Linshang Chemical
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2-Chloro-4-Fluoro-1-Nitrobenzene
Linshang Chemical
|
HS Code |
511172 |
| Chemical Formula | C6H3ClFNO2 |
| Molar Mass | 177.545 g/mol |
| Appearance | Yellow to orange - red liquid |
| Boiling Point | 216 - 217 °C |
| Melting Point | 15 - 16 °C |
| Density | 1.494 g/cm³ |
| Flash Point | 93 °C |
| Solubility In Water | Insoluble |
| Vapor Pressure | Low |
| Pka | No data available |
| Logp | 2.73 |
As an accredited 2-Chloro-4-Fluoro-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250 - gram bottle of 2 - chloro - 4 - fluoro - 1 - nitrobenzene, well - sealed for chemical storage. |
| Storage | 2 - Chloro - 4 - fluoro - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. Keep it in a tightly closed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and reactive substances to avoid potential chemical reactions. Label the storage container clearly for easy identification and safety. |
| Shipping | 2 - chloro - 4 - fluoro - 1 - nitrobenzene is shipped in well - sealed, corrosion - resistant containers. It's transported under regulated conditions, following strict safety protocols due to its chemical nature, ensuring secure delivery. |
Competitive 2-Chloro-4-Fluoro-1-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Chloro-4-Fluoro-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chloro-4-fluoro-1-nitrobenzene?
2-Chloro-4-fluoro-1-nitrobenzene is an important class of organic compounds. It has a wide range of uses and is involved in many fields of chemical industry.
First, this compound is often a key intermediate in the synthesis of medicine. Due to the characteristics of chlorine, fluorine and nitro groups, it endows the molecule with specific reactivity and pharmacological properties. Through a series of organic reactions, it can be converted into drug molecules with specific biological activities, such as the preparation of antibacterial, anti-inflammatory and other drugs. 2-chloro-4-fluoro-1-nitrobenzene is often one of the starting materials, and complex drug structures are constructed through delicate reaction steps.
Second, in the field of pesticide creation, it also occupies an important position. Due to its structural characteristics, pesticide components can be derived that have high-efficiency killing or inhibitory effects on pests. After modification and reaction, pesticides such as insecticides and fungicides are prepared, which make great contributions to agricultural pest control. It can precisely act on the specific physiological processes of pests, and has relatively little impact on the environment, meeting the needs of modern agriculture for high-efficiency and low-toxicity pesticides.
Furthermore, in the field of materials science, 2-chloro-4-fluoro-1-nitrobenzene can participate in the synthesis of special materials. Its structure can introduce specific functional groups and change the physical and chemical properties of materials. For example, it is used to synthesize polymer materials with special optical and electrical properties, which play a unique role in electronic devices, optical instruments, etc., and help technological progress and product upgrades in related fields.
In short, 2-chloro-4-fluoro-1-nitrobenzene, with its unique structure, has shown diverse and important uses in the fields of medicine, pesticides and materials science, and is of great significance to promote the development of chemical-related industries.
First, this compound is often a key intermediate in the synthesis of medicine. Due to the characteristics of chlorine, fluorine and nitro groups, it endows the molecule with specific reactivity and pharmacological properties. Through a series of organic reactions, it can be converted into drug molecules with specific biological activities, such as the preparation of antibacterial, anti-inflammatory and other drugs. 2-chloro-4-fluoro-1-nitrobenzene is often one of the starting materials, and complex drug structures are constructed through delicate reaction steps.
Second, in the field of pesticide creation, it also occupies an important position. Due to its structural characteristics, pesticide components can be derived that have high-efficiency killing or inhibitory effects on pests. After modification and reaction, pesticides such as insecticides and fungicides are prepared, which make great contributions to agricultural pest control. It can precisely act on the specific physiological processes of pests, and has relatively little impact on the environment, meeting the needs of modern agriculture for high-efficiency and low-toxicity pesticides.
Furthermore, in the field of materials science, 2-chloro-4-fluoro-1-nitrobenzene can participate in the synthesis of special materials. Its structure can introduce specific functional groups and change the physical and chemical properties of materials. For example, it is used to synthesize polymer materials with special optical and electrical properties, which play a unique role in electronic devices, optical instruments, etc., and help technological progress and product upgrades in related fields.
In short, 2-chloro-4-fluoro-1-nitrobenzene, with its unique structure, has shown diverse and important uses in the fields of medicine, pesticides and materials science, and is of great significance to promote the development of chemical-related industries.
What are the physical properties of 2-chloro-4-fluoro-1-nitrobenzene?
2-Chloro-4-fluoro-1-nitrobenzene is one of the organic compounds. Its physical properties are worth exploring, and it is of great significance to chemical research and industrial applications.
First of all, its appearance, under room temperature and pressure, 2-chloro-4-fluoro-1-nitrobenzene is often a light yellow to brown liquid, and it has a specific color and shape. This intuitively shows the physical properties.
As for the melting point and boiling point, the melting point is about -13 ° C, and the boiling point is between 205 ° C and 207 ° C. The melting point is low, so it is a liquid at room temperature; the boiling point value shows that specific temperature conditions are required to gasify it into a gaseous state. This boiling point characteristic is crucial for separation, purification and control of reaction conditions.
Furthermore, its density is about 1.49 g/cm ³, compared to the density of water 1.0 g/cm ³, which shows that its density is relatively high. If mixed with water, it will sink underwater. This density characteristic is a key consideration in operations involving liquid-liquid separation.
In terms of solubility, 2-chloro-4-fluoro-1-nitrobenzene is insoluble in water, but soluble in many organic solvents, such as ethanol, ether, acetone, etc. This difference in solubility is due to its molecular structure and polarity, with weak interaction with water molecules and strong interaction with organic solvent molecules. In organic synthesis and extraction, its solubility characteristics affect the choice of reaction medium and product separation method.
In terms of volatility, 2-chloro-4-fluoro-1-nitrobenzene is volatile to a certain extent, and in an open environment, it will slowly evaporate into the air. This property needs to be taken into account during storage and use to prevent loss or harm caused by its escape.
The physical properties of 2-chloro-4-fluoro-1-nitrobenzene are essential basic information in chemical research, industrial production and related application fields, and are related to operational feasibility and reaction effectiveness.
First of all, its appearance, under room temperature and pressure, 2-chloro-4-fluoro-1-nitrobenzene is often a light yellow to brown liquid, and it has a specific color and shape. This intuitively shows the physical properties.
As for the melting point and boiling point, the melting point is about -13 ° C, and the boiling point is between 205 ° C and 207 ° C. The melting point is low, so it is a liquid at room temperature; the boiling point value shows that specific temperature conditions are required to gasify it into a gaseous state. This boiling point characteristic is crucial for separation, purification and control of reaction conditions.
Furthermore, its density is about 1.49 g/cm ³, compared to the density of water 1.0 g/cm ³, which shows that its density is relatively high. If mixed with water, it will sink underwater. This density characteristic is a key consideration in operations involving liquid-liquid separation.
In terms of solubility, 2-chloro-4-fluoro-1-nitrobenzene is insoluble in water, but soluble in many organic solvents, such as ethanol, ether, acetone, etc. This difference in solubility is due to its molecular structure and polarity, with weak interaction with water molecules and strong interaction with organic solvent molecules. In organic synthesis and extraction, its solubility characteristics affect the choice of reaction medium and product separation method.
In terms of volatility, 2-chloro-4-fluoro-1-nitrobenzene is volatile to a certain extent, and in an open environment, it will slowly evaporate into the air. This property needs to be taken into account during storage and use to prevent loss or harm caused by its escape.
The physical properties of 2-chloro-4-fluoro-1-nitrobenzene are essential basic information in chemical research, industrial production and related application fields, and are related to operational feasibility and reaction effectiveness.
Is 2-chloro-4-fluoro-1-nitrobenzene chemically stable?
The stability of the chemical properties of 2-chloro-4-fluoro-1-nitrobenzene depends on various factors. This compound contains functional groups such as chlorine, fluorine, and nitro. Each functional group has unique chemical properties, which affect each other and cause its overall chemical properties to be complex and changeable.
Let's talk about nitro first. It has strong electron absorption, which can greatly reduce the electron cloud density of the benzene ring and greatly reduce the activity of the electrophilic substitution reaction of the benzene ring. In case of electrophilic reagents, it is difficult to replace with the benzene ring, which is one end of its chemical stability. Furthermore, because of its strong electron absorption, it can enhance the activity of ortho and para-hydrogen atoms, making this part prone to nucleophilic substitution reactions, which shows its active side.
Chlorine and fluorine atoms are both halogen atoms, but fluorine is more electronegative than chlorine. Halogen atoms belong to ortho-para-localization groups on benzene rings, with weak electron-sucking induction effect and strong electron-giving conjugation effect. However, the radius of fluorine atoms is small, and the conjugation effect formed with benzene rings is weaker than that of chlorine, so fluorine reduces the electron cloud density of the benzene ring more than chlorine. These two atoms on the ring make the electron cloud of the benzene ring unevenly distributed and increase the reactivity, but also contribute to the overall stability due to the stability of the halogen atoms themselves.
Under normal conditions, if there is no specific reagent or suitable reaction environment, 2-chloro-4-fluoro-1-nitrobenzene is relatively However, under conditions such as strong nucleophilic reagents, high temperatures, and specific catalysts, nucleophilic substitution and reduction are prone to occur due to the activity of various functional groups, and its stability is difficult to maintain at this time. In summary, the chemical stability of 2-chloro-4-fluoro-1-nitrobenzene depends on the specific reaction conditions and reagents, and cannot be generalized.
Let's talk about nitro first. It has strong electron absorption, which can greatly reduce the electron cloud density of the benzene ring and greatly reduce the activity of the electrophilic substitution reaction of the benzene ring. In case of electrophilic reagents, it is difficult to replace with the benzene ring, which is one end of its chemical stability. Furthermore, because of its strong electron absorption, it can enhance the activity of ortho and para-hydrogen atoms, making this part prone to nucleophilic substitution reactions, which shows its active side.
Chlorine and fluorine atoms are both halogen atoms, but fluorine is more electronegative than chlorine. Halogen atoms belong to ortho-para-localization groups on benzene rings, with weak electron-sucking induction effect and strong electron-giving conjugation effect. However, the radius of fluorine atoms is small, and the conjugation effect formed with benzene rings is weaker than that of chlorine, so fluorine reduces the electron cloud density of the benzene ring more than chlorine. These two atoms on the ring make the electron cloud of the benzene ring unevenly distributed and increase the reactivity, but also contribute to the overall stability due to the stability of the halogen atoms themselves.
Under normal conditions, if there is no specific reagent or suitable reaction environment, 2-chloro-4-fluoro-1-nitrobenzene is relatively However, under conditions such as strong nucleophilic reagents, high temperatures, and specific catalysts, nucleophilic substitution and reduction are prone to occur due to the activity of various functional groups, and its stability is difficult to maintain at this time. In summary, the chemical stability of 2-chloro-4-fluoro-1-nitrobenzene depends on the specific reaction conditions and reagents, and cannot be generalized.
What is the preparation method of 2-chloro-4-fluoro-1-nitrobenzene?
There are many ways to prepare 2-chloro-4-fluoro-1-nitrobenzene. The common ones are described in detail below.
First, fluorobenzene is used as the starting material. First, fluorobenzene is co-heated with mixed acid (a mixture of sulfuric acid and nitric acid), and a nitrification reaction is performed. In this reaction, nitric acid is catalyzed by sulfuric acid to form nitroyl positive ion (NO 2), which has strong electrophilicity and attacks the benzene ring of fluorobenzene. After electrophilic substitution, nitro is introduced into the benzene ring to obtain 4-fluoro-1-nitrobenzene. Subsequently, 4-fluoro-1-nitrobenzene is reacted with chlorine in the presence of a suitable catalyst (such as ferric trichloride). Due to the localization effect of nitro and fluorine atoms, chlorine atoms will selectively replace hydrogen atoms at specific positions on the benzene ring, and finally generate 2-chloro-4-fluoro-1-nitrobenzene.
Second, 2-chloro-4-fluoroaniline is used as the starting material. First, 2-chloro-4-fluoroaniline is reacted with sodium nitrite and hydrochloric acid at low temperature (usually 0-5 ° C) to form diazonium salts. Then, the diazonium salt undergoes a Sandmeier reaction with sodium nitrite and copper powder (or copper salt), and the diazonium group is replaced by the nitro group to obtain 2-chloro-4-fluoro-1-nitrobenzene.
Furthermore, 1,3-dichloro-4-fluorobenzene is used as the raw material. Under specific conditions, 1,3-dichloro-4-fluorobenzene is reacted with sodium nitrite and suitable nucleophiles (such as potassium nitrate, etc.). The nucleophiles attack the benzene ring and replace one of the chlorine atoms to generate 2-chloro-4-fluoro-1-nitrobenzene.
Each of the above preparation methods has its own advantages and disadvantages. The selection of raw materials, the control of reaction conditions, and the separation and purification of products all need to be carefully selected according to actual needs and experimental conditions. During the preparation process, attention should also be paid to the safety and environmental protection of the reaction, and relevant procedures and guidelines should be followed.
First, fluorobenzene is used as the starting material. First, fluorobenzene is co-heated with mixed acid (a mixture of sulfuric acid and nitric acid), and a nitrification reaction is performed. In this reaction, nitric acid is catalyzed by sulfuric acid to form nitroyl positive ion (NO 2), which has strong electrophilicity and attacks the benzene ring of fluorobenzene. After electrophilic substitution, nitro is introduced into the benzene ring to obtain 4-fluoro-1-nitrobenzene. Subsequently, 4-fluoro-1-nitrobenzene is reacted with chlorine in the presence of a suitable catalyst (such as ferric trichloride). Due to the localization effect of nitro and fluorine atoms, chlorine atoms will selectively replace hydrogen atoms at specific positions on the benzene ring, and finally generate 2-chloro-4-fluoro-1-nitrobenzene.
Second, 2-chloro-4-fluoroaniline is used as the starting material. First, 2-chloro-4-fluoroaniline is reacted with sodium nitrite and hydrochloric acid at low temperature (usually 0-5 ° C) to form diazonium salts. Then, the diazonium salt undergoes a Sandmeier reaction with sodium nitrite and copper powder (or copper salt), and the diazonium group is replaced by the nitro group to obtain 2-chloro-4-fluoro-1-nitrobenzene.
Furthermore, 1,3-dichloro-4-fluorobenzene is used as the raw material. Under specific conditions, 1,3-dichloro-4-fluorobenzene is reacted with sodium nitrite and suitable nucleophiles (such as potassium nitrate, etc.). The nucleophiles attack the benzene ring and replace one of the chlorine atoms to generate 2-chloro-4-fluoro-1-nitrobenzene.
Each of the above preparation methods has its own advantages and disadvantages. The selection of raw materials, the control of reaction conditions, and the separation and purification of products all need to be carefully selected according to actual needs and experimental conditions. During the preparation process, attention should also be paid to the safety and environmental protection of the reaction, and relevant procedures and guidelines should be followed.
2-chloro-4-fluoro-1-nitrobenzene need to pay attention to when storing and transporting
2-Chloro-4-fluoro-1-nitrobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First word storage. This compound is more active in nature and should be stored in a cool and ventilated warehouse. Because it is more sensitive to heat, high temperature can easily cause decomposition or cause other chemical reactions, so the warehouse temperature should be controlled in an appropriate range, not too high. And keep away from fire and heat sources to prevent the risk of fire. In addition, because it is toxic and corrosive, it needs to be stored separately from oxidants and food chemicals, and must not be mixed to avoid mutual reaction and cause danger. The storage area should also be equipped with suitable materials to contain leaks, just in case of leaks, which can be dealt with in time to avoid greater harm.
Second talk about transportation. Be sure to ensure that the packaging is complete and well sealed before transportation. Select suitable means of transportation, and ensure that the container does not leak, collapse, fall, or damage during transportation. It is necessary to strictly follow the relevant transportation regulations. When transporting, it should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. During transportation, it should be protected from exposure to the sun, rain, and high temperature. When transporting by road, it should be driven according to the specified route, and do not stop in residential areas and densely populated areas.
In conclusion, the storage and transportation of 2-chloro-4-fluoro-1-nitrobenzene should be handled with caution and in strict accordance with relevant regulations to ensure the safety of personnel and the environment.
First word storage. This compound is more active in nature and should be stored in a cool and ventilated warehouse. Because it is more sensitive to heat, high temperature can easily cause decomposition or cause other chemical reactions, so the warehouse temperature should be controlled in an appropriate range, not too high. And keep away from fire and heat sources to prevent the risk of fire. In addition, because it is toxic and corrosive, it needs to be stored separately from oxidants and food chemicals, and must not be mixed to avoid mutual reaction and cause danger. The storage area should also be equipped with suitable materials to contain leaks, just in case of leaks, which can be dealt with in time to avoid greater harm.
Second talk about transportation. Be sure to ensure that the packaging is complete and well sealed before transportation. Select suitable means of transportation, and ensure that the container does not leak, collapse, fall, or damage during transportation. It is necessary to strictly follow the relevant transportation regulations. When transporting, it should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. During transportation, it should be protected from exposure to the sun, rain, and high temperature. When transporting by road, it should be driven according to the specified route, and do not stop in residential areas and densely populated areas.
In conclusion, the storage and transportation of 2-chloro-4-fluoro-1-nitrobenzene should be handled with caution and in strict accordance with relevant regulations to ensure the safety of personnel and the environment.
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