Linshang Chemical
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2-Chloro-4-(Chloromethyl)-1-Fluoro-Benzene
Linshang Chemical
|
HS Code |
975208 |
| Chemical Formula | C7H5Cl2F |
| Molecular Weight | 181.018 |
| Appearance | Liquid (usually) |
| Boiling Point | Approximately 200 - 220 °C |
| Solubility In Water | Insoluble (organic nature) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone |
| Vapor Pressure | Low at room temperature |
As an accredited 2-Chloro-4-(Chloromethyl)-1-Fluoro-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 2 - chloro - 4 - (chloromethyl)-1 - fluorobenzene in sealed glass bottle. |
| Storage | 2 - chloro - 4 - (chloromethyl)-1 - fluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources, open flames, and oxidizing agents. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Label the storage container clearly to prevent misidentification and ensure compliance with safety regulations. |
| Shipping | 2 - chloro - 4 - (chloromethyl)-1 - fluorobenzene is a chemical. Shipping requires proper containment in approved vessels, following regulations for hazardous chemicals, with clear labeling indicating its nature and safety precautions. |
Competitive 2-Chloro-4-(Chloromethyl)-1-Fluoro-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 2-chloro-4- (chloromethyl) -1-fluoro-benzene?
2-Chloro-4- (chloromethyl) -1-fluorobenzene, this is an organic compound. Looking at its structure, there are chlorine atoms, chloromethyl and fluorine atoms attached to the benzene ring. These three give the compound unique chemical properties.
Let's talk about the influence of halogen atoms first. Both chlorine and fluorine atoms have strong electronegativity, which plays a significant role in the electron cloud distribution of the benzene ring. Because its electronegativity is greater than that of carbon, it can absorb electrons, reducing the electron cloud density of the benzene ring, thus reducing the activity of the electrophilic substitution reaction of the benzene ring. For example, in the aromatic electrophilic substitution reaction, the reaction difficulty of this compound will increase compared with benzene. On the other hand, the presence of halogen atoms can undergo nucleophilic substitution reactions under Like chlorine atoms and fluorine atoms can be attacked by nucleophiles and replaced. For example, under the condition of strong bases and suitable solvents, fluorine atoms can be replaced by nucleophiles such as hydroxyl groups to form corresponding phenolic derivatives.
Look at chloromethyl groups again. The introduction of this group not only increases the molecular steric resistance, but also the chlorine atoms of chloromethyl groups are equally active. The carbon-chlorine bonds in chloromethyl groups are polar due to the electronegativity of chlorine, and are vulnerable to attack by nucleophiles. Common nucleophiles, such as sodium alcohol and amines, can react with chloromethyl groups to form new carbon-oxygen bonds or carbon-nitrogen bonds, etc., and many organic compounds are derived. At the same time, chloromethyl can be converted into other functional groups through a series of reactions, such as oxidation to carboxyl groups, or reduction to methyl groups, etc., which greatly expands the way for this compound to participate in organic synthesis and is widely used in the field of organic synthetic chemistry.
Let's talk about the influence of halogen atoms first. Both chlorine and fluorine atoms have strong electronegativity, which plays a significant role in the electron cloud distribution of the benzene ring. Because its electronegativity is greater than that of carbon, it can absorb electrons, reducing the electron cloud density of the benzene ring, thus reducing the activity of the electrophilic substitution reaction of the benzene ring. For example, in the aromatic electrophilic substitution reaction, the reaction difficulty of this compound will increase compared with benzene. On the other hand, the presence of halogen atoms can undergo nucleophilic substitution reactions under Like chlorine atoms and fluorine atoms can be attacked by nucleophiles and replaced. For example, under the condition of strong bases and suitable solvents, fluorine atoms can be replaced by nucleophiles such as hydroxyl groups to form corresponding phenolic derivatives.
Look at chloromethyl groups again. The introduction of this group not only increases the molecular steric resistance, but also the chlorine atoms of chloromethyl groups are equally active. The carbon-chlorine bonds in chloromethyl groups are polar due to the electronegativity of chlorine, and are vulnerable to attack by nucleophiles. Common nucleophiles, such as sodium alcohol and amines, can react with chloromethyl groups to form new carbon-oxygen bonds or carbon-nitrogen bonds, etc., and many organic compounds are derived. At the same time, chloromethyl can be converted into other functional groups through a series of reactions, such as oxidation to carboxyl groups, or reduction to methyl groups, etc., which greatly expands the way for this compound to participate in organic synthesis and is widely used in the field of organic synthetic chemistry.
What are the main uses of 2-chloro-4- (chloromethyl) -1-fluoro-benzene?
2-Chloro-4- (chloromethyl) -1-fluorobenzene, this substance has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
The use of organic synthesis, due to the active chemical properties of chlorine, fluorine and chloromethyl contained in the molecule, can undergo various chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc., and react with many reagents to build the structure of complex organic compounds. Through nucleophilic substitution, chlorine atoms and chloromethyl groups can be replaced by other functional groups, creating conditions for the synthesis of organic molecules with specific structures and functions. The introduction of fluorine atoms into organic molecules can significantly change their physical and chemical properties, such as enhancing the stability and lipophilicity of compounds, which is of great significance in the fields of medicinal chemistry and materials science.
In the field of drug synthesis, using this as a starting material can synthesize drug molecules with specific biological activities through a series of reactions. The unique electronic effect and biocompatibility of fluorine atoms can regulate the interaction between drug molecules and biological targets, improve drug efficacy and selectivity, and reduce toxic and side effects.
In the field of materials science, 2-chloro-4- (chloromethyl) -1-fluorobenzene can participate in polymer synthesis. After appropriate reaction, the structure is introduced into the main chain or side chain of the polymer to endow the material with special properties, such as improving the heat resistance, chemical corrosion resistance and electrical properties of the material. In this way, it shows potential application value in the preparation of high-performance engineering plastics and electronic materials.
In addition, in the preparation of fine chemical products, such as special fragrances, dyes, etc., 2-chloro-4- (chloromethyl) -1-fluorobenzene can also play an important role. By ingeniously designing the reaction path and taking advantage of its functional group characteristics, fine chemicals with novel structures and unique properties can be synthesized to meet the specific needs of different industries.
The use of organic synthesis, due to the active chemical properties of chlorine, fluorine and chloromethyl contained in the molecule, can undergo various chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc., and react with many reagents to build the structure of complex organic compounds. Through nucleophilic substitution, chlorine atoms and chloromethyl groups can be replaced by other functional groups, creating conditions for the synthesis of organic molecules with specific structures and functions. The introduction of fluorine atoms into organic molecules can significantly change their physical and chemical properties, such as enhancing the stability and lipophilicity of compounds, which is of great significance in the fields of medicinal chemistry and materials science.
In the field of drug synthesis, using this as a starting material can synthesize drug molecules with specific biological activities through a series of reactions. The unique electronic effect and biocompatibility of fluorine atoms can regulate the interaction between drug molecules and biological targets, improve drug efficacy and selectivity, and reduce toxic and side effects.
In the field of materials science, 2-chloro-4- (chloromethyl) -1-fluorobenzene can participate in polymer synthesis. After appropriate reaction, the structure is introduced into the main chain or side chain of the polymer to endow the material with special properties, such as improving the heat resistance, chemical corrosion resistance and electrical properties of the material. In this way, it shows potential application value in the preparation of high-performance engineering plastics and electronic materials.
In addition, in the preparation of fine chemical products, such as special fragrances, dyes, etc., 2-chloro-4- (chloromethyl) -1-fluorobenzene can also play an important role. By ingeniously designing the reaction path and taking advantage of its functional group characteristics, fine chemicals with novel structures and unique properties can be synthesized to meet the specific needs of different industries.
What is the synthesis method of 2-chloro-4- (chloromethyl) -1-fluoro-benzene?
The synthesis of 2-chloro-4- (chloromethyl) -1-fluorobenzene is an important topic in the field of organic synthesis. The synthesis process needs to follow certain chemical principles and steps.
First, appropriate aromatic compounds can be considered as starting materials. Common starting materials, such as p-fluorotoluene, can lay the foundation for the subsequent introduction of chlorine atoms because their structures already contain fluorine atoms and methyl groups.
Under specific reaction conditions, p-fluorotoluene can be converted from methyl to chloromethyl through chlorination. This step usually requires the reaction of chlorine gas as a chlorine source under the action of light or initiator. For example, under the condition of light, chlorine gas and p-fluorotoluene undergo free radical substitution reaction, and the hydrogen atom on the methyl group is gradually replaced by the chlorine atom to form the intermediate containing chlorine methyl group.
Then, for the substitution reaction on the benzene ring, 2-chlorine atoms can be introduced, and an electrophilic substitution reaction can be used. In this process, the electron cloud distribution of the benzene ring and the localization effect of the substituent play a key role. Since the fluorine atom and the generated chloromethyl group are both ortho-para-localizers, under suitable reaction conditions, the substitution of chlorine atoms in the 2-position can be achieved, so as to achieve the synthesis of 2-chloro-4- (chloromethyl) -1-fluorobenzene.
In addition, the reaction conditions, such as temperature, reaction time, and the proportion of reactants, need to be carefully adjusted during the reaction process to improve the yield and purity of the product. And after each step of the reaction, it is often necessary to use separation and purification methods, such as distillation, recrystallization, column chromatography, etc., to obtain pure intermediates and final products to ensure the efficient and accurate synthesis path.
First, appropriate aromatic compounds can be considered as starting materials. Common starting materials, such as p-fluorotoluene, can lay the foundation for the subsequent introduction of chlorine atoms because their structures already contain fluorine atoms and methyl groups.
Under specific reaction conditions, p-fluorotoluene can be converted from methyl to chloromethyl through chlorination. This step usually requires the reaction of chlorine gas as a chlorine source under the action of light or initiator. For example, under the condition of light, chlorine gas and p-fluorotoluene undergo free radical substitution reaction, and the hydrogen atom on the methyl group is gradually replaced by the chlorine atom to form the intermediate containing chlorine methyl group.
Then, for the substitution reaction on the benzene ring, 2-chlorine atoms can be introduced, and an electrophilic substitution reaction can be used. In this process, the electron cloud distribution of the benzene ring and the localization effect of the substituent play a key role. Since the fluorine atom and the generated chloromethyl group are both ortho-para-localizers, under suitable reaction conditions, the substitution of chlorine atoms in the 2-position can be achieved, so as to achieve the synthesis of 2-chloro-4- (chloromethyl) -1-fluorobenzene.
In addition, the reaction conditions, such as temperature, reaction time, and the proportion of reactants, need to be carefully adjusted during the reaction process to improve the yield and purity of the product. And after each step of the reaction, it is often necessary to use separation and purification methods, such as distillation, recrystallization, column chromatography, etc., to obtain pure intermediates and final products to ensure the efficient and accurate synthesis path.
What are the physical properties of 2-chloro-4- (chloromethyl) -1-fluoro-benzene
2-Chloro-4- (chloromethyl) -1-fluorobenzene is also an organic compound. Its physical properties are quite well researched, as detailed below.
First appearance, this compound is often colorless to light yellow liquid, and it looks clear and transparent, like a clear spring, reflecting its pure state. Such appearance characteristics are particularly important for the observation and identification of chemical production.
times and boiling point, the boiling point of this substance is about a certain range. The boiling point is the critical temperature at which a substance changes from liquid to gaseous state, and its value reflects the strength of the force between the molecules of the substance. The determination of boiling point provides a key basis for the separation and purification of this compound. In the method of distillation, by virtue of the difference in boiling point, it can be precisely precipitated from the mixture.
In addition, the melting point, although its melting point value is specific, under low temperature environment, the compound may condense from liquid to solid. The characteristics of the melting point are related to its storage and transportation conditions. Knowing the melting point can avoid the phase transition at uncomfortable temperatures, resulting in quality damage.
The density of the compound has a certain value, which may be different from the density of water. This difference is significant in the operation of liquid-liquid separation. If the density is greater than that of water, it is stored in the lower layer when separating the liquid, and vice versa, it is in the upper layer, which can be easily separated.
Solubility is also an important physical property. 2-Chloro-4- (chloromethyl) -1-fluorobenzene has good solubility in organic solvents, such as ethanol, ether, etc., just like fish get water, and they blend seamlessly. However, the solubility in water is not good, and this property is related to the polarity of the molecule. Its molecular structure makes the polarity weak, and the interaction with water molecules with strong polarity is weak, so it is difficult to dissolve.
In addition, odor is also one end of its physical properties. It often has a special smell, although it is not as pleasant as a flower fragrance, but it is its unique identification. In chemical analysis, odor may be a clue for preliminary judgment.
In summary, the physical properties of 2-chloro-4- (chloromethyl) -1-fluorobenzene are of great significance in chemical synthesis, separation and purification, storage and transportation, and are the cornerstone for in-depth research and rational application of this substance.
First appearance, this compound is often colorless to light yellow liquid, and it looks clear and transparent, like a clear spring, reflecting its pure state. Such appearance characteristics are particularly important for the observation and identification of chemical production.
times and boiling point, the boiling point of this substance is about a certain range. The boiling point is the critical temperature at which a substance changes from liquid to gaseous state, and its value reflects the strength of the force between the molecules of the substance. The determination of boiling point provides a key basis for the separation and purification of this compound. In the method of distillation, by virtue of the difference in boiling point, it can be precisely precipitated from the mixture.
In addition, the melting point, although its melting point value is specific, under low temperature environment, the compound may condense from liquid to solid. The characteristics of the melting point are related to its storage and transportation conditions. Knowing the melting point can avoid the phase transition at uncomfortable temperatures, resulting in quality damage.
The density of the compound has a certain value, which may be different from the density of water. This difference is significant in the operation of liquid-liquid separation. If the density is greater than that of water, it is stored in the lower layer when separating the liquid, and vice versa, it is in the upper layer, which can be easily separated.
Solubility is also an important physical property. 2-Chloro-4- (chloromethyl) -1-fluorobenzene has good solubility in organic solvents, such as ethanol, ether, etc., just like fish get water, and they blend seamlessly. However, the solubility in water is not good, and this property is related to the polarity of the molecule. Its molecular structure makes the polarity weak, and the interaction with water molecules with strong polarity is weak, so it is difficult to dissolve.
In addition, odor is also one end of its physical properties. It often has a special smell, although it is not as pleasant as a flower fragrance, but it is its unique identification. In chemical analysis, odor may be a clue for preliminary judgment.
In summary, the physical properties of 2-chloro-4- (chloromethyl) -1-fluorobenzene are of great significance in chemical synthesis, separation and purification, storage and transportation, and are the cornerstone for in-depth research and rational application of this substance.
What are the precautions for storing and transporting 2-chloro-4- (chloromethyl) -1-fluoro-benzene?
2-Chloro-4- (chloromethyl) -1-fluorobenzene is an organic compound. When storing and transporting it, more attention should be paid.
First words storage, because it has a certain chemical activity, it should be stored in a cool, dry and well-ventilated place. If it is in a high temperature and humid environment, it may cause the compound to deteriorate, affecting its quality and performance. This compound may be sensitive to light, under light, or cause luminescent chemical reactions, so when storing it, it should be kept away from direct light, and it can be stored in dark containers such as brown bottles. In addition, it needs to be stored separately from oxidants, strong alkalis and other substances. Because of its encounter with oxidizing agents, or violent oxidation reactions, with strong alkalis or chemical reactions, resulting in safety accidents. At the same time, the storage place should be equipped with obvious warning signs, indicating the characteristics and hazards of the compound, reminding personnel to operate with caution.
As for transportation, be sure to ensure that the packaging is complete and well sealed. To prevent the leakage of compounds during transportation, pollute the environment and endanger the safety of personnel. Transportation vehicles also need to choose adapters, with necessary ventilation, sun protection, rain protection and other facilities. During transportation, drivers and escorts should be familiar with the characteristics of compounds and emergency treatment methods. In case of emergencies such as leaks, they can be disposed of quickly and correctly. And when planning transportation routes, densely populated areas and environmentally sensitive areas should be avoided to reduce the risk of accidents. Overall, 2-chloro-4- (chloromethyl) -1-fluorobenzene needs to be carefully considered in terms of environmental conditions, material isolation, packaging protection, and personnel awareness during storage and transportation to ensure safety.
First words storage, because it has a certain chemical activity, it should be stored in a cool, dry and well-ventilated place. If it is in a high temperature and humid environment, it may cause the compound to deteriorate, affecting its quality and performance. This compound may be sensitive to light, under light, or cause luminescent chemical reactions, so when storing it, it should be kept away from direct light, and it can be stored in dark containers such as brown bottles. In addition, it needs to be stored separately from oxidants, strong alkalis and other substances. Because of its encounter with oxidizing agents, or violent oxidation reactions, with strong alkalis or chemical reactions, resulting in safety accidents. At the same time, the storage place should be equipped with obvious warning signs, indicating the characteristics and hazards of the compound, reminding personnel to operate with caution.
As for transportation, be sure to ensure that the packaging is complete and well sealed. To prevent the leakage of compounds during transportation, pollute the environment and endanger the safety of personnel. Transportation vehicles also need to choose adapters, with necessary ventilation, sun protection, rain protection and other facilities. During transportation, drivers and escorts should be familiar with the characteristics of compounds and emergency treatment methods. In case of emergencies such as leaks, they can be disposed of quickly and correctly. And when planning transportation routes, densely populated areas and environmentally sensitive areas should be avoided to reduce the risk of accidents. Overall, 2-chloro-4- (chloromethyl) -1-fluorobenzene needs to be carefully considered in terms of environmental conditions, material isolation, packaging protection, and personnel awareness during storage and transportation to ensure safety.
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