Linshang Chemical
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2-Chloro-4-Fluoro-1-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
207528 |
| Chemical Formula | C7H3ClF4 |
| Molecular Weight | 198.54 |
| Appearance | Liquid (usually) |
| Boiling Point | Around 112 - 114 °C |
| Density | Approx. 1.45 - 1.55 g/cm³ |
| Vapor Pressure | Low at room temperature |
| Solubility In Water | Insoluble (organic nature) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Flash Point | Around 22 - 24 °C |
As an accredited 2-Chloro-4-Fluoro-1-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 4 - fluoro - 1 - (trifluoromethyl)benzene packaged in a sealed bottle. |
| Storage | 2 - Chloro - 4 - fluoro - 1 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials like stainless steel or certain plastics, to prevent leakage and exposure to air or moisture. |
| Shipping | 2 - chloro - 4 - fluoro - 1 - (trifluoromethyl)benzene is shipped in specialized containers designed for hazardous chemicals. Shipment adheres to strict regulations, ensuring secure transport to prevent leakage and environmental risks. |
Competitive 2-Chloro-4-Fluoro-1-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Chloro-4-Fluoro-1-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chloro-4-fluoro-1- (trifluoromethyl) benzene?
2-Chloro-4-fluoro-1- (trifluoromethyl) benzene has a wide range of uses and has its own impact in various fields of chemical industry.
First, it is a key intermediate in the process of pharmaceutical synthesis. Taking the development of specific antimalarial drugs as an example, it is necessary to construct a benzene ring structure with specific activities. The chlorine, fluorine and trifluoromethyl of 2-chloro-4-fluoro-1- (trifluoromethyl) benzene can be embedded in the target molecular structure by means of organic synthesis through subtle steps such as halogenation reaction and nucleophilic substitution, giving the drug unique pharmacological activity and suitable pharmacokinetic properties.
Second, it is also crucial in the field of pesticide creation. The development of many new pesticides and fungicides relies on such fluorobenzene compounds. Due to the unique electronic effect and physiological activity of fluorine atoms, the introduction of molecules can significantly enhance the effect of pesticides on pests and pathogens, improve the efficacy, and optimize the molecular stability and environmental adaptability due to the presence of fluorine atoms, which helps pesticides to play a long-term role under different environmental conditions.
Third, in the field of materials science, its use should not be underestimated. When preparing high-performance fluoropolymer materials, it can be used as a starting material. After polymerization, its structural units are introduced into the main chain or side chain of the polymer. With the characteristics of low surface energy and high chemical stability of fluorine atoms, the polymer is endowed with excellent properties such as excellent weather resistance, chemical corrosion resistance and low friction coefficient. It is widely used in aerospace, automobile manufacturing and other fields that require strict material properties.
In addition, in the field of dye synthesis, it can be used as an important raw material for building chromophores or chromophores, giving unique color and light stability to dyes to meet different dyeing needs. Overall, 2-chloro-4-fluoro-1- (trifluoromethyl) benzene, with its unique structure and properties, plays an indispensable role in many chemical-related industries, promoting technological progress and development in various fields.
First, it is a key intermediate in the process of pharmaceutical synthesis. Taking the development of specific antimalarial drugs as an example, it is necessary to construct a benzene ring structure with specific activities. The chlorine, fluorine and trifluoromethyl of 2-chloro-4-fluoro-1- (trifluoromethyl) benzene can be embedded in the target molecular structure by means of organic synthesis through subtle steps such as halogenation reaction and nucleophilic substitution, giving the drug unique pharmacological activity and suitable pharmacokinetic properties.
Second, it is also crucial in the field of pesticide creation. The development of many new pesticides and fungicides relies on such fluorobenzene compounds. Due to the unique electronic effect and physiological activity of fluorine atoms, the introduction of molecules can significantly enhance the effect of pesticides on pests and pathogens, improve the efficacy, and optimize the molecular stability and environmental adaptability due to the presence of fluorine atoms, which helps pesticides to play a long-term role under different environmental conditions.
Third, in the field of materials science, its use should not be underestimated. When preparing high-performance fluoropolymer materials, it can be used as a starting material. After polymerization, its structural units are introduced into the main chain or side chain of the polymer. With the characteristics of low surface energy and high chemical stability of fluorine atoms, the polymer is endowed with excellent properties such as excellent weather resistance, chemical corrosion resistance and low friction coefficient. It is widely used in aerospace, automobile manufacturing and other fields that require strict material properties.
In addition, in the field of dye synthesis, it can be used as an important raw material for building chromophores or chromophores, giving unique color and light stability to dyes to meet different dyeing needs. Overall, 2-chloro-4-fluoro-1- (trifluoromethyl) benzene, with its unique structure and properties, plays an indispensable role in many chemical-related industries, promoting technological progress and development in various fields.
What are the physical properties of 2-chloro-4-fluoro-1- (trifluoromethyl) benzene
2-Chloro-4-fluoro-1- (trifluoromethyl) benzene, this is an organic compound. Its physical properties are rich and diverse, let me tell them one by one.
Looking at its properties, under room temperature and pressure, it is mostly a colorless to light yellow transparent liquid with a clear texture, like the purity of a clear spring. Its smell has a special aroma, but it is not pleasant. It has a slightly pungent smell, and the smell is alarming.
As for the boiling point, it is between 130 and 140 degrees Celsius. When the temperature rises to this range, the substance gradually converts from liquid to gaseous state, such as the rise of clouds. This boiling point characteristic is of great significance in chemical operations such as separation and purification.
In terms of melting point, it is usually around -30 ° C. When the temperature drops to this point, the substance will condense from a flowing liquid to a solid state, just like water freezes into ice, and the shape will change fundamentally.
The density is about 1.4-1.5g/cm ³, which is more dense than the density of water. If it is placed in one place with water, it is like sinking into the sea and sinking to the bottom.
Solubility is also an important physical property. In water, its solubility is very small, and the two seem to be distinct and difficult to blend. However, organic solvents, such as ethanol, ether, and acetone, can dissolve well, just like fish get water, and the miscibility is perfect. This difference in solubility is very useful in organic synthesis, extraction and other processes.
Its vapor pressure is lower at room temperature, indicating that the substance volatilizes relatively slowly and does not easily dissipate into the air like light smoke. However, when the temperature increases, the vapor pressure will also increase and the volatilization rate will accelerate.
The many physical properties of 2-chloro-4-fluoro-1- (trifluoromethyl) benzene lay a solid foundation for its application in chemical, pharmaceutical, materials and other fields. In practical applications, it is necessary to operate reasonably according to its physical characteristics in order to make the best use of it and achieve the desired purpose.
Looking at its properties, under room temperature and pressure, it is mostly a colorless to light yellow transparent liquid with a clear texture, like the purity of a clear spring. Its smell has a special aroma, but it is not pleasant. It has a slightly pungent smell, and the smell is alarming.
As for the boiling point, it is between 130 and 140 degrees Celsius. When the temperature rises to this range, the substance gradually converts from liquid to gaseous state, such as the rise of clouds. This boiling point characteristic is of great significance in chemical operations such as separation and purification.
In terms of melting point, it is usually around -30 ° C. When the temperature drops to this point, the substance will condense from a flowing liquid to a solid state, just like water freezes into ice, and the shape will change fundamentally.
The density is about 1.4-1.5g/cm ³, which is more dense than the density of water. If it is placed in one place with water, it is like sinking into the sea and sinking to the bottom.
Solubility is also an important physical property. In water, its solubility is very small, and the two seem to be distinct and difficult to blend. However, organic solvents, such as ethanol, ether, and acetone, can dissolve well, just like fish get water, and the miscibility is perfect. This difference in solubility is very useful in organic synthesis, extraction and other processes.
Its vapor pressure is lower at room temperature, indicating that the substance volatilizes relatively slowly and does not easily dissipate into the air like light smoke. However, when the temperature increases, the vapor pressure will also increase and the volatilization rate will accelerate.
The many physical properties of 2-chloro-4-fluoro-1- (trifluoromethyl) benzene lay a solid foundation for its application in chemical, pharmaceutical, materials and other fields. In practical applications, it is necessary to operate reasonably according to its physical characteristics in order to make the best use of it and achieve the desired purpose.
What are the synthesis methods of 2-chloro-4-fluoro-1- (trifluoromethyl) benzene
2-Chloro-4-fluoro-1- (trifluoromethyl) benzene can be synthesized in the following ways.
First, chlorine and fluorine atoms can be introduced from a suitable aromatic compound through a halogenation reaction, and trifluoromethyl can be introduced at the same time. For example, with toluene derivatives as the starting material, it is first chlorinated. Under suitable conditions, chlorine gas is used as the chlorine source. In the presence of catalysts such as ferric chloride, the specific position of the benzene ring of toluene can be chlorinated to obtain the corresponding chlorotoluene derivative. Subsequently, the fluorination reaction is carried out. In this step, a suitable fluorination reagent, such as potassium fluoride, can be used to replace specific chlorine atoms on the benzene ring with fluorine atoms with the assistance of a phase transfer catalyst. Finally, trifluoromethyl is introduced by a specific method, such as the use of trifluoromethylation reagents, such as sodium trifluoromethanesulfonate, etc., under suitable reaction conditions, such as heating and specific solvents, trifluoromethyl is introduced to achieve the introduction of trifluoromethyl, thereby obtaining the target product 2-chloro-4-fluoro-1- (trifluoromethyl) benzene.
Second, fluorine-containing benzene derivatives can also be used. If the starting material is fluorobenzene, a chlorine atom is introduced first, and the benzene ring can be chlorinated at a specific position by reacting with a suitable chlorination reagent, such as dichlorosulfoxide, under suitable conditions. Then, a suitable trifluoromethylation method is used, such as using a variant of the Ullmann reaction, using a copper salt as a catalyst, and reacting with a reagent such as a trifluoromethyl halide under basic conditions, trifluoromethyl is introduced into the benzene ring, and the final product is obtained.
Furthermore, the strategy of gradually constructing the benzene ring can also be used. Using appropriate small molecules containing chlorine, fluorine and trifluoromethyl as raw materials, with the help of classic organic reactions such as the Fourier-gram reaction, the ben For example, first, the halogenated hydrocarbons containing chlorine and fluorine and the acyl halides containing trifluoromethyl are used as raw materials, and in the presence of Lewis acid catalysts such as anhydrous aluminum trichloride, the acylation reaction is carried out to obtain the intermediates containing acyl groups. Subsequently, through reduction and other steps, the acyl groups are converted into methyl groups, and finally the benzene ring is formed by cyclization and other reactions to generate 2-chloro-4-fluoro-1- (trifluoromethyl) benzene.
First, chlorine and fluorine atoms can be introduced from a suitable aromatic compound through a halogenation reaction, and trifluoromethyl can be introduced at the same time. For example, with toluene derivatives as the starting material, it is first chlorinated. Under suitable conditions, chlorine gas is used as the chlorine source. In the presence of catalysts such as ferric chloride, the specific position of the benzene ring of toluene can be chlorinated to obtain the corresponding chlorotoluene derivative. Subsequently, the fluorination reaction is carried out. In this step, a suitable fluorination reagent, such as potassium fluoride, can be used to replace specific chlorine atoms on the benzene ring with fluorine atoms with the assistance of a phase transfer catalyst. Finally, trifluoromethyl is introduced by a specific method, such as the use of trifluoromethylation reagents, such as sodium trifluoromethanesulfonate, etc., under suitable reaction conditions, such as heating and specific solvents, trifluoromethyl is introduced to achieve the introduction of trifluoromethyl, thereby obtaining the target product 2-chloro-4-fluoro-1- (trifluoromethyl) benzene.
Second, fluorine-containing benzene derivatives can also be used. If the starting material is fluorobenzene, a chlorine atom is introduced first, and the benzene ring can be chlorinated at a specific position by reacting with a suitable chlorination reagent, such as dichlorosulfoxide, under suitable conditions. Then, a suitable trifluoromethylation method is used, such as using a variant of the Ullmann reaction, using a copper salt as a catalyst, and reacting with a reagent such as a trifluoromethyl halide under basic conditions, trifluoromethyl is introduced into the benzene ring, and the final product is obtained.
Furthermore, the strategy of gradually constructing the benzene ring can also be used. Using appropriate small molecules containing chlorine, fluorine and trifluoromethyl as raw materials, with the help of classic organic reactions such as the Fourier-gram reaction, the ben For example, first, the halogenated hydrocarbons containing chlorine and fluorine and the acyl halides containing trifluoromethyl are used as raw materials, and in the presence of Lewis acid catalysts such as anhydrous aluminum trichloride, the acylation reaction is carried out to obtain the intermediates containing acyl groups. Subsequently, through reduction and other steps, the acyl groups are converted into methyl groups, and finally the benzene ring is formed by cyclization and other reactions to generate 2-chloro-4-fluoro-1- (trifluoromethyl) benzene.
What are the precautions for 2-chloro-4-fluoro-1- (trifluoromethyl) benzene in storage and transportation?
2-Chloro-4-fluoro-1- (trifluoromethyl) benzene is an organic compound. During storage and transportation, many matters need to be taken into account.
First words storage, this compound should be placed in a cool, dry and well-ventilated place. Because of its volatility, if it is exposed to high temperature or humidity, it may increase volatilization or react with water vapor, which will damage its quality. And it must be kept away from fire and heat sources to prevent the risk of explosion. Although this substance is not extremely flammable, organic compounds are mostly flammable, so caution is necessary. Furthermore, it should be stored separately from oxidizing agents, acids, alkalis, etc., because of its active chemical properties, it can mix with various chemicals, or cause violent chemical reactions, resulting in the growth of danger.
As for transportation, there are also many precautions. Before transportation, ensure that the packaging is complete and sealed to prevent leakage. During transportation, the speed of the vehicle should be slow and stable to avoid severe vibration and impact, so as to avoid damage to the packaging. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. In the event of a leak, personnel from the leaked contaminated area must be quickly evacuated to a safe area, and quarantined to strictly restrict access. Emergency personnel should wear self-contained positive pressure breathing apparatus, wear anti-toxic clothing, and do not directly contact leaks. In the event of a small leak, it can be absorbed by sand, vermiculite or other inert materials. In the event of a large leak, build a dike or dig a pit to contain it, cover it with foam to reduce the vapor hazard, and transfer it to a tanker or a special collector for recycling or transportation to a waste treatment site for disposal.
In short, the storage and transportation of 2-chloro-4-fluoro-1- (trifluoromethyl) benzene must be strictly adhered to to regulations to ensure the safety of personnel and the environment, so as to avoid accidents.
First words storage, this compound should be placed in a cool, dry and well-ventilated place. Because of its volatility, if it is exposed to high temperature or humidity, it may increase volatilization or react with water vapor, which will damage its quality. And it must be kept away from fire and heat sources to prevent the risk of explosion. Although this substance is not extremely flammable, organic compounds are mostly flammable, so caution is necessary. Furthermore, it should be stored separately from oxidizing agents, acids, alkalis, etc., because of its active chemical properties, it can mix with various chemicals, or cause violent chemical reactions, resulting in the growth of danger.
As for transportation, there are also many precautions. Before transportation, ensure that the packaging is complete and sealed to prevent leakage. During transportation, the speed of the vehicle should be slow and stable to avoid severe vibration and impact, so as to avoid damage to the packaging. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. In the event of a leak, personnel from the leaked contaminated area must be quickly evacuated to a safe area, and quarantined to strictly restrict access. Emergency personnel should wear self-contained positive pressure breathing apparatus, wear anti-toxic clothing, and do not directly contact leaks. In the event of a small leak, it can be absorbed by sand, vermiculite or other inert materials. In the event of a large leak, build a dike or dig a pit to contain it, cover it with foam to reduce the vapor hazard, and transfer it to a tanker or a special collector for recycling or transportation to a waste treatment site for disposal.
In short, the storage and transportation of 2-chloro-4-fluoro-1- (trifluoromethyl) benzene must be strictly adhered to to regulations to ensure the safety of personnel and the environment, so as to avoid accidents.
2-chloro-4-fluoro-1- (trifluoromethyl) benzene impact on the environment
2-Chloro-4-fluoro-1- (trifluoromethyl) benzene. The impact of this substance on the environment is a matter of great concern to the world today.
First, its chemical properties. This benzene compound contains groups such as chlorine, fluorine and trifluoromethyl. Chlorine atoms have certain electronegativity and are released in the environment or through various reactions. If they enter the water body, they may react with substances in the water, or affect the physiological processes of aquatic organisms. The same is true for fluorine atoms. Although they are stable, they may participate in reactions under specific environmental conditions and interfere with the balance of the ecosystem. The presence of trifluoromethyl gives the compound unique hydrophobicity and chemical stability, which may make it difficult to degrade in the environment and easy to accumulate.
In the atmospheric environment, the compound may exist in the air due to volatilization. Its fluorine-containing components may pose a potential threat to the ozone layer. Although more research is needed to clarify the specific extent of the impact, fluoride has always been an important research object in atmospheric chemistry. It may participate in complex photochemical reactions and change the composition and properties of the atmosphere.
In the soil environment, due to its hydrophobicity, or adsorption on the surface of soil particles, it affects the structure and function of soil microbial communities. Soil microorganisms are crucial in soil fertility maintenance and material circulation. Their community changes may cause imbalances in soil ecosystems, which in turn affect plant growth.
In aquatic ecosystems, after the substance enters the water body, it may produce acute and chronic toxicity to aquatic organisms. Its refractory degradability causes the concentration to gradually rise in the water body or enrich through the food chain, causing more serious effects on high trophic organisms, such as damage to the nervous system and reproductive system of organisms, and ultimately endangering the stability and balance of the entire aquatic ecosystem.
To sum up, 2-chloro-4-fluoro-1 - (trifluoromethyl) benzene has potential effects on the environment in many aspects, and the world needs to increase research efforts to clarify its mechanism of action and the degree of harm, in order to find appropriate countermeasures to ensure environmental safety and ecological balance.
First, its chemical properties. This benzene compound contains groups such as chlorine, fluorine and trifluoromethyl. Chlorine atoms have certain electronegativity and are released in the environment or through various reactions. If they enter the water body, they may react with substances in the water, or affect the physiological processes of aquatic organisms. The same is true for fluorine atoms. Although they are stable, they may participate in reactions under specific environmental conditions and interfere with the balance of the ecosystem. The presence of trifluoromethyl gives the compound unique hydrophobicity and chemical stability, which may make it difficult to degrade in the environment and easy to accumulate.
In the atmospheric environment, the compound may exist in the air due to volatilization. Its fluorine-containing components may pose a potential threat to the ozone layer. Although more research is needed to clarify the specific extent of the impact, fluoride has always been an important research object in atmospheric chemistry. It may participate in complex photochemical reactions and change the composition and properties of the atmosphere.
In the soil environment, due to its hydrophobicity, or adsorption on the surface of soil particles, it affects the structure and function of soil microbial communities. Soil microorganisms are crucial in soil fertility maintenance and material circulation. Their community changes may cause imbalances in soil ecosystems, which in turn affect plant growth.
In aquatic ecosystems, after the substance enters the water body, it may produce acute and chronic toxicity to aquatic organisms. Its refractory degradability causes the concentration to gradually rise in the water body or enrich through the food chain, causing more serious effects on high trophic organisms, such as damage to the nervous system and reproductive system of organisms, and ultimately endangering the stability and balance of the entire aquatic ecosystem.
To sum up, 2-chloro-4-fluoro-1 - (trifluoromethyl) benzene has potential effects on the environment in many aspects, and the world needs to increase research efforts to clarify its mechanism of action and the degree of harm, in order to find appropriate countermeasures to ensure environmental safety and ecological balance.
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