Linshang Chemical
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2-Chloro-3,5-Difluoronitrobenzene
Linshang Chemical
|
HS Code |
856043 |
| Chemical Formula | C6H2ClF2NO2 |
| Molecular Weight | 193.536 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 203 - 205 °C |
| Density | Approx. 1.58 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone |
| Flash Point | Around 81 °C |
| Vapor Pressure | Low vapor pressure at room temperature |
| Odor | Pungent odor |
As an accredited 2-Chloro-3,5-Difluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250 - gram bottle of 2 - chloro - 3,5 - difluoronitrobenzene, well - sealed for safety. |
| Storage | 2 - chloro - 3,5 - difluoronitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store it in a tightly closed container, preferably made of corrosion - resistant materials. This is to prevent decomposition, leakage, and potential reactions that could pose safety risks. |
| Shipping | 2 - chloro - 3,5 - difluoronitrobenzene is a chemical. Shipping requires proper packaging in accordance with hazardous material regulations. It must be labeled clearly, transported by approved carriers, and handled with care to prevent spills and ensure safety. |
Competitive 2-Chloro-3,5-Difluoronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Chloro-3,5-Difluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 2-chloro-3, 5-difluoronitrobenzene
2-Chloro-3,5-difluoronitrobenzene is an important intermediate in organic synthesis and has a wide range of uses.
It plays a key role in the field of medicine. The preparation of many new antibacterial and antiviral drugs often starts with 2-chloro-3,5-difluoronitrobenzene. Due to its unique chemical structure, it can introduce specific functional groups and construct the active core structure of the drug through multi-step reactions. For example, chlorine or fluorine atoms can be replaced by other biologically active groups through nucleophilic substitution reactions, thereby optimizing the molecular properties of the drug and enhancing its affinity and pharmacological activity to specific targets.
In the field of pesticides, 2-chloro-3,5-difluoronitrobenzene is also indispensable. The synthesis of some high-efficiency and low-toxicity pesticides depends on this. By modifying its structure, pesticides that target specific pests or weeds can be prepared. For example, by adjusting the surrounding substituents of nitro and halogen atoms, the mechanism of action and biological activity of pesticides can be changed, making them more selective and durable, improving the control effect, and reducing the impact on the environment and non-target organisms.
In the field of materials science, 2-chloro-3,5-difluoronitrobenzene can be used to synthesize organic materials with special properties. Because of its nitro and halogen atoms, it imparts high reactivity and electronic properties to molecules. On this basis, through polymerization or other reactions, materials with unique optical and electrical properties can be prepared, such as luminescent materials and semiconductor materials used in the field of organic optoelectronics, which open up new paths for the development of materials science.
In short, 2-chloro-3,5-difluoronitrobenzene has important uses in many fields such as medicine, pesticides and materials science due to its special structure and reactivity, and is of great significance to promote the development of related industries.
It plays a key role in the field of medicine. The preparation of many new antibacterial and antiviral drugs often starts with 2-chloro-3,5-difluoronitrobenzene. Due to its unique chemical structure, it can introduce specific functional groups and construct the active core structure of the drug through multi-step reactions. For example, chlorine or fluorine atoms can be replaced by other biologically active groups through nucleophilic substitution reactions, thereby optimizing the molecular properties of the drug and enhancing its affinity and pharmacological activity to specific targets.
In the field of pesticides, 2-chloro-3,5-difluoronitrobenzene is also indispensable. The synthesis of some high-efficiency and low-toxicity pesticides depends on this. By modifying its structure, pesticides that target specific pests or weeds can be prepared. For example, by adjusting the surrounding substituents of nitro and halogen atoms, the mechanism of action and biological activity of pesticides can be changed, making them more selective and durable, improving the control effect, and reducing the impact on the environment and non-target organisms.
In the field of materials science, 2-chloro-3,5-difluoronitrobenzene can be used to synthesize organic materials with special properties. Because of its nitro and halogen atoms, it imparts high reactivity and electronic properties to molecules. On this basis, through polymerization or other reactions, materials with unique optical and electrical properties can be prepared, such as luminescent materials and semiconductor materials used in the field of organic optoelectronics, which open up new paths for the development of materials science.
In short, 2-chloro-3,5-difluoronitrobenzene has important uses in many fields such as medicine, pesticides and materials science due to its special structure and reactivity, and is of great significance to promote the development of related industries.
2-Chloro-3, what are the physical properties of 5-difluoronitrobenzene
2-Chloro-3,5-difluoronitrobenzene is one of the organic compounds. Its physical properties are quite impressive, and it is related to various chemical applications.
Looking at its properties, under normal temperature and pressure, it is mostly in a liquid state, which is convenient for many reactions and operations. Its color may be colorless to light yellow. When it is pure, it is nearly colorless. If there are a little impurities, it will be light yellow. This change in color can be used to determine the purity.
When it comes to boiling point, it is about a specific temperature range. The value of boiling point varies depending on the testing environment and method, or is slightly different, but it is roughly within a certain range. The boiling point is related to the separation of distillation. If you want to separate and purify this compound from the mixed system, the boiling point is the key parameter. It can be set according to the appropriate temperature, so that 2-chloro-3,5-difluoronitrobenzene is gasified and then condensed to collect, to achieve the purpose of separation.
Melting point is also an important physical property. The melting point of this product or at a specific temperature, the measurement of the melting point can help determine its purity and crystallization characteristics. The melting point of the pure product is relatively fixed. If it contains impurities, the melting point may decrease and the melting range may be widened. With this, the quality can be tested.
Furthermore, the density cannot be ignored. Its density is specific, and in many reactions and storage, the density depends on the ratio of the material and the choice of container. If you participate in the reaction, you can accurately know the density, and you can accurately measure the volume to determine the amount of the substance, so as to ensure that the reaction proceeds as expected.
In terms of solubility, it may have a certain solubility in organic solvents such as ethanol and ether. This property is extremely important in organic synthesis. Many reactions need to take place in the solution system. A suitable solvent can promote the contact of the reactants and speed up the reaction rate. In water, its solubility is poor, which is related to the chlorine, fluorine, nitro and other groups contained in the molecular structure. These groups make the molecular polarity different from water, so it is difficult to dissolve.
To sum up, the physical properties of 2-chloro-3,5-difluoronitrobenzene, such as properties, boiling point, melting point, density, solubility, etc., are of indispensable significance in chemical synthesis, separation and purification, and quality testing. It is an important research content in the field of organic chemistry.
Looking at its properties, under normal temperature and pressure, it is mostly in a liquid state, which is convenient for many reactions and operations. Its color may be colorless to light yellow. When it is pure, it is nearly colorless. If there are a little impurities, it will be light yellow. This change in color can be used to determine the purity.
When it comes to boiling point, it is about a specific temperature range. The value of boiling point varies depending on the testing environment and method, or is slightly different, but it is roughly within a certain range. The boiling point is related to the separation of distillation. If you want to separate and purify this compound from the mixed system, the boiling point is the key parameter. It can be set according to the appropriate temperature, so that 2-chloro-3,5-difluoronitrobenzene is gasified and then condensed to collect, to achieve the purpose of separation.
Melting point is also an important physical property. The melting point of this product or at a specific temperature, the measurement of the melting point can help determine its purity and crystallization characteristics. The melting point of the pure product is relatively fixed. If it contains impurities, the melting point may decrease and the melting range may be widened. With this, the quality can be tested.
Furthermore, the density cannot be ignored. Its density is specific, and in many reactions and storage, the density depends on the ratio of the material and the choice of container. If you participate in the reaction, you can accurately know the density, and you can accurately measure the volume to determine the amount of the substance, so as to ensure that the reaction proceeds as expected.
In terms of solubility, it may have a certain solubility in organic solvents such as ethanol and ether. This property is extremely important in organic synthesis. Many reactions need to take place in the solution system. A suitable solvent can promote the contact of the reactants and speed up the reaction rate. In water, its solubility is poor, which is related to the chlorine, fluorine, nitro and other groups contained in the molecular structure. These groups make the molecular polarity different from water, so it is difficult to dissolve.
To sum up, the physical properties of 2-chloro-3,5-difluoronitrobenzene, such as properties, boiling point, melting point, density, solubility, etc., are of indispensable significance in chemical synthesis, separation and purification, and quality testing. It is an important research content in the field of organic chemistry.
What are the synthesis methods of 2-chloro-3, 5-difluoronitrobenzene
The synthesis of 2-chloro-3,5-difluoronitrobenzene is an important topic in the field of organic synthesis. In the past, there were mainly the following methods for preparing this compound.
First, 3,5-difluoronitrobenzene was used as the starting material to react with chlorination reagents under suitable conditions. Commonly used chlorination reagents such as chlorine gas, sulfoxide chloride, etc. Taking chlorine gas as an example, in the presence of light or catalyst, chlorine gas and 3,5-difluoronitrobenzene undergo free radical substitution reaction, and chlorine atoms replace hydrogen atoms on the benzene ring, thereby generating 2-chloro-3,5-difluoronitrobenzene. However, this method requires attention to the control of the reaction conditions. The light intensity, reaction temperature and chlorine gas entry rate all have a great influence on the reaction. If the conditions are improper, it is easy to cause the formation of polychlorinated by-products, which affects the purity and yield of the products.
Second, starting from 2-chloro-3,5-difluoroaniline, it is prepared by a series of reactions such as diazotization and nitrification. First, 2-chloro-3,5-difluoroaniline is diazotized with sodium nitrite and inorganic acids (such as hydrochloric acid) at low temperature to form diazonium salts. After that, the diazonium salt reacts with nitrifying reagents (such as mixed acids of nitric acid and sulfuric acid) under specific conditions to introduce nitro groups to obtain the target product 2-chloro-3,5-difluoronitrobenzene. Although this route has a little more steps, the reaction selectivity of each step is relatively good, which can effectively reduce side reactions. However, the diazotization reaction requires strict control of temperature, usually between 0-5 ° C, to prevent the decomposition of diazonium salts, and the operation requirements are relatively strict.
Third, the coupling reaction strategy of transition metal catalysis is adopted. Using halogenated aromatics containing chlorine and fluorine as substrates, under the action of transition metal catalysts (such as palladium, copper and other catalysts) and ligands, the coupling reaction occurs with nitrogenation reagents. Such methods have the advantages of mild reaction conditions and high selectivity. However, the high cost of transition metal catalysts and the complex synthesis of partial distributors limit their large-scale industrial applications to a certain extent.
All methods for synthesizing 2-chloro-3,5-difluoronitrobenzene have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material cost, reaction conditions, product purity and yield according to specific needs to choose the most suitable synthesis path.
First, 3,5-difluoronitrobenzene was used as the starting material to react with chlorination reagents under suitable conditions. Commonly used chlorination reagents such as chlorine gas, sulfoxide chloride, etc. Taking chlorine gas as an example, in the presence of light or catalyst, chlorine gas and 3,5-difluoronitrobenzene undergo free radical substitution reaction, and chlorine atoms replace hydrogen atoms on the benzene ring, thereby generating 2-chloro-3,5-difluoronitrobenzene. However, this method requires attention to the control of the reaction conditions. The light intensity, reaction temperature and chlorine gas entry rate all have a great influence on the reaction. If the conditions are improper, it is easy to cause the formation of polychlorinated by-products, which affects the purity and yield of the products.
Second, starting from 2-chloro-3,5-difluoroaniline, it is prepared by a series of reactions such as diazotization and nitrification. First, 2-chloro-3,5-difluoroaniline is diazotized with sodium nitrite and inorganic acids (such as hydrochloric acid) at low temperature to form diazonium salts. After that, the diazonium salt reacts with nitrifying reagents (such as mixed acids of nitric acid and sulfuric acid) under specific conditions to introduce nitro groups to obtain the target product 2-chloro-3,5-difluoronitrobenzene. Although this route has a little more steps, the reaction selectivity of each step is relatively good, which can effectively reduce side reactions. However, the diazotization reaction requires strict control of temperature, usually between 0-5 ° C, to prevent the decomposition of diazonium salts, and the operation requirements are relatively strict.
Third, the coupling reaction strategy of transition metal catalysis is adopted. Using halogenated aromatics containing chlorine and fluorine as substrates, under the action of transition metal catalysts (such as palladium, copper and other catalysts) and ligands, the coupling reaction occurs with nitrogenation reagents. Such methods have the advantages of mild reaction conditions and high selectivity. However, the high cost of transition metal catalysts and the complex synthesis of partial distributors limit their large-scale industrial applications to a certain extent.
All methods for synthesizing 2-chloro-3,5-difluoronitrobenzene have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material cost, reaction conditions, product purity and yield according to specific needs to choose the most suitable synthesis path.
2-Chloro-3, 5-difluoronitrobenzene what to pay attention to when storing and transporting
2-Chloro-3,5-difluoronitrobenzene is an important intermediate in organic synthesis, which is dangerous. When storing and transporting, many aspects need to be paid attention to.
First talk about storage. Because of its chemical activity, it must be stored in a cool and ventilated warehouse. High temperature can easily increase its reactivity or cause danger, so the warehouse temperature should be strictly controlled, not too high. And keep away from fire and heat sources, both of which may trigger chemical reactions and cause accidents. Because it is an organic substance, it should be stored separately from oxidants, reducing agents, bases, etc., to avoid mixed storage. This is because these substances meet with 2-chloro-3,5-difluoronitrobenzene, or cause violent chemical reactions, endangering safety. The warehouse needs to have suitable materials to contain the leakage, so as to prevent accidental leakage and deal with it in time to reduce the harm.
Let's talk about transportation again. Before transportation, the packaging must be tight, and the packaging materials used should be able to effectively prevent its leakage. During transportation, make sure that the container does not leak, collapse, fall, or damage. Vehicles should run smoothly, and avoid violent actions such as sudden braking and sharp turns to prevent package damage. When transporting, you need to follow the specified route, and do not stop in densely populated areas, residential areas, etc., to reduce transportation risks. Transport vehicles should be equipped with the appropriate variety and quantity of fire equipment and leakage emergency treatment equipment, in case of emergencies can be timely response. Escort personnel should also be familiar with the characteristics of the goods transported and emergency treatment methods to ensure transportation safety.
First talk about storage. Because of its chemical activity, it must be stored in a cool and ventilated warehouse. High temperature can easily increase its reactivity or cause danger, so the warehouse temperature should be strictly controlled, not too high. And keep away from fire and heat sources, both of which may trigger chemical reactions and cause accidents. Because it is an organic substance, it should be stored separately from oxidants, reducing agents, bases, etc., to avoid mixed storage. This is because these substances meet with 2-chloro-3,5-difluoronitrobenzene, or cause violent chemical reactions, endangering safety. The warehouse needs to have suitable materials to contain the leakage, so as to prevent accidental leakage and deal with it in time to reduce the harm.
Let's talk about transportation again. Before transportation, the packaging must be tight, and the packaging materials used should be able to effectively prevent its leakage. During transportation, make sure that the container does not leak, collapse, fall, or damage. Vehicles should run smoothly, and avoid violent actions such as sudden braking and sharp turns to prevent package damage. When transporting, you need to follow the specified route, and do not stop in densely populated areas, residential areas, etc., to reduce transportation risks. Transport vehicles should be equipped with the appropriate variety and quantity of fire equipment and leakage emergency treatment equipment, in case of emergencies can be timely response. Escort personnel should also be familiar with the characteristics of the goods transported and emergency treatment methods to ensure transportation safety.
What are the effects of 2-chloro-3, 5-difluoronitrobenzene on the environment and human health?
2-Chloro-3,5-difluoronitrobenzene is a group of organic compounds. This substance is often used in industrial fields, such as chemical synthesis. However, it has potential effects on the environment and human health.
First talk about its impact on the environment. If this compound is released into the environment, it is difficult to degrade naturally or cause environmental accumulation because of its certain chemical stability. In the soil, it may change the chemical properties of the soil, affect the community structure and function of soil microorganisms, and then interfere with the material cycle and energy flow of the soil ecosystem. If it flows into the water body, it will also cause harm to aquatic organisms. It may damage the physiological functions of aquatic organisms, such as affecting the physiological processes of fish such as respiration and reproduction, causing the decline of aquatic organisms and destroying the balance of aquatic ecosystems.
As for the impact on human health, 2-chloro-3,5-difluoronitrobenzene has certain toxicity. Inhalation through the respiratory tract or skin contact can enter the human body. It may irritate the respiratory tract and skin. If inhaled, it can cause symptoms such as cough, asthma, breathing difficulties; contact with the skin may cause allergic or irritating reactions such as skin redness, itching, pain, etc. Long-term exposure to this substance environment may pose more serious health risks. It may affect the nervous system of the human body, causing headache, dizziness, fatigue and other discomfort; it may also cause damage to important organs such as the liver and kidneys, affecting their normal metabolism and detoxification functions. And this substance may be potentially carcinogenic, long-term exposure or increase the risk of cancer.
Therefore, when using and handling 2-chloro-3,5-difluoronitrobenzene, it is necessary to exercise caution and take appropriate protective measures and environmental protection measures to reduce its potential harm to the environment and human health.
First talk about its impact on the environment. If this compound is released into the environment, it is difficult to degrade naturally or cause environmental accumulation because of its certain chemical stability. In the soil, it may change the chemical properties of the soil, affect the community structure and function of soil microorganisms, and then interfere with the material cycle and energy flow of the soil ecosystem. If it flows into the water body, it will also cause harm to aquatic organisms. It may damage the physiological functions of aquatic organisms, such as affecting the physiological processes of fish such as respiration and reproduction, causing the decline of aquatic organisms and destroying the balance of aquatic ecosystems.
As for the impact on human health, 2-chloro-3,5-difluoronitrobenzene has certain toxicity. Inhalation through the respiratory tract or skin contact can enter the human body. It may irritate the respiratory tract and skin. If inhaled, it can cause symptoms such as cough, asthma, breathing difficulties; contact with the skin may cause allergic or irritating reactions such as skin redness, itching, pain, etc. Long-term exposure to this substance environment may pose more serious health risks. It may affect the nervous system of the human body, causing headache, dizziness, fatigue and other discomfort; it may also cause damage to important organs such as the liver and kidneys, affecting their normal metabolism and detoxification functions. And this substance may be potentially carcinogenic, long-term exposure or increase the risk of cancer.
Therefore, when using and handling 2-chloro-3,5-difluoronitrobenzene, it is necessary to exercise caution and take appropriate protective measures and environmental protection measures to reduce its potential harm to the environment and human health.
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