Linshang Chemical
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2-Chloro-2-Fluorobromobenzene
Linshang Chemical
|
HS Code |
502354 |
| Chemical Formula | C6H3BrClF |
| Appearance | Liquid (expected, no standard data on color) |
| Solubility In Water | Insoluble (common for aryl halides) |
| Solubility In Organic Solvents | Soluble in common organic solvents like benzene, toluene, dichloromethane etc. |
| Vapor Pressure | Low (due to relatively high molecular weight and presence of halogens) |
As an accredited 2-Chloro-2-Fluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle of 2 - chloro - 2 - fluorobromobenzene, well - sealed for storage. |
| Storage | 2 - Chloro - 2 - fluorobromobenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. It should be stored in a tightly - sealed container to prevent vapor leakage. Keep it separate from oxidizing agents, reducing agents, and reactive substances. Store in a dedicated chemical storage cabinet for halogen - containing aromatic compounds to ensure safety and prevent cross - contamination. |
| Shipping | 2 - chloro - 2 - fluorobromobenzene should be shipped in accordance with hazardous chemical regulations. It must be properly packaged in suitable containers, labeled clearly, and transported by carriers approved for such chemicals to ensure safety during transit. |
Competitive 2-Chloro-2-Fluorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Chloro-2-Fluorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 2-chloro-2-fluorobromobenzene?
2-Chloro-2-fluorobromobenzene, this is an organic compound. To understand its chemical structure, we need to look at the benzene ring. The benzene ring is a planar structure of a six-membered ring, which is connected by a conjugated large π bond. Each carbon atom is bonded to a hydrogen atom.
On the basis of the benzene ring, in "2-chloro-2-fluorobromobenzene", "2-chlorine" means the hydrogen atom on the second carbon atom of the benzene ring, which is replaced by the chlorine atom; "2-fluorine" means that on the second carbon atom, there is also a fluorine atom that replaces the original hydrogen atom; and "bromobenzene" indicates that there is still a bromine atom on the benzene ring that replaces a certain hydrogen atom. Although the specific position of the bromine atom is not clearly indicated, according to the naming rules, in the case where there are two substitutions based on the 2 position, the bromine atom is either in the 3 position carbon adjacent to the 2 position, or in the 4 position carbon of the intermediate position, Carbon 5.
Overall, the chemical structure of 2-chloro-2-fluorobromobenzene is based on the benzene ring, with chlorine and fluorine atoms connected to the second carbon of the benzene ring, and a bromine atom connected to other positions of the benzene ring (one of the 3, 4, and 5 carbons). The determination of its structure depends on the naming rules of organic chemistry, which are rigorous and orderly, providing clear guidelines for the analysis and expression of the structure of organic compounds.
On the basis of the benzene ring, in "2-chloro-2-fluorobromobenzene", "2-chlorine" means the hydrogen atom on the second carbon atom of the benzene ring, which is replaced by the chlorine atom; "2-fluorine" means that on the second carbon atom, there is also a fluorine atom that replaces the original hydrogen atom; and "bromobenzene" indicates that there is still a bromine atom on the benzene ring that replaces a certain hydrogen atom. Although the specific position of the bromine atom is not clearly indicated, according to the naming rules, in the case where there are two substitutions based on the 2 position, the bromine atom is either in the 3 position carbon adjacent to the 2 position, or in the 4 position carbon of the intermediate position, Carbon 5.
Overall, the chemical structure of 2-chloro-2-fluorobromobenzene is based on the benzene ring, with chlorine and fluorine atoms connected to the second carbon of the benzene ring, and a bromine atom connected to other positions of the benzene ring (one of the 3, 4, and 5 carbons). The determination of its structure depends on the naming rules of organic chemistry, which are rigorous and orderly, providing clear guidelines for the analysis and expression of the structure of organic compounds.
What are the physical properties of 2-chloro-2-fluorobromobenzene?
2-Chloro-2-fluorobromobenzene is a kind of organic compound. Its physical properties are particularly important, and it is related to its behavior in various chemical processes and practical applications.
First of all, its appearance is often colorless to light yellow liquid, clear and has a special smell. Although this smell is not strongly pungent, it is also unique and can be slightly identified by the sense of smell. Its density is heavier than water, about a certain value, so that when mixed with water, it will sink to the bottom.
As for the boiling point, it is within a certain temperature range. At this temperature, the substance changes from liquid to gaseous state. The exact value of the boiling point varies according to its purity and external pressure. Generally speaking, under standard atmospheric pressure, the boiling point falls in a certain range, which allows it to be separated from other substances in separation and purification operations such as distillation.
Melting point also has a specific value. When the temperature drops below the melting point, 2-chloro-2-fluorobrobenzene will solidify from liquid to solid. This melting point is one of the important indicators for identifying and identifying the substance.
Solubility is also an important physical property. In organic solvents, such as ethanol, ether, etc., it exhibits good solubility and can dissolve with it to form a uniform solution. However, in water, its solubility is extremely low and almost insoluble, which is due to the significant difference between the molecular structure of the compound and the polarity of the water molecule.
In addition, 2-chloro-2-fluorobromobenzene is moderately volatile. Although it is not highly volatile, it will gradually evaporate into the air under certain conditions. This volatility should be paid attention to during storage and use to prevent its escape from causing loss or harm.
First of all, its appearance is often colorless to light yellow liquid, clear and has a special smell. Although this smell is not strongly pungent, it is also unique and can be slightly identified by the sense of smell. Its density is heavier than water, about a certain value, so that when mixed with water, it will sink to the bottom.
As for the boiling point, it is within a certain temperature range. At this temperature, the substance changes from liquid to gaseous state. The exact value of the boiling point varies according to its purity and external pressure. Generally speaking, under standard atmospheric pressure, the boiling point falls in a certain range, which allows it to be separated from other substances in separation and purification operations such as distillation.
Melting point also has a specific value. When the temperature drops below the melting point, 2-chloro-2-fluorobrobenzene will solidify from liquid to solid. This melting point is one of the important indicators for identifying and identifying the substance.
Solubility is also an important physical property. In organic solvents, such as ethanol, ether, etc., it exhibits good solubility and can dissolve with it to form a uniform solution. However, in water, its solubility is extremely low and almost insoluble, which is due to the significant difference between the molecular structure of the compound and the polarity of the water molecule.
In addition, 2-chloro-2-fluorobromobenzene is moderately volatile. Although it is not highly volatile, it will gradually evaporate into the air under certain conditions. This volatility should be paid attention to during storage and use to prevent its escape from causing loss or harm.
What are the main uses of 2-chloro-2-fluorobromobenzene?
2-Chloro-2-fluorobromobenzene, an organic compound, has a wide range of uses and is of great significance in many fields.
In the field of organic synthesis, it is a key intermediate. With its special molecular structure, it can participate in many chemical reactions. For example, nucleophilic substitution reactions, halogen atoms can be replaced by other functional groups to build complex organic molecular structures. Chemists use this to expand molecular diversity and synthesize various organic compounds with specific properties and functions, such as drugs, materials and other fields.
It also plays an important role in the field of drug development. Pharmaceutical chemists use it as a starting material to modify molecules through a series of reactions, aiming to obtain compounds with specific biological activities. By modifying and optimizing its structure, effective drugs targeting specific disease targets may be found, contributing to the cause of human health.
In the field of materials science, 2-chloro-2-fluorobromobenzene can be used to prepare materials with special properties. After polymerization with other monomers, polymer materials with unique electrical, optical or mechanical properties may be prepared. Such materials may exhibit excellent properties in electronic devices, optical instruments and other fields, promoting the development and progress of related technologies.
2-chloro-2-fluorobromobenzene, as an important organic compound, plays an indispensable role in the fields of organic synthesis, drug development, and materials science, providing key support and motivation for the development of many fields.
In the field of organic synthesis, it is a key intermediate. With its special molecular structure, it can participate in many chemical reactions. For example, nucleophilic substitution reactions, halogen atoms can be replaced by other functional groups to build complex organic molecular structures. Chemists use this to expand molecular diversity and synthesize various organic compounds with specific properties and functions, such as drugs, materials and other fields.
It also plays an important role in the field of drug development. Pharmaceutical chemists use it as a starting material to modify molecules through a series of reactions, aiming to obtain compounds with specific biological activities. By modifying and optimizing its structure, effective drugs targeting specific disease targets may be found, contributing to the cause of human health.
In the field of materials science, 2-chloro-2-fluorobromobenzene can be used to prepare materials with special properties. After polymerization with other monomers, polymer materials with unique electrical, optical or mechanical properties may be prepared. Such materials may exhibit excellent properties in electronic devices, optical instruments and other fields, promoting the development and progress of related technologies.
2-chloro-2-fluorobromobenzene, as an important organic compound, plays an indispensable role in the fields of organic synthesis, drug development, and materials science, providing key support and motivation for the development of many fields.
What are 2-chloro-2-fluorobromobenzene synthesis methods?
To prepare 2-chloro-2-fluorobromobenzene, there are three methods.
First, it starts with o-bromobenzoic acid, and first coheats with thionyl chloride to obtain o-bromobenzoyl chloride. Later, hydrogen fluoride gas is passed through, and chlorine is exchanged for fluorine to obtain o-bromobenzoyl fluoride. Then magnesium metal and anhydrous ether are used to make Grignard reagent, which reacts with carbon dioxide and acidifies to obtain 2-fluoro-2-bromobenzoic acid. Finally, phosphorus trichloride or phosphorus pentachloride is used to change the carboxyl group into chlorine, and then the target product is obtained. Although there are many steps in this process, the reaction conditions of each step are clear, and the product purity is also good
Second, use o-bromochlorobenzene as the starting material. First, it reacts with n-butyl lithium at low temperature to form an active intermediate, and then quickly introduces fluorine-containing reagents, such as silver trifluoromethanesulfonate, etc., and introduces fluorine atoms through substitution reaction. Subsequent bromination reactions introduce bromine atoms at the ortho position to achieve the synthesis of 2-chloro-2-fluorobromobenzene. The key to this path is to control the low temperature reaction conditions and the reaction sequence of each step to ensure the selectivity of the reaction.
Third, use o-bromoaniline as the raw material. It is first diazotized to obtain diazonium salts, and then reacted with cuprous chloride, resulting in a Sandmeier reaction to replace the amino group with chlorine to obtain o-bromochlorobenzene. Then fluorine and bromine are introduced according to the above-mentioned second path, and 2-chloro-2-fluorobromobenzene is finally obtained. The starting material of this route is easy to obtain, but the diazotization reaction needs to be handled carefully to prevent accidents.
All synthesis methods have advantages and disadvantages. In practical application, the best one should be chosen according to the availability of raw materials, cost and requirements for product purity.
First, it starts with o-bromobenzoic acid, and first coheats with thionyl chloride to obtain o-bromobenzoyl chloride. Later, hydrogen fluoride gas is passed through, and chlorine is exchanged for fluorine to obtain o-bromobenzoyl fluoride. Then magnesium metal and anhydrous ether are used to make Grignard reagent, which reacts with carbon dioxide and acidifies to obtain 2-fluoro-2-bromobenzoic acid. Finally, phosphorus trichloride or phosphorus pentachloride is used to change the carboxyl group into chlorine, and then the target product is obtained. Although there are many steps in this process, the reaction conditions of each step are clear, and the product purity is also good
Second, use o-bromochlorobenzene as the starting material. First, it reacts with n-butyl lithium at low temperature to form an active intermediate, and then quickly introduces fluorine-containing reagents, such as silver trifluoromethanesulfonate, etc., and introduces fluorine atoms through substitution reaction. Subsequent bromination reactions introduce bromine atoms at the ortho position to achieve the synthesis of 2-chloro-2-fluorobromobenzene. The key to this path is to control the low temperature reaction conditions and the reaction sequence of each step to ensure the selectivity of the reaction.
Third, use o-bromoaniline as the raw material. It is first diazotized to obtain diazonium salts, and then reacted with cuprous chloride, resulting in a Sandmeier reaction to replace the amino group with chlorine to obtain o-bromochlorobenzene. Then fluorine and bromine are introduced according to the above-mentioned second path, and 2-chloro-2-fluorobromobenzene is finally obtained. The starting material of this route is easy to obtain, but the diazotization reaction needs to be handled carefully to prevent accidents.
All synthesis methods have advantages and disadvantages. In practical application, the best one should be chosen according to the availability of raw materials, cost and requirements for product purity.
2-chloro-2-fluorobromobenzene what are the precautions during storage and transportation?
2-Chloro-2-fluorobromobenzene is an organic compound. During storage and transportation, many matters need to be paid attention to.
The first safety protection. This compound is toxic and irritating, and contact can cause human damage. When storing, operators must wear appropriate protective equipment, such as protective clothing, gloves, protective glasses and gas masks, to prevent skin, eye contact and inhalation of its volatile gases. During transportation, transportation personnel should also strictly abide by safety procedures and avoid direct contact.
The second is the storage condition. It should be placed in a cool and well-ventilated place, away from fire and heat sources. Because it is easy to decompose when heated, it produces toxic and corrosive gases, so the temperature should be controlled at a low level, and the warehouse should be well ventilated to prevent gas accumulation. It needs to be stored separately from oxidants, acids, alkalis, etc., and should not be mixed. Because of the violent chemical reaction with these substances, it may cause fires, explosions and other accidents.
Then transport the packaging. The packaging must be tight to ensure that there is no risk of leakage. The packaging materials used should have good corrosion resistance and sealing to resist the erosion of 2-chloro-2-fluorobromobenzene. The transportation vehicle should also be equipped with corresponding fire equipment and leakage emergency treatment equipment. In the event of leakage, it can be responded to in time. During transportation, it is necessary to follow the specified route to avoid densely populated areas and traffic arteries to reduce the risk of accidents.
In addition, whether it is storage or transportation, it is necessary to strictly record. Records include the quantity of compounds, time of entry and exit, transportation routes and other information for traceability and management. In the event of leakage, fire and other accidents, it is necessary to report to relevant departments in a timely manner and take effective measures to deal with them to minimize harm.
The first safety protection. This compound is toxic and irritating, and contact can cause human damage. When storing, operators must wear appropriate protective equipment, such as protective clothing, gloves, protective glasses and gas masks, to prevent skin, eye contact and inhalation of its volatile gases. During transportation, transportation personnel should also strictly abide by safety procedures and avoid direct contact.
The second is the storage condition. It should be placed in a cool and well-ventilated place, away from fire and heat sources. Because it is easy to decompose when heated, it produces toxic and corrosive gases, so the temperature should be controlled at a low level, and the warehouse should be well ventilated to prevent gas accumulation. It needs to be stored separately from oxidants, acids, alkalis, etc., and should not be mixed. Because of the violent chemical reaction with these substances, it may cause fires, explosions and other accidents.
Then transport the packaging. The packaging must be tight to ensure that there is no risk of leakage. The packaging materials used should have good corrosion resistance and sealing to resist the erosion of 2-chloro-2-fluorobromobenzene. The transportation vehicle should also be equipped with corresponding fire equipment and leakage emergency treatment equipment. In the event of leakage, it can be responded to in time. During transportation, it is necessary to follow the specified route to avoid densely populated areas and traffic arteries to reduce the risk of accidents.
In addition, whether it is storage or transportation, it is necessary to strictly record. Records include the quantity of compounds, time of entry and exit, transportation routes and other information for traceability and management. In the event of leakage, fire and other accidents, it is necessary to report to relevant departments in a timely manner and take effective measures to deal with them to minimize harm.
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