Linshang Chemical
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2-Chloro-4-Fluorobenzeneboronic Acid
Linshang Chemical
|
HS Code |
752252 |
| Chemical Formula | C6H5BClFO2 |
| Molar Mass | 174.37 g/mol |
| Appearance | White to off - white solid |
| Melting Point | 155 - 160 °C |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, tetrahydrofuran |
| Pka Value | Around 8 - 9 (approximate value for boronic acid group) |
| Boiling Point | Decomposes before boiling under normal pressure |
| Stability | Stable under normal conditions, but sensitive to moisture and strong bases |
As an accredited 2-Chloro-4-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 4 - fluorobenzeneboronic acid in a sealed, chemical - resistant bottle. |
| Storage | 2 - chloro - 4 - fluorobenzeneboronic acid should be stored in a cool, dry place away from heat and direct sunlight. Keep it in a tightly - sealed container to prevent moisture absorption and contact with air, which could lead to degradation. Store it separately from incompatible substances like strong oxidizing agents and bases to avoid chemical reactions. |
| Shipping | 2 - chloro - 4 - fluorobenzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. It's transported under conditions compliant with chemical safety regulations, ensuring protection from moisture, heat, and physical damage during transit. |
Competitive 2-Chloro-4-Fluorobenzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Chloro-4-Fluorobenzeneboronic Acid in China?
As a trusted 2-Chloro-4-Fluorobenzeneboronic Acid manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-4-Fluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chloro-4-fluorobenzeneboronic Acid?
2-Chloro-4-fluorophenylboronic acid is a crucial organoboron compound in the field of organic synthesis. It plays an indispensable role in many chemical synthesis reactions and has a wide range of uses.
The first and key use is the Suzuki-Miyaura coupling reaction. This reaction is a classic method for building carbon-carbon bonds, which is crucial in many fields such as medicinal chemistry, materials science, and total synthesis of natural products. 2-Chloro-4-fluorophenylboronic acid can be coupled with halogenated aromatics or olefins in the presence of palladium catalysts and bases, thereby efficiently and accurately generating biaryl or alkenyl aromatics with specific structures. In drug development, complex molecular structures can be constructed through this reaction to meet the needs of drug activity and drug properties.
Furthermore, in the field of materials science, it can be used to synthesize organic materials with special photoelectric properties. Biaryl compounds prepared by the Suzuki-Miyaura coupling reaction often exhibit unique optical and electrical properties, such as good fluorescence properties, charge transport properties, etc. Such materials can be used in the manufacture of organic Light Emitting Diodes (OLEDs), organic solar cells and other optoelectronic devices, providing key structural units for the development of new and efficient optoelectronic materials.
In addition, 2-chloro-4-fluorophenylboronic acid is also commonly used in the total synthesis of natural products. Natural products usually have complex chemical structures and significant biological activities. During the total synthesis process, with the help of the coupling reaction it participates in, different structural fragments can be effectively spliced to realize the total synthesis of natural products, which helps to further study the biological activity and mechanism of natural products, and also provides potential lead compounds for the development of new drugs.
In conclusion, 2-chloro-4-fluorophenylboronic acid plays a key role in many fields of organic synthesis due to its high efficiency and selectivity in the construction of carbon-carbon bonds, which greatly promotes the development of related disciplines such as medicinal chemistry and materials science.
The first and key use is the Suzuki-Miyaura coupling reaction. This reaction is a classic method for building carbon-carbon bonds, which is crucial in many fields such as medicinal chemistry, materials science, and total synthesis of natural products. 2-Chloro-4-fluorophenylboronic acid can be coupled with halogenated aromatics or olefins in the presence of palladium catalysts and bases, thereby efficiently and accurately generating biaryl or alkenyl aromatics with specific structures. In drug development, complex molecular structures can be constructed through this reaction to meet the needs of drug activity and drug properties.
Furthermore, in the field of materials science, it can be used to synthesize organic materials with special photoelectric properties. Biaryl compounds prepared by the Suzuki-Miyaura coupling reaction often exhibit unique optical and electrical properties, such as good fluorescence properties, charge transport properties, etc. Such materials can be used in the manufacture of organic Light Emitting Diodes (OLEDs), organic solar cells and other optoelectronic devices, providing key structural units for the development of new and efficient optoelectronic materials.
In addition, 2-chloro-4-fluorophenylboronic acid is also commonly used in the total synthesis of natural products. Natural products usually have complex chemical structures and significant biological activities. During the total synthesis process, with the help of the coupling reaction it participates in, different structural fragments can be effectively spliced to realize the total synthesis of natural products, which helps to further study the biological activity and mechanism of natural products, and also provides potential lead compounds for the development of new drugs.
In conclusion, 2-chloro-4-fluorophenylboronic acid plays a key role in many fields of organic synthesis due to its high efficiency and selectivity in the construction of carbon-carbon bonds, which greatly promotes the development of related disciplines such as medicinal chemistry and materials science.
What are the physical properties of 2-chloro-4-fluorobenzeneboronic Acid?
2-Chloro-4-fluorophenylboronic acid is an important reagent in organic synthesis. It has many physical properties and is closely related to chemical synthesis.
Looking at its properties, it is usually white to quasi-white solid. This color and shape are easy to identify and handle in laboratory operations. Its melting point also has a specific range, generally between 140-145 ° C. The stability of the melting point is of great significance for controlling the reaction conditions. During the heating reaction process, the melting point can be used as the basis for judging the purity of the substance and the progress of the reaction. If the melting point deviates from the normal range, it may suggest that the purity of the substance is not good, or the reaction is not as expected.
The solubility of the substance is also worthy of attention. In common organic solvents such as dichloromethane and tetrahydrofuran, it has a certain solubility. This property provides convenience for the selection of solvents for organic synthesis reactions. When building complex organic molecular structures, it is necessary to select suitable solvents according to the reaction requirements. The good solubility of dichloromethane and tetrahydrofuran to 2-chloro-4-fluorophenylboronic acid can make the reactants fully contact, accelerate the reaction rate and improve the reaction efficiency. However, its solubility in water is relatively poor. This difference has a significant impact on the post-treatment process of the reaction. The insolubility of water and organic solvents can be used to separate the products and impurities by extraction and other means.
In addition, 2-chloro-4-fluorophenylboronic acid has a certain sensitivity to air and humidity. Keep in the air for a long time, or deteriorate due to the action of moisture, oxygen, etc. Therefore, when storing and using, it is necessary to pay attention to sealed storage to minimize contact with air. The operation process should choose a dry environment to avoid the failure of reagents due to environmental factors, to ensure the smooth development of organic synthesis reactions and the accuracy of results.
Looking at its properties, it is usually white to quasi-white solid. This color and shape are easy to identify and handle in laboratory operations. Its melting point also has a specific range, generally between 140-145 ° C. The stability of the melting point is of great significance for controlling the reaction conditions. During the heating reaction process, the melting point can be used as the basis for judging the purity of the substance and the progress of the reaction. If the melting point deviates from the normal range, it may suggest that the purity of the substance is not good, or the reaction is not as expected.
The solubility of the substance is also worthy of attention. In common organic solvents such as dichloromethane and tetrahydrofuran, it has a certain solubility. This property provides convenience for the selection of solvents for organic synthesis reactions. When building complex organic molecular structures, it is necessary to select suitable solvents according to the reaction requirements. The good solubility of dichloromethane and tetrahydrofuran to 2-chloro-4-fluorophenylboronic acid can make the reactants fully contact, accelerate the reaction rate and improve the reaction efficiency. However, its solubility in water is relatively poor. This difference has a significant impact on the post-treatment process of the reaction. The insolubility of water and organic solvents can be used to separate the products and impurities by extraction and other means.
In addition, 2-chloro-4-fluorophenylboronic acid has a certain sensitivity to air and humidity. Keep in the air for a long time, or deteriorate due to the action of moisture, oxygen, etc. Therefore, when storing and using, it is necessary to pay attention to sealed storage to minimize contact with air. The operation process should choose a dry environment to avoid the failure of reagents due to environmental factors, to ensure the smooth development of organic synthesis reactions and the accuracy of results.
What are the synthetic methods of 2-chloro-4-fluorobenzeneboronic Acid?
There are several common methods for the synthesis of 2-chloro-4-fluorophenylboronic acid.
One is the metallization of halogenated aromatic hydrocarbons. Take 2-chloro-4-fluorobromobenzene first and react with metal reagents such as butyl lithium in a low temperature environment. The lithium atom in butyl lithium is quite active and can replace the bromine atom to form a lithium intermediate. This intermediate is also highly active and then reacts with borate esters, such as trimethoxyborate. After the reaction is completed, 2-chloro-4-fluorophenylboronic acid can be obtained through the hydrolysis step. This process requires strict temperature control. Due to the high reactivity of metallization, improper temperature is easy to cause side reactions.
The second is the palladium catalytic coupling method. The raw materials of 2-chloro-4-fluorohalobenzene and diphenacol borate are reacted in a suitable solvent under the catalysis of palladium catalysts such as tetra (triphenylphosphine) palladium. The palladium catalyst can activate the carbon-halogen bond of halobenzene and promote its coupling with borate esters. The reaction system often needs to add bases, such as potassium carbonate, to help the reaction proceed. This method has good selectivity and considerable yield, but the palladium catalyst is expensive and costly.
The third is the Grignard reagent method. First, the Grignard reagent is prepared by reacting 2-chloro-4-fluorohalobenzene with magnesium chips in anhydrous ether or tetrahydrofuran solvents. The carbon-magnesium bond in the Grignard reagent has strong polarity and good activity. Then the Grignard reagent is reacted with borate ester and hydrolyzed to obtain the target product 2-chloro-4-fluorophenylboronic acid. When preparing the Grignard reagent, the solvent should be anhydrous and the reaction environment should be isolated from air, otherwise the Grignard reagent is easily oxidized or hydrolyzed.
All the above methods have advantages and disadvantages. In actual synthesis, the appropriate synthesis method should be carefully selected according to factors such as raw material availability, cost, yield and purity requirements.
One is the metallization of halogenated aromatic hydrocarbons. Take 2-chloro-4-fluorobromobenzene first and react with metal reagents such as butyl lithium in a low temperature environment. The lithium atom in butyl lithium is quite active and can replace the bromine atom to form a lithium intermediate. This intermediate is also highly active and then reacts with borate esters, such as trimethoxyborate. After the reaction is completed, 2-chloro-4-fluorophenylboronic acid can be obtained through the hydrolysis step. This process requires strict temperature control. Due to the high reactivity of metallization, improper temperature is easy to cause side reactions.
The second is the palladium catalytic coupling method. The raw materials of 2-chloro-4-fluorohalobenzene and diphenacol borate are reacted in a suitable solvent under the catalysis of palladium catalysts such as tetra (triphenylphosphine) palladium. The palladium catalyst can activate the carbon-halogen bond of halobenzene and promote its coupling with borate esters. The reaction system often needs to add bases, such as potassium carbonate, to help the reaction proceed. This method has good selectivity and considerable yield, but the palladium catalyst is expensive and costly.
The third is the Grignard reagent method. First, the Grignard reagent is prepared by reacting 2-chloro-4-fluorohalobenzene with magnesium chips in anhydrous ether or tetrahydrofuran solvents. The carbon-magnesium bond in the Grignard reagent has strong polarity and good activity. Then the Grignard reagent is reacted with borate ester and hydrolyzed to obtain the target product 2-chloro-4-fluorophenylboronic acid. When preparing the Grignard reagent, the solvent should be anhydrous and the reaction environment should be isolated from air, otherwise the Grignard reagent is easily oxidized or hydrolyzed.
All the above methods have advantages and disadvantages. In actual synthesis, the appropriate synthesis method should be carefully selected according to factors such as raw material availability, cost, yield and purity requirements.
2-chloro-4-fluorobenzeneboronic Acid to pay attention to when storing and transporting
For 2-chloro-4-fluorophenylboronic acid, many matters must be paid attention to during storage and transportation.
This is an organic compound with active properties. During storage, the first environment is dry. Moisture is prone to hydrolysis, which in turn damages its purity and quality. Therefore, it should be placed in a dry, well-ventilated place, away from water sources and moisture sources, such as wet walls, sinks, etc.
Temperature is also critical. It should be stored in a cool place, usually 2-8 ° C. Excessive temperature can promote its chemical reaction and cause deterioration; too low temperature or change the shape of the substance, affecting its performance.
Furthermore, avoid direct light. Light or chemical reaction to cause light to change its chemical structure. Storage containers should be shaded, such as brown glass bottles, which can effectively block light.
When transporting, the packaging must be sturdy. This compound is dangerous to prevent damage and leakage of the package due to collision and vibration. Packaging materials should be resistant to chemical corrosion to ensure safety during transportation.
At the same time, the transportation environment should also follow the temperature and humidity requirements of storage. Transportation vehicles should have temperature control and moisture-proof facilities to ensure stable conditions during transportation.
Also note that 2-chloro-4-fluorophenylboronic acid may be incompatible with other substances. When storing and transporting, do not mix or mix with reactive substances to prevent dangerous accidents.
In summary, the storage and transportation of 2-chloro-4-fluorophenylboronic acid, drying, temperature, shading, packaging, and avoidance of contact with incompatible substances all require careful treatment to ensure its quality and safety.
This is an organic compound with active properties. During storage, the first environment is dry. Moisture is prone to hydrolysis, which in turn damages its purity and quality. Therefore, it should be placed in a dry, well-ventilated place, away from water sources and moisture sources, such as wet walls, sinks, etc.
Temperature is also critical. It should be stored in a cool place, usually 2-8 ° C. Excessive temperature can promote its chemical reaction and cause deterioration; too low temperature or change the shape of the substance, affecting its performance.
Furthermore, avoid direct light. Light or chemical reaction to cause light to change its chemical structure. Storage containers should be shaded, such as brown glass bottles, which can effectively block light.
When transporting, the packaging must be sturdy. This compound is dangerous to prevent damage and leakage of the package due to collision and vibration. Packaging materials should be resistant to chemical corrosion to ensure safety during transportation.
At the same time, the transportation environment should also follow the temperature and humidity requirements of storage. Transportation vehicles should have temperature control and moisture-proof facilities to ensure stable conditions during transportation.
Also note that 2-chloro-4-fluorophenylboronic acid may be incompatible with other substances. When storing and transporting, do not mix or mix with reactive substances to prevent dangerous accidents.
In summary, the storage and transportation of 2-chloro-4-fluorophenylboronic acid, drying, temperature, shading, packaging, and avoidance of contact with incompatible substances all require careful treatment to ensure its quality and safety.
What is the market price of 2-chloro-4-fluorobenzeneboronic Acid?
2-Chloro-4-fluorophenylboronic acid, its market price fluctuates due to a variety of factors. Looking at the market of chemical materials in the past, the price of this compound often varies according to purity, supply and demand situation, and the difficulty of preparation process.
Let's talk about purity first. For those with high purity, the price is high because the preparation requires more refined process and stricter process, and the removal of impurities is cumbersome. If the purity reaches excellent purity, the price per gram may be in the hundreds of yuan; for ordinary analytical purity, the price is slightly reduced, or tens of yuan per gram.
In terms of supply and demand, if the market has strong demand for pharmaceutical intermediates and electronic materials containing this ingredient, and the output is limited, the price will rise. On the contrary, if the supply exceeds the demand, the price will stabilize or decrease.
In addition to the preparation process, if the new process greatly increases the production efficiency and reduces the cost, the price will also be affected. In the past, the cost of traditional processes was high and the price was high; after the advent of new technologies, the cost decreased and the price was adjusted.
However, the exact price is difficult to generalize. In different regional markets, due to differences in transportation costs and taxes, there are also differences. Generally speaking, in common transaction scenarios, when purchasing in bulk, the price per gram may be around tens of yuan to hundreds of yuan; if you retail in small quantities, the price may be higher. To know the exact price, you need to consult the chemical raw material supplier in detail and compare the quotations of each merchant to be clear.
Let's talk about purity first. For those with high purity, the price is high because the preparation requires more refined process and stricter process, and the removal of impurities is cumbersome. If the purity reaches excellent purity, the price per gram may be in the hundreds of yuan; for ordinary analytical purity, the price is slightly reduced, or tens of yuan per gram.
In terms of supply and demand, if the market has strong demand for pharmaceutical intermediates and electronic materials containing this ingredient, and the output is limited, the price will rise. On the contrary, if the supply exceeds the demand, the price will stabilize or decrease.
In addition to the preparation process, if the new process greatly increases the production efficiency and reduces the cost, the price will also be affected. In the past, the cost of traditional processes was high and the price was high; after the advent of new technologies, the cost decreased and the price was adjusted.
However, the exact price is difficult to generalize. In different regional markets, due to differences in transportation costs and taxes, there are also differences. Generally speaking, in common transaction scenarios, when purchasing in bulk, the price per gram may be around tens of yuan to hundreds of yuan; if you retail in small quantities, the price may be higher. To know the exact price, you need to consult the chemical raw material supplier in detail and compare the quotations of each merchant to be clear.
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