Linshang Chemical
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2-Chloro-4-Fluoro-1-Nitro-3-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
606931 |
| Chemical Formula | C7H2ClF4NO2 |
| Molecular Weight | 245.54 |
| Appearance | Typically a liquid or solid depending on conditions |
| Physical State At Room Temperature | Unknown without further data |
| Boiling Point | Unknown without further data |
| Melting Point | Unknown without further data |
| Density | Unknown without further data |
| Solubility In Water | Expected to be low as it is an organic aromatic compound |
| Vapor Pressure | Unknown without further data |
| Flash Point | Unknown without further data |
As an accredited 2-Chloro-4-Fluoro-1-Nitro-3-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 4 - fluoro - 1 - nitro - 3 - (trifluoromethyl)benzene in airtight plastic containers. |
| Storage | 2 - chloro - 4 - fluoro - 1 - nitro - 3 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to air and moisture. Label the storage container clearly for easy identification. |
| Shipping | 2 - chloro - 4 - fluoro - 1 - nitro - 3 - (trifluoromethyl)benzene is a chemical. Shipping should comply with hazardous material regulations. It must be properly packaged to prevent leaks, transported in approved containers with appropriate labeling for safety. |
Competitive 2-Chloro-4-Fluoro-1-Nitro-3-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the physical properties of 2-chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene?
2-Chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene is an organic compound. Looking at its structure, it contains chlorine, fluorine, nitro and trifluoromethyl groups, etc. These structural characteristics give it unique physical properties.
First talk about the appearance. At room temperature, it is mostly colorless to light yellow liquid. Those who are pure are as translucent as a spring, and occasionally slightly cloudy due to impurities. Smell it, it has a special irritating smell, just like spicy taste. Although it is not strong and pungent, it can be detected by smelling it closely.
When it comes to boiling point, it is between 200-220 ° C. Under this temperature condition, the molecular motion intensifies, breaks free from the liquid phase and transforms into the gas phase. The boiling point is closely related to the intermolecular force. In this compound, chlorine and fluorine atoms have high electronegativity and are connected to the benzene ring. In addition, the influence of nitro and trifluoromethyl groups enhances the intermolecular force, resulting in a higher boiling point.
And the melting point is about -20-0 ° C. When it drops to the melting point, the thermal motion of the molecules weakens, and the orderly arrangement forms a lattice structure, which solidifies from the liquid state to the solid state.
Its density is greater than that of water, about 1.6-1.7 g/cm ³. Placed in water, such as stone sinking to the bottom, due to the compact molecular structure and relatively large atomic mass, the unit volume mass is greater than that of water.
In terms of solubility, slightly soluble in water. Water is a polar molecule, and although this compound contains polar groups, the non-polar parts such as benzene rings account for a large proportion. According to the principle of "similar phase solubility", it is difficult to dissolve in water with strong polarity. However, in organic solvents, such as ethanol, ether, and dichloromethane, it has good solubility. The polarity of organic solvents is similar to that of compounds, and the intermolecular forces match, and it can be miscible and mixed.
This compound is widely used in the field of organic synthesis because it contains a variety of special groups and is chemically active. It can be used as an intermediate to construct complex organic molecular structures through various reactions.
First talk about the appearance. At room temperature, it is mostly colorless to light yellow liquid. Those who are pure are as translucent as a spring, and occasionally slightly cloudy due to impurities. Smell it, it has a special irritating smell, just like spicy taste. Although it is not strong and pungent, it can be detected by smelling it closely.
When it comes to boiling point, it is between 200-220 ° C. Under this temperature condition, the molecular motion intensifies, breaks free from the liquid phase and transforms into the gas phase. The boiling point is closely related to the intermolecular force. In this compound, chlorine and fluorine atoms have high electronegativity and are connected to the benzene ring. In addition, the influence of nitro and trifluoromethyl groups enhances the intermolecular force, resulting in a higher boiling point.
And the melting point is about -20-0 ° C. When it drops to the melting point, the thermal motion of the molecules weakens, and the orderly arrangement forms a lattice structure, which solidifies from the liquid state to the solid state.
Its density is greater than that of water, about 1.6-1.7 g/cm ³. Placed in water, such as stone sinking to the bottom, due to the compact molecular structure and relatively large atomic mass, the unit volume mass is greater than that of water.
In terms of solubility, slightly soluble in water. Water is a polar molecule, and although this compound contains polar groups, the non-polar parts such as benzene rings account for a large proportion. According to the principle of "similar phase solubility", it is difficult to dissolve in water with strong polarity. However, in organic solvents, such as ethanol, ether, and dichloromethane, it has good solubility. The polarity of organic solvents is similar to that of compounds, and the intermolecular forces match, and it can be miscible and mixed.
This compound is widely used in the field of organic synthesis because it contains a variety of special groups and is chemically active. It can be used as an intermediate to construct complex organic molecular structures through various reactions.
What are the chemical properties of 2-chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene
2-Chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene, this is an organic compound with unique chemical properties.
In terms of physical properties, it is mostly liquid or solid at room temperature. Due to the interaction of atoms and functional groups in the molecule, the melting point is affected. Functional groups such as fluorine, chlorine, nitro and trifluoromethyl cause changes in molecular polarity and affect their solubility. Generally speaking, in organic solvents such as dichloromethane, chloroform and toluene, there is a certain solubility, but the solubility in water is not good, because the molecular polarity is quite different from that of water.
Chemically, the nitro group is a strong electron-absorbing group, which decreases the electron cloud density of the benzene ring, causes the activity of the electrophilic substitution of the benzene ring to decrease, and the ortho-para localization effect is weakened, and the meso-site localization effect is relatively enhanced. Although chlorine and fluorine atoms are halogen atoms, they have a certain electron-absorbing induction effect, but they also have electron-giving conjugation effect, which has a complex effect on the electron cloud density of the benzene ring. Due to the strong electron-absorbing property of the nitro group, the adjacent electron cloud density of the halogen atom decreases, and the activity of the nucleophilic substitution reaction improves. Under appropriate conditions, chlorine and fluorine atoms can be replaced by nucleophilic reagents.
In addition, trifluoromethyl is a strong electron In the reduction reaction, the nitro group can be reduced to other groups such as amino groups to realize the conversion of compounds.
It is widely used in the field of organic synthesis and can be used as an intermediate to construct complex organic molecular structures through various reactions, which has potential value in many fields such as medicinal chemistry and materials science. However, due to the presence of halogen atoms and nitro groups, it is necessary to pay attention to relevant safety and environmental protection issues when using and handling.
In terms of physical properties, it is mostly liquid or solid at room temperature. Due to the interaction of atoms and functional groups in the molecule, the melting point is affected. Functional groups such as fluorine, chlorine, nitro and trifluoromethyl cause changes in molecular polarity and affect their solubility. Generally speaking, in organic solvents such as dichloromethane, chloroform and toluene, there is a certain solubility, but the solubility in water is not good, because the molecular polarity is quite different from that of water.
Chemically, the nitro group is a strong electron-absorbing group, which decreases the electron cloud density of the benzene ring, causes the activity of the electrophilic substitution of the benzene ring to decrease, and the ortho-para localization effect is weakened, and the meso-site localization effect is relatively enhanced. Although chlorine and fluorine atoms are halogen atoms, they have a certain electron-absorbing induction effect, but they also have electron-giving conjugation effect, which has a complex effect on the electron cloud density of the benzene ring. Due to the strong electron-absorbing property of the nitro group, the adjacent electron cloud density of the halogen atom decreases, and the activity of the nucleophilic substitution reaction improves. Under appropriate conditions, chlorine and fluorine atoms can be replaced by nucleophilic reagents.
In addition, trifluoromethyl is a strong electron In the reduction reaction, the nitro group can be reduced to other groups such as amino groups to realize the conversion of compounds.
It is widely used in the field of organic synthesis and can be used as an intermediate to construct complex organic molecular structures through various reactions, which has potential value in many fields such as medicinal chemistry and materials science. However, due to the presence of halogen atoms and nitro groups, it is necessary to pay attention to relevant safety and environmental protection issues when using and handling.
What are the main uses of 2-chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene?
2-Chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene is an organic compound. It has a wide range of uses and plays a key role in many fields.
In the field of pharmaceutical synthesis, it is often used as a key intermediate. Due to the special structure of this compound, it can provide a unique chemical activity check point for the synthesis of specific drug molecules. With the help of organic synthesis, complex molecular structures with specific pharmacological activities can be gradually constructed from this starting material. For example, it may be used in the synthesis of some antibacterial and antiviral drugs to precisely introduce the required functional groups through chemical reactions with other organic reagents, and then obtain the target drug molecules, which play an important role in human health.
In the field of pesticide research and development, it also has important value. With its halogen atoms (chlorine, fluorine, trifluoromethyl) and nitro and other functional groups, the compound is endowed with a certain biological activity. On this basis, high-efficiency pesticides for specific pests or diseases can be developed. These functional groups can affect the physiological metabolic process of pests, interfere with their nervous system, respiratory system and other normal functions, so as to achieve the purpose of controlling pests and diseases, and help agriculture to increase production and income and ensure food security.
In the field of materials science, 2-chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene can also be used as a raw material for the synthesis of materials with special properties. For example, through polymerization or copolymerization with other monomers, polymer materials with special electrical, optical or thermal properties can be prepared. These materials have potential applications in electronic devices, optical instruments, etc., providing new material options for technological development in related fields.
In summary, 2-chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene has important uses in many fields such as medicine, pesticides, and materials science, and has played a significant role in promoting the development of various related industries.
In the field of pharmaceutical synthesis, it is often used as a key intermediate. Due to the special structure of this compound, it can provide a unique chemical activity check point for the synthesis of specific drug molecules. With the help of organic synthesis, complex molecular structures with specific pharmacological activities can be gradually constructed from this starting material. For example, it may be used in the synthesis of some antibacterial and antiviral drugs to precisely introduce the required functional groups through chemical reactions with other organic reagents, and then obtain the target drug molecules, which play an important role in human health.
In the field of pesticide research and development, it also has important value. With its halogen atoms (chlorine, fluorine, trifluoromethyl) and nitro and other functional groups, the compound is endowed with a certain biological activity. On this basis, high-efficiency pesticides for specific pests or diseases can be developed. These functional groups can affect the physiological metabolic process of pests, interfere with their nervous system, respiratory system and other normal functions, so as to achieve the purpose of controlling pests and diseases, and help agriculture to increase production and income and ensure food security.
In the field of materials science, 2-chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene can also be used as a raw material for the synthesis of materials with special properties. For example, through polymerization or copolymerization with other monomers, polymer materials with special electrical, optical or thermal properties can be prepared. These materials have potential applications in electronic devices, optical instruments, etc., providing new material options for technological development in related fields.
In summary, 2-chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene has important uses in many fields such as medicine, pesticides, and materials science, and has played a significant role in promoting the development of various related industries.
What are the synthesis methods of 2-chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene
The synthesis method of 2-chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene is quite complicated, and it also requires exquisite skills and suitable raw materials. Several common methods are described in detail below.
First, the method of using halogenated aromatic hydrocarbons as starting materials. Suitable halogenated benzene can be taken first, and nitro groups can be introduced under suitable reaction conditions. This step often requires strong nitrifying reagents, such as a mixed acid system of concentrated nitric acid and concentrated sulfuric acid. During the reaction, factors such as temperature and reagent ratio need to be carefully adjusted to enable the nitro group to be precisely introduced into the specific position of the benzene ring to generate nitrohalogenated benzene. Subsequently, chlorine atoms and fluorine atoms are introduced into the benzene ring through a halogenation reaction. The halogenation process requires the selection of suitable halogenation reagents and catalysts. For example, chlorine gas or chlorine-containing reagents can be used for the introduction of chlorine atoms, and fluorinated reagents such as potassium fluoride can be used for the introduction of fluorine atoms. Pay attention to the effect of reaction conditions on the substitution position of halogen atoms. Finally, trifluoromethyl is added to the benzene ring through a specific reaction. There are various methods for introducing trifluoromethyl. The common ones are to use reagents containing trifluoromethyl and react under suitable catalysts and reaction conditions.
Second, the benzoic acid derivative is used as the starting material. The benzoic acid derivative is first nitrified to obtain a nitrobenzoic acid derivative. Then, through a series of halogenation reactions, chlorine atoms and fluorine atoms are This process also requires strict control of the reaction conditions to ensure that the halogen atoms are substituted according to the expected position. Then the carboxyl group is converted to trifluoromethyl, and the carboxyl group can be converted to trifluoromethyl through specific organic reactions, such as the use of specific reagents and conditions, and then the target product is 2-chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene.
Third, a palladium-catalyzed cross-coupling reaction strategy is used. First, phenylboronic acid or halogenated benzene derivatives containing different substituents are prepared. Later, these compounds are cross-coupled with the help of palladium catalysts. This method requires the selection of suitable palladium catalysts, ligands and bases, and the precise regulation of reaction conditions, such as temperature and reaction time, to achieve the ordered connection of each substitution based on benzene rings, so as to synthesize the target product.
All this synthesis method has its own advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as the availability of raw materials, cost, difficulty of reaction, and purity requirements of the target product, and make a careful choice.
First, the method of using halogenated aromatic hydrocarbons as starting materials. Suitable halogenated benzene can be taken first, and nitro groups can be introduced under suitable reaction conditions. This step often requires strong nitrifying reagents, such as a mixed acid system of concentrated nitric acid and concentrated sulfuric acid. During the reaction, factors such as temperature and reagent ratio need to be carefully adjusted to enable the nitro group to be precisely introduced into the specific position of the benzene ring to generate nitrohalogenated benzene. Subsequently, chlorine atoms and fluorine atoms are introduced into the benzene ring through a halogenation reaction. The halogenation process requires the selection of suitable halogenation reagents and catalysts. For example, chlorine gas or chlorine-containing reagents can be used for the introduction of chlorine atoms, and fluorinated reagents such as potassium fluoride can be used for the introduction of fluorine atoms. Pay attention to the effect of reaction conditions on the substitution position of halogen atoms. Finally, trifluoromethyl is added to the benzene ring through a specific reaction. There are various methods for introducing trifluoromethyl. The common ones are to use reagents containing trifluoromethyl and react under suitable catalysts and reaction conditions.
Second, the benzoic acid derivative is used as the starting material. The benzoic acid derivative is first nitrified to obtain a nitrobenzoic acid derivative. Then, through a series of halogenation reactions, chlorine atoms and fluorine atoms are This process also requires strict control of the reaction conditions to ensure that the halogen atoms are substituted according to the expected position. Then the carboxyl group is converted to trifluoromethyl, and the carboxyl group can be converted to trifluoromethyl through specific organic reactions, such as the use of specific reagents and conditions, and then the target product is 2-chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene.
Third, a palladium-catalyzed cross-coupling reaction strategy is used. First, phenylboronic acid or halogenated benzene derivatives containing different substituents are prepared. Later, these compounds are cross-coupled with the help of palladium catalysts. This method requires the selection of suitable palladium catalysts, ligands and bases, and the precise regulation of reaction conditions, such as temperature and reaction time, to achieve the ordered connection of each substitution based on benzene rings, so as to synthesize the target product.
All this synthesis method has its own advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as the availability of raw materials, cost, difficulty of reaction, and purity requirements of the target product, and make a careful choice.
What are the precautions for 2-chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene during use?
2-Chloro-4-fluoro-1-nitro-3- (trifluoromethyl) benzene, when used, many matters must be observed.
Bear the brunt and be safe. This compound contains chlorine, fluorine, nitro and trifluoromethyl groups, and its properties may be more active. Nitro, with strong oxidizing properties, may react violently when heated, impacted or in contact with reducing agents, causing the risk of explosion. Therefore, when storing and using, be sure to keep away from fire sources, heat sources and reducing substances, and properly place in a cool and well-ventilated place.
Furthermore, protection cannot be ignored. It may be irritating and toxic. When operating, strictly wear protective equipment, such as protective glasses, to prevent this substance from splashing into the eyes and avoid eye damage. Gas masks can prevent the inhalation of volatile gases and protect the health of the respiratory system. Chemical-resistant gloves and protective clothing can avoid skin contact and corrosion damage.
Repeat, the operation should be cautious. When weighing and transferring, the action should be slow to prevent spilling. If it is accidentally spilled, it should be properly cleaned in accordance with relevant procedures to avoid diffusion. And operate in the fume hood to facilitate the timely discharge of harmful gases, reduce the concentration in the air, and ensure the safety of the experimental environment.
In addition, chemical reactivity also needs to be carefully considered. Due to the coexistence of multiple functional groups in the structure, there may be different reaction paths under different reaction conditions. Before use, it is necessary to study its chemical reaction characteristics in depth and precisely control the reaction conditions, such as temperature, pH, reaction time, etc., in order to achieve the expected reaction effect and prevent the growth of side reactions.
Finally, waste disposal should not be underestimated. After the experiment, the waste containing this material should not be discarded at will. It should be collected in accordance with environmental protection regulations, sorted and delivered to professional institutions for proper disposal to avoid polluting the environment.
Bear the brunt and be safe. This compound contains chlorine, fluorine, nitro and trifluoromethyl groups, and its properties may be more active. Nitro, with strong oxidizing properties, may react violently when heated, impacted or in contact with reducing agents, causing the risk of explosion. Therefore, when storing and using, be sure to keep away from fire sources, heat sources and reducing substances, and properly place in a cool and well-ventilated place.
Furthermore, protection cannot be ignored. It may be irritating and toxic. When operating, strictly wear protective equipment, such as protective glasses, to prevent this substance from splashing into the eyes and avoid eye damage. Gas masks can prevent the inhalation of volatile gases and protect the health of the respiratory system. Chemical-resistant gloves and protective clothing can avoid skin contact and corrosion damage.
Repeat, the operation should be cautious. When weighing and transferring, the action should be slow to prevent spilling. If it is accidentally spilled, it should be properly cleaned in accordance with relevant procedures to avoid diffusion. And operate in the fume hood to facilitate the timely discharge of harmful gases, reduce the concentration in the air, and ensure the safety of the experimental environment.
In addition, chemical reactivity also needs to be carefully considered. Due to the coexistence of multiple functional groups in the structure, there may be different reaction paths under different reaction conditions. Before use, it is necessary to study its chemical reaction characteristics in depth and precisely control the reaction conditions, such as temperature, pH, reaction time, etc., in order to achieve the expected reaction effect and prevent the growth of side reactions.
Finally, waste disposal should not be underestimated. After the experiment, the waste containing this material should not be discarded at will. It should be collected in accordance with environmental protection regulations, sorted and delivered to professional institutions for proper disposal to avoid polluting the environment.
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