2-Chloro-3,5-Dibromo-1-Fluorobenzene

Linshang Chemical

Specifications

HS Code

994288

Chemical Formula C6H2Br2ClF
Molecular Weight 290.34
Appearance Solid (usually)
Physical State At Room Temp Solid
Odor Typical halogenated benzene odor
Melting Point Specific value would require literature search
Boiling Point Specific value would require literature search
Density Specific value would require literature search
Solubility In Water Low (organic halide, relatively non - polar)
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Flash Point Specific value would require literature search
Vapor Pressure Low due to being a solid at room temp

As an accredited 2-Chloro-3,5-Dibromo-1-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 2 - chloro - 3,5 - dibromo - 1 - fluorobenzene in a sealed chemical - grade bottle.
Storage 2 - chloro - 3,5 - dibromo - 1 - fluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions.
Shipping 2 - chloro - 3,5 - dibromo - 1 - fluorobenzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling, secure packaging to prevent leakage during transit.
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2-Chloro-3,5-Dibromo-1-Fluorobenzene 2-Chloro-3,5-Dibromo-1-Fluorobenzene
General Information
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Frequently Asked Questions

As a leading 2-Chloro-3,5-Dibromo-1-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 2-chloro-3, 5-dibromo-1-fluorobenzene?
2-Chloro-3,5-dibromo-1-fluorobenzene, an organohalogenated aromatic hydrocarbon. Its chemical properties are unique and closely related to many chemical reactions. It is described as follows:
Nucleophilic Substitution Reaction: Halogen atoms can be replaced by nucleophilic reagents. Chlorine, bromine, and fluorine atoms all have certain activities. Among them, fluorine atoms have high C-F bond energy due to their high electronegativity and are relatively difficult to replace; while chlorine and bromine atoms are relatively easy to be replaced. For example, under appropriate alkali and solvent conditions, hydroxy (-OH), amino (-NH ²) and other nucleophiles can attack the carbon atoms of the halogen atoms on the benzene ring, and the halogen atoms leave to form corresponding substitution products. If co-heated with sodium hydroxide aqueous solution, chlorine and bromine atoms may be replaced by hydroxyl groups to obtain phenolic compounds; when reacted with ammonia or amine, nitrogen-containing derivatives can be formed.
Aromatic electrophilic substitution reaction: The benzene ring is electron-rich and prone to electrophilic substitution. However, because the chlorine, bromine, and fluorine atoms are all electron-withdrawing groups, the electron cloud density of the benzene ring will decrease, and the reactivity will decrease compared with benzene. In terms of localization effect, they are both ortho and para-localizers, and new electrophilic reagents tend to enter the ortho and para-sites of halogen atoms. If nitrification occurs, nitro (-NO ³) mainly enters the ortho and para-sites of chlorine, bromine, and fluorine atoms to form nitro substitutions.
Reduction Reaction: Halogen atoms can be reduced and removed under the action of specific reducing agents. For example, the use of a system composed of metal zinc and an acid (such as hydrochloric acid) can gradually replace halogen atoms with hydrogen atoms, and finally the halogen atoms on the benzene ring are reduced, resulting in a reduction product.
Mutual conversion between halogen atoms: Under certain special reagents and conditions, different halogen atoms can be converted into each other. For example, chlorine atoms can be converted into bromine atoms through specific halogenation reagents and reaction conditions, or vice versa, the type of halogen atoms can be adjusted to meet different synthesis needs.
2-chloro-3,5-dibromo-1-fluorobenzene is widely used in the field of organic synthesis due to these chemical properties, and can be used to prepare a variety of organic compounds, such as pharmaceutical intermediates, material intermediates, etc.
What are the physical properties of 2-chloro-3, 5-dibromo-1-fluorobenzene?
2-Chloro-3,5-dibromo-1-fluorobenzene is also an organic halogenated aromatic compound. Its physical properties are quite unique, let me tell them one by one.
Looking at its appearance, under normal circumstances, it is mostly colorless to light yellow liquid, clear and with a certain fluidity. The cause of this state is due to the interaction between the rigidity of the benzene ring and the characteristics of the halogen atom in its molecular structure, which makes the intermolecular force moderate, so that it does not condense into a solid state, nor does it reach the looseness of the gaseous state.
Smell its smell, often emitting a pungent smell. The introduction of halogen atoms causes the chemical activity of the molecule to change. This pungent smell is a manifestation of its chemical properties in the senses, warning everyone that it has a certain irritation.
As for the melting point and boiling point, the melting point value is quite low, usually several degrees Celsius below zero. This is because although the halogen atom increases the molecular weight, the benzene ring structure prevents the molecule from being closely arranged, and the lattice energy is reduced, so the melting point is not high. The boiling point is relatively high, or above 100 degrees Celsius. Because the halogen atom increases the intermolecular force, and the benzene ring conjugate system enhances the stability of the molecule, more energy is required to overcome the attractive force between molecules.
In terms of density, the halogen atom has a larger relative atomic weight, which makes it denser than water. When it is mixed with water, it can be seen that it sinks to the bottom of the water, which is an important feature of separation and identification.
In terms of solubility, the solubility in water is very small. Water is a polar molecule, and this compound has a weak overall polarity due to the non-polarity of the benzene ring and the weak polarity of the halogen atom. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, in organic solvents, such as ethanol, ether, dichloromethane, etc., the solubility is quite good. The non-polar or weak polarity of the organic solvent is compatible with the compound, and interactions such as van der Waals forces can be formed between the molecules, resulting in mutual miscibility.
The physical properties of 2-chloro-3,5-dibromo-1-fluorobenzene are of great significance in organic synthesis, chemical production and related research fields, providing a basis for its application and treatment.
What are the main uses of 2-chloro-3, 5-dibromo-1-fluorobenzene?
2-Chloro-3,5-dibromo-1-fluorobenzene is an important category of organic compounds. It has a wide range of uses, especially in the field of pharmaceutical synthesis. The compound has a unique structure and can be used as a key intermediate to prepare various specific drugs. For example, some antibacterial and antiviral agents, the synthesis process often relies on this as the starting material. Through delicate chemical reactions, complex drug molecular structures are constructed to achieve the purpose of treating diseases.
In the field of pesticide creation, 2-chloro-3,5-dibromo-1-fluorobenzene also plays a pivotal role. It can be converted into highly efficient pesticides, fungicides and other pesticide products by a specific reaction path. Such pesticides can precisely act on pests, inhibit their growth and reproduction, thereby protecting the robust growth of crops and ensuring a bumper harvest in agriculture.
Furthermore, in the field of materials science, this compound has also emerged. Due to its special chemical properties, it can participate in the preparation of functional materials with excellent performance. For example, some materials with special optical and electrical properties, 2-chloro-3,5-dibromo-1-fluorobenzene, are indispensable in their synthesis steps, endowing materials with unique physical and chemical properties to meet the special needs of materials in different fields.
In conclusion, although 2-chloro-3,5-dibromo-1-fluorobenzene is an organic compound, it plays a key role in many fields such as medicine, pesticides, materials, and has a profound impact on human life and industrial development.
What are the synthesis methods of 2-chloro-3, 5-dibromo-1-fluorobenzene?
The method for preparing 2-chloro-3,5-dibromo-1-fluorobenzene follows the following methods.
First, fluorobenzene is used as the starting material. The bromination reaction of shilling fluorobenzene requires careful selection of brominating reagents, such as liquid bromine, and iron or iron tribromide is used as the catalyst. Under suitable temperature and reaction conditions, bromine atoms will enter the adjacent and para-position of fluorine atoms on the benzene ring. After careful regulation of the reaction process and the proportion of materials, 3,5-dibromo-1-fluorobenzene can be obtained. Subsequently, 3,5-dibromo-1-fluorobenzene is chlorinated again. The chlorination reagent can be chlorine gas or tert-butyl hypochlorite, etc. In a specific reaction environment, chlorine atoms can be introduced into the benzene ring to obtain 2-chloro-3,5-dibromo-1-fluorobenzene. The key to this route lies in the precise control of the reaction conditions at each step to avoid side reactions.
Second, chlorobenzene can also be used as the starting material. First fluoride the chlorobenzene, select a suitable fluorination reagent, such as potassium fluoride, and add a phase transfer catalyst to facilitate the reaction. 1-chloro-2-fluorobenzene can be obtained through this step. After that, the bromination reaction of 1-chloro-2-fluorobenzene is carried out, and bromine is used as the bromine source. Under the action of the catalyst, bromine atoms will enter the benzene ring. After adjusting the reaction conditions, bromine atoms can mainly enter the 3,5-position, so as to obtain the target product 2-chloro-3,5-dibromo-1-fluorobenzene. This path requires attention to the efficiency and selectivity of the fluorination reaction, and the control of the reaction check point in the bromination step.
Or, you can start with 2-chloro-1-fluorobenzene. Through bromination reaction, in a suitable reaction system, bromine and catalyst are used to promote the reaction. After fine regulation, bromine atoms are introduced into the 3,5-position of the benzene ring to achieve the synthesis of 2-chloro-3,5-dibromo-1-fluorobenzene. The key to this approach lies in the optimization of bromination reaction conditions to ensure the purity and yield of the product.
All such synthesis methods need to carefully consider the reaction conditions, reagents, and catalyst effects. After each step of the reaction, separation and purification should be carried out to obtain high-purity 2-chloro-3,5-dibromo-1-fluorobenzene.
What are the precautions for storage and transportation of 2-chloro-3, 5-dibromo-1-fluorobenzene?
2-Chloro-3,5-dibromo-1-fluorobenzene is an organic compound. When storing and transporting it, you must pay attention to the following matters:
First, when storing, choose a cool, dry and well-ventilated place. This compound is easy to decompose when heated, and the high temperature environment may cause changes in its chemical properties, which can cause danger. If placed in a humid place or reacts with moisture, the quality will be damaged. Furthermore, keep away from fires and heat sources. Because the compound may be flammable, it will encounter open flames, hot topics or cause combustion or even explosions.
Second, the choice of storage container is crucial. It is advisable to use corrosion-resistant materials, such as glass or containers made of specific plastic materials. Because 2-chloro-3,5-dibromo-1-fluorobenzene contains halogen atoms, it is corrosive to a certain extent, and ordinary metal containers may be corroded, resulting in damage to the container and leakage of compounds. And the container must be tightly sealed to prevent volatilization from escaping, polluting the environment and endangering personal safety.
Third, when transporting, it must be strictly operated in accordance with the relevant regulations on the transportation of hazardous chemicals. It needs to be properly packaged to ensure that it is not damaged and leaked due to bumps and collisions during transportation. Transportation vehicles should also be equipped with corresponding fire protection equipment and leakage emergency treatment equipment to prevent accidents.
Fourth, whether it is storage or transportation, it must be managed and supervised by a special person. Management personnel should be familiar with the characteristics, hazards and emergency treatment measures of the compound. In the event of a leak and other accidents, they can respond quickly and effectively to reduce the harm.
In short, the storage and transportation of 2-chloro-3,5-dibromo-1-fluorobenzene must be treated with caution, and the relevant norms and requirements must be strictly followed to ensure that personnel safety and the environment are not damaged.