Linshang Chemical
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2-Chloro-4-Fluorobenzene-1-Sulfonyl Chloride
Linshang Chemical
|
HS Code |
275521 |
| Chemical Formula | C6H3Cl2FO2S |
| Molecular Weight | 231.055 g/mol |
| Appearance | A colorless to pale yellow liquid |
| Odor | Pungent |
| Boiling Point | Approximately 260 - 265 °C |
| Density | Around 1.62 g/cm³ |
| Solubility | Soluble in many organic solvents like dichloromethane, chloroform |
| Vapor Pressure | Low at room temperature |
| Stability | Reactive, especially with water and nucleophiles |
| Hazard Class | Corrosive, harmful if inhaled, swallowed or in contact with skin |
As an accredited 2-Chloro-4-Fluorobenzene-1-Sulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 4 - fluorobenzene - 1 - sulfonyl chloride in a sealed chemical - grade bottle. |
| Storage | 2 - Chloro - 4 - fluorobenzene - 1 - sulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat and ignition sources. Keep it in a tightly sealed container to prevent moisture and air contact, as it may react with them. Store separately from incompatible substances like bases, reducing agents, and water - reactive materials to avoid dangerous reactions. |
| Shipping | 2 - chloro - 4 - fluorobenzene - 1 - sulfonyl chloride is a chemical. Ship it in tightly sealed, corrosion - resistant containers. Follow all hazardous material shipping regulations, ensuring proper labeling and handling to prevent spills and ensure safety during transit. |
Competitive 2-Chloro-4-Fluorobenzene-1-Sulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemistry of 2-chloro-4-fluorobenzene-1-sulfonyl Chloride?
2-Chloro-4-fluorobenzene-1-sulfonyl chloride, this material has unique chemical properties. Its appearance is often colorless to slightly yellow liquid, volatile in the air, and emits a pungent odor.
Discuss the reactivity, because it contains sulfonyl chloride groups, the activity is quite high. It hydrolyzes rapidly in contact with water, releasing hydrogen chloride gas and generating corresponding sulfonic acids. This hydrolysis reaction is violent and requires careful operation.
In the field of organic synthesis, it is a very important intermediate. It can react with alcohols and form sulfonates through nucleophilic substitution processes. The reaction conditions are mild and the product yield is quite high. It is often the preferred route for the preparation of sulfonate esters.
meets amines and also undergoes nucleophilic substitution to form sulfonamides. Sulfonamides are widely used in the fields of medicine and pesticides. Many drugs and pesticides contain this group in their structures to impart specific biological activities to the products.
In addition, due to the presence of chlorine and fluorine atoms on the benzene ring, they can participate in various reactions of aromatics. For example, under the action of appropriate catalysts, the coupling reaction of halogenated aromatics can occur, expanding the carbon chain of the molecule or introducing other functional groups, providing an effective strategy for building complex organic molecular structures.
However, it should be noted that 2-chloro-4-fluorobenzene-1-sulfonyl chloride is corrosive and can cause strong irritation to the skin, eyes and respiratory tract. When operating, be sure to take strict protective measures in a well-ventilated environment to prevent endangering personal safety and health.
Discuss the reactivity, because it contains sulfonyl chloride groups, the activity is quite high. It hydrolyzes rapidly in contact with water, releasing hydrogen chloride gas and generating corresponding sulfonic acids. This hydrolysis reaction is violent and requires careful operation.
In the field of organic synthesis, it is a very important intermediate. It can react with alcohols and form sulfonates through nucleophilic substitution processes. The reaction conditions are mild and the product yield is quite high. It is often the preferred route for the preparation of sulfonate esters.
meets amines and also undergoes nucleophilic substitution to form sulfonamides. Sulfonamides are widely used in the fields of medicine and pesticides. Many drugs and pesticides contain this group in their structures to impart specific biological activities to the products.
In addition, due to the presence of chlorine and fluorine atoms on the benzene ring, they can participate in various reactions of aromatics. For example, under the action of appropriate catalysts, the coupling reaction of halogenated aromatics can occur, expanding the carbon chain of the molecule or introducing other functional groups, providing an effective strategy for building complex organic molecular structures.
However, it should be noted that 2-chloro-4-fluorobenzene-1-sulfonyl chloride is corrosive and can cause strong irritation to the skin, eyes and respiratory tract. When operating, be sure to take strict protective measures in a well-ventilated environment to prevent endangering personal safety and health.
What are the main uses of 2-chloro-4-fluorobenzene-1-sulfonyl Chloride?
2-Chloro-4-fluorobenzene-1-sulfonyl chloride, this substance has a wide range of uses and is a key intermediate in the field of organic synthesis.
First, in the creation of medicine, it can be used as a cornerstone to help build a variety of drug molecular structures. Due to the high activity of sulfonyl chloride groups, it can react with many compounds containing nitrogen, oxygen, sulfur and other heteroatoms, and then derive substances with specific biological activities. If you want to develop antibacterial drugs, 2-chloro-4-fluorobenzene-1-sulfonyl chloride can be condensed with amino-containing compounds to generate sulfonamide derivatives. Such derivatives may have antibacterial effects, opening up new avenues for pharmaceutical research and development.
Second, in the field of pesticide preparation, it also plays an important role. After reacting with specific organic reagents, a variety of pesticide active ingredients can be prepared. For example, when reacting with certain alcohols under suitable conditions, the resulting sulfonate compounds may have the functions of insecticides and weeds, providing effective means for agricultural pest control and weed control.
Third, in the field of materials science, 2-chloro-4-fluorobenzene-1-sulfonyl chloride is also useful. It can participate in the synthesis of polymer materials, introducing it into the polymer main chain or side chain through chemical reactions, thus giving polymer materials unique properties. For example, it can be introduced into some engineering plastics synthesis processes, or it can enhance the chemical resistance and thermal stability of materials, broaden the application scenarios of polymer materials, and show its talents in aerospace, automobile manufacturing and other fields that require strict material properties.
First, in the creation of medicine, it can be used as a cornerstone to help build a variety of drug molecular structures. Due to the high activity of sulfonyl chloride groups, it can react with many compounds containing nitrogen, oxygen, sulfur and other heteroatoms, and then derive substances with specific biological activities. If you want to develop antibacterial drugs, 2-chloro-4-fluorobenzene-1-sulfonyl chloride can be condensed with amino-containing compounds to generate sulfonamide derivatives. Such derivatives may have antibacterial effects, opening up new avenues for pharmaceutical research and development.
Second, in the field of pesticide preparation, it also plays an important role. After reacting with specific organic reagents, a variety of pesticide active ingredients can be prepared. For example, when reacting with certain alcohols under suitable conditions, the resulting sulfonate compounds may have the functions of insecticides and weeds, providing effective means for agricultural pest control and weed control.
Third, in the field of materials science, 2-chloro-4-fluorobenzene-1-sulfonyl chloride is also useful. It can participate in the synthesis of polymer materials, introducing it into the polymer main chain or side chain through chemical reactions, thus giving polymer materials unique properties. For example, it can be introduced into some engineering plastics synthesis processes, or it can enhance the chemical resistance and thermal stability of materials, broaden the application scenarios of polymer materials, and show its talents in aerospace, automobile manufacturing and other fields that require strict material properties.
What is the synthesis method of 2-chloro-4-fluorobenzene-1-sulfonyl Chloride?
The synthesis of 2-chloro-4-fluorobenzene-1-sulfonyl chloride is an important topic in the field of organic synthesis. The synthesis of this compound often requires several carefully designed reactions.
The choice of starting materials is crucial, and most of them are benzene derivatives containing corresponding substituents. If 2-chloro-4-fluorobenzene is used as a starting material, a specific sulfonation reagent is required to introduce a sulfonyl chloride group. A common sulfonation reagent is chlorosulfonic acid (ClSO 🥰 H), which reacts with 2-chloro-4-fluorobenzene to introduce a sulfonyl chloride group on the benzene ring.
During the reaction, 2-chloro-4-fluorobenzene is slowly added dropwise to the cold chlorosulfonic acid, and the reaction temperature needs to be strictly controlled. Due to the strong corrosiveness and reactivity of chlorosulfonic acid, high temperature is prone to side reactions, such as polysulfonation or other substitution reactions. Usually, the initial temperature of the reaction can be controlled at 0-5 ° C. After the dropwise addition is completed, gradually heat up to room temperature, and continue to stir to make the reaction fully proceed.
After the reaction is completed, the reaction mixture needs to go through post-treatment steps. The reaction solution is often carefully poured into ice water, and solids will precipitate at this time. Because the sulfonyl chloride is unstable in water and will partially hydrolyze, the operation needs to be rapid and careful. After that, the solid is collected by filtration, and then washed with a suitable organic solvent (such as ether, dichloromethane, etc.) to remove impurities.
If the starting material is other similar compounds, the appropriate reaction path needs to be selected according to its structural characteristics. For some benzene derivatives containing protective groups, the protective group needs to be removed first, and then the sulfonyl chloride group is introduced. The reaction conditions and steps are also different.
In addition, during the reaction process, the reaction process needs to be closely monitored. The reaction can be tracked by thin layer chromatography (TLC), and the reaction endpoint can be determined by comparing the changes of the raw material and the product spots.
Synthesis of 2-chloro-4-fluorobenzene-1-sulfonyl chloride requires comprehensive consideration of many factors such as raw material selection, reaction condition control, post-treatment and reaction monitoring, and careful operation can obtain high yield and purity of the target product.
The choice of starting materials is crucial, and most of them are benzene derivatives containing corresponding substituents. If 2-chloro-4-fluorobenzene is used as a starting material, a specific sulfonation reagent is required to introduce a sulfonyl chloride group. A common sulfonation reagent is chlorosulfonic acid (ClSO 🥰 H), which reacts with 2-chloro-4-fluorobenzene to introduce a sulfonyl chloride group on the benzene ring.
During the reaction, 2-chloro-4-fluorobenzene is slowly added dropwise to the cold chlorosulfonic acid, and the reaction temperature needs to be strictly controlled. Due to the strong corrosiveness and reactivity of chlorosulfonic acid, high temperature is prone to side reactions, such as polysulfonation or other substitution reactions. Usually, the initial temperature of the reaction can be controlled at 0-5 ° C. After the dropwise addition is completed, gradually heat up to room temperature, and continue to stir to make the reaction fully proceed.
After the reaction is completed, the reaction mixture needs to go through post-treatment steps. The reaction solution is often carefully poured into ice water, and solids will precipitate at this time. Because the sulfonyl chloride is unstable in water and will partially hydrolyze, the operation needs to be rapid and careful. After that, the solid is collected by filtration, and then washed with a suitable organic solvent (such as ether, dichloromethane, etc.) to remove impurities.
If the starting material is other similar compounds, the appropriate reaction path needs to be selected according to its structural characteristics. For some benzene derivatives containing protective groups, the protective group needs to be removed first, and then the sulfonyl chloride group is introduced. The reaction conditions and steps are also different.
In addition, during the reaction process, the reaction process needs to be closely monitored. The reaction can be tracked by thin layer chromatography (TLC), and the reaction endpoint can be determined by comparing the changes of the raw material and the product spots.
Synthesis of 2-chloro-4-fluorobenzene-1-sulfonyl chloride requires comprehensive consideration of many factors such as raw material selection, reaction condition control, post-treatment and reaction monitoring, and careful operation can obtain high yield and purity of the target product.
What are the precautions for 2-chloro-4-fluorobenzene-1-sulfonyl Chloride during storage and transportation?
2-Chloro-4-fluorobenzene-1-sulfonyl chloride is one of the chemical substances. During storage and transportation, many matters need to be paid attention to.
Bear the brunt, and the storage place must be dry and cool. This substance is very easy to react in contact with water, so the humidity of the environment must be strictly controlled to prevent moisture absorption and deterioration. If the environment is humid, water can react with the sulfonyl chloride, or cause the product to be impure, or even more, or cause dangerous chemical changes. And a cool place can reduce its reactivity caused by excessive temperature and reduce the risk of spontaneous reactions.
Furthermore, when storing and transporting, the substance must be isolated from alkalis, alcohols and other substances. Due to its strong oxidizing and reactive properties, neutralization reactions can occur when exposed to alkali, and reactions such as alcohol or raw substitution can cause its chemical properties to change and lose its original function.
Packaging is also crucial. It needs to be packaged with corrosion-resistant materials, such as specific plastic or glass containers, and the containers must be well sealed. If the packaging is not good, the substance will escape, not only polluting the environment, but also seriously harming those who come into contact, or causing skin burns, respiratory damage, etc.
During transportation, the speed should be stable to avoid bumps and vibrations. Excessive vibration may damage the packaging, increasing the risk of leakage. And transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods. If an accident occurs, they can respond in time to reduce losses.
Storage and transportation of 2-chloro-4-fluorobenzene-1-sulfonyl chloride requires caution in all aspects to ensure personnel safety and material stability.
Bear the brunt, and the storage place must be dry and cool. This substance is very easy to react in contact with water, so the humidity of the environment must be strictly controlled to prevent moisture absorption and deterioration. If the environment is humid, water can react with the sulfonyl chloride, or cause the product to be impure, or even more, or cause dangerous chemical changes. And a cool place can reduce its reactivity caused by excessive temperature and reduce the risk of spontaneous reactions.
Furthermore, when storing and transporting, the substance must be isolated from alkalis, alcohols and other substances. Due to its strong oxidizing and reactive properties, neutralization reactions can occur when exposed to alkali, and reactions such as alcohol or raw substitution can cause its chemical properties to change and lose its original function.
Packaging is also crucial. It needs to be packaged with corrosion-resistant materials, such as specific plastic or glass containers, and the containers must be well sealed. If the packaging is not good, the substance will escape, not only polluting the environment, but also seriously harming those who come into contact, or causing skin burns, respiratory damage, etc.
During transportation, the speed should be stable to avoid bumps and vibrations. Excessive vibration may damage the packaging, increasing the risk of leakage. And transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods. If an accident occurs, they can respond in time to reduce losses.
Storage and transportation of 2-chloro-4-fluorobenzene-1-sulfonyl chloride requires caution in all aspects to ensure personnel safety and material stability.
2-chloro-4-fluorobenzene-1-sulfonyl Chloride affects the environment and the human body
2-Chloro-4-fluorobenzene-1-sulfonyl chloride has a considerable impact on the environment and human body.
First of all, its impact on the environment. If released in nature, the first to bear the brunt is the soil. This compound contains elements such as chlorine and fluorine, which gradually accumulate in the soil, or cause soil physicochemical properties to change. Excessive chlorine may change the pH of the soil, making it acidic, which in turn damages soil fertility, hinders plant growth, reduces crop production, and affects vegetation communities.
Furthermore, if it flows into water bodies, it is very harmful to aquatic ecosystems. 2-Chloro-4-fluorobenzene-1-sulfonyl chloride may be toxic, and the physiological functions of aquatic organisms such as fish and shellfish may be damaged after contact. Or cause breathing difficulties in fish, affect their reproduction and development, and in severe cases, cause a sharp decrease in the population and destroy the aquatic ecological balance. And this compound may be difficult to degrade and stay in water for a long time, and the harm will continue.
As for the impact on the human body, the first route of contact is involved. If it is exposed to the skin, it is corrosive, or causes skin burns, redness, swelling, and pain. If it is not treated in time, the wound or infection will worsen. If inhaled its volatile gas, significant irritation in the respiratory tract, mild cause cough, asthma, breathing difficulties, severe or damage to lung tissue, causing lung diseases, such as pulmonary edema.
Accidental ingestion is also a major disease. After entering the human body, it may corrode the digestive tract, causing severe pain in the mouth, throat, stomach, mucosa damage, causing ulcers, bleeding and other symptoms. Long-term exposure or ingestion of a small amount of this compound also poses hidden dangers. Because of its potential carcinogenicity and teratogenicity, it interferes with the human endocrine system, affects hormone balance, and then affects the normal growth and development of the human body and physiological functions.
In short, 2-chloro-4-fluorobenzene-1-sulfonyl chloride poses great harm to the environment and the human body. When using and handling, be careful to prevent adverse consequences.
First of all, its impact on the environment. If released in nature, the first to bear the brunt is the soil. This compound contains elements such as chlorine and fluorine, which gradually accumulate in the soil, or cause soil physicochemical properties to change. Excessive chlorine may change the pH of the soil, making it acidic, which in turn damages soil fertility, hinders plant growth, reduces crop production, and affects vegetation communities.
Furthermore, if it flows into water bodies, it is very harmful to aquatic ecosystems. 2-Chloro-4-fluorobenzene-1-sulfonyl chloride may be toxic, and the physiological functions of aquatic organisms such as fish and shellfish may be damaged after contact. Or cause breathing difficulties in fish, affect their reproduction and development, and in severe cases, cause a sharp decrease in the population and destroy the aquatic ecological balance. And this compound may be difficult to degrade and stay in water for a long time, and the harm will continue.
As for the impact on the human body, the first route of contact is involved. If it is exposed to the skin, it is corrosive, or causes skin burns, redness, swelling, and pain. If it is not treated in time, the wound or infection will worsen. If inhaled its volatile gas, significant irritation in the respiratory tract, mild cause cough, asthma, breathing difficulties, severe or damage to lung tissue, causing lung diseases, such as pulmonary edema.
Accidental ingestion is also a major disease. After entering the human body, it may corrode the digestive tract, causing severe pain in the mouth, throat, stomach, mucosa damage, causing ulcers, bleeding and other symptoms. Long-term exposure or ingestion of a small amount of this compound also poses hidden dangers. Because of its potential carcinogenicity and teratogenicity, it interferes with the human endocrine system, affects hormone balance, and then affects the normal growth and development of the human body and physiological functions.
In short, 2-chloro-4-fluorobenzene-1-sulfonyl chloride poses great harm to the environment and the human body. When using and handling, be careful to prevent adverse consequences.
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