Linshang Chemical
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2-Chloro-3-Fluoronitrobenzene
Linshang Chemical
|
HS Code |
223700 |
| Chemical Formula | C6H3ClFNO2 |
| Molecular Weight | 177.545 |
| Appearance | Yellow to light brown liquid |
| Boiling Point | 230 - 232 °C |
| Melting Point | 2 - 4 °C |
| Density | 1.454 g/cm³ |
| Vapor Pressure | 0.013 hPa (20 °C) |
| Solubility In Water | Insoluble |
| Flash Point | 103 °C |
| Refractive Index | 1.565 |
As an accredited 2-Chloro-3-Fluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 2 - chloro - 3 - fluoronitrobenzene packaged in 25 - kg drums. |
| Storage | 2 - chloro - 3 - fluoronitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage. It is best stored in a dedicated chemical storage cabinet, clearly labeled, and separated from incompatible substances to ensure safety. |
| Shipping | 2 - chloro - 3 - fluoronitrobenzene is a hazardous chemical. Shipping must follow strict regulations. It should be properly packaged in suitable containers, labeled clearly, and transported by carriers compliant with hazardous material shipping rules. |
Competitive 2-Chloro-3-Fluoronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Chloro-3-Fluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chloro-3-fluoronitrobenzene?
2-Chloro-3-fluoronitrobenzene is also an organic compound. It has a wide range of uses and is useful in all fields of chemical industry.
First in the field of drug synthesis. Because of its specific chemical structure, it can be a key intermediate for the creation of many drugs. Chemists use it to introduce specific functional groups and construct complex drug molecular structures through a series of reactions. For example, when developing antibacterial, anti-inflammatory and other drugs, 2-chloro-3-fluoronitrobenzene can participate in the reaction, endowing the drug with specific activity and curative effect, helping to accurately act on pathogenic targets and improve the therapeutic effect of drugs.
Furthermore, it has applications in the field of materials science. It may be used to synthesize special polymer materials. Due to its chlorine, fluorine, nitro and other functional groups, it can affect the physical and chemical properties of materials. The prepared materials may have unique electrical and optical properties, such as used in the manufacture of organic optoelectronic devices, such as organic Light Emitting Diode (OLED), to improve the luminous efficiency, stability and other properties of the device, making the display technology more advanced.
In addition, it is also indispensable in pesticide synthesis. With clever design of the reaction, 2-chloro-3-fluoronitrobenzene can be converted into highly efficient pesticide components. Its structural characteristics make pesticides have good biological activity, which can effectively control crop diseases and pests, and because it contains fluorine and chlorine atoms, it may enhance the environmental stability and biological activity persistence of pesticides, which is of great significance in ensuring agricultural harvest and improving the quality of agricultural products.
In the field of dye synthesis, 2-chloro-3-fluoronitrobenzene can provide special chromophore groups and structural support for dye molecules. After chemical modification, dyes with bright colors and excellent fastness are prepared, which are used in textile, printing and dyeing industries to meet people's needs for beautiful color and durability of fabrics.
Overall, 2-chloro-3-fluoronitrobenzene plays an important role in many chemical fields such as drugs, materials, pesticides, dyes, etc. Its unique structure lays the foundation for many product innovations and performance improvements.
First in the field of drug synthesis. Because of its specific chemical structure, it can be a key intermediate for the creation of many drugs. Chemists use it to introduce specific functional groups and construct complex drug molecular structures through a series of reactions. For example, when developing antibacterial, anti-inflammatory and other drugs, 2-chloro-3-fluoronitrobenzene can participate in the reaction, endowing the drug with specific activity and curative effect, helping to accurately act on pathogenic targets and improve the therapeutic effect of drugs.
Furthermore, it has applications in the field of materials science. It may be used to synthesize special polymer materials. Due to its chlorine, fluorine, nitro and other functional groups, it can affect the physical and chemical properties of materials. The prepared materials may have unique electrical and optical properties, such as used in the manufacture of organic optoelectronic devices, such as organic Light Emitting Diode (OLED), to improve the luminous efficiency, stability and other properties of the device, making the display technology more advanced.
In addition, it is also indispensable in pesticide synthesis. With clever design of the reaction, 2-chloro-3-fluoronitrobenzene can be converted into highly efficient pesticide components. Its structural characteristics make pesticides have good biological activity, which can effectively control crop diseases and pests, and because it contains fluorine and chlorine atoms, it may enhance the environmental stability and biological activity persistence of pesticides, which is of great significance in ensuring agricultural harvest and improving the quality of agricultural products.
In the field of dye synthesis, 2-chloro-3-fluoronitrobenzene can provide special chromophore groups and structural support for dye molecules. After chemical modification, dyes with bright colors and excellent fastness are prepared, which are used in textile, printing and dyeing industries to meet people's needs for beautiful color and durability of fabrics.
Overall, 2-chloro-3-fluoronitrobenzene plays an important role in many chemical fields such as drugs, materials, pesticides, dyes, etc. Its unique structure lays the foundation for many product innovations and performance improvements.
What are the physical properties of 2-chloro-3-fluoronitrobenzene?
2-Chloro-3-fluoronitrobenzene is one of the organic compounds. Its physical properties are particularly important and are relevant to all things in the chemical industry.
Looking at its properties, under normal temperature and pressure, 2-chloro-3-fluoronitrobenzene is mostly in the shape of a liquid. Its color or colorless, or slightly yellow shape, and has a special smell. Although this smell is not strong and pungent, it is also one of its characteristics.
When it comes to the melting point, it is about -20 ° C. This low temperature melting point makes it easy to maintain a liquid state at normal room temperature. The boiling point is roughly between 240 ° C and 250 ° C. This boiling point is quite high, indicating that if it is to be vaporized, a higher temperature needs to be applied.
2-chloro-3-fluoronitrobenzene has a density of about 1.5g/cm ³, which is higher than that of water. Therefore, if it is mixed with water, it will sink to the bottom. As for solubility, this compound is extremely difficult to dissolve in water, and the interaction between it and water molecules is weak due to its molecular structure. However, in organic solvents such as ethanol, ether, acetone, etc., it has good solubility and can be well miscible with various organic solvents. This property is of great benefit in the extraction and separation steps of organic synthesis.
Furthermore, its volatility is low, and it is not easy to evaporate rapidly in general environments. This property also makes it relatively stable during storage and use, and there is no need to worry too much about its rapid volatilization and loss or safety risks.
In addition, the refractive index of 2-chloro-3-fluoronitrobenzene also has a certain value, about 1.56-1.58. This physical parameter may be valuable in optical research and applications, and can be used as one of the bases for the identification and analysis of this compound.
In summary, the physical properties of 2-chloro-3-fluoronitrobenzene are important factors in the chemical industry, organic synthesis and related research fields, and have guiding significance for their application and operation.
Looking at its properties, under normal temperature and pressure, 2-chloro-3-fluoronitrobenzene is mostly in the shape of a liquid. Its color or colorless, or slightly yellow shape, and has a special smell. Although this smell is not strong and pungent, it is also one of its characteristics.
When it comes to the melting point, it is about -20 ° C. This low temperature melting point makes it easy to maintain a liquid state at normal room temperature. The boiling point is roughly between 240 ° C and 250 ° C. This boiling point is quite high, indicating that if it is to be vaporized, a higher temperature needs to be applied.
2-chloro-3-fluoronitrobenzene has a density of about 1.5g/cm ³, which is higher than that of water. Therefore, if it is mixed with water, it will sink to the bottom. As for solubility, this compound is extremely difficult to dissolve in water, and the interaction between it and water molecules is weak due to its molecular structure. However, in organic solvents such as ethanol, ether, acetone, etc., it has good solubility and can be well miscible with various organic solvents. This property is of great benefit in the extraction and separation steps of organic synthesis.
Furthermore, its volatility is low, and it is not easy to evaporate rapidly in general environments. This property also makes it relatively stable during storage and use, and there is no need to worry too much about its rapid volatilization and loss or safety risks.
In addition, the refractive index of 2-chloro-3-fluoronitrobenzene also has a certain value, about 1.56-1.58. This physical parameter may be valuable in optical research and applications, and can be used as one of the bases for the identification and analysis of this compound.
In summary, the physical properties of 2-chloro-3-fluoronitrobenzene are important factors in the chemical industry, organic synthesis and related research fields, and have guiding significance for their application and operation.
What is the chemistry of 2-chloro-3-fluoronitrobenzene?
2-Chloro-3-fluoronitrobenzene is also an organic compound. Its molecules contain chlorine, fluorine, nitro and other functional groups, which endow it with unique chemical properties.
In terms of reactivity, the nitro group is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring and weakens the electrophilic substitution activity of the benzene ring, but enhances the nucleophilicity of its neighbor and para-position carbon atoms. Therefore, when encountering nucleophiles, nucleophiles are prone to attack the neighbor and para-position of the nitro group. In this compound, although both chlorine and fluorine are halogen atoms, the electronegativity of fluorine is stronger than that of chlorine, and the two have different effects on the electron cloud density of the benzene ring. Fluorine reduces the electron cloud density of the benzene ring more than chlorine, resulting in different reactivity of the benzene ring carbon atoms connected to the two.
During the hydrolysis reaction, the halogen atom can be replaced by the hydroxyl group. However, due to the higher bond energy between the fluorine atom and the benzene ring, the hydrolysis of the fluorine atom is more difficult than that of the chlorine atom. If the fluorine atom is hydrolyzed, more severe reaction conditions are often required, such as high temperature, strong base, etc.
In the nucleophilic substitution reaction, the carbon atom connected to the chlorine atom and the fluorine atom is more vulnerable to the attack of the nucleophilic reagent due to the electron-withdrawing action of the nitro group. Because the chlorine atom is easier to leave than the fluorine atom However, when the nucleophilic reagents are extremely nucleophilic, fluorine atoms may also undergo substitution reactions.
In reduction reactions, nitro groups can be reduced to nitrogen-containing groups with different valence states such as amino groups. Commonly used reducing agents include iron and hydrochloric acid, hydrogen and catalysts. This reduction reaction can be used to prepare amino-containing derivatives, which is an important step in organic synthesis.
The functional groups contained in 2-chloro-3-fluoronitrobenzene interact with each other and exhibit unique chemical properties. It is widely used in the field of organic synthesis and can prepare various organic compounds through various reaction paths.
In terms of reactivity, the nitro group is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring and weakens the electrophilic substitution activity of the benzene ring, but enhances the nucleophilicity of its neighbor and para-position carbon atoms. Therefore, when encountering nucleophiles, nucleophiles are prone to attack the neighbor and para-position of the nitro group. In this compound, although both chlorine and fluorine are halogen atoms, the electronegativity of fluorine is stronger than that of chlorine, and the two have different effects on the electron cloud density of the benzene ring. Fluorine reduces the electron cloud density of the benzene ring more than chlorine, resulting in different reactivity of the benzene ring carbon atoms connected to the two.
During the hydrolysis reaction, the halogen atom can be replaced by the hydroxyl group. However, due to the higher bond energy between the fluorine atom and the benzene ring, the hydrolysis of the fluorine atom is more difficult than that of the chlorine atom. If the fluorine atom is hydrolyzed, more severe reaction conditions are often required, such as high temperature, strong base, etc.
In the nucleophilic substitution reaction, the carbon atom connected to the chlorine atom and the fluorine atom is more vulnerable to the attack of the nucleophilic reagent due to the electron-withdrawing action of the nitro group. Because the chlorine atom is easier to leave than the fluorine atom However, when the nucleophilic reagents are extremely nucleophilic, fluorine atoms may also undergo substitution reactions.
In reduction reactions, nitro groups can be reduced to nitrogen-containing groups with different valence states such as amino groups. Commonly used reducing agents include iron and hydrochloric acid, hydrogen and catalysts. This reduction reaction can be used to prepare amino-containing derivatives, which is an important step in organic synthesis.
The functional groups contained in 2-chloro-3-fluoronitrobenzene interact with each other and exhibit unique chemical properties. It is widely used in the field of organic synthesis and can prepare various organic compounds through various reaction paths.
What are 2-chloro-3-fluoronitrobenzene synthesis methods?
There are several methods for the synthesis of 2-chloro-3-fluoronitrobenzene.
First, 2-chloro-3-fluoroaniline is used as the starting material. 2-chloro-3-fluoroaniline is first subjected to a diazotization reaction. In a low temperature environment, it interacts with sodium nitrite and inorganic acids (such as hydrochloric acid or sulfuric acid) to form diazonium salts. Subsequently, the diazonium salt undergoes a Sandmeier reaction, and an appropriate amount of copper salt (such as cuprous chloride or cuprous bromide) is added to replace the diazoyl group with a nitro group to obtain 2-chloro-3-fluoronitrobenzene. This method is relatively direct, but the diazotization reaction requires strict control of the reaction conditions, and slight deviations in temperature and reactant ratio may affect the yield and product purity.
Second, 2-chloro-3-fluorobenzoic acid is used as the starting material. First, 2-chloro-3-fluorobenzoic acid is converted into an acyl chloride, which can be achieved by reacting with dichlorosulfoxide or phosphorus trichloride. After that, the acyl chloride reacts with ammonia to form an amide. Then the amide undergoes a Hoffmann degradation reaction. Under alkaline conditions, it interacts with bromine or chlorine, and the amide is converted into an amine with one less carbon atom. At the same time, the generated amine can be further introduced into the nitro group through nitrification reaction, and finally the target product 2-chloro-3-fluoronitrobenzene is obtained. This pathway has a little more steps, but the reaction conditions of each step are relatively mild, which is conducive to control, but the overall process is long and complicated.
Third, nitrobenzene derivatives are used as raw materials. For example, select a suitable nitrobenzene derivative with groups that can be replaced by chlorine and fluorine atoms. Under appropriate nucleophilic substitution conditions, chlorine reagents (such as copper chloride, sodium chloride, etc.) and fluorine reagents (such as potassium fluoride, hydrogen fluoride, etc.) are used to carry out chlorination and fluorination reactions respectively, and gradually construct the structure of 2-chloro-3-fluoronitrobenzene. This method requires careful selection of raw materials and reaction conditions to ensure that the substitution reaction can occur accurately at the desired position, and the control of reaction conditions is quite high.
The above synthesis methods have their own advantages and disadvantages. In practical applications, the most suitable method should be selected according to the comprehensive consideration of many factors such as raw material availability, reaction conditions, cost and yield.
First, 2-chloro-3-fluoroaniline is used as the starting material. 2-chloro-3-fluoroaniline is first subjected to a diazotization reaction. In a low temperature environment, it interacts with sodium nitrite and inorganic acids (such as hydrochloric acid or sulfuric acid) to form diazonium salts. Subsequently, the diazonium salt undergoes a Sandmeier reaction, and an appropriate amount of copper salt (such as cuprous chloride or cuprous bromide) is added to replace the diazoyl group with a nitro group to obtain 2-chloro-3-fluoronitrobenzene. This method is relatively direct, but the diazotization reaction requires strict control of the reaction conditions, and slight deviations in temperature and reactant ratio may affect the yield and product purity.
Second, 2-chloro-3-fluorobenzoic acid is used as the starting material. First, 2-chloro-3-fluorobenzoic acid is converted into an acyl chloride, which can be achieved by reacting with dichlorosulfoxide or phosphorus trichloride. After that, the acyl chloride reacts with ammonia to form an amide. Then the amide undergoes a Hoffmann degradation reaction. Under alkaline conditions, it interacts with bromine or chlorine, and the amide is converted into an amine with one less carbon atom. At the same time, the generated amine can be further introduced into the nitro group through nitrification reaction, and finally the target product 2-chloro-3-fluoronitrobenzene is obtained. This pathway has a little more steps, but the reaction conditions of each step are relatively mild, which is conducive to control, but the overall process is long and complicated.
Third, nitrobenzene derivatives are used as raw materials. For example, select a suitable nitrobenzene derivative with groups that can be replaced by chlorine and fluorine atoms. Under appropriate nucleophilic substitution conditions, chlorine reagents (such as copper chloride, sodium chloride, etc.) and fluorine reagents (such as potassium fluoride, hydrogen fluoride, etc.) are used to carry out chlorination and fluorination reactions respectively, and gradually construct the structure of 2-chloro-3-fluoronitrobenzene. This method requires careful selection of raw materials and reaction conditions to ensure that the substitution reaction can occur accurately at the desired position, and the control of reaction conditions is quite high.
The above synthesis methods have their own advantages and disadvantages. In practical applications, the most suitable method should be selected according to the comprehensive consideration of many factors such as raw material availability, reaction conditions, cost and yield.
2-chloro-3-fluoronitrobenzene need to pay attention to when storing and transporting
2-Chloro-3-fluoronitrobenzene is a commonly used raw material in organic synthesis. When storing and transporting it, special attention should be paid to the following things:
First, when storing, choose a cool, dry and well-ventilated place. Because it is easy to decompose when heated, if it is in a high temperature environment, or causes a chemical reaction, causing material deterioration, and even safety risks. The warehouse temperature should be controlled within a specific range, and direct sunlight should be avoided to prevent it from accelerating decomposition due to light.
Second, the substance is toxic and corrosive, and the storage container must be made of suitable materials. If corrosion-resistant glass containers or specific plastic containers are used to prevent material leakage caused by corrosion of the container. At the same time, the container must be tightly sealed to avoid contact with the air, due to moisture, oxygen and other components in the air or react with it.
Third, during transportation, it is also necessary to ensure that the environment is stable. Vehicles should be equipped with temperature control equipment to maintain a suitable temperature to avoid bumps and violent vibrations to prevent materials from damaging the packaging due to collisions and then leaking. Transport personnel need to strictly follow relevant regulations and take protective measures, such as wearing protective clothing, wearing protective gloves and masks, etc., to ensure their own safety.
Fourth, storage and transportation sites should be equipped with complete emergency treatment equipment and plans. In the event of an unexpected situation such as a leak, effective measures can be taken quickly, such as the use of adsorbent materials to treat the leak to prevent its spread, and ventilation equipment can be started to reduce the concentration of harmful substances in the air, and relevant professionals can be notified in a timely manner for treatment.
First, when storing, choose a cool, dry and well-ventilated place. Because it is easy to decompose when heated, if it is in a high temperature environment, or causes a chemical reaction, causing material deterioration, and even safety risks. The warehouse temperature should be controlled within a specific range, and direct sunlight should be avoided to prevent it from accelerating decomposition due to light.
Second, the substance is toxic and corrosive, and the storage container must be made of suitable materials. If corrosion-resistant glass containers or specific plastic containers are used to prevent material leakage caused by corrosion of the container. At the same time, the container must be tightly sealed to avoid contact with the air, due to moisture, oxygen and other components in the air or react with it.
Third, during transportation, it is also necessary to ensure that the environment is stable. Vehicles should be equipped with temperature control equipment to maintain a suitable temperature to avoid bumps and violent vibrations to prevent materials from damaging the packaging due to collisions and then leaking. Transport personnel need to strictly follow relevant regulations and take protective measures, such as wearing protective clothing, wearing protective gloves and masks, etc., to ensure their own safety.
Fourth, storage and transportation sites should be equipped with complete emergency treatment equipment and plans. In the event of an unexpected situation such as a leak, effective measures can be taken quickly, such as the use of adsorbent materials to treat the leak to prevent its spread, and ventilation equipment can be started to reduce the concentration of harmful substances in the air, and relevant professionals can be notified in a timely manner for treatment.
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