chlorine atoms to connect to carbon atoms, and chlorine atoms leave to form new compounds.
The chemical properties of this compound are affected by the interaction of various groups, and they exhibit various reactivity and characteristics under different reaction conditions. It is of great significance in organic synthesis and other fields.
First, the halogen atom chlorine is above the benzene ring, and the chlorine atom has an electron-absorbing induction effect. This effect reduces the electron cloud density of the benzene ring and weakens the electrophilic substitution activity of the benzene ring. Moreover, the electron cloud density of the ortho and para-sites of the chlorine atom is relatively higher than that of the meta-site, and the electrophilic reagents are prone to attack the ortho and para-sites. For example, in the case of electrophilic reagents, the reaction may occur preferentially over the ortho and para-sites of the chlorine atom.
Furthermore, methyl is attached to the benzene ring, and methyl presents a donor electron induction effect and a superconjugation effect, which can increase the electron cloud density of the benzene ring and enhance the electrophilic substitution activity of the benzene ring. However, methyl has a greater impact on the density of ortho and para-potential electron clouds. Therefore, in the electrophilic substitution reaction, the products are mainly ortho and para-sites.
And the methyl sulfonyl group is also connected to the benzene ring. This group has strong electron-absorbing ability, which significantly reduces the electron cloud density of the benzene ring and greatly weakens the electrophilic substitution activity of the benzene ring. It has a wide influence on the electron cloud density of the benzene ring, which changes the overall reactivity of the benzene ring.
From the perspective However, under the action of specific strong oxidants, methyl or methyl sulfonyl groups may be partially oxidized. In case of strong oxidizing substances, the valence state of sulfur atoms in methyl sulfonyl groups may change and an oxidation reaction occurs.
Under basic conditions, chlorine atoms may undergo nucleophilic substitution reactions. In basic reagents, nucleophilic groups attack chlorine atoms to connect to carbon atoms, and chlorine atoms leave to form new compounds.
The chemical properties of this compound are affected by the interaction of various groups, and they exhibit various reactivity and characteristics under different reaction conditions. It is of great significance in organic synthesis and other fields.
What is the main use of 2-chloro-1-methyl-4- (methylsulfonyl) benzene?
2-Chloro-1-methyl-4- (methylsulfonyl) benzene has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate.
The process of organic synthesis and the creation of many delicate compounds depend on such intermediates as the foundation. For example, when building complex aromatic compounds, 2-chloro-1-methyl-4- (methylsulfonyl) benzene can react with a variety of nucleophiles due to its specific chemical structure. The activity of chlorine atoms makes nucleophilic substitution reactions easy to carry out, and various functional groups can be introduced, which can be derived into compounds with diverse structures. The presence of methyl sulfonyl groups not only affects the electron cloud distribution of the molecule, but also affects the selectivity and activity of the reaction.
Furthermore, in the field of medicinal chemistry, this compound also has its uses. The design and synthesis of some drug molecules will use 2-chloro-1-methyl-4 - (methyl sulfonyl) benzene as the starting material. Through subsequent reaction modifications, the final product is given specific pharmacological activity. After its structure is ingeniously modified, it may interact with specific biological targets to exert the effect of treating diseases.
In addition, in the field of materials science, materials constructed on the basis of this substance may exhibit unique physicochemical properties. For example, in the synthesis of some functional polymer materials, the introduction of it as a structural unit is expected to change the electrical, optical or mechanical properties of the material, so as to meet the needs of different fields for special materials.
In short, although 2-chloro-1-methyl-4 - (methylsulfonyl) benzene is an organic compound, it plays an indispensable role in many important fields such as organic synthesis, pharmaceutical chemistry, and materials science. It is a chemical substance with a wide range of uses.
The process of organic synthesis and the creation of many delicate compounds depend on such intermediates as the foundation. For example, when building complex aromatic compounds, 2-chloro-1-methyl-4- (methylsulfonyl) benzene can react with a variety of nucleophiles due to its specific chemical structure. The activity of chlorine atoms makes nucleophilic substitution reactions easy to carry out, and various functional groups can be introduced, which can be derived into compounds with diverse structures. The presence of methyl sulfonyl groups not only affects the electron cloud distribution of the molecule, but also affects the selectivity and activity of the reaction.
Furthermore, in the field of medicinal chemistry, this compound also has its uses. The design and synthesis of some drug molecules will use 2-chloro-1-methyl-4 - (methyl sulfonyl) benzene as the starting material. Through subsequent reaction modifications, the final product is given specific pharmacological activity. After its structure is ingeniously modified, it may interact with specific biological targets to exert the effect of treating diseases.
In addition, in the field of materials science, materials constructed on the basis of this substance may exhibit unique physicochemical properties. For example, in the synthesis of some functional polymer materials, the introduction of it as a structural unit is expected to change the electrical, optical or mechanical properties of the material, so as to meet the needs of different fields for special materials.
In short, although 2-chloro-1-methyl-4 - (methylsulfonyl) benzene is an organic compound, it plays an indispensable role in many important fields such as organic synthesis, pharmaceutical chemistry, and materials science. It is a chemical substance with a wide range of uses.
What are the synthesis methods of 2-chloro-1-methyl-4- (methylsulfonyl) benzene
The synthesis of 2-chloro-1-methyl-4- (methylsulfonyl) benzene is a subject of research in the field of organic synthesis. There are several common methods for preparing this substance.
One is to start with an appropriate aromatic hydrocarbon. First, methylation reagents, such as iodomethane, and corresponding bases are used to methylate aromatic hydrocarbons, and methyl groups are introduced into the benzene ring. Subsequently, through the sulfonylation reaction, methylsulfonyl chloride and other reagents are used to introduce methylsulfonyl groups at specific positions in the benzene ring. At this time, methyl groups and methylsulfonyl groups are already on the benzene ring. Finally, through the halogenation reaction, chlorine gas or suitable chlorination reagents are used to introduce chlorine atoms at designated positions to obtain the target product 2-chloro-1-methyl-4 - (methylsulfonyl) benzene.
Second, another approach can also be found. First halogenate aromatic hydrocarbons and introduce chlorine atoms. After that, methylation and sulfonylation reactions are carried out in sequence. Through reasonable selection of reaction conditions and reagents, the reaction check point is controlled, so as to achieve the purpose of introducing methyl and methylsulfonyl groups at specific positions respectively, and finally obtain the target compound.
Furthermore, some more novel synthesis strategies may be used, such as transition metal catalyzed reactions. With the help of transition metal catalysts such as palladium and copper, the selective construction of functional groups on the benzene ring is achieved. For example, using halogenated aromatics as substrates, through metal-catalyzed coupling reaction, methyl and methyl sulfonyl groups are gradually introduced, which may improve the selectivity and efficiency of the reaction, and then effectively synthesize 2-chloro-1-methyl-4- (methyl sulfonyl) benzene. However, no matter what method is used, the reaction conditions, the selection of reagents and the control of side reactions need to be carefully considered to achieve the desired synthesis effect.
One is to start with an appropriate aromatic hydrocarbon. First, methylation reagents, such as iodomethane, and corresponding bases are used to methylate aromatic hydrocarbons, and methyl groups are introduced into the benzene ring. Subsequently, through the sulfonylation reaction, methylsulfonyl chloride and other reagents are used to introduce methylsulfonyl groups at specific positions in the benzene ring. At this time, methyl groups and methylsulfonyl groups are already on the benzene ring. Finally, through the halogenation reaction, chlorine gas or suitable chlorination reagents are used to introduce chlorine atoms at designated positions to obtain the target product 2-chloro-1-methyl-4 - (methylsulfonyl) benzene.
Second, another approach can also be found. First halogenate aromatic hydrocarbons and introduce chlorine atoms. After that, methylation and sulfonylation reactions are carried out in sequence. Through reasonable selection of reaction conditions and reagents, the reaction check point is controlled, so as to achieve the purpose of introducing methyl and methylsulfonyl groups at specific positions respectively, and finally obtain the target compound.
Furthermore, some more novel synthesis strategies may be used, such as transition metal catalyzed reactions. With the help of transition metal catalysts such as palladium and copper, the selective construction of functional groups on the benzene ring is achieved. For example, using halogenated aromatics as substrates, through metal-catalyzed coupling reaction, methyl and methyl sulfonyl groups are gradually introduced, which may improve the selectivity and efficiency of the reaction, and then effectively synthesize 2-chloro-1-methyl-4- (methyl sulfonyl) benzene. However, no matter what method is used, the reaction conditions, the selection of reagents and the control of side reactions need to be carefully considered to achieve the desired synthesis effect.
2-chloro-1-methyl-4- (methylsulfonyl) benzene in storage and transportation
2-Chloro-1-methyl-4- (methylsulfonyl) benzene, this is an organic compound. When storing and transporting, many key matters need to be paid careful attention.
The first to bear the brunt is the choice of storage place. It is necessary to find a cool, dry and well-ventilated place. Because of the high temperature environment, the chemical properties of the compound may change due to excessive temperature, or even cause the risk of decomposition and combustion. Humid environment is also not advisable, because it may react with water vapor, resulting in quality damage. And it is necessary to keep away from fire and heat sources to prevent open flames, which are all necessary measures to prevent combustion and explosion.
Furthermore, the choice of storage container is also crucial. It is advisable to use a container with good sealing performance to prevent it from evaporating and escaping, polluting the environment, and avoiding reaction with air components. And the material of the container must be compatible with the compound and not chemically react with it, so as not to corrode the container and cause leakage.
When transporting, the packaging must be stable. To ensure that during transportation, even if it encounters bumps and vibrations, it will not cause the package to be damaged and leak. The transportation vehicle must also meet relevant safety standards and have facilities such as fire protection, explosion protection, and anti-static. Transportation personnel should be professionally trained and familiar with the characteristics of the compound and emergency treatment methods.
In addition, whether it is storage or transportation, it is necessary to strictly follow relevant regulations and standards. Keep detailed records, such as the time of entry and exit, quantity, storage conditions, etc. Once abnormal conditions are detected, such as leaks, odors, etc., emergency plans should be activated immediately and properly handled to ensure the safety of personnel and the environment. In this way, it is necessary to ensure the safety of 2-chloro-1-methyl-4- (methylsulfonyl) benzene during storage and transportation.
The first to bear the brunt is the choice of storage place. It is necessary to find a cool, dry and well-ventilated place. Because of the high temperature environment, the chemical properties of the compound may change due to excessive temperature, or even cause the risk of decomposition and combustion. Humid environment is also not advisable, because it may react with water vapor, resulting in quality damage. And it is necessary to keep away from fire and heat sources to prevent open flames, which are all necessary measures to prevent combustion and explosion.
Furthermore, the choice of storage container is also crucial. It is advisable to use a container with good sealing performance to prevent it from evaporating and escaping, polluting the environment, and avoiding reaction with air components. And the material of the container must be compatible with the compound and not chemically react with it, so as not to corrode the container and cause leakage.
When transporting, the packaging must be stable. To ensure that during transportation, even if it encounters bumps and vibrations, it will not cause the package to be damaged and leak. The transportation vehicle must also meet relevant safety standards and have facilities such as fire protection, explosion protection, and anti-static. Transportation personnel should be professionally trained and familiar with the characteristics of the compound and emergency treatment methods.
In addition, whether it is storage or transportation, it is necessary to strictly follow relevant regulations and standards. Keep detailed records, such as the time of entry and exit, quantity, storage conditions, etc. Once abnormal conditions are detected, such as leaks, odors, etc., emergency plans should be activated immediately and properly handled to ensure the safety of personnel and the environment. In this way, it is necessary to ensure the safety of 2-chloro-1-methyl-4- (methylsulfonyl) benzene during storage and transportation.
What are the environmental effects of 2-chloro-1-methyl-4- (methylsulfonyl) benzene?
2-Chloro-1-methyl-4- (methylsulfonyl) benzene, the impact of this substance on the environment should not be underestimated.
Its chemical properties are unique, and it may exist in the state of migration and transformation in the environment. First of all, its persistence, because its structure contains chlorine atoms and methyl sulfonyl groups, resulting in high chemical stability, is difficult to be decomposed in the natural environment, or long-term retention. This long-term retention, or accumulated in soil and water bodies, gradually accumulates and eventually leads to environmental hazards.
Furthermore, it is related to its bioaccumulation. This compound has a certain lipid solubility, is easily absorbed by organisms and enriched in the body. If plankton swallows the particles containing this substance, small fish eat plankton, and big fish eat small fish, the concentration may reach an alarming level in the high-end organisms of the food chain. The accumulation of this organism may affect the health of the organism, causing physiological abnormalities, reproduction disorders, and even a sharp decrease in the population.
Also known as its toxicity. Although there is no conclusive detailed list of the toxicity of the whole ecosystem, the toxicity of similar structural compounds can be used as a reference. Chlorine atoms and methyl sulfonyl groups may be cytotoxic, genotoxic, or damage the normal function of biological cells, causing genetic mutations. In the long run, it may reduce biodiversity and disrupt the ecological balance.
And its transformation in the environment, or the generation of new harmful substances. In case of light, heat, microorganisms, or chemical structure changes, new products may be more toxic and easier to migrate, making environmental problems more complex and difficult.
In summary, 2-chloro-1-methyl-4 - (methyl sulfonyl) benzene has a complex and far-reaching impact on the environment, and it is urgent to explore in depth in order to find good measures to reduce its harm and protect ecological security.
Its chemical properties are unique, and it may exist in the state of migration and transformation in the environment. First of all, its persistence, because its structure contains chlorine atoms and methyl sulfonyl groups, resulting in high chemical stability, is difficult to be decomposed in the natural environment, or long-term retention. This long-term retention, or accumulated in soil and water bodies, gradually accumulates and eventually leads to environmental hazards.
Furthermore, it is related to its bioaccumulation. This compound has a certain lipid solubility, is easily absorbed by organisms and enriched in the body. If plankton swallows the particles containing this substance, small fish eat plankton, and big fish eat small fish, the concentration may reach an alarming level in the high-end organisms of the food chain. The accumulation of this organism may affect the health of the organism, causing physiological abnormalities, reproduction disorders, and even a sharp decrease in the population.
Also known as its toxicity. Although there is no conclusive detailed list of the toxicity of the whole ecosystem, the toxicity of similar structural compounds can be used as a reference. Chlorine atoms and methyl sulfonyl groups may be cytotoxic, genotoxic, or damage the normal function of biological cells, causing genetic mutations. In the long run, it may reduce biodiversity and disrupt the ecological balance.
And its transformation in the environment, or the generation of new harmful substances. In case of light, heat, microorganisms, or chemical structure changes, new products may be more toxic and easier to migrate, making environmental problems more complex and difficult.
In summary, 2-chloro-1-methyl-4 - (methyl sulfonyl) benzene has a complex and far-reaching impact on the environment, and it is urgent to explore in depth in order to find good measures to reduce its harm and protect ecological security.
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