Linshang Chemical
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2-Chloro-3-Fluorobromobenzene
Linshang Chemical
|
HS Code |
367516 |
| Chemical Formula | C6H3BrClF |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 190 - 200 °C |
| Density | Approx. 1.8 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Vapor Pressure | Low at room temperature |
As an accredited 2-Chloro-3-Fluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle packaging for 2 - chloro - 3 - fluorobromobenzene chemical. |
| Storage | 2 - Chloro - 3 - fluorobromobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions. Regularly check for any signs of leakage or degradation. |
| Shipping | 2 - chloro - 3 - fluorobromobenzene, a hazardous chemical, must be shipped in specialized, well - sealed containers. Follow strict regulations for proper labeling, handling, and transportation to prevent spills and ensure safety during transit. |
Competitive 2-Chloro-3-Fluorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 2-Chloro-3-Fluorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 2-chloro-3-fluorobromobenzene?
2-Chloro-3-fluorobromobenzene is also an organic compound. Its chemical properties are quite interesting and it has important applications in many chemical fields.
First of all, its substitution reaction. Because the benzene ring has an electron cloud, this compound is vulnerable to attack by electrophilic reagents. Although chlorine, fluorine and bromine atoms are all electron-absorbing groups, they can make the electron cloud density of the benzene ring o and para-position relatively high. Electrophilic reagents such as nitro cations are easy to attack the benzene ring o and para-position, so electrophilic substitution reactions occur, which can generate products such as 2-chloro-3-fluoro-4-nitrobromobenzene.
Describe its reaction with metal reagents. 2-Chloro-3-fluorobromobenzene can form Grignard reagents with metals such as magnesium. For example, in an anhydrous ether environment, bromine atoms can interact with magnesium to form corresponding Grignard reagents. This Grignard reagent is extremely active and can undergo nucleophilic addition reactions with a variety of carbonyl compounds. It is an important means to construct carbon-carbon bonds and is widely used in organic synthesis.
Furthermore, the activity of its halogen atoms is also worthy of investigation. Chlorine, fluorine and bromine atoms vary in activity due to their electronegativity and atomic radius. Generally speaking, bromine atoms are relatively active and easily replaced by nucleophiles under suitable conditions, while fluorine atoms are relatively difficult to replace due to their high C-F bond energy.
In addition, 2-chloro-3-fluorobromobenzene can be used as a substrate in some catalytic reactions. Under the action of specific catalysts, it can participate in coupling reactions such as palladium catalysis, and react with reagents containing alkenyl groups and aryl groups to realize the coupling of carbon-carbon bonds, providing an effective way for the synthesis of complex organic molecules.
In addition, due to the halogen atom, this compound may produce corrosive gases such as hydrogen halide when burned. When performing relevant operations, care should be taken to prevent harm to the environment and human health.
In summary, 2-chloro-3-fluorobromobenzene is rich in chemical properties and plays an important role in organic synthesis, materials science and other fields. However, it is also necessary to pay attention to its potential hazards when operating.
First of all, its substitution reaction. Because the benzene ring has an electron cloud, this compound is vulnerable to attack by electrophilic reagents. Although chlorine, fluorine and bromine atoms are all electron-absorbing groups, they can make the electron cloud density of the benzene ring o and para-position relatively high. Electrophilic reagents such as nitro cations are easy to attack the benzene ring o and para-position, so electrophilic substitution reactions occur, which can generate products such as 2-chloro-3-fluoro-4-nitrobromobenzene.
Describe its reaction with metal reagents. 2-Chloro-3-fluorobromobenzene can form Grignard reagents with metals such as magnesium. For example, in an anhydrous ether environment, bromine atoms can interact with magnesium to form corresponding Grignard reagents. This Grignard reagent is extremely active and can undergo nucleophilic addition reactions with a variety of carbonyl compounds. It is an important means to construct carbon-carbon bonds and is widely used in organic synthesis.
Furthermore, the activity of its halogen atoms is also worthy of investigation. Chlorine, fluorine and bromine atoms vary in activity due to their electronegativity and atomic radius. Generally speaking, bromine atoms are relatively active and easily replaced by nucleophiles under suitable conditions, while fluorine atoms are relatively difficult to replace due to their high C-F bond energy.
In addition, 2-chloro-3-fluorobromobenzene can be used as a substrate in some catalytic reactions. Under the action of specific catalysts, it can participate in coupling reactions such as palladium catalysis, and react with reagents containing alkenyl groups and aryl groups to realize the coupling of carbon-carbon bonds, providing an effective way for the synthesis of complex organic molecules.
In addition, due to the halogen atom, this compound may produce corrosive gases such as hydrogen halide when burned. When performing relevant operations, care should be taken to prevent harm to the environment and human health.
In summary, 2-chloro-3-fluorobromobenzene is rich in chemical properties and plays an important role in organic synthesis, materials science and other fields. However, it is also necessary to pay attention to its potential hazards when operating.
What are the physical properties of 2-chloro-3-fluorobromobenzene?
2-Chloro-3-fluorobromobenzene is also an organic compound. Its physical properties are particularly important, related to chemical and pharmaceutical matters.
First of all, its properties are mostly liquid at room temperature, but they may vary slightly due to purity and impurities. Its color is often nearly colorless, or with a very light yellow, clear and transparent, just like jade liquid.
As for the smell, it has a special aromatic aroma, but this gas is pungent and uncomfortable to smell. If it is encountered in a closed environment, it should be avoided quickly to prevent damage to the body.
When it comes to boiling point, it is about a specific temperature range. This value varies slightly depending on the method of measurement and the precision of the instrument. It is generally above a few hundred degrees Celsius, and its intermolecular forces and relative molecular weights are determined by factors such as. The boiling point is crucial in chemical operations such as distillation and separation.
The melting point also has its value, or the temperature below zero, which is the critical point between solid and liquid states. The characteristic of the melting point helps to determine its purity. If there are many impurities, the melting point will drop and the melting range will increase.
The density is related to its mixing state with other substances. The density of 2-chloro-3-fluorobromobenzene is higher than that of water, so when mixed with water, it will sink underwater and be well-defined.
Solubility is also essential. It is soluble in organic solvents such as ethanol and ether; it is insoluble in water. This property is determined by the difference in the polarity of its molecules and the polarity of its water molecules.
In addition, its volatility cannot be ignored. Although it is not a highly volatile substance, it gradually disperses in the air in a warm and ventilated place. This property should be handled with caution when storing and using it to prevent escape and safety risks.
All these physical properties are interrelated and are important parameters in chemical synthesis, pharmaceutical research and development, material preparation and other fields. Only by understanding its properties can it be used effectively.
First of all, its properties are mostly liquid at room temperature, but they may vary slightly due to purity and impurities. Its color is often nearly colorless, or with a very light yellow, clear and transparent, just like jade liquid.
As for the smell, it has a special aromatic aroma, but this gas is pungent and uncomfortable to smell. If it is encountered in a closed environment, it should be avoided quickly to prevent damage to the body.
When it comes to boiling point, it is about a specific temperature range. This value varies slightly depending on the method of measurement and the precision of the instrument. It is generally above a few hundred degrees Celsius, and its intermolecular forces and relative molecular weights are determined by factors such as. The boiling point is crucial in chemical operations such as distillation and separation.
The melting point also has its value, or the temperature below zero, which is the critical point between solid and liquid states. The characteristic of the melting point helps to determine its purity. If there are many impurities, the melting point will drop and the melting range will increase.
The density is related to its mixing state with other substances. The density of 2-chloro-3-fluorobromobenzene is higher than that of water, so when mixed with water, it will sink underwater and be well-defined.
Solubility is also essential. It is soluble in organic solvents such as ethanol and ether; it is insoluble in water. This property is determined by the difference in the polarity of its molecules and the polarity of its water molecules.
In addition, its volatility cannot be ignored. Although it is not a highly volatile substance, it gradually disperses in the air in a warm and ventilated place. This property should be handled with caution when storing and using it to prevent escape and safety risks.
All these physical properties are interrelated and are important parameters in chemical synthesis, pharmaceutical research and development, material preparation and other fields. Only by understanding its properties can it be used effectively.
What are the main uses of 2-chloro-3-fluorobromobenzene?
2-Chloro-3-fluorobromobenzene is also an organic compound. It has a wide range of uses and has important applications in various fields.
In the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of drugs. With its unique chemical structure, it can participate in a variety of chemical reactions and help build molecular structures with specific biological activities. Through fine synthesis steps, it can be converted into drugs for the treatment of various diseases, such as antibacterial and antiviral agents, adding to human health and well-being.
In materials science, 2-chloro-3-fluorobrobenzene also has potential value. It can be used as a starting material, chemically modified and polymerized to prepare functional materials with specific properties. Such materials may have good electrical and optical properties, and are expected to show their skills in the fields of electronic devices, optical instruments, etc., such as the creation of new display materials or high-performance semiconductor materials.
In the field of pesticide chemistry, it is also indispensable. Through rational molecular design and synthesis, pesticide products with high insecticidal and herbicide properties can be derived. Using its structural characteristics, it can precisely act on the physiological targets of pests, effectively prevent and control crop diseases and pests, and ensure the harvest of agriculture. It is of great significance to maintain agricultural ecological balance.
Furthermore, in the study of organic synthetic chemistry, 2-chloro-3-fluorobromobenzene is often used as a model compound for researchers to explore novel reaction pathways and synthesis methods. Because it contains a variety of halogen atoms, it can provide rich chemical selectivity and reactivity for reactions, which helps to develop new strategies for organic synthesis and promote the continuous progress of organic chemistry.
In the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of drugs. With its unique chemical structure, it can participate in a variety of chemical reactions and help build molecular structures with specific biological activities. Through fine synthesis steps, it can be converted into drugs for the treatment of various diseases, such as antibacterial and antiviral agents, adding to human health and well-being.
In materials science, 2-chloro-3-fluorobrobenzene also has potential value. It can be used as a starting material, chemically modified and polymerized to prepare functional materials with specific properties. Such materials may have good electrical and optical properties, and are expected to show their skills in the fields of electronic devices, optical instruments, etc., such as the creation of new display materials or high-performance semiconductor materials.
In the field of pesticide chemistry, it is also indispensable. Through rational molecular design and synthesis, pesticide products with high insecticidal and herbicide properties can be derived. Using its structural characteristics, it can precisely act on the physiological targets of pests, effectively prevent and control crop diseases and pests, and ensure the harvest of agriculture. It is of great significance to maintain agricultural ecological balance.
Furthermore, in the study of organic synthetic chemistry, 2-chloro-3-fluorobromobenzene is often used as a model compound for researchers to explore novel reaction pathways and synthesis methods. Because it contains a variety of halogen atoms, it can provide rich chemical selectivity and reactivity for reactions, which helps to develop new strategies for organic synthesis and promote the continuous progress of organic chemistry.
What is 2-chloro-3-fluorobromobenzene synthesis method?
To prepare 2-chloro-3-fluorobromobenzene, the following method can be followed.
First, benzene is taken as the starting material, and anhydrous aluminum trichloride is used as the catalyst to react with bromine. In this reaction, the bromine atom is affected by the electron cloud of the benzene ring, and with the assistance of the catalyst, it attacks the benzene ring to generate bromobenzene. This step of the reaction needs to be carried out at a suitable temperature and dry environment to ensure the smooth reaction.
After obtaining bromobenzene, iron filings or ferric chloride are used as the catalyst to react with chlorine gas. At this time, the chlorine atom binds to the ortho or para-position of the bromine atom Because bromine is an ortho-para-localization group, although it passivates the benzene ring, it still guides the chlorine atom to be substituted in the ortho-para-position. After this reaction, a mixture of o-chlorobrobenzene and p-chlorobrobenzene can be obtained. Fractionation or other separation means are required to obtain pure o-chlorobrobenzene.
O-chlorobrobenzene has been obtained, and the next step is fluorination. React with fluorine sources such as potassium fluoride in the presence of suitable organic solvents and catalysts. This reaction condition is quite critical, and factors such as temperature, pressure and reaction time need to be strictly controlled. Due to the high activity of fluorine atoms, improper reaction conditions can easily lead In this reaction, the fluorine atom replaces the chlorine atom at a specific position of o-chlorobrobenzene, and after careful operation and separation, the final product 2-chloro-3-fluorobrobenzene is obtained.
Each step of the reaction requires careful regulation of the ratio of reactants and reaction conditions, and the purity detection and separation of the intermediate and final products to ensure the quality and yield of the obtained 2-chloro-3-fluorobrobenzene.
First, benzene is taken as the starting material, and anhydrous aluminum trichloride is used as the catalyst to react with bromine. In this reaction, the bromine atom is affected by the electron cloud of the benzene ring, and with the assistance of the catalyst, it attacks the benzene ring to generate bromobenzene. This step of the reaction needs to be carried out at a suitable temperature and dry environment to ensure the smooth reaction.
After obtaining bromobenzene, iron filings or ferric chloride are used as the catalyst to react with chlorine gas. At this time, the chlorine atom binds to the ortho or para-position of the bromine atom Because bromine is an ortho-para-localization group, although it passivates the benzene ring, it still guides the chlorine atom to be substituted in the ortho-para-position. After this reaction, a mixture of o-chlorobrobenzene and p-chlorobrobenzene can be obtained. Fractionation or other separation means are required to obtain pure o-chlorobrobenzene.
O-chlorobrobenzene has been obtained, and the next step is fluorination. React with fluorine sources such as potassium fluoride in the presence of suitable organic solvents and catalysts. This reaction condition is quite critical, and factors such as temperature, pressure and reaction time need to be strictly controlled. Due to the high activity of fluorine atoms, improper reaction conditions can easily lead In this reaction, the fluorine atom replaces the chlorine atom at a specific position of o-chlorobrobenzene, and after careful operation and separation, the final product 2-chloro-3-fluorobrobenzene is obtained.
Each step of the reaction requires careful regulation of the ratio of reactants and reaction conditions, and the purity detection and separation of the intermediate and final products to ensure the quality and yield of the obtained 2-chloro-3-fluorobrobenzene.
What are the precautions in storage and transportation of 2-chloro-3-fluorobromobenzene?
2-Chloro-3-fluorobromobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage, this compound may be more active, and it should be placed in a cool and dry place. Because moisture is prone to reactions such as hydrolysis, its quality is damaged. The temperature of the warehouse should be controlled within a specific range, not too high, to prevent its volatilization from intensifying, or to cause dangerous reactions due to excessive temperature. And it must be kept away from fire and heat sources, which are sources of ignition. Contact with the compound may cause fire or even explosion. Furthermore, it should be stored separately from oxidizing agents, acids, alkalis, etc. Due to its chemical properties, it can encounter various substances or cause severe chemical reactions, resulting in catastrophe.
As for transportation, it is necessary to ensure that the packaging is complete and sealed. To prevent leakage during transportation, if it leaks outside, it will not only damage the goods, but also endanger the surrounding environment and personal safety. During transportation, vehicles should be equipped with corresponding varieties and quantities of fire protection equipment and leakage emergency treatment equipment. Drivers and escorts must also be familiar with the nature, hazards and emergency treatment methods of the chemical. When driving, avoid water sources, residential areas and other crowded and environmentally sensitive places to prevent accidental leakage from causing serious impact on the public and the environment.
In summary, 2-chloro-3-fluorobromobenzene must be stored and transported with caution and follow relevant regulations to ensure safety.
First words storage, this compound may be more active, and it should be placed in a cool and dry place. Because moisture is prone to reactions such as hydrolysis, its quality is damaged. The temperature of the warehouse should be controlled within a specific range, not too high, to prevent its volatilization from intensifying, or to cause dangerous reactions due to excessive temperature. And it must be kept away from fire and heat sources, which are sources of ignition. Contact with the compound may cause fire or even explosion. Furthermore, it should be stored separately from oxidizing agents, acids, alkalis, etc. Due to its chemical properties, it can encounter various substances or cause severe chemical reactions, resulting in catastrophe.
As for transportation, it is necessary to ensure that the packaging is complete and sealed. To prevent leakage during transportation, if it leaks outside, it will not only damage the goods, but also endanger the surrounding environment and personal safety. During transportation, vehicles should be equipped with corresponding varieties and quantities of fire protection equipment and leakage emergency treatment equipment. Drivers and escorts must also be familiar with the nature, hazards and emergency treatment methods of the chemical. When driving, avoid water sources, residential areas and other crowded and environmentally sensitive places to prevent accidental leakage from causing serious impact on the public and the environment.
In summary, 2-chloro-3-fluorobromobenzene must be stored and transported with caution and follow relevant regulations to ensure safety.
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