Linshang Chemical
PRODUCTS
2-Chloro-4-Fluorobenzene-1-Carbonyl Chloride
Linshang Chemical
|
HS Code |
519955 |
| Chemical Formula | C7H3Cl2FO |
| Molecular Weight | 193.002 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 205 - 207 °C |
| Density | 1.483 g/cm³ |
| Flash Point | 88.3 °C |
| Solubility | Reacts with water, soluble in organic solvents |
| Vapor Pressure | Low |
| Refractive Index | 1.524 |
| Stability | Stable under normal conditions, but reacts with moisture |
As an accredited 2-Chloro-4-Fluorobenzene-1-Carbonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 2 - chloro - 4 - fluorobenzene - 1 - carbonyl chloride in a sealed glass bottle. |
| Storage | 2 - chloro - 4 - fluorobenzene - 1 - carbonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. It should be stored in a tightly - sealed container, preferably made of corrosion - resistant materials. Due to its reactivity, keep it separate from incompatible substances like bases, alcohols, and water to prevent dangerous reactions. |
| Shipping | 2 - chloro - 4 - fluorobenzene - 1 - carbonyl chloride is a hazardous chemical. Shipping requires proper containment in corrosion - resistant containers. It must comply with strict regulations, with careful labeling indicating its hazardous nature for safe transport. |
Competitive 2-Chloro-4-Fluorobenzene-1-Carbonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Chloro-4-Fluorobenzene-1-Carbonyl Chloride in China?
As a trusted 2-Chloro-4-Fluorobenzene-1-Carbonyl Chloride manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-4-Fluorobenzene-1-Carbonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chloro-4-fluorobenzene-1-carbonyl Chloride?
2-Chloro-4-fluorobenzene-1-carbonyl Chloride (2-chloro-4-fluorobenzene-1-carbonyl Chloride) has a wide range of uses. In the field of pharmaceutical synthesis, it is a key intermediate. It plays an indispensable role in the preparation of many drugs. For example, when developing specific antibacterial drugs, this compound can cleverly react with other reagents to build a key structure of drug molecules. With its unique chemical structure, it gives the drug precise antibacterial activity.
In the creation of pesticides, 2-chloro-4-fluorobenzyl chloride also has extraordinary value. Due to its active chemical properties, it can react with a wide range of organic compounds to create pesticide active ingredients with highly effective insecticidal, bactericidal or herbicidal effects. For example, in the synthesis of some new herbicides, it is used as a starting material, through a series of chemical reactions, to shape compounds that can precisely act on specific physiological processes of weeds, inhibit their growth and even kill them.
In the field of materials science, it can be used to synthesize polymer materials with special properties. When polymerized with specific monomers, it can give materials unique properties such as excellent heat resistance and chemical corrosion resistance. For example, in the preparation of high-end engineering plastics, the introduction of this compound structural unit can significantly improve the mechanical properties and chemical stability of the plastic, making it suitable for more severe environments, such as the aerospace field, which requires extremely high material properties.
In addition, in the production of fine chemical products, 2-chloro-4-fluorobenzoyl chloride is often used in the synthesis of various fragrances, dyes, etc. In the synthesis of fragrances, it can be used as a key intermediate, adding unique chemical groups through chemical reactions to impart unique aroma characteristics to fragrances. In dye synthesis, it can participate in the construction of chromophore groups, determine the color and dyeing properties of dyes, and help produce dye products with rich colors and good color fastness.
In the creation of pesticides, 2-chloro-4-fluorobenzyl chloride also has extraordinary value. Due to its active chemical properties, it can react with a wide range of organic compounds to create pesticide active ingredients with highly effective insecticidal, bactericidal or herbicidal effects. For example, in the synthesis of some new herbicides, it is used as a starting material, through a series of chemical reactions, to shape compounds that can precisely act on specific physiological processes of weeds, inhibit their growth and even kill them.
In the field of materials science, it can be used to synthesize polymer materials with special properties. When polymerized with specific monomers, it can give materials unique properties such as excellent heat resistance and chemical corrosion resistance. For example, in the preparation of high-end engineering plastics, the introduction of this compound structural unit can significantly improve the mechanical properties and chemical stability of the plastic, making it suitable for more severe environments, such as the aerospace field, which requires extremely high material properties.
In addition, in the production of fine chemical products, 2-chloro-4-fluorobenzoyl chloride is often used in the synthesis of various fragrances, dyes, etc. In the synthesis of fragrances, it can be used as a key intermediate, adding unique chemical groups through chemical reactions to impart unique aroma characteristics to fragrances. In dye synthesis, it can participate in the construction of chromophore groups, determine the color and dyeing properties of dyes, and help produce dye products with rich colors and good color fastness.
What are the physical properties of 2-chloro-4-fluorobenzene-1-carbonyl Chloride?
2-Chloro-4-fluorobenzoyl chloride is a crucial raw material in organic synthesis. Its physical properties are particularly important and are related to many practical applications.
Looking at its properties, under room temperature and pressure, this substance is a colorless to light yellow liquid with a clear texture and can be seen. The characterization of its color and state provides an intuitive basis for preliminary identification.
Smell, there is a pungent and uncomfortable smell. This odor has significant characteristics. When operating and using, because it is irritating, it can strongly warn people to pay attention to protection, so as not to damage the respiratory tract and other organs.
When it comes to the melting point, it is about -10 ° C, which indicates that the substance can still maintain a liquid state in a relatively low temperature environment. The boiling point is roughly in the range of 200-205 ° C, and the boiling point is higher, reflecting the relatively strong intermolecular force. The transition from liquid to gaseous state occurs only under high temperature conditions.
In terms of density, it is about 1.45-1.55 g/cm ³, which is significantly larger than the density of water. If it is accidentally leaked into the water, it will sink to the bottom. This property is of great significance for dealing with leakage accidents.
In terms of solubility, 2-chloro-4-fluorobenzoyl chloride is insoluble in water. This is due to the benzene ring and chlorine, fluorine and other atoms contained in its molecular structure, which makes the molecular polarity relatively weak, and the force between water molecules is difficult to overcome the strong hydrogen bond between water molecules, so it is not easy to dissolve. However, it is soluble in common organic solvents, such as dichloromethane, chloroform, ether, etc. This solubility characteristic facilitates the selection of reaction solvents during the organic synthesis reaction. It can flexibly select suitable organic solvents according to the reaction requirements to ensure the smooth progress of the reaction.
In addition, 2-chloro-4-fluorobenzoyl chloride is relatively volatile, and in an open environment, it is easy to gradually evaporate into the air, which not only causes material loss, but also poses a threat to the environment and human health due to its pungent odor and potential toxicity. Therefore, when storing and using, it is necessary to take sealing measures to prevent evaporation and escape.
Looking at its properties, under room temperature and pressure, this substance is a colorless to light yellow liquid with a clear texture and can be seen. The characterization of its color and state provides an intuitive basis for preliminary identification.
Smell, there is a pungent and uncomfortable smell. This odor has significant characteristics. When operating and using, because it is irritating, it can strongly warn people to pay attention to protection, so as not to damage the respiratory tract and other organs.
When it comes to the melting point, it is about -10 ° C, which indicates that the substance can still maintain a liquid state in a relatively low temperature environment. The boiling point is roughly in the range of 200-205 ° C, and the boiling point is higher, reflecting the relatively strong intermolecular force. The transition from liquid to gaseous state occurs only under high temperature conditions.
In terms of density, it is about 1.45-1.55 g/cm ³, which is significantly larger than the density of water. If it is accidentally leaked into the water, it will sink to the bottom. This property is of great significance for dealing with leakage accidents.
In terms of solubility, 2-chloro-4-fluorobenzoyl chloride is insoluble in water. This is due to the benzene ring and chlorine, fluorine and other atoms contained in its molecular structure, which makes the molecular polarity relatively weak, and the force between water molecules is difficult to overcome the strong hydrogen bond between water molecules, so it is not easy to dissolve. However, it is soluble in common organic solvents, such as dichloromethane, chloroform, ether, etc. This solubility characteristic facilitates the selection of reaction solvents during the organic synthesis reaction. It can flexibly select suitable organic solvents according to the reaction requirements to ensure the smooth progress of the reaction.
In addition, 2-chloro-4-fluorobenzoyl chloride is relatively volatile, and in an open environment, it is easy to gradually evaporate into the air, which not only causes material loss, but also poses a threat to the environment and human health due to its pungent odor and potential toxicity. Therefore, when storing and using, it is necessary to take sealing measures to prevent evaporation and escape.
What are the synthesis methods of 2-chloro-4-fluorobenzene-1-carbonyl Chloride?
The method of preparing 2-chloro-4-fluorobenzoyl chloride has various paths to follow. First, it can be started from 2-chloro-4-fluorobenzoic acid. Take an appropriate amount of 2-chloro-4-fluorobenzoic acid, place it in the reactor, and add a chlorination reagent, such as thionyl chloride ($SOCl_2 $). This thionyl chloride is very active and can react with the hydroxyl groups in the acid. During the reaction, it must be controlled at a moderate temperature, generally in a state of heating and reflux. Because the boiling point of thionyl chloride is not high, heating can promote it to boil, so that the reaction is sufficient. In this process, the resulting gases, such as sulfur dioxide and hydrogen chloride, can escape the system, causing the reaction to proceed in the direction of generating 2-chloro-4-fluorobenzoyl chloride. After the reaction is completed, a little cooling is performed, and the excess sulfoxide chloride is removed by rotary evaporation to obtain a crude product. After purification methods such as rectification, a pure 2-chloro-4-fluorobenzoyl chloride can be obtained.
Second, it can be derived from the corresponding benzene ring derivatives. With a suitable halogenated benzene derivative, a formyl group is first introduced through an acylation reaction, and then chlorine and fluorine atoms are introduced at specific locations through a halogenation step. During acylation, commonly used catalysts, such as anhydrous aluminum trichloride, can activate the reaction substrate and smoothly introduce the acyl group into the benzene ring. In the halogenation step, the substitution positions of chlorine and fluorine atoms can be precisely controlled according to different halogenation reagents and reaction conditions. However, this path step is slightly complicated, and each step of the reaction requires fine control of conditions, such as temperature, reagent ratio, reaction time, etc., in order to improve the yield and selectivity.
Third, the method of phase transfer catalysis can also be used for reference. If benzene containing an appropriate substituent is used as a raw material, in the presence of a phase transfer catalyst, it can also be prepared by reacting with halogenated reagents and carbon monoxide. The beauty of the phase transfer catalyst is that it can promote the rapid transfer of reactants between different phases, accelerate the reaction process and improve the reaction efficiency. However, this method requires quite high requirements for the selection of catalysts and the regulation of the reaction system, and needs to be carefully studied to achieve the best reaction effect.
Second, it can be derived from the corresponding benzene ring derivatives. With a suitable halogenated benzene derivative, a formyl group is first introduced through an acylation reaction, and then chlorine and fluorine atoms are introduced at specific locations through a halogenation step. During acylation, commonly used catalysts, such as anhydrous aluminum trichloride, can activate the reaction substrate and smoothly introduce the acyl group into the benzene ring. In the halogenation step, the substitution positions of chlorine and fluorine atoms can be precisely controlled according to different halogenation reagents and reaction conditions. However, this path step is slightly complicated, and each step of the reaction requires fine control of conditions, such as temperature, reagent ratio, reaction time, etc., in order to improve the yield and selectivity.
Third, the method of phase transfer catalysis can also be used for reference. If benzene containing an appropriate substituent is used as a raw material, in the presence of a phase transfer catalyst, it can also be prepared by reacting with halogenated reagents and carbon monoxide. The beauty of the phase transfer catalyst is that it can promote the rapid transfer of reactants between different phases, accelerate the reaction process and improve the reaction efficiency. However, this method requires quite high requirements for the selection of catalysts and the regulation of the reaction system, and needs to be carefully studied to achieve the best reaction effect.
2-chloro-4-fluorobenzene-1-carbonyl Chloride in Storage and Transportation
2-Chloro-4-fluorobenzoyl chloride is a chemical substance, and many matters need to be paid attention to when storing and transporting.
Let's talk about storage first. Because of its active nature, it is easy to react with many substances, so it needs to be stored in a cool, dry and well-ventilated place. Do not approach fire and heat sources to prevent danger. This substance is sensitive to air and moisture, and should be sealed and stored to avoid contact with air and water, otherwise it will deteriorate easily. Storage containers are also particular. Corrosion-resistant materials, such as glass or specific metal containers, must be used to prevent the container from being corroded and leaking.
Then transport. Be sure to ensure that the packaging is tight before transportation, and choose suitable packaging materials, which can effectively prevent collision and vibration from causing damage. During transportation, the temperature should be strictly controlled, and the temperature should not be too high or too low, so as not to affect its stability. Those engaged in transportation need professional training to be familiar with the characteristics of the substance and emergency treatment methods. Transportation vehicles should also be equipped with corresponding emergency equipment and protective equipment. If there is a sudden leakage on the way, they can be properly handled in time to ensure transportation safety. In short, when storing and transporting 2-chloro-4-fluorobenzoyl chloride, it is necessary to understand its characteristics in detail and operate strictly according to the specifications to ensure safety.
Let's talk about storage first. Because of its active nature, it is easy to react with many substances, so it needs to be stored in a cool, dry and well-ventilated place. Do not approach fire and heat sources to prevent danger. This substance is sensitive to air and moisture, and should be sealed and stored to avoid contact with air and water, otherwise it will deteriorate easily. Storage containers are also particular. Corrosion-resistant materials, such as glass or specific metal containers, must be used to prevent the container from being corroded and leaking.
Then transport. Be sure to ensure that the packaging is tight before transportation, and choose suitable packaging materials, which can effectively prevent collision and vibration from causing damage. During transportation, the temperature should be strictly controlled, and the temperature should not be too high or too low, so as not to affect its stability. Those engaged in transportation need professional training to be familiar with the characteristics of the substance and emergency treatment methods. Transportation vehicles should also be equipped with corresponding emergency equipment and protective equipment. If there is a sudden leakage on the way, they can be properly handled in time to ensure transportation safety. In short, when storing and transporting 2-chloro-4-fluorobenzoyl chloride, it is necessary to understand its characteristics in detail and operate strictly according to the specifications to ensure safety.
2-chloro-4-fluorobenzene-1-carbonyl Chloride Effects on the Environment and Human Body
2-Chloro-4-fluorobenzoyl chloride is one of the organic compounds. Its effects on the environment and human body are described as follows:
Effects on the environment
1. ** Aquatic organisms **: If this compound enters the water body, it can cause poisoning to aquatic organisms. Its chemical properties may interfere with the physiological processes of aquatic organisms, such as hindering their respiration, feeding and reproduction. If fish are exposed to this substance, it may cause damage to the gills, affecting gas exchange, which in turn makes the fish breathing difficulties and threatened survival. For plankton, it may destroy its cell structure, interfere with its photosynthesis, cause changes in population numbers, and affect the food chain foundation of aquatic ecosystems.
2. ** Soil **: If it penetrates into the soil, or changes the chemical properties of the soil. or reacts with minerals and organic matter in the soil, affecting soil fertility and microbial activity. Soil microorganisms are essential for maintaining soil health and nutrient cycling. This compound may inhibit the growth of beneficial microorganisms, causing the decomposition of organic matter in the soil to be blocked, affecting the absorption of nutrients by plants, and then affecting the growth and distribution of plants in terrestrial ecosystems.
3. ** Atmosphere **: Although the amount of volatilization to the atmosphere at room temperature may be limited, in a specific industrial production environment, if not properly treated, it will evaporate to the atmosphere, or participate in photochemical reactions. Interacts with other pollutants in the atmosphere to generate secondary pollutants, such as ozone, etc., which exacerbates air pollution, affects air quality, and has an indirect impact on regional climate and ecological environment.
Effects on the human body
1. ** Skin and eyes **: Strong irritation. If accidentally touched with the skin, it can cause skin redness, swelling, pain, and burns. Because it can damage the stratum corneum of the skin, which in turn damages skin cells and triggers an inflammatory reaction. If splashed into the eyes, it is particularly harmful, or causes severe eye pain, tears, blurred vision, and in severe cases, it can damage the cornea and even cause blindness.
2. ** Respiratory system **: Inhalation of its volatile gaseous substances can irritate the respiratory tract. Light cause cough, asthma, breathing difficulties, severe can cause chemical pneumonia, pulmonary edema. After entering the respiratory tract, it comes into contact with the respiratory mucosa, and a chemical reaction occurs, destroying the mucosal tissue, affecting gas exchange, resulting in impaired lung function, threatening life and health.
3. ** Digestive system **: Careless ingestion can burn the mouth, throat and gastrointestinal tract. Causes nausea, vomiting, abdominal pain, diarrhea and other symptoms. In severe cases, it can cause gastrointestinal mucosal erosion, ulcers, affect digestion and absorption function, and cause long-term or chronic diseases of the digestive system.
4. ** Systemic effects **: After being absorbed into the human body through the skin, respiratory tract or digestive tract, or accumulated in the body. Long-term exposure or systemic toxicity can affect the function of important organs such as the liver and kidneys. The liver is a detoxification organ. This compound may increase the metabolic burden of the liver and damage liver cells; the kidneys are responsible for excretion, or are damaged as a result, affecting the excretion function, which in turn affects the normal metabolism of the body and the stability of the internal environment.
Effects on the environment
1. ** Aquatic organisms **: If this compound enters the water body, it can cause poisoning to aquatic organisms. Its chemical properties may interfere with the physiological processes of aquatic organisms, such as hindering their respiration, feeding and reproduction. If fish are exposed to this substance, it may cause damage to the gills, affecting gas exchange, which in turn makes the fish breathing difficulties and threatened survival. For plankton, it may destroy its cell structure, interfere with its photosynthesis, cause changes in population numbers, and affect the food chain foundation of aquatic ecosystems.
2. ** Soil **: If it penetrates into the soil, or changes the chemical properties of the soil. or reacts with minerals and organic matter in the soil, affecting soil fertility and microbial activity. Soil microorganisms are essential for maintaining soil health and nutrient cycling. This compound may inhibit the growth of beneficial microorganisms, causing the decomposition of organic matter in the soil to be blocked, affecting the absorption of nutrients by plants, and then affecting the growth and distribution of plants in terrestrial ecosystems.
3. ** Atmosphere **: Although the amount of volatilization to the atmosphere at room temperature may be limited, in a specific industrial production environment, if not properly treated, it will evaporate to the atmosphere, or participate in photochemical reactions. Interacts with other pollutants in the atmosphere to generate secondary pollutants, such as ozone, etc., which exacerbates air pollution, affects air quality, and has an indirect impact on regional climate and ecological environment.
Effects on the human body
1. ** Skin and eyes **: Strong irritation. If accidentally touched with the skin, it can cause skin redness, swelling, pain, and burns. Because it can damage the stratum corneum of the skin, which in turn damages skin cells and triggers an inflammatory reaction. If splashed into the eyes, it is particularly harmful, or causes severe eye pain, tears, blurred vision, and in severe cases, it can damage the cornea and even cause blindness.
2. ** Respiratory system **: Inhalation of its volatile gaseous substances can irritate the respiratory tract. Light cause cough, asthma, breathing difficulties, severe can cause chemical pneumonia, pulmonary edema. After entering the respiratory tract, it comes into contact with the respiratory mucosa, and a chemical reaction occurs, destroying the mucosal tissue, affecting gas exchange, resulting in impaired lung function, threatening life and health.
3. ** Digestive system **: Careless ingestion can burn the mouth, throat and gastrointestinal tract. Causes nausea, vomiting, abdominal pain, diarrhea and other symptoms. In severe cases, it can cause gastrointestinal mucosal erosion, ulcers, affect digestion and absorption function, and cause long-term or chronic diseases of the digestive system.
4. ** Systemic effects **: After being absorbed into the human body through the skin, respiratory tract or digestive tract, or accumulated in the body. Long-term exposure or systemic toxicity can affect the function of important organs such as the liver and kidneys. The liver is a detoxification organ. This compound may increase the metabolic burden of the liver and damage liver cells; the kidneys are responsible for excretion, or are damaged as a result, affecting the excretion function, which in turn affects the normal metabolism of the body and the stability of the internal environment.
Scan to WhatsApp
