Linshang Chemical
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2-Chloro-4-Fluoro-1-Methylbenzene
Linshang Chemical
|
HS Code |
157174 |
| Chemical Formula | C7H6ClF |
| Molar Mass | 144.574 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 156 - 158 °C |
| Density | 1.193 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Flash Point | 47 °C |
| Refractive Index | 1.502 - 1.504 |
As an accredited 2-Chloro-4-Fluoro-1-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottle packaging for 2 - chloro - 4 - fluoro - 1 - methylbenzene chemical. |
| Storage | 2 - chloro - 4 - fluoro - 1 - methylbenzene should be stored in a cool, well - ventilated area away from direct sunlight. Keep it in a tightly sealed container to prevent evaporation and leakage. Store it separate from oxidizing agents, bases, and reactive materials. Ensure the storage area has proper fire - fighting equipment in case of ignition risks associated with this flammable organic compound. |
| Shipping | 2 - chloro - 4 - fluoro - 1 - methylbenzene is shipped in tightly sealed, corrosion - resistant containers. It follows strict hazardous material regulations, with proper labeling and secure packaging to prevent leakage during transit. |
Competitive 2-Chloro-4-Fluoro-1-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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What is the chemistry of 2-chloro-4-fluoro-1-methylbenzene?
2-Chloro-4-fluoro-1-methylbenzene, this is an organic compound. Its chemical properties are unique and valuable for investigation.
In terms of its reactivity, the benzene ring is connected with halogen atoms such as chlorine and fluorine and methyl groups. Chlorine and fluorine atoms have electron-sucking induction effects, while methyl groups have electron-giving induction effects. This structure causes the electron cloud density of the benzene ring to be unevenly distributed, and the electron cloud density of the ortho and para-position is relatively high. As a result, in the electrophilic substitution reaction, it is more vulnerable to the attack of electrophilic reagents in the ortho and para-position, showing an active state. For example, when substituted with bromine catalyzed by iron bromide, bromine tends to attack the ortho and para-positions of chlorine and fluorine atoms on the benzene ring.
In terms of stability, although the electron cloud density of the benzene ring is changed due to the presence of halogen atoms and methyl groups, the conjugate system of the benzene ring itself still exists, giving the compound certain stability. However, compared with benzene itself, its stability changes. For example, under the action of high temperature or strong oxidizing agent, the compound is more prone to reaction, because chlorine and fluorine atoms weaken the electron cloud of the benzene ring, making the benzene ring more susceptible to oxidation or other reactions.
From the interaction of substituents, chlorine and fluorine atoms absorb electrons, causing the benzene ring electron cloud to shift towards the halogen atom, reducing the density of the methyl electron cloud and weakening the electron-giving ability of the methyl group. On the contrary, the methyl group gives electrons, which can alleviate the attraction of the halogen atom to the benzene ring electron cloud to a certain extent, affecting the electrophilic substitution reaction activity and positional selectivity.
Its solubility also has characteristics. As an organic compound, it is difficult to dissolve in water because its molecules are non-polar or less polar, and water is a polar solvent. According to the principle of "similarity and compatibility", the two are incompatible. However, it is easily soluble in common organic solvents, such as ethanol, ether, carbon tetrachloride, etc. These organic solvents are mostly non-polar or weakly polar, and are similar to the intermolecular forces of 2-chloro-4-fluoro-1-methylbenzene.
In summary, the unique structure of 2-chloro-4-fluoro-1-methylbenzene shows special chemical properties in terms of reactivity, stability and solubility.
In terms of its reactivity, the benzene ring is connected with halogen atoms such as chlorine and fluorine and methyl groups. Chlorine and fluorine atoms have electron-sucking induction effects, while methyl groups have electron-giving induction effects. This structure causes the electron cloud density of the benzene ring to be unevenly distributed, and the electron cloud density of the ortho and para-position is relatively high. As a result, in the electrophilic substitution reaction, it is more vulnerable to the attack of electrophilic reagents in the ortho and para-position, showing an active state. For example, when substituted with bromine catalyzed by iron bromide, bromine tends to attack the ortho and para-positions of chlorine and fluorine atoms on the benzene ring.
In terms of stability, although the electron cloud density of the benzene ring is changed due to the presence of halogen atoms and methyl groups, the conjugate system of the benzene ring itself still exists, giving the compound certain stability. However, compared with benzene itself, its stability changes. For example, under the action of high temperature or strong oxidizing agent, the compound is more prone to reaction, because chlorine and fluorine atoms weaken the electron cloud of the benzene ring, making the benzene ring more susceptible to oxidation or other reactions.
From the interaction of substituents, chlorine and fluorine atoms absorb electrons, causing the benzene ring electron cloud to shift towards the halogen atom, reducing the density of the methyl electron cloud and weakening the electron-giving ability of the methyl group. On the contrary, the methyl group gives electrons, which can alleviate the attraction of the halogen atom to the benzene ring electron cloud to a certain extent, affecting the electrophilic substitution reaction activity and positional selectivity.
Its solubility also has characteristics. As an organic compound, it is difficult to dissolve in water because its molecules are non-polar or less polar, and water is a polar solvent. According to the principle of "similarity and compatibility", the two are incompatible. However, it is easily soluble in common organic solvents, such as ethanol, ether, carbon tetrachloride, etc. These organic solvents are mostly non-polar or weakly polar, and are similar to the intermolecular forces of 2-chloro-4-fluoro-1-methylbenzene.
In summary, the unique structure of 2-chloro-4-fluoro-1-methylbenzene shows special chemical properties in terms of reactivity, stability and solubility.
What are the main uses of 2-chloro-4-fluoro-1-methylbenzene?
2-Chloro-4-fluoro-1-methylbenzene has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to the different groups such as chlorine, fluorine and methyl attached to the benzene ring, it is endowed with unique chemical activity and can be converted into other organic compounds by many chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc. When synthesizing a drug molecule with a specific structure, the required functional group can be introduced by nucleophilic substitution reaction on its chlorine or fluorine atom to lay the foundation for drug synthesis.
In the field of materials science, 2-chloro-4-fluoro-1-methylbenzene also has important uses. Polymer materials with special properties can be prepared by polymerization or copolymerization with other monomers. Because of its fluorine atom, it can improve the chemical corrosion resistance, heat resistance and surface properties of the material. For example, when it is introduced into the polymer structure, the prepared material may have good water and oil repellent properties, which can be applied to fabric finishing, coating and other industries.
In the field of agricultural chemistry, it may also be used as an important raw material for synthetic pesticides. Through further chemical modification, pesticides with specific biological activities can be developed for the control of pests, weeds, etc., providing effective protection for agricultural production.
In addition, in the preparation of fine chemical products, 2-chloro-4-fluoro-1-methylbenzene also plays an important role. It can be used to synthesize flavors, dyes and other products, giving these products unique properties and colors.
In summary, 2-chloro-4-fluoro-1-methylbenzene has important applications in many fields such as organic synthesis, materials science, agricultural chemistry and fine chemicals, and is of great significance to promote the development of various industries.
In the field of materials science, 2-chloro-4-fluoro-1-methylbenzene also has important uses. Polymer materials with special properties can be prepared by polymerization or copolymerization with other monomers. Because of its fluorine atom, it can improve the chemical corrosion resistance, heat resistance and surface properties of the material. For example, when it is introduced into the polymer structure, the prepared material may have good water and oil repellent properties, which can be applied to fabric finishing, coating and other industries.
In the field of agricultural chemistry, it may also be used as an important raw material for synthetic pesticides. Through further chemical modification, pesticides with specific biological activities can be developed for the control of pests, weeds, etc., providing effective protection for agricultural production.
In addition, in the preparation of fine chemical products, 2-chloro-4-fluoro-1-methylbenzene also plays an important role. It can be used to synthesize flavors, dyes and other products, giving these products unique properties and colors.
In summary, 2-chloro-4-fluoro-1-methylbenzene has important applications in many fields such as organic synthesis, materials science, agricultural chemistry and fine chemicals, and is of great significance to promote the development of various industries.
What is the preparation method of 2-chloro-4-fluoro-1-methylbenzene?
2-Chloro-4-fluoro-1-methylbenzene can be prepared by the following methods.
First, p-methylaniline is used as the starting material. It is first reacted with acetyl chloride to form p-methylacetaniline. This step is designed to protect the amino group from overreacting in subsequent reactions. Then, p-methylacetaniline is reacted with a chlorine reagent, such as chlorine gas, under suitable conditions, and the chlorine atom selectively enters the amino para-position to form 2-chloro-4-acetaminotoluene. Then, by hydrolysis reaction, under acidic or basic conditions, the acetamide group is hydrolyzed into an amino group to obtain 2-chloro-4-aminotoluene. Then, by diazotization of fluoroboronic acid, the amino group is converted into a diazonium salt, and then reacts with fluoroboronic acid to generate 2-chloro-4-fluorotoluene. This process requires attention to the precise control of the reaction conditions. Temperature and the proportion of reactants have a great influence on the formation of the product.
Second, use p-methyl chlorobenzene as the starting material. In the presence of anhydrous aluminum trichloride and other catalysts, methyl chloride is introduced into the benzene ring to generate 2-chloro-1-methylbenzene. Then, by means of electrophilic substitution reaction, a suitable fluorination reagent, such as a mixture of hydrogen fluoride and potassium fluoride, is used to replace the hydrogen atom at a specific position on the benzene ring under specific conditions to obtain 2-chloro-4-fluoro-1-methylbenzene. In this path, the choice and dosage of catalyst, reaction temperature and time are all key factors affecting the reaction process and product purity.
Or, the starting material is o-chlorotoluene. It is first nitrified to form o-chloro-4-nitrotoluene under the action of suitable nitrifying reagents such as concentrated nitric acid and concentrated sulfuric acid. Then, through reduction reaction, the nitro group is reduced to amino group with iron powder, hydrochloric acid and other reducing agents to obtain o-chloro-4-aminotoluene. Subsequently, similar to the above, through diazotization and fluorination, 2-chloro-4-fluoro-1-methylbenzene is obtained. The whole process, the separation and purification operation after each step of the reaction is also extremely important, which is related to the quality of the final product.
First, p-methylaniline is used as the starting material. It is first reacted with acetyl chloride to form p-methylacetaniline. This step is designed to protect the amino group from overreacting in subsequent reactions. Then, p-methylacetaniline is reacted with a chlorine reagent, such as chlorine gas, under suitable conditions, and the chlorine atom selectively enters the amino para-position to form 2-chloro-4-acetaminotoluene. Then, by hydrolysis reaction, under acidic or basic conditions, the acetamide group is hydrolyzed into an amino group to obtain 2-chloro-4-aminotoluene. Then, by diazotization of fluoroboronic acid, the amino group is converted into a diazonium salt, and then reacts with fluoroboronic acid to generate 2-chloro-4-fluorotoluene. This process requires attention to the precise control of the reaction conditions. Temperature and the proportion of reactants have a great influence on the formation of the product.
Second, use p-methyl chlorobenzene as the starting material. In the presence of anhydrous aluminum trichloride and other catalysts, methyl chloride is introduced into the benzene ring to generate 2-chloro-1-methylbenzene. Then, by means of electrophilic substitution reaction, a suitable fluorination reagent, such as a mixture of hydrogen fluoride and potassium fluoride, is used to replace the hydrogen atom at a specific position on the benzene ring under specific conditions to obtain 2-chloro-4-fluoro-1-methylbenzene. In this path, the choice and dosage of catalyst, reaction temperature and time are all key factors affecting the reaction process and product purity.
Or, the starting material is o-chlorotoluene. It is first nitrified to form o-chloro-4-nitrotoluene under the action of suitable nitrifying reagents such as concentrated nitric acid and concentrated sulfuric acid. Then, through reduction reaction, the nitro group is reduced to amino group with iron powder, hydrochloric acid and other reducing agents to obtain o-chloro-4-aminotoluene. Subsequently, similar to the above, through diazotization and fluorination, 2-chloro-4-fluoro-1-methylbenzene is obtained. The whole process, the separation and purification operation after each step of the reaction is also extremely important, which is related to the quality of the final product.
2-chloro-4-fluoro-1-methylbenzene What are the precautions during storage and transportation?
2-Chloro-4-fluoro-1-methylbenzene is also an organic compound. When storing and transporting, be sure to pay attention to many matters.
The first thing to bear the brunt is related to storage. Because of its certain chemical activity, it should be placed in a cool and ventilated warehouse. Due to high temperature, it may cause chemical reactions or even cause danger. The temperature of the warehouse should be controlled within a suitable range and protected from direct sunlight. This is to prevent it from deteriorating or causing unstable reactions due to light. And it needs to be kept away from fire and heat sources. Open flames and hot topics can cause it to burn or even explode, which is truly invisible.
Furthermore, when storing, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. Due to its chemical properties, it may encounter the above-mentioned substances or cause severe chemical reactions, endangering safety. The storage area should also be equipped with suitable materials to contain leaks in case of leakage, which can be dealt with in time to prevent their spread from causing greater harm.
As for transportation, it should not be underestimated. Transportation vehicles must ensure that they are in good condition and have corresponding safety facilities. During transportation, it is necessary to ensure that containers do not leak, collapse, fall, or damage. Driving routes should avoid densely populated areas and important facilities to prevent accidents from endangering public safety. When transporting, you need to follow the specified route and do not stop in residential areas and densely populated areas. Escort personnel must also be familiar with its nature and emergency handling methods, and keep an eye on the condition of the goods at any time on the way. If there is any abnormality, take immediate measures.
All of these are for those who should pay attention when storing and transporting 2-chloro-4-fluoro-1-methylbenzene. They must not be negligent to avoid major disasters.
The first thing to bear the brunt is related to storage. Because of its certain chemical activity, it should be placed in a cool and ventilated warehouse. Due to high temperature, it may cause chemical reactions or even cause danger. The temperature of the warehouse should be controlled within a suitable range and protected from direct sunlight. This is to prevent it from deteriorating or causing unstable reactions due to light. And it needs to be kept away from fire and heat sources. Open flames and hot topics can cause it to burn or even explode, which is truly invisible.
Furthermore, when storing, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. Due to its chemical properties, it may encounter the above-mentioned substances or cause severe chemical reactions, endangering safety. The storage area should also be equipped with suitable materials to contain leaks in case of leakage, which can be dealt with in time to prevent their spread from causing greater harm.
As for transportation, it should not be underestimated. Transportation vehicles must ensure that they are in good condition and have corresponding safety facilities. During transportation, it is necessary to ensure that containers do not leak, collapse, fall, or damage. Driving routes should avoid densely populated areas and important facilities to prevent accidents from endangering public safety. When transporting, you need to follow the specified route and do not stop in residential areas and densely populated areas. Escort personnel must also be familiar with its nature and emergency handling methods, and keep an eye on the condition of the goods at any time on the way. If there is any abnormality, take immediate measures.
All of these are for those who should pay attention when storing and transporting 2-chloro-4-fluoro-1-methylbenzene. They must not be negligent to avoid major disasters.
2-chloro-4-fluoro-1-methylbenzene impact on the environment and human health
2-Chloro-4-fluoro-1-methylbenzene, an organic compound, is widely used in the chemical industry. However, it has potential effects on both the environment and human health.
First talk about the impact on the environment. If this compound is released into the environment, it is difficult to degrade naturally due to its chemical stability, and will persist in the environment. In the soil, it may change the chemical properties of the soil, hinder the absorption of nutrients by plant roots, and then affect plant growth and development, resulting in poor vegetation growth and destruction of ecological balance. If it enters the water body, it will cause water pollution and pose a threat to aquatic organisms. Because of its certain toxicity, it may poison aquatic organisms such as fish and shellfish, destroy the food chain structure of aquatic ecosystems, and damage aquatic biodiversity.
Re-discuss the impact on human health. If the human body is exposed to this substance through breathing, skin contact or accidental ingestion, it is very harmful. It may irritate the human respiratory tract, causing symptoms such as cough, asthma, breathing difficulties, etc. If it comes into contact with the skin, it may cause skin allergies, redness, swelling, itching and other discomforts, and even corrode the skin in severe cases. If accidentally ingested, it will damage the digestive system, cause nausea, vomiting, abdominal pain and other symptoms. Long-term exposure or ingestion may also cause damage to the human nervous system, liver, kidneys and other important organs, affect their normal function, and even pose a potential carcinogenic risk.
In summary, 2-chloro-4-fluoro-1-methylbenzene poses significant potential hazards to the environment and human health. Strict protective and control measures must be taken when manufacturing, using and disposing of this substance to reduce its adverse effects on the environment and human body.
First talk about the impact on the environment. If this compound is released into the environment, it is difficult to degrade naturally due to its chemical stability, and will persist in the environment. In the soil, it may change the chemical properties of the soil, hinder the absorption of nutrients by plant roots, and then affect plant growth and development, resulting in poor vegetation growth and destruction of ecological balance. If it enters the water body, it will cause water pollution and pose a threat to aquatic organisms. Because of its certain toxicity, it may poison aquatic organisms such as fish and shellfish, destroy the food chain structure of aquatic ecosystems, and damage aquatic biodiversity.
Re-discuss the impact on human health. If the human body is exposed to this substance through breathing, skin contact or accidental ingestion, it is very harmful. It may irritate the human respiratory tract, causing symptoms such as cough, asthma, breathing difficulties, etc. If it comes into contact with the skin, it may cause skin allergies, redness, swelling, itching and other discomforts, and even corrode the skin in severe cases. If accidentally ingested, it will damage the digestive system, cause nausea, vomiting, abdominal pain and other symptoms. Long-term exposure or ingestion may also cause damage to the human nervous system, liver, kidneys and other important organs, affect their normal function, and even pose a potential carcinogenic risk.
In summary, 2-chloro-4-fluoro-1-methylbenzene poses significant potential hazards to the environment and human health. Strict protective and control measures must be taken when manufacturing, using and disposing of this substance to reduce its adverse effects on the environment and human body.
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