Linshang Chemical
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2-Chloro-4-Fluorobenzene-1-Thiol
Linshang Chemical
|
HS Code |
949741 |
| Chemical Formula | C6H4ClFS |
| Appearance | Solid (Typical description for such compounds) |
| Solubility In Water | Insoluble (Aromatic sulfur - containing halides are generally hydrophobic) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Odor | Characteristic sulfur - containing and aromatic odor |
| Stability | Stable under normal conditions but may react with strong oxidizing agents |
As an accredited 2-Chloro-4-Fluorobenzene-1-Thiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 2 - chloro - 4 - fluorobenzene - 1 - thiol packaged in a sealed, chemical - resistant bottle. |
| Storage | 2 - Chloro - 4 - fluorobenzene - 1 - thiol should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container made of materials resistant to corrosion by the chemical, such as glass or certain plastics. Avoid storing near incompatible substances to prevent reactions and potential hazards. |
| Shipping | 2 - chloro - 4 - fluorobenzene - 1 - thiol should be shipped in tightly sealed, corrosion - resistant containers. Label it clearly as a chemical with proper hazard warnings. Ensure compliance with all relevant shipping regulations for hazardous substances. |
Competitive 2-Chloro-4-Fluorobenzene-1-Thiol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What is the chemical structure of 2-chloro-4-fluorobenzene-1-thiol?
2-Chloro-4-fluorobenzene-1-thiol, which is a kind of organic compound. Its chemical structure is based on the benzene ring. On the benzene ring, a chlorine atom is connected at position 2, a fluorine atom is connected at position 4, and a thiol group (-SH) is connected at position 1.
The benzene ring is a six-membered ring structure composed of six carbon atoms connected by conjugated double bonds, which has unique stability and electron cloud distribution characteristics. The chlorine atom is a halogen element atom with high electronegativity. It is connected to the benzene ring and will affect the electron cloud density distribution of the benzene ring. Due to its electron-withdrawing induction effect, the electron cloud density of the benzene ring can be reduced, especially in the adjacent and para-positions of the chlorine atom. The fluorine atom is also a halogen element and has extremely strong electronegativity. Its effect on the electron cloud density of the benzene ring is similar to that of the chlorine atom. However, because its atomic radius is smaller than that of the chlorine atom, the performance of some electronic effects may be different.
And the thiol group (-SH) at position 1 is a sulfur-containing functional group, and the sulfur atom is connected to the hydrogen atom by a covalent bond. The sulfhydryl group has a certain acidity, and the sulfur atom has more electrons in the outer layer, which can participate in a variety of chemical reactions, such as oxidation reaction, nucleophilic substitution reaction, etc.
In the chemical structure of 2-chloro-4-fluorobenzene-1-thiol, each atom interacts with the functional group, endowing this compound with specific physical and chemical properties, and may have potential application value in many fields such as organic synthesis and medicinal chemistry.
The benzene ring is a six-membered ring structure composed of six carbon atoms connected by conjugated double bonds, which has unique stability and electron cloud distribution characteristics. The chlorine atom is a halogen element atom with high electronegativity. It is connected to the benzene ring and will affect the electron cloud density distribution of the benzene ring. Due to its electron-withdrawing induction effect, the electron cloud density of the benzene ring can be reduced, especially in the adjacent and para-positions of the chlorine atom. The fluorine atom is also a halogen element and has extremely strong electronegativity. Its effect on the electron cloud density of the benzene ring is similar to that of the chlorine atom. However, because its atomic radius is smaller than that of the chlorine atom, the performance of some electronic effects may be different.
And the thiol group (-SH) at position 1 is a sulfur-containing functional group, and the sulfur atom is connected to the hydrogen atom by a covalent bond. The sulfhydryl group has a certain acidity, and the sulfur atom has more electrons in the outer layer, which can participate in a variety of chemical reactions, such as oxidation reaction, nucleophilic substitution reaction, etc.
In the chemical structure of 2-chloro-4-fluorobenzene-1-thiol, each atom interacts with the functional group, endowing this compound with specific physical and chemical properties, and may have potential application value in many fields such as organic synthesis and medicinal chemistry.
What are the physical properties of 2-chloro-4-fluorobenzene-1-thiol?
2-Chloro-4-fluorobenzene-1-mercaptan is also an organic compound. It has unique physical properties and is widely used in various fields of chemical industry.
Looking at its properties, under normal temperature and pressure, it is mostly liquid or crystalline. Color or colorless, or microstrip color, this may be different due to the mixing of impurities.
On its melting point, determined by fine experiments, it is about [specific melting point value] ℃. The melting point is the critical temperature at which a substance changes from solid to liquid. This property can be an important indicator when separating, purifying and identifying the compound. When heated to the melting point, the lattice structure disintegrates, the molecules are energized, and the movement intensifies, so they are solid and liquid.
The boiling point is also a key physical property, about [specific boiling point value] ℃. At the boiling point, the inside and surface of the liquid are violently vaporized at the same time. This property can be used in chemical operations such as distillation to separate the compound from others. Different compounds have different boiling points. Using this point, fractionation can be carried out according to the difference in boiling points to obtain a pure product.
Its density is about [specific density value] g/cm ³. The density is the mass of the substance per unit volume. This value helps to consider the distribution and behavior of the compound in different systems. If mixed with water, it can be judged to float on water or sink under water due to different densities. It is of great significance in the phase separation operation of chemical production.
The solubility cannot be ignored either. 2-Chloro-4-fluorobenzene-1-mercaptan has good solubility in organic solvents such as ethanol and ether. Due to the principle of "similar miscibility", the compound is similar to the force between organic solvent molecules, so it can be miscible. In water, the solubility is limited. Due to the large difference between the molecular structure and the polarity of water, it is difficult for water molecules to effectively interact with it, and the solubility is not high.
Furthermore, the compound has a special odor. Its smell is pungent and corrosive. When operating, you need to take care not to contact the skin and respiratory tract to avoid injury.
These are the physical properties of 2-chloro-4-fluorobenzene-1-mercaptan, which can be well used in the fields of chemical synthesis and material preparation to achieve the desired purpose.
Looking at its properties, under normal temperature and pressure, it is mostly liquid or crystalline. Color or colorless, or microstrip color, this may be different due to the mixing of impurities.
On its melting point, determined by fine experiments, it is about [specific melting point value] ℃. The melting point is the critical temperature at which a substance changes from solid to liquid. This property can be an important indicator when separating, purifying and identifying the compound. When heated to the melting point, the lattice structure disintegrates, the molecules are energized, and the movement intensifies, so they are solid and liquid.
The boiling point is also a key physical property, about [specific boiling point value] ℃. At the boiling point, the inside and surface of the liquid are violently vaporized at the same time. This property can be used in chemical operations such as distillation to separate the compound from others. Different compounds have different boiling points. Using this point, fractionation can be carried out according to the difference in boiling points to obtain a pure product.
Its density is about [specific density value] g/cm ³. The density is the mass of the substance per unit volume. This value helps to consider the distribution and behavior of the compound in different systems. If mixed with water, it can be judged to float on water or sink under water due to different densities. It is of great significance in the phase separation operation of chemical production.
The solubility cannot be ignored either. 2-Chloro-4-fluorobenzene-1-mercaptan has good solubility in organic solvents such as ethanol and ether. Due to the principle of "similar miscibility", the compound is similar to the force between organic solvent molecules, so it can be miscible. In water, the solubility is limited. Due to the large difference between the molecular structure and the polarity of water, it is difficult for water molecules to effectively interact with it, and the solubility is not high.
Furthermore, the compound has a special odor. Its smell is pungent and corrosive. When operating, you need to take care not to contact the skin and respiratory tract to avoid injury.
These are the physical properties of 2-chloro-4-fluorobenzene-1-mercaptan, which can be well used in the fields of chemical synthesis and material preparation to achieve the desired purpose.
What are the main uses of 2-chloro-4-fluorobenzene-1-thiol?
2-Chloro-4-fluorobenzene-1-mercaptan, this is an organic compound. It has a wide range of uses and has important applications in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate. In the process of drug development, its unique chemical structure can participate in various reactions and help build drug molecules with specific physiological activities. With the activity of thiol groups, it can react with other compounds to synthesize drugs with complex structures, providing a key foundation for the creation of disease treatment drugs.
In the field of materials science, it can be used to prepare materials with special properties. Mercaptan groups can interact with the surface of metal ions or other materials, such as modifying the surface of materials, imparting new properties to materials, such as improving the hydrophilicity of materials, improving the compatibility of materials with other substances, etc., so that materials can exhibit unique properties in coatings, composites, etc.
In the field of organic synthetic chemistry, as an important synthetic building block. Due to the presence of chlorine atoms, fluorine atoms and thiol groups, it can construct a variety of organic compound structures through different chemical reaction paths. For example, chlorine atoms and fluorine atoms can participate in nucleophilic substitution reactions, and thiol groups can undergo oxidation, condensation and other reactions, providing an effective way for the synthesis of organic compounds with specific functions and structures.
In the field of pesticide chemistry, it also plays an important role. It can be used as a raw material for synthesizing pesticide active ingredients, and its structure helps to develop pesticide products with high-efficiency insecticidal, bactericidal or herbicidal activities, providing strong support for pest control and weed control in agricultural production.
2-chloro-4-fluorobenzene-1-thiol, with its special chemical structure, plays an important role in many fields such as medicine, materials, organic synthesis and pesticides, and is of great significance to promote the development of these fields.
In the field of medicinal chemistry, it is often used as a key intermediate. In the process of drug development, its unique chemical structure can participate in various reactions and help build drug molecules with specific physiological activities. With the activity of thiol groups, it can react with other compounds to synthesize drugs with complex structures, providing a key foundation for the creation of disease treatment drugs.
In the field of materials science, it can be used to prepare materials with special properties. Mercaptan groups can interact with the surface of metal ions or other materials, such as modifying the surface of materials, imparting new properties to materials, such as improving the hydrophilicity of materials, improving the compatibility of materials with other substances, etc., so that materials can exhibit unique properties in coatings, composites, etc.
In the field of organic synthetic chemistry, as an important synthetic building block. Due to the presence of chlorine atoms, fluorine atoms and thiol groups, it can construct a variety of organic compound structures through different chemical reaction paths. For example, chlorine atoms and fluorine atoms can participate in nucleophilic substitution reactions, and thiol groups can undergo oxidation, condensation and other reactions, providing an effective way for the synthesis of organic compounds with specific functions and structures.
In the field of pesticide chemistry, it also plays an important role. It can be used as a raw material for synthesizing pesticide active ingredients, and its structure helps to develop pesticide products with high-efficiency insecticidal, bactericidal or herbicidal activities, providing strong support for pest control and weed control in agricultural production.
2-chloro-4-fluorobenzene-1-thiol, with its special chemical structure, plays an important role in many fields such as medicine, materials, organic synthesis and pesticides, and is of great significance to promote the development of these fields.
What are 2-chloro-4-fluorobenzene-1-thiol synthesis methods?
The synthesis method of 2-chloro-4-fluorobenzene-1-mercaptan is very elegant. In the past, Xian Da had his own innovations in the synthesis of this substance.
First, it can start from halogenated aromatics. Take 2-chloro-4-fluorobromobenzene as raw material, mix it with thiourea, put it in a suitable solvent, such as ethanol, and heat it back. The two go through a nucleophilic substitution reaction, and the sulfur atom of thiourea attacks the carbon attached to the halogenated aromatics atom to form an intermediate. Then, the intermediate is hydrolyzed with a strong base such as sodium hydroxide solution to obtain the target product 2-chloro-4-fluorobenzene-1-thiol. In this pathway, the activity of halogenated aromatics, the reaction temperature and time are all key. If the temperature is too low, the reaction will be slow; if it is too high, side reactions will occur.
Second, it can also be derived from phenolic compounds. First, 2-chloro-4-fluorophenol is protected by appropriate protective groups to prevent it from interfering in subsequent reactions. Then, a vulcanizing agent, such as phosphorus pentasulfide, is reacted under suitable conditions to convert the phenolic hydroxyl group into a thiol group. After the reaction is completed, the protective group is removed to obtain the product. In this process, the selection of protective groups is extremely important. It is necessary to effectively protect the phenolic hydroxyl group and gently remove it at the end of the reaction.
Furthermore, the method of using Grignard's reagent is also quite feasible. React 2-chloro-4-fluorobromobenzene with magnesium chips in anhydrous ether or tetrahydrofuran to make Grignard's reagent. Subsequently, the Grignard's reagent reacts with sulfur elemental substance to form thiomagnesium salt intermediates, which are then acidified to obtain 2-chloro-4-fluorobenzene-1-thiol. In this way, the anhydrous and anaerobic conditions of the reaction system are severe, and if there is a little carelessness, the Grignard reagent is easily inactivated and the reaction fails.
All synthesis methods have their own advantages and disadvantages, and they all need to be carefully selected according to actual needs, weighing factors such as the availability of raw materials, the difficulty of reaction conditions, and the purity of the product.
First, it can start from halogenated aromatics. Take 2-chloro-4-fluorobromobenzene as raw material, mix it with thiourea, put it in a suitable solvent, such as ethanol, and heat it back. The two go through a nucleophilic substitution reaction, and the sulfur atom of thiourea attacks the carbon attached to the halogenated aromatics atom to form an intermediate. Then, the intermediate is hydrolyzed with a strong base such as sodium hydroxide solution to obtain the target product 2-chloro-4-fluorobenzene-1-thiol. In this pathway, the activity of halogenated aromatics, the reaction temperature and time are all key. If the temperature is too low, the reaction will be slow; if it is too high, side reactions will occur.
Second, it can also be derived from phenolic compounds. First, 2-chloro-4-fluorophenol is protected by appropriate protective groups to prevent it from interfering in subsequent reactions. Then, a vulcanizing agent, such as phosphorus pentasulfide, is reacted under suitable conditions to convert the phenolic hydroxyl group into a thiol group. After the reaction is completed, the protective group is removed to obtain the product. In this process, the selection of protective groups is extremely important. It is necessary to effectively protect the phenolic hydroxyl group and gently remove it at the end of the reaction.
Furthermore, the method of using Grignard's reagent is also quite feasible. React 2-chloro-4-fluorobromobenzene with magnesium chips in anhydrous ether or tetrahydrofuran to make Grignard's reagent. Subsequently, the Grignard's reagent reacts with sulfur elemental substance to form thiomagnesium salt intermediates, which are then acidified to obtain 2-chloro-4-fluorobenzene-1-thiol. In this way, the anhydrous and anaerobic conditions of the reaction system are severe, and if there is a little carelessness, the Grignard reagent is easily inactivated and the reaction fails.
All synthesis methods have their own advantages and disadvantages, and they all need to be carefully selected according to actual needs, weighing factors such as the availability of raw materials, the difficulty of reaction conditions, and the purity of the product.
2-chloro-4-fluorobenzene-1-thiol what are the precautions during storage and use?
2-Chloro-4-fluorobenzene-1-mercaptan is a rather special chemical substance. When storing and using it, many matters must be carefully paid attention to to prevent accidents from happening, endangering personal safety and the surrounding environment.
First words storage, this substance should be stored in a cool, dry and well-ventilated place. Because of its active nature, it is prone to adverse reactions when heated or wet. If it is exposed to a high temperature environment or causes its volatilization to intensify, not only will the material be lost, but the volatile gaseous substances may be toxic and irritating, harming people nearby. The humid environment may cause reactions such as hydrolysis, causing the substance to deteriorate.
In addition, the storage must be kept away from fire and heat sources. This substance may be flammable, and in case of open flames and hot topics, it may cause combustion or even explosion, so smoking and fire are strictly prohibited in the storage area. And should be stored separately from oxidants, acids, alkalis, etc., because it is easy to react violently with these substances and cause danger.
As for the use, personal protective measures must be taken. Wear appropriate protective clothing, gloves and goggles to prevent the substance from coming into contact with the skin and eyes. Because it may be strongly irritating and corrosive to the skin and eyes, once in contact, it may cause serious injuries such as burns.
The operation process should be carried out in the fume hood to ensure that the generated exhaust gas can be discharged in time to avoid the operator's inhalation. If inhaled inadvertently, it may cause respiratory irritation, poisoning and other symptoms. After use, it is also crucial to dispose of the remaining substances and the equipment used. The remaining substances cannot be discarded at will, and must be properly disposed of in accordance with relevant regulations to prevent environmental pollution. The equipment used should also be thoroughly cleaned to ensure that there is no residue, so as to avoid accidents caused by the next use.
In short, the storage and use of 2-chloro-4-fluorobenzene-1-thiol must strictly follow the relevant norms and safe operation procedures, and must not be taken lightly, so as to ensure safety and avoid accidents.
First words storage, this substance should be stored in a cool, dry and well-ventilated place. Because of its active nature, it is prone to adverse reactions when heated or wet. If it is exposed to a high temperature environment or causes its volatilization to intensify, not only will the material be lost, but the volatile gaseous substances may be toxic and irritating, harming people nearby. The humid environment may cause reactions such as hydrolysis, causing the substance to deteriorate.
In addition, the storage must be kept away from fire and heat sources. This substance may be flammable, and in case of open flames and hot topics, it may cause combustion or even explosion, so smoking and fire are strictly prohibited in the storage area. And should be stored separately from oxidants, acids, alkalis, etc., because it is easy to react violently with these substances and cause danger.
As for the use, personal protective measures must be taken. Wear appropriate protective clothing, gloves and goggles to prevent the substance from coming into contact with the skin and eyes. Because it may be strongly irritating and corrosive to the skin and eyes, once in contact, it may cause serious injuries such as burns.
The operation process should be carried out in the fume hood to ensure that the generated exhaust gas can be discharged in time to avoid the operator's inhalation. If inhaled inadvertently, it may cause respiratory irritation, poisoning and other symptoms. After use, it is also crucial to dispose of the remaining substances and the equipment used. The remaining substances cannot be discarded at will, and must be properly disposed of in accordance with relevant regulations to prevent environmental pollution. The equipment used should also be thoroughly cleaned to ensure that there is no residue, so as to avoid accidents caused by the next use.
In short, the storage and use of 2-chloro-4-fluorobenzene-1-thiol must strictly follow the relevant norms and safe operation procedures, and must not be taken lightly, so as to ensure safety and avoid accidents.
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