Linshang Chemical
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2-Chloro-4-Fluoro-1-Methoxybenzene
Linshang Chemical
|
HS Code |
106284 |
| Chemical Formula | C7H6ClFO |
| Molecular Weight | 160.57 |
| Appearance | Liquid (usually) |
| Boiling Point | Around 160 - 170 °C |
| Density | Approx. 1.25 - 1.35 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Relatively low, flammable |
| Vapor Pressure | Low at room temperature |
As an accredited 2-Chloro-4-Fluoro-1-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 4 - fluoro - 1 - methoxybenzene packaged in a sealed glass bottle. |
| Storage | 2 - chloro - 4 - fluoro - 1 - methoxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals to avoid potential chemical reactions. Ensure the storage area is out of reach of unauthorized personnel. |
| Shipping | 2 - chloro - 4 - fluoro - 1 - methoxybenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported under proper temperature control, adhering to strict hazardous chemical shipping regulations to ensure safety during transit. |
Competitive 2-Chloro-4-Fluoro-1-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Chloro-4-Fluoro-1-Methoxybenzene in China?
As a trusted 2-Chloro-4-Fluoro-1-Methoxybenzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-4-Fluoro-1-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 2-chloro-4-fluoro-1-methoxybenzene?
2-Chloro-4-fluoro-1-methoxybenzene is also an organic compound. It has unique chemical properties and has attracted much attention in the field of organic synthesis.
This compound contains chlorine, fluorine, methoxy and other functional groups, each of which has its specific chemical activity. Chlorine atoms have certain electronegativity and can participate in nucleophilic substitution reactions. Under suitable reaction conditions, nucleophiles can attack the benzene ring carbon atoms connected to chlorine, causing the chlorine atoms to be replaced, thereby forming new carbon-heteroatomic bonds.
Fluorine atoms also have high electronegativity, which can significantly affect the electron cloud distribution of molecules. It can enhance the stability of molecules, and in some reactions, it can change the selectivity of the reaction. Due to the special properties of fluorine atoms, fluorine-containing organic compounds often exhibit unique biological activities and physical properties.
Methoxy group is the power supply group, which can increase the electron cloud density of the benzene ring. This characteristic makes the benzene ring more prone to electrophilic substitution reaction, and the localization effect of methoxy group makes the electrophilic reagent more inclined to attack the specific position of the benzene ring, that is, ortho and para-sites.
The synergistic effect of 2-chloro-4-fluoro-1-methoxybenzene has potential application value in pharmaceutical chemistry, materials science and other fields. In drug development, it can be used to design and synthesize drug molecules with specific biological activities, or in materials science, it can be used to build functional organic materials to meet different performance requirements.
This compound contains chlorine, fluorine, methoxy and other functional groups, each of which has its specific chemical activity. Chlorine atoms have certain electronegativity and can participate in nucleophilic substitution reactions. Under suitable reaction conditions, nucleophiles can attack the benzene ring carbon atoms connected to chlorine, causing the chlorine atoms to be replaced, thereby forming new carbon-heteroatomic bonds.
Fluorine atoms also have high electronegativity, which can significantly affect the electron cloud distribution of molecules. It can enhance the stability of molecules, and in some reactions, it can change the selectivity of the reaction. Due to the special properties of fluorine atoms, fluorine-containing organic compounds often exhibit unique biological activities and physical properties.
Methoxy group is the power supply group, which can increase the electron cloud density of the benzene ring. This characteristic makes the benzene ring more prone to electrophilic substitution reaction, and the localization effect of methoxy group makes the electrophilic reagent more inclined to attack the specific position of the benzene ring, that is, ortho and para-sites.
The synergistic effect of 2-chloro-4-fluoro-1-methoxybenzene has potential application value in pharmaceutical chemistry, materials science and other fields. In drug development, it can be used to design and synthesize drug molecules with specific biological activities, or in materials science, it can be used to build functional organic materials to meet different performance requirements.
What are the common uses of 2-chloro-4-fluoro-1-methoxybenzene?
2-Chloro-4-fluoro-1-methoxybenzene, this is an organic compound with a wide range of uses.
In the field of organic synthesis, it is often used as a key intermediate. The presence of chlorine, fluorine and methoxy groups in the Gein molecule endows the compound with unique reactivity and properties. Chlorine atoms have good leaving properties and can participate in many nucleophilic substitution reactions. For example, they can interact with nucleophiles such as alkoxides and amines to form new carbon-oxygen or carbon-nitrogen bonds, and then construct complex organic molecular structures, which is of great significance in drug synthesis and material preparation.
In the field of medicinal chemistry, 2-chloro-4-fluoro-1-methoxybenzene can be used to create new drugs. The introduction of fluorine atoms into organic molecules can often enhance the lipophilicity of drugs, improve their transmembrane transport capacity, and enhance bioavailability. At the same time, specific substituent combinations may be able to precisely fit biological targets, giving drugs high selectivity and activity.
In the field of materials science, it can participate in the synthesis of functional materials. The power supply of methoxy groups works together with the electronic effects of chlorine and fluorine atoms, which may make materials based on this compound have unique electrical and optical properties, and show application potential in organic optoelectronic materials.
In addition, it is also an important raw material in the production of fine chemicals. After a series of reactions, a variety of fine chemicals can be prepared, such as special fragrances, additives, etc., to meet different industrial and daily needs.
In the field of organic synthesis, it is often used as a key intermediate. The presence of chlorine, fluorine and methoxy groups in the Gein molecule endows the compound with unique reactivity and properties. Chlorine atoms have good leaving properties and can participate in many nucleophilic substitution reactions. For example, they can interact with nucleophiles such as alkoxides and amines to form new carbon-oxygen or carbon-nitrogen bonds, and then construct complex organic molecular structures, which is of great significance in drug synthesis and material preparation.
In the field of medicinal chemistry, 2-chloro-4-fluoro-1-methoxybenzene can be used to create new drugs. The introduction of fluorine atoms into organic molecules can often enhance the lipophilicity of drugs, improve their transmembrane transport capacity, and enhance bioavailability. At the same time, specific substituent combinations may be able to precisely fit biological targets, giving drugs high selectivity and activity.
In the field of materials science, it can participate in the synthesis of functional materials. The power supply of methoxy groups works together with the electronic effects of chlorine and fluorine atoms, which may make materials based on this compound have unique electrical and optical properties, and show application potential in organic optoelectronic materials.
In addition, it is also an important raw material in the production of fine chemicals. After a series of reactions, a variety of fine chemicals can be prepared, such as special fragrances, additives, etc., to meet different industrial and daily needs.
What are 2-chloro-4-fluoro-1-methoxybenzene synthesis methods?
To prepare 2-chloro-4-fluoro-1-methoxybenzene, there are several common methods.
First, halogenated aromatics are used as starting materials. Suitable halogenated benzene can be taken first, and the methoxy group can be introduced by nucleophilic substitution reaction under specific conditions. For example, 2-chloro-4-fluorochlorobenzene and sodium methoxide are mixed in a suitable organic solvent. At a certain temperature and reaction time, the chlorine atom can be replaced by methoxy group to obtain the target product. This reaction requires careful control of the reaction conditions. If the temperature is too high, or side reactions occur, the purity and yield of the product will be affected.
Second, starting from phenolic compounds. First, 2-chloro-4-fluorophenol is used as raw material, and methoxy is introduced through methylation reaction. Commonly used methylation reagents include dimethyl sulfate, etc. Under basic conditions, phenolic hydroxyl reacts with methylation reagents to form methoxy groups. During the reaction, factors such as alkalinity and the proportion of reagents used have a great influence on the reaction process and need to be carefully regulated.
Third, the Grignard reagent method is used. The Grignard reagent is made from halogenated aromatics, and then reacts with methoxy-related reagents. If 2-chloro-4-fluorobromobenzene is first made into Grignard reagent, and then reacts with methoxy halide or corresponding methoxy reagent in an anhydrous and anaerobic environment, the target molecular structure can be constructed. This process requires strict reaction environments, and anhydrous and anaerobic operations need to be strictly performed to prevent Grignard reagents from failing.
All methods have advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider the availability of raw materials, the difficulty of reaction conditions, the separation and purification of products, and many other factors to choose the optimal synthesis path.
First, halogenated aromatics are used as starting materials. Suitable halogenated benzene can be taken first, and the methoxy group can be introduced by nucleophilic substitution reaction under specific conditions. For example, 2-chloro-4-fluorochlorobenzene and sodium methoxide are mixed in a suitable organic solvent. At a certain temperature and reaction time, the chlorine atom can be replaced by methoxy group to obtain the target product. This reaction requires careful control of the reaction conditions. If the temperature is too high, or side reactions occur, the purity and yield of the product will be affected.
Second, starting from phenolic compounds. First, 2-chloro-4-fluorophenol is used as raw material, and methoxy is introduced through methylation reaction. Commonly used methylation reagents include dimethyl sulfate, etc. Under basic conditions, phenolic hydroxyl reacts with methylation reagents to form methoxy groups. During the reaction, factors such as alkalinity and the proportion of reagents used have a great influence on the reaction process and need to be carefully regulated.
Third, the Grignard reagent method is used. The Grignard reagent is made from halogenated aromatics, and then reacts with methoxy-related reagents. If 2-chloro-4-fluorobromobenzene is first made into Grignard reagent, and then reacts with methoxy halide or corresponding methoxy reagent in an anhydrous and anaerobic environment, the target molecular structure can be constructed. This process requires strict reaction environments, and anhydrous and anaerobic operations need to be strictly performed to prevent Grignard reagents from failing.
All methods have advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider the availability of raw materials, the difficulty of reaction conditions, the separation and purification of products, and many other factors to choose the optimal synthesis path.
2-chloro-4-fluoro-1-methoxybenzene what are the precautions during storage and transportation?
For 2-chloro-4-fluoro-1-methoxybenzene, there are several matters to be paid attention to during storage and transportation.
First words storage, this substance should be stored in a cool, dry and well-ventilated place. Cover its properties or be affected by changes in temperature and humidity. If it is placed in a high temperature and humid place, it may cause deterioration and damage its quality. And it must be kept away from fires and heat sources. Because the substance may be flammable, it is easy to cause danger in case of open flames and hot topics.
Furthermore, the storage place should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to its chemical properties, or violent reactions with the above-mentioned substances, accidents can occur. At the same time, the storage area should be equipped with suitable materials to contain the leakage, in case of leakage, it can be properly handled in time to avoid the expansion of harm.
As for transportation, be sure to ensure that the packaging is complete and sealed before transportation. Whether the packaging is good or not is related to the safety of the whole transportation process. If the packaging is damaged and the material leaks, it will be a disaster. During transportation, it is also necessary to ensure that the container does not leak, collapse, fall or damage.
Vehicles used during transportation should travel according to the specified route and do not stop in densely populated areas and residential areas. Because if the substance leaks, it will be more harmful where there are many people. And transport personnel should be familiar with the characteristics of the transported substances and emergency treatment methods, and in case of emergencies on the way, they can respond in time to reduce damage.
In short, in the storage and transportation of 2-chloro-4-fluoro-1-methoxybenzene, all links need to be cautious and follow relevant rules to ensure safety.
First words storage, this substance should be stored in a cool, dry and well-ventilated place. Cover its properties or be affected by changes in temperature and humidity. If it is placed in a high temperature and humid place, it may cause deterioration and damage its quality. And it must be kept away from fires and heat sources. Because the substance may be flammable, it is easy to cause danger in case of open flames and hot topics.
Furthermore, the storage place should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to its chemical properties, or violent reactions with the above-mentioned substances, accidents can occur. At the same time, the storage area should be equipped with suitable materials to contain the leakage, in case of leakage, it can be properly handled in time to avoid the expansion of harm.
As for transportation, be sure to ensure that the packaging is complete and sealed before transportation. Whether the packaging is good or not is related to the safety of the whole transportation process. If the packaging is damaged and the material leaks, it will be a disaster. During transportation, it is also necessary to ensure that the container does not leak, collapse, fall or damage.
Vehicles used during transportation should travel according to the specified route and do not stop in densely populated areas and residential areas. Because if the substance leaks, it will be more harmful where there are many people. And transport personnel should be familiar with the characteristics of the transported substances and emergency treatment methods, and in case of emergencies on the way, they can respond in time to reduce damage.
In short, in the storage and transportation of 2-chloro-4-fluoro-1-methoxybenzene, all links need to be cautious and follow relevant rules to ensure safety.
What are the effects of 2-chloro-4-fluoro-1-methoxybenzene on the environment and human health?
2-Chloro-4-fluoro-1-methoxybenzene is also an organic compound. The impact of this compound on the environment and human health is really relevant to everyone.
In terms of the environment, it may pose a certain hazard. If this substance is released in nature, or retained in soil and water bodies. It may prevent plant roots from absorbing nutrients in the soil, causing plant growth to be blocked. After entering the water body, it may affect aquatic organisms. Such as fish and shellfish, or it may cause physiological abnormalities or even death. And this substance may be enriched in the food chain and passed through layers, endangering higher organisms.
As for human health, exposure to this compound also poses a risk. If it enters the body through breathing, or irritates the respiratory tract, causing cough, asthma and other diseases. Skin contact, or cause allergies, redness, swelling, itching. Long-term exposure to this substance may damage human organs. Such as the liver, which is an important organ for detoxification, or is injured due to metabolism of this harmful substance. The kidneys mainly excrete, or are involved, resulting in abnormal excretion function. What's more, it may be potentially carcinogenic, and long-term exposure increases the risk of cancer.
From this point of view, 2-chloro-4-fluoro-1-methoxybenzene has a significant impact on the environment and human health. Its production, use and discharge should be strictly controlled to ensure environmental and personal safety.
In terms of the environment, it may pose a certain hazard. If this substance is released in nature, or retained in soil and water bodies. It may prevent plant roots from absorbing nutrients in the soil, causing plant growth to be blocked. After entering the water body, it may affect aquatic organisms. Such as fish and shellfish, or it may cause physiological abnormalities or even death. And this substance may be enriched in the food chain and passed through layers, endangering higher organisms.
As for human health, exposure to this compound also poses a risk. If it enters the body through breathing, or irritates the respiratory tract, causing cough, asthma and other diseases. Skin contact, or cause allergies, redness, swelling, itching. Long-term exposure to this substance may damage human organs. Such as the liver, which is an important organ for detoxification, or is injured due to metabolism of this harmful substance. The kidneys mainly excrete, or are involved, resulting in abnormal excretion function. What's more, it may be potentially carcinogenic, and long-term exposure increases the risk of cancer.
From this point of view, 2-chloro-4-fluoro-1-methoxybenzene has a significant impact on the environment and human health. Its production, use and discharge should be strictly controlled to ensure environmental and personal safety.
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