Linshang Chemical
PRODUCTS
2-Chloro-4-Fluoro-1-Iodobenzene
Linshang Chemical
|
HS Code |
263555 |
| Chemical Formula | C6H3ClFI |
| Appearance | colorless to light yellow liquid |
| Boiling Point | around 205 - 207 °C |
| Melting Point | N/A (liquid at room temperature) |
| Density | around 2.084 g/cm³ |
| Solubility In Water | insoluble |
| Solubility In Organic Solvents | soluble in common organic solvents like ethanol, ether |
| Flash Point | ca. 88.6 °C |
| Vapor Pressure | low at room temperature |
| Odor | characteristic aromatic odor |
As an accredited 2-Chloro-4-Fluoro-1-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 2 - chloro - 4 - fluoro - 1 - iodobenzene packaged in a sealed glass bottle. |
| Storage | 2 - chloro - 4 - fluoro - 1 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals to avoid potential reactions. Protect it from direct sunlight to maintain its stability. |
| Shipping | 2 - chloro - 4 - fluoro - 1 - iodobenzene is shipped in sealed, corrosion - resistant containers. It adheres to strict hazardous material regulations, ensuring proper handling, labeling, and transportation to prevent any leakage or safety risks. |
Competitive 2-Chloro-4-Fluoro-1-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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What are the chemical properties of 2-chloro-4-fluoro-1-iodobenzene?
2-Chloro-4-fluoro-1-iodobenzene is one of the organohalogenated aromatic hydrocarbons. Its chemical properties are unique. The halogen atoms of chlorine, fluorine and iodine are substituted at different positions on the benzene ring, resulting in different reactivity and characteristics.
As far as the electrophilic substitution reaction is concerned, the halogen atom is an ortho-para-site on the benzene ring. Although it has electron-absorbing induction effect, it also has electron-giving conjugation effect. Among them, the electronegativity of the fluorine atom is the strongest, and the electron-absorbing induction effect is significant, but the conjugation of the lone pair electron with the benzene ring should not be underestimated. The electronegativity of the chlorine and iodine atoms is slightly weaker than that of The electrophilic substitution reaction of this compound often occurs in the adjacent and para-position of the halogen atom. Due to the conjugation effect of the halogen atom, the electron cloud density of the adjacent and para-position is relatively high, which is conducive to the attack of the electrophilic reagent.
The reaction with the nucleophilic reagent, the halogen atom can leave and be replaced by the nucleophilic reagent. The iodine atom is relatively easy to leave due to the large atomic radius and the relatively small bond energy of the C-I bond, so the iodine atom is often replaced first in the nucleophilic substitution reaction. However, the substitution reaction is relatively difficult to occur due to the large bond energy of the chlorine and fluorine atoms due to the C-Cl and C-F bonds. However, under specific conditions, such as high temperature and
In addition, 2-chloro-4-fluoro-1-iodobenzene still has certain chemical stability. However, when it encounters strong oxidizing agents, reducing agents or specific catalysts, oxidation, reduction and other reactions will also occur, resulting in changes in its molecular structure and different products. It is widely used in the field of organic synthesis and can be used as a key intermediate to construct complex organic molecular structures through various reaction pathways.
As far as the electrophilic substitution reaction is concerned, the halogen atom is an ortho-para-site on the benzene ring. Although it has electron-absorbing induction effect, it also has electron-giving conjugation effect. Among them, the electronegativity of the fluorine atom is the strongest, and the electron-absorbing induction effect is significant, but the conjugation of the lone pair electron with the benzene ring should not be underestimated. The electronegativity of the chlorine and iodine atoms is slightly weaker than that of The electrophilic substitution reaction of this compound often occurs in the adjacent and para-position of the halogen atom. Due to the conjugation effect of the halogen atom, the electron cloud density of the adjacent and para-position is relatively high, which is conducive to the attack of the electrophilic reagent.
The reaction with the nucleophilic reagent, the halogen atom can leave and be replaced by the nucleophilic reagent. The iodine atom is relatively easy to leave due to the large atomic radius and the relatively small bond energy of the C-I bond, so the iodine atom is often replaced first in the nucleophilic substitution reaction. However, the substitution reaction is relatively difficult to occur due to the large bond energy of the chlorine and fluorine atoms due to the C-Cl and C-F bonds. However, under specific conditions, such as high temperature and
In addition, 2-chloro-4-fluoro-1-iodobenzene still has certain chemical stability. However, when it encounters strong oxidizing agents, reducing agents or specific catalysts, oxidation, reduction and other reactions will also occur, resulting in changes in its molecular structure and different products. It is widely used in the field of organic synthesis and can be used as a key intermediate to construct complex organic molecular structures through various reaction pathways.
What are the common uses of 2-chloro-4-fluoro-1-iodobenzene?
2-Chloro-4-fluoro-1-iodobenzene is a commonly used organic halide in the field of organic synthesis, which is widely used in many fields such as medicine, pesticides, materials, etc. Its common preparation routes are as follows:
First, halogenation reaction. Using benzene derivatives as starting materials, chlorine, fluorine and iodine atoms are introduced through halogenation reaction. If 2-chloro-4-fluorobenzene is used as a substrate, under suitable reaction conditions, it can be reacted with iodine substitutes to obtain 2-chloro-4-fluoro-1-iodobenzene. This reaction usually requires the participation of catalysts and suitable solvents to improve the reaction efficiency and selectivity. For example, under the action of some metal catalysts, heating the reaction in an organic solvent can prompt iodine atoms to precisely replace hydrogen atoms at specific positions on the benzene ring.
Second, nucleophilic substitution reaction. When there are suitable leaving groups on the benzene ring, the desired halogen atoms can be introduced through nucleophilic substitution reaction. For example, with suitable leaving groups on the benzene ring, nucleophilic substitution occurs under the action of nucleophilic reagents such as fluoride ion, chloride ion, iodine ion, etc., to construct the target product. In this process, the control of reaction conditions is crucial, such as reaction temperature, reaction time, solvent type, etc., which will affect the reaction process and product yield.
Third, it is synthesized through a multi-step reaction. Sometimes a single reaction is difficult to directly achieve the goal, and multi-step reaction coordination is required. First, some substituents are introduced into the benzene ring through a series of reactions, and then the molecular structure is gradually improved through subsequent reactions, and finally 2-chloro-4-fluoro-1-iodobenzene is obtained. This strategy requires fine regulation of the conditions and selectivity of each step of the reaction to ensure the feasibility and efficiency of the entire synthesis route.
Fourth, cross-coupling reaction with the help of metal catalysis. Using the unique activity of metal catalysts, different halogenated aromatics or halogenated hydrocarbons are cross-coupled with reagents containing chlorine, fluorine and iodine, and then the target product is synthesized. Such reactions are widely used in modern organic synthesis, which can effectively construct complex organic molecular structures and have high atomic economy and selectivity. In practical applications, it is necessary to rationally select the preparation method according to the specific requirements and conditions, and pay attention to the optimization and control of the reaction conditions to achieve the efficient synthesis of 2-chloro-4-fluoro-1-iodobenzene.
First, halogenation reaction. Using benzene derivatives as starting materials, chlorine, fluorine and iodine atoms are introduced through halogenation reaction. If 2-chloro-4-fluorobenzene is used as a substrate, under suitable reaction conditions, it can be reacted with iodine substitutes to obtain 2-chloro-4-fluoro-1-iodobenzene. This reaction usually requires the participation of catalysts and suitable solvents to improve the reaction efficiency and selectivity. For example, under the action of some metal catalysts, heating the reaction in an organic solvent can prompt iodine atoms to precisely replace hydrogen atoms at specific positions on the benzene ring.
Second, nucleophilic substitution reaction. When there are suitable leaving groups on the benzene ring, the desired halogen atoms can be introduced through nucleophilic substitution reaction. For example, with suitable leaving groups on the benzene ring, nucleophilic substitution occurs under the action of nucleophilic reagents such as fluoride ion, chloride ion, iodine ion, etc., to construct the target product. In this process, the control of reaction conditions is crucial, such as reaction temperature, reaction time, solvent type, etc., which will affect the reaction process and product yield.
Third, it is synthesized through a multi-step reaction. Sometimes a single reaction is difficult to directly achieve the goal, and multi-step reaction coordination is required. First, some substituents are introduced into the benzene ring through a series of reactions, and then the molecular structure is gradually improved through subsequent reactions, and finally 2-chloro-4-fluoro-1-iodobenzene is obtained. This strategy requires fine regulation of the conditions and selectivity of each step of the reaction to ensure the feasibility and efficiency of the entire synthesis route.
Fourth, cross-coupling reaction with the help of metal catalysis. Using the unique activity of metal catalysts, different halogenated aromatics or halogenated hydrocarbons are cross-coupled with reagents containing chlorine, fluorine and iodine, and then the target product is synthesized. Such reactions are widely used in modern organic synthesis, which can effectively construct complex organic molecular structures and have high atomic economy and selectivity. In practical applications, it is necessary to rationally select the preparation method according to the specific requirements and conditions, and pay attention to the optimization and control of the reaction conditions to achieve the efficient synthesis of 2-chloro-4-fluoro-1-iodobenzene.
What are 2-chloro-4-fluoro-1-iodobenzene synthesis methods?
There are several common methods for preparing 2-chloro-4-fluoro-1-iodobenzene.
One of them can be initiated by halogenation reaction. First, take a suitable benzene derivative with a substitutable group on it. Under suitable reaction conditions, such as chlorine-containing reagents, such as thionyl chloride or phosphorus trichloride, under suitable reaction conditions, such as in the presence of a specific catalyst, chlorine atoms are introduced at a specific position on the benzene ring. This catalyst may be a Lewis acid, such as aluminum trichloride, which can promote the progress of the reaction, so that the chlorine atoms fall precisely on the target position.
After that, fluorine atoms are introduced. Often a nucleophilic substitution reaction is achieved, and a suitable fluorine-containing reagent, such as potassium fluoride, is selected. In order to make the reaction smooth, a phase transfer catalyst may be added to improve the activity and solubility of fluoride ions in the reaction system. The temperature of the reaction environment and the choice of solvent are all crucial. For example, polar aprotic solvents such as dimethyl sulfoxide can be used to optimize the reaction process.
The last step is to introduce iodine atoms. Often iodine substitutes are used, such as a combination of potassium iodide and an oxidizing agent. The oxidizing agent can be hydrogen peroxide or nitric acid, etc. Its function is to oxidize iodine ions into active iodine species, thereby substituting with the benzene ring to obtain 2-chloro-4-fluoro-1-iodobenzene. During the reaction process, the fine regulation of the reaction conditions, such as temperature, reaction time, and the ratio of reagent dosage, all affect the yield and purity of the product.
Another way is to start from the existing polyhalogenated benzene and use the strategy of selective dehalogenation and re-halogenation. First, benzene derivatives containing multiple halogen atoms are removed by selective dehalogenation reaction to remove unwanted halogen atoms, and then the required chlorine, fluorine and iodine atoms are gradually introduced according to the above halogenation reaction method. After multi-step reaction, the target product 2-chloro-4-fluoro-1-iodobenzene can also be obtained. However, this process requires more stringent reaction conditions and operation steps, and each step needs to be carefully controlled to ensure the quality and yield of the product.
One of them can be initiated by halogenation reaction. First, take a suitable benzene derivative with a substitutable group on it. Under suitable reaction conditions, such as chlorine-containing reagents, such as thionyl chloride or phosphorus trichloride, under suitable reaction conditions, such as in the presence of a specific catalyst, chlorine atoms are introduced at a specific position on the benzene ring. This catalyst may be a Lewis acid, such as aluminum trichloride, which can promote the progress of the reaction, so that the chlorine atoms fall precisely on the target position.
After that, fluorine atoms are introduced. Often a nucleophilic substitution reaction is achieved, and a suitable fluorine-containing reagent, such as potassium fluoride, is selected. In order to make the reaction smooth, a phase transfer catalyst may be added to improve the activity and solubility of fluoride ions in the reaction system. The temperature of the reaction environment and the choice of solvent are all crucial. For example, polar aprotic solvents such as dimethyl sulfoxide can be used to optimize the reaction process.
The last step is to introduce iodine atoms. Often iodine substitutes are used, such as a combination of potassium iodide and an oxidizing agent. The oxidizing agent can be hydrogen peroxide or nitric acid, etc. Its function is to oxidize iodine ions into active iodine species, thereby substituting with the benzene ring to obtain 2-chloro-4-fluoro-1-iodobenzene. During the reaction process, the fine regulation of the reaction conditions, such as temperature, reaction time, and the ratio of reagent dosage, all affect the yield and purity of the product.
Another way is to start from the existing polyhalogenated benzene and use the strategy of selective dehalogenation and re-halogenation. First, benzene derivatives containing multiple halogen atoms are removed by selective dehalogenation reaction to remove unwanted halogen atoms, and then the required chlorine, fluorine and iodine atoms are gradually introduced according to the above halogenation reaction method. After multi-step reaction, the target product 2-chloro-4-fluoro-1-iodobenzene can also be obtained. However, this process requires more stringent reaction conditions and operation steps, and each step needs to be carefully controlled to ensure the quality and yield of the product.
2-chloro-4-fluoro-1-iodobenzene what are the precautions during storage and transportation?
2-Chloro-4-fluoro-1-iodobenzene is an organic compound. When storing and transporting, it is necessary to pay attention to many matters to ensure safety.
First storage, this compound should be placed in a cool, dry and well-ventilated place. Because it is quite sensitive to heat, high temperature is easy to decompose or cause other chemical reactions, so it is the first thing to keep away from heat and fire sources. The temperature of the warehouse should be controlled within a specific range to prevent excessive temperature fluctuations. At the same time, direct sunlight should be avoided, as it can accelerate photochemical reactions and damage the stability of the compound.
Furthermore, this compound should be stored separately from oxidants, reducing agents, alkalis and other substances. Due to its active chemical properties, contact with the above substances may occur violent reactions, causing serious accidents such as combustion and explosion. Such as strong oxidizing agents, can react with 2-chloro-4-fluoro-1-iodobenzene oxidation, or release a lot of energy, causing danger.
Packaging should also not be underestimated. A well-sealed packaging material must be used to prevent leakage. Common such as glass bottles, plastic bottles, outer wrapping buffer materials, packed into strong cartons or wooden boxes. Packaging materials must be able to withstand corrosion of 2-chloro-4-fluoro-1-iodobenzene, and can effectively isolate air and moisture.
As for transportation, transportation vehicles must be equipped with good ventilation equipment to disperse volatile gases that may leak. During transportation, ensure that the vehicle runs smoothly, avoid severe bumps and vibrations, and prevent packaging damage. And transportation personnel should be familiar with the properties of this compound and emergency treatment methods. In case of emergencies, they can respond quickly.
In addition, no matter whether it is stored or transported, obvious warning signs should be set up to indicate its danger. At the same time, make detailed records, including warehousing time, quantity, storage conditions, etc., for traceability and management. In this way, the process of storing and transporting 2-chloro-4-fluoro-1-iodobenzene can ensure safety and prevent problems before they occur.
First storage, this compound should be placed in a cool, dry and well-ventilated place. Because it is quite sensitive to heat, high temperature is easy to decompose or cause other chemical reactions, so it is the first thing to keep away from heat and fire sources. The temperature of the warehouse should be controlled within a specific range to prevent excessive temperature fluctuations. At the same time, direct sunlight should be avoided, as it can accelerate photochemical reactions and damage the stability of the compound.
Furthermore, this compound should be stored separately from oxidants, reducing agents, alkalis and other substances. Due to its active chemical properties, contact with the above substances may occur violent reactions, causing serious accidents such as combustion and explosion. Such as strong oxidizing agents, can react with 2-chloro-4-fluoro-1-iodobenzene oxidation, or release a lot of energy, causing danger.
Packaging should also not be underestimated. A well-sealed packaging material must be used to prevent leakage. Common such as glass bottles, plastic bottles, outer wrapping buffer materials, packed into strong cartons or wooden boxes. Packaging materials must be able to withstand corrosion of 2-chloro-4-fluoro-1-iodobenzene, and can effectively isolate air and moisture.
As for transportation, transportation vehicles must be equipped with good ventilation equipment to disperse volatile gases that may leak. During transportation, ensure that the vehicle runs smoothly, avoid severe bumps and vibrations, and prevent packaging damage. And transportation personnel should be familiar with the properties of this compound and emergency treatment methods. In case of emergencies, they can respond quickly.
In addition, no matter whether it is stored or transported, obvious warning signs should be set up to indicate its danger. At the same time, make detailed records, including warehousing time, quantity, storage conditions, etc., for traceability and management. In this way, the process of storing and transporting 2-chloro-4-fluoro-1-iodobenzene can ensure safety and prevent problems before they occur.
What are the effects of 2-chloro-4-fluoro-1-iodobenzene on the environment and human health?
2-Chloro-4-fluoro-1-iodobenzene is one of the organic halogenated aromatic hydrocarbons. The impact on the environment and human health is of particular concern.
In the environment, due to the halogen atoms, the stability is quite high and the degradation is slow. When it enters natural water and soil, it can remain for a long time and cause accumulation in the environment. If it is in the soil, it may hinder the uptake of nutrients and moisture by plant roots, inhibit plant growth and reduce crop yield. And it can evaporate into the atmosphere, participate in photochemical reactions, damage air quality, or cause bad weather such as smog.
As for human health, it enters the human body through breathing, diet, skin contact, etc. After entering the body, halogen atoms are lipophilic and easily accumulate in adipose tissue. Or disturb the human endocrine system, such as interfering with the synthesis and metabolism of thyroid hormones, causing thyroid dysfunction, affecting metabolism and growth and development. It also damages the nervous system, causing headaches, dizziness, memory loss, and even cognitive and behavioral impairment. Long-term exposure may increase the risk of cancer. Halogenated aromatics or carcinogens cause gene mutations, abnormal cell proliferation, and tumors.
Therefore, the potential harm of 2-chloro-4-fluoro-1-iodobenzene to the environment and human health should be taken seriously to prevent it from polluting the environment and protect public health.
In the environment, due to the halogen atoms, the stability is quite high and the degradation is slow. When it enters natural water and soil, it can remain for a long time and cause accumulation in the environment. If it is in the soil, it may hinder the uptake of nutrients and moisture by plant roots, inhibit plant growth and reduce crop yield. And it can evaporate into the atmosphere, participate in photochemical reactions, damage air quality, or cause bad weather such as smog.
As for human health, it enters the human body through breathing, diet, skin contact, etc. After entering the body, halogen atoms are lipophilic and easily accumulate in adipose tissue. Or disturb the human endocrine system, such as interfering with the synthesis and metabolism of thyroid hormones, causing thyroid dysfunction, affecting metabolism and growth and development. It also damages the nervous system, causing headaches, dizziness, memory loss, and even cognitive and behavioral impairment. Long-term exposure may increase the risk of cancer. Halogenated aromatics or carcinogens cause gene mutations, abnormal cell proliferation, and tumors.
Therefore, the potential harm of 2-chloro-4-fluoro-1-iodobenzene to the environment and human health should be taken seriously to prevent it from polluting the environment and protect public health.
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