Linshang Chemical
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2-Chloro-1-Methyl-4-Nitrobenzene
Linshang Chemical
|
HS Code |
218736 |
| Chemical Formula | C7H6ClNO2 |
| Molar Mass | 171.58 g/mol |
| Appearance | Yellow - solid |
| Melting Point | 43 - 45 °C |
| Boiling Point | 246 - 248 °C |
| Density | 1.369 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in ethanol, ether, etc. |
| Odor | Characteristic - pungent |
| Flash Point | 110 °C |
| Cas Number | 89 - 63 - 4 |
| Hazard Class | Harmful |
As an accredited 2-Chloro-1-Methyl-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 2 - chloro - 1 - methyl - 4 - nitrobenzene in a sealed, labeled chemical bottle. |
| Storage | 2 - Chloro - 1 - methyl - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is potentially flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances to avoid dangerous reactions. Label containers clearly for easy identification and safety. |
| Shipping | 2 - Chloro - 1 - methyl - 4 - nitrobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring secure transit to prevent leakage and environmental or safety risks. |
Competitive 2-Chloro-1-Methyl-4-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the physical properties of 2-chloro-1-methyl-4-nitrobenzene?
2-Chloro-1-methyl-4-nitrobenzene is one of the organic compounds. It has the following physical properties:
Viewed, this compound is a light yellow solid at room temperature and pressure, with a fine texture. To the eye, it is quite clear. Its yellowish color may be caused by the interaction of chlorine, nitro and other functional groups contained in the molecular structure.
Smell it, it has a special smell. This smell is specific and pungent. If people are close to it, it is very easy to perceive. This smell originates from its molecular structure. It is composed of chlorine atoms, nitro groups and benzene rings, which create such a smell.
When it comes to the melting point, the melting point is about 32-34 ° C, and the boiling point is about 251-252 ° C. The melting point is low, and at a slightly higher room temperature, it may be in a molten state; the boiling point is relatively high, and a higher temperature is required to make it boil into a gaseous state. This melting boiling point characteristic is related to the intermolecular force. There is a van der Waals force between molecules, and due to the polarity of the nitro group, there is also a certain dipole-dipole force. The two act together to cause the melting boiling point to appear in this state.
In terms of solubility, it is slightly soluble in water. Water is a polar solvent, and although 2-chloro-1-methyl-4-nitrobenzene molecules contain polar functional groups, as a whole, the non-polar influence of the benzene ring is greater, which makes the interaction between it and water molecules weak and difficult to dissolve in water. However, it is soluble in organic solvents such as ethanol, ether, benzene, etc. This is because these organic solvents and the compound molecules can form similar intermolecular forces, following the principle of "similar miscibility", so they can be better miscible.
The density is slightly larger than that of water, and when placed in water, it will sink to the bottom. This density characteristic is also closely related to its molecular structure. The type and arrangement of atoms in the molecule determine that its unit volume mass is greater than that of water.
Viewed, this compound is a light yellow solid at room temperature and pressure, with a fine texture. To the eye, it is quite clear. Its yellowish color may be caused by the interaction of chlorine, nitro and other functional groups contained in the molecular structure.
Smell it, it has a special smell. This smell is specific and pungent. If people are close to it, it is very easy to perceive. This smell originates from its molecular structure. It is composed of chlorine atoms, nitro groups and benzene rings, which create such a smell.
When it comes to the melting point, the melting point is about 32-34 ° C, and the boiling point is about 251-252 ° C. The melting point is low, and at a slightly higher room temperature, it may be in a molten state; the boiling point is relatively high, and a higher temperature is required to make it boil into a gaseous state. This melting boiling point characteristic is related to the intermolecular force. There is a van der Waals force between molecules, and due to the polarity of the nitro group, there is also a certain dipole-dipole force. The two act together to cause the melting boiling point to appear in this state.
In terms of solubility, it is slightly soluble in water. Water is a polar solvent, and although 2-chloro-1-methyl-4-nitrobenzene molecules contain polar functional groups, as a whole, the non-polar influence of the benzene ring is greater, which makes the interaction between it and water molecules weak and difficult to dissolve in water. However, it is soluble in organic solvents such as ethanol, ether, benzene, etc. This is because these organic solvents and the compound molecules can form similar intermolecular forces, following the principle of "similar miscibility", so they can be better miscible.
The density is slightly larger than that of water, and when placed in water, it will sink to the bottom. This density characteristic is also closely related to its molecular structure. The type and arrangement of atoms in the molecule determine that its unit volume mass is greater than that of water.
What are the chemical properties of 2-chloro-1-methyl-4-nitrobenzene?
2-Chloro-1-methyl-4-nitrobenzene, an organic compound, whose molecular structure contains chlorine atoms, methyl groups and nitro groups, connected to the benzene ring. Its chemical properties are unique and caused by the interaction of each group.
Let's talk about the benzene ring first, which is aromatic, relatively stable, and has a special electron cloud distribution. In the electrophilic substitution reaction, because the methyl group is the power supply group, the electron cloud density of the benzene ring is increased, and it is more vulnerable to the attack of electrophilic reagents; the nitro group is a strong electron-absorbing group, which will reduce the electron cloud density of the benzene ring, especially the ortho and para-position, so that the meta-position is relatively more prone to electrophilic substitution.
The chlorine atom, although it is an ortho-and para-localized group, has a high electronegativity and an electron-absorbing induction effect, which reduces the electron cloud density of the benzene ring. However, its lone pair electron energy conjugates with the benzene ring, and the electron-donating conjugation effect plays a major role, which affects the reactivity and selectivity to a certain extent.
methyl, the electron-donating group, enhances the electron cloud density of the benzene ring, activates the benzene ring, and makes the benzene ring more prone to electrophilic substitution reactions, which mainly occur in the ortho and para-sites.
This compound can participate in many reactions. During electrophilic substitution, each group competes with each other due to the positioning effect of each group. The specific reaction check point depends on the reaction conditions and the activity of the reagent. Under suitable conditions, halogenation, nitrification, sulfonation and other reactions can be carried out. It can also participate in nucleophilic substitution, and chlorine atoms can be replaced by nucleophilic reagents to generate new compounds.
In addition, in the reduction reaction, nitro groups can be reduced to amino groups to obtain new compounds containing amino groups, expanding their use in organic synthesis. Under specific conditions, methyl groups may also participate in the reaction, such as oxidation to carboxyl groups. In short, 2-chloro-1-methyl-4-nitrobenzene is rich in chemical properties and is widely used in the field of organic synthesis.
Let's talk about the benzene ring first, which is aromatic, relatively stable, and has a special electron cloud distribution. In the electrophilic substitution reaction, because the methyl group is the power supply group, the electron cloud density of the benzene ring is increased, and it is more vulnerable to the attack of electrophilic reagents; the nitro group is a strong electron-absorbing group, which will reduce the electron cloud density of the benzene ring, especially the ortho and para-position, so that the meta-position is relatively more prone to electrophilic substitution.
The chlorine atom, although it is an ortho-and para-localized group, has a high electronegativity and an electron-absorbing induction effect, which reduces the electron cloud density of the benzene ring. However, its lone pair electron energy conjugates with the benzene ring, and the electron-donating conjugation effect plays a major role, which affects the reactivity and selectivity to a certain extent.
methyl, the electron-donating group, enhances the electron cloud density of the benzene ring, activates the benzene ring, and makes the benzene ring more prone to electrophilic substitution reactions, which mainly occur in the ortho and para-sites.
This compound can participate in many reactions. During electrophilic substitution, each group competes with each other due to the positioning effect of each group. The specific reaction check point depends on the reaction conditions and the activity of the reagent. Under suitable conditions, halogenation, nitrification, sulfonation and other reactions can be carried out. It can also participate in nucleophilic substitution, and chlorine atoms can be replaced by nucleophilic reagents to generate new compounds.
In addition, in the reduction reaction, nitro groups can be reduced to amino groups to obtain new compounds containing amino groups, expanding their use in organic synthesis. Under specific conditions, methyl groups may also participate in the reaction, such as oxidation to carboxyl groups. In short, 2-chloro-1-methyl-4-nitrobenzene is rich in chemical properties and is widely used in the field of organic synthesis.
What are the main uses of 2-chloro-1-methyl-4-nitrobenzene?
2-Chloro-1-methyl-4-nitrobenzene is an important raw material in the field of organic synthesis. It has a wide range of uses and can be used as a key intermediate in the synthesis of medicines. For example, in the synthesis of some antibacterial drugs, it is used as the starting material and through a series of delicate chemical reactions, the specific chemical structure required by the drug is built, giving the drug antibacterial effect.
In the field of pesticide preparation, this compound also plays an important role. It can be converted into pesticide active ingredients through a specific process to resist crop diseases and insect pests and ensure a bumper grain harvest. For example, the synthesis of some pesticides and fungicides relies on them as the basic raw materials. With their unique chemical properties, pesticides have efficient insecticidal and bactericidal abilities, and have relatively little impact on the environment.
Furthermore, in the dye industry, 2-chloro-1-methyl-4-nitrobenzene can be used to synthesize a variety of dyes with bright colors and excellent fastness. Because of its molecular structure, it can participate in the construction of dye color systems, and react with other compounds to generate dyes with specific colors and dyeing properties. It is widely used in textiles, printing and dyeing and other industries to give rich colors to fabrics.
In addition, in the field of materials science, it has also emerged as a raw material for the synthesis of some high-performance materials. After complex polymerization or modification processes, it can be introduced into the material structure to impart special electrical, optical or mechanical properties to the material, meeting the special needs of high-tech fields such as electronics and optics.
In the field of pesticide preparation, this compound also plays an important role. It can be converted into pesticide active ingredients through a specific process to resist crop diseases and insect pests and ensure a bumper grain harvest. For example, the synthesis of some pesticides and fungicides relies on them as the basic raw materials. With their unique chemical properties, pesticides have efficient insecticidal and bactericidal abilities, and have relatively little impact on the environment.
Furthermore, in the dye industry, 2-chloro-1-methyl-4-nitrobenzene can be used to synthesize a variety of dyes with bright colors and excellent fastness. Because of its molecular structure, it can participate in the construction of dye color systems, and react with other compounds to generate dyes with specific colors and dyeing properties. It is widely used in textiles, printing and dyeing and other industries to give rich colors to fabrics.
In addition, in the field of materials science, it has also emerged as a raw material for the synthesis of some high-performance materials. After complex polymerization or modification processes, it can be introduced into the material structure to impart special electrical, optical or mechanical properties to the material, meeting the special needs of high-tech fields such as electronics and optics.
What are 2-chloro-1-methyl-4-nitrobenzene synthesis methods?
There are several methods for synthesizing 2-chloro-1-methyl-4-nitrobenzene.
First, toluene can be started. First, toluene is nitrified with mixed acid (a mixture of sulfuric acid and nitric acid). The methyl group of toluene is an ortho-para-locator. Under suitable conditions, nitrate will mainly attack the para-position of methyl to generate p-nitrotoluene. This step requires attention to the control of the reaction temperature. Excessive temperature can easily lead to polynitroylation side reactions. Then, the chlorination reaction of p-nitrotoluene is carried out with chlorine gas in the presence of light or initiator. Due to the influence of methyl, the chlorine atom will preferentially replace the hydrogen of the methyl ortho-position, thereby obtaining 2-chloro-1-methyl-4-nitrobenzene. This route step is relatively simple, but the selectivity of the chlorination reaction may be insufficient, or some other chloroisomer impurities may be generated.
Second, it can be started from p-chlorotoluene. First, p-chlorotoluene is nitrified. Although the chlorine atom is an ortho-para-site group, due to steric barrier and electronic effect, the nitro group mainly enters the para-site of the chlorine atom to generate 2-chloro-1-methyl-4-nitrobenzene. The advantage of this path is that the starting material p-chlorotoluene is easier to obtain, and the nitration step is more selective, but the price of p-chlorotoluene may be higher, which affects the cost.
Third, m-nitrotoluene can also be used as a raw material. First, m-nitrotoluene is chlorinated. Because the nitro group is the meta-site group, the chlorine atom will mainly enter the nitro meta-site to generate 2-chloro-3-nitrotoluene. Then through a specific reduction and rearrangement reaction, the nitro group is converted to the 4-position, and finally 2-chloro-1-methyl-4-nitrobenzene is obtained. This method step is slightly complicated, but if the raw material m-nitrotoluene is properly utilized, it can also be a feasible path.
The above synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material availability, cost, and product purity requirements to choose the most suitable solution.
First, toluene can be started. First, toluene is nitrified with mixed acid (a mixture of sulfuric acid and nitric acid). The methyl group of toluene is an ortho-para-locator. Under suitable conditions, nitrate will mainly attack the para-position of methyl to generate p-nitrotoluene. This step requires attention to the control of the reaction temperature. Excessive temperature can easily lead to polynitroylation side reactions. Then, the chlorination reaction of p-nitrotoluene is carried out with chlorine gas in the presence of light or initiator. Due to the influence of methyl, the chlorine atom will preferentially replace the hydrogen of the methyl ortho-position, thereby obtaining 2-chloro-1-methyl-4-nitrobenzene. This route step is relatively simple, but the selectivity of the chlorination reaction may be insufficient, or some other chloroisomer impurities may be generated.
Second, it can be started from p-chlorotoluene. First, p-chlorotoluene is nitrified. Although the chlorine atom is an ortho-para-site group, due to steric barrier and electronic effect, the nitro group mainly enters the para-site of the chlorine atom to generate 2-chloro-1-methyl-4-nitrobenzene. The advantage of this path is that the starting material p-chlorotoluene is easier to obtain, and the nitration step is more selective, but the price of p-chlorotoluene may be higher, which affects the cost.
Third, m-nitrotoluene can also be used as a raw material. First, m-nitrotoluene is chlorinated. Because the nitro group is the meta-site group, the chlorine atom will mainly enter the nitro meta-site to generate 2-chloro-3-nitrotoluene. Then through a specific reduction and rearrangement reaction, the nitro group is converted to the 4-position, and finally 2-chloro-1-methyl-4-nitrobenzene is obtained. This method step is slightly complicated, but if the raw material m-nitrotoluene is properly utilized, it can also be a feasible path.
The above synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material availability, cost, and product purity requirements to choose the most suitable solution.
2-chloro-1-methyl-4-nitrobenzene impact on the environment
2-Chloro-1-methyl-4-nitrobenzene, the impact of this substance on the environment is quite complex and far-reaching.
Its chemical properties are active and difficult to degrade in the environment. If it escapes into the atmosphere, it will be transported by wind, causing the scope of pollution to expand. Because it is volatile, it can be breathed into organisms, damaging the respiratory system, long-term exposure or increasing the risk of cancer.
In water bodies, although the solubility is limited, it can adhere to suspended particles and migrate with water flow. Once ingested, aquatic organisms will accumulate in the body, interfering with their physiological functions, such as hindering growth and development, affecting reproduction, and causing population reduction. Transmitted through the food chain, it will be highly enriched in high nutrient-level organisms and endanger human health.
In soil, it will inhibit soil microbial activities, affect soil ecological balance and material circulation, and then inhibit crop growth, reduce crop yield and quality. And may penetrate into groundwater, pollute groundwater resources, and threaten human drinking water safety.
2-chloro-1-methyl-4-nitrobenzene is harmful to all environmental media, seriously threatening ecological balance and human survival. It needs to be treated with caution to prevent its large-scale release into the environment.
Its chemical properties are active and difficult to degrade in the environment. If it escapes into the atmosphere, it will be transported by wind, causing the scope of pollution to expand. Because it is volatile, it can be breathed into organisms, damaging the respiratory system, long-term exposure or increasing the risk of cancer.
In water bodies, although the solubility is limited, it can adhere to suspended particles and migrate with water flow. Once ingested, aquatic organisms will accumulate in the body, interfering with their physiological functions, such as hindering growth and development, affecting reproduction, and causing population reduction. Transmitted through the food chain, it will be highly enriched in high nutrient-level organisms and endanger human health.
In soil, it will inhibit soil microbial activities, affect soil ecological balance and material circulation, and then inhibit crop growth, reduce crop yield and quality. And may penetrate into groundwater, pollute groundwater resources, and threaten human drinking water safety.
2-chloro-1-methyl-4-nitrobenzene is harmful to all environmental media, seriously threatening ecological balance and human survival. It needs to be treated with caution to prevent its large-scale release into the environment.
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