Linshang Chemical
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2-Chloro-4-Fluorobenzenethiol
Linshang Chemical
|
HS Code |
165648 |
| Chemical Formula | C6H4ClFS |
| Molar Mass | 162.61 g/mol |
| Appearance | Typically a liquid |
| Boiling Point | Data may vary, needs specific literature |
| Melting Point | Data may vary, needs specific literature |
| Density | Data may vary, needs specific literature |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Data may vary, needs specific literature |
| Odor | Characteristically sulfur - like odor |
As an accredited 2-Chloro-4-Fluorobenzenethiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 2 - chloro - 4 - fluorobenzenethiol packaged in 500 - gram bottles. |
| Storage | 2 - chloro - 4 - fluorobenzenethiol should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent evaporation and exposure to air, which could lead to degradation. Use corrosion - resistant materials for storage vessels due to its potential reactivity. Label clearly for easy identification and safety. |
| Shipping | 2 - chloro - 4 - fluorobenzenethiol is shipped in tightly - sealed, corrosion - resistant containers. Shipment adheres to strict hazardous chemical regulations, ensuring proper handling, labeling, and transportation to prevent spills and ensure safety. |
Competitive 2-Chloro-4-Fluorobenzenethiol prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 2-chloro-4-fluorobenzenethiol?
2-Chloro-4-fluorothiophenol is an organic compound. It has a wide range of uses and has important applications in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate. In the process of drug development, it can be converted into compounds with specific pharmacological activities through a series of chemical reactions. For example, in the synthesis of some antibacterial and antiviral drugs, 2-chloro-4-fluorothiophenol may be involved, contributing to the construction of the core structure of drug molecules and helping to develop new drugs with better efficacy and fewer side effects.
In the field of materials science, it also shows unique value. For example, in the preparation of some high-performance polymer materials, it can be introduced as a functional monomer. In this way, the prepared polymer materials may have special physical and chemical properties, such as enhancing the stability of the material and improving its electrical properties, etc., so as to meet the strict requirements of special materials in electronic devices, aerospace and other fields.
In the field of organic synthetic chemistry, it is a commonly used synthetic block. With its unique structure and reactivity, chemists can use it as a starting material to construct complex and diverse organic compounds through ingeniously designed reaction routes. This not only enriches the variety of organic compounds, but also lays a solid foundation for exploring new organic functional materials and bioactive molecules. With its unique chemical structure and properties, 2-chloro-4-fluorothiophenol plays an indispensable role in many fields such as medicine, materials and organic synthesis, and is of great significance to the development of related fields.
In the field of medicinal chemistry, it is often used as a key intermediate. In the process of drug development, it can be converted into compounds with specific pharmacological activities through a series of chemical reactions. For example, in the synthesis of some antibacterial and antiviral drugs, 2-chloro-4-fluorothiophenol may be involved, contributing to the construction of the core structure of drug molecules and helping to develop new drugs with better efficacy and fewer side effects.
In the field of materials science, it also shows unique value. For example, in the preparation of some high-performance polymer materials, it can be introduced as a functional monomer. In this way, the prepared polymer materials may have special physical and chemical properties, such as enhancing the stability of the material and improving its electrical properties, etc., so as to meet the strict requirements of special materials in electronic devices, aerospace and other fields.
In the field of organic synthetic chemistry, it is a commonly used synthetic block. With its unique structure and reactivity, chemists can use it as a starting material to construct complex and diverse organic compounds through ingeniously designed reaction routes. This not only enriches the variety of organic compounds, but also lays a solid foundation for exploring new organic functional materials and bioactive molecules. With its unique chemical structure and properties, 2-chloro-4-fluorothiophenol plays an indispensable role in many fields such as medicine, materials and organic synthesis, and is of great significance to the development of related fields.
What are the physical properties of 2-chloro-4-fluorobenzenethiol?
2-Chloro-4-fluoro-thiophenol is one of the organic compounds. Its physical properties, first of all appearance, at room temperature, are mostly colorless to light yellow liquid, which is caused by the characteristics of its molecular structure. Looking at its color, the sign of light color is due to the limited absorption of intra-molecular electron transitions in the visible region.
As for the smell, it has a strong and pungent smell, due to the presence of thiophenol groups. Thiophenol compounds, whose sulfur-hydrogen bonds are active, volatile and interact with olfactory receptors, have this strong odor.
The boiling point is about a specific temperature range, probably due to the intermolecular force. There is van der Waals force between molecules, and due to the presence of electronegative atoms such as chlorine and fluorine, or a certain degree of dipole-dipole interaction, the boiling point is in the corresponding range. The value of boiling point is a key parameter when separating and purifying this compound.
Melting point also has its specific value, which is related to the arrangement regularity and interaction strength of the molecule. The spatial position of chlorine and fluorine atoms in the molecular structure affects the way of molecular accumulation, which in turn determines the melting point.
In terms of solubility, it is slightly soluble in water. Because its molecule is an organic structure, it has a certain hydrophobicity, and the hydrogen bond between water molecules is strong, which is very different from the force between the molecules of this compound, so it is difficult to dissolve. However, it is soluble in many organic solvents, such as ethanol, ether, etc. Because organic solvents and the molecules of this compound can form similar van der Waals forces or other weak interactions, it follows the principle of similar dissolution.
Density is also an important physical property, and the specific density value reflects the molecular weight and the degree of intermolecular packing. This property has practical significance in chemical operation, storage, etc., and is related to material measurement, stratification and other operations.
As for the smell, it has a strong and pungent smell, due to the presence of thiophenol groups. Thiophenol compounds, whose sulfur-hydrogen bonds are active, volatile and interact with olfactory receptors, have this strong odor.
The boiling point is about a specific temperature range, probably due to the intermolecular force. There is van der Waals force between molecules, and due to the presence of electronegative atoms such as chlorine and fluorine, or a certain degree of dipole-dipole interaction, the boiling point is in the corresponding range. The value of boiling point is a key parameter when separating and purifying this compound.
Melting point also has its specific value, which is related to the arrangement regularity and interaction strength of the molecule. The spatial position of chlorine and fluorine atoms in the molecular structure affects the way of molecular accumulation, which in turn determines the melting point.
In terms of solubility, it is slightly soluble in water. Because its molecule is an organic structure, it has a certain hydrophobicity, and the hydrogen bond between water molecules is strong, which is very different from the force between the molecules of this compound, so it is difficult to dissolve. However, it is soluble in many organic solvents, such as ethanol, ether, etc. Because organic solvents and the molecules of this compound can form similar van der Waals forces or other weak interactions, it follows the principle of similar dissolution.
Density is also an important physical property, and the specific density value reflects the molecular weight and the degree of intermolecular packing. This property has practical significance in chemical operation, storage, etc., and is related to material measurement, stratification and other operations.
What are the chemical properties of 2-chloro-4-fluorobenzenethiol?
2-Chloro-4-fluoro-thiophenol, an organic compound containing chlorine, fluorine and thiophenol functional groups, has unique chemical properties and is widely used in the field of organic synthesis.
The first word about its nucleophilicity. In the thiophenol group, the sulfur atom has a lone pair of electrons, making it nucleophilic and can react with many electrophilic reagents. For example, it can undergo nucleophilic substitution reactions with halogenated hydrocarbons. The thiophenol-sulfur atom attacks the carbon atom connected to the halogen atom in the halogenated hydrocarbon, and the halogen atom leaves to form a new sulfur-containing organic compound. This reaction is commonly used in the construction of carbon-sulfur bonds and is of great significance in the fields of drug synthesis and materials science. It can be used to introduce specific
Second discussion on its acidity. Compared with the oxygen-hydrogen bond of alcohol, the sulfur-hydrogen bond of thiophenol has a smaller bond energy, so 2-chloro-4-fluorobenzothiophenol has a certain acidity and can react with bases to generate corresponding salts. In organic synthesis, this acidic property can be used to separate and purify compounds through acid-base reaction, or to convert thiophenol into corresponding thiophenol salts to enhance its nucleophilicity and facilitate subsequent reactions.
Furthermore, the chlorine atom in this compound is also reactive with the fluorine atom. Chlorine atoms, as a good leaving group, can participate in nucleophilic substitution reactions. Fluorine atoms have high electronegativity, which can affect the density distribution of electron clouds in the benzene ring, and then change the reactivity at other positions on the benzene ring. For example, in electrophilic substitution reactions, the presence of fluorine atoms will reduce the density of electron clouds in the benzene ring, change the reactivity, and its localization effect will affect the position of substituents entering the benzene ring.
In addition, 2-chloro-4-fluorothiophenol may also participate in redox reactions. Thiophenol is easily oxidized to form disulfides. Under the action of appropriate oxidants, sulfur atoms in two 2-chloro-4-fluorothiophenol molecules can form disulfide bonds. This reaction has applications in the study of protein structure and the synthesis of some bioactive molecules, and disulfide bonds are crucial for stabilizing high-level protein structures.
The first word about its nucleophilicity. In the thiophenol group, the sulfur atom has a lone pair of electrons, making it nucleophilic and can react with many electrophilic reagents. For example, it can undergo nucleophilic substitution reactions with halogenated hydrocarbons. The thiophenol-sulfur atom attacks the carbon atom connected to the halogen atom in the halogenated hydrocarbon, and the halogen atom leaves to form a new sulfur-containing organic compound. This reaction is commonly used in the construction of carbon-sulfur bonds and is of great significance in the fields of drug synthesis and materials science. It can be used to introduce specific
Second discussion on its acidity. Compared with the oxygen-hydrogen bond of alcohol, the sulfur-hydrogen bond of thiophenol has a smaller bond energy, so 2-chloro-4-fluorobenzothiophenol has a certain acidity and can react with bases to generate corresponding salts. In organic synthesis, this acidic property can be used to separate and purify compounds through acid-base reaction, or to convert thiophenol into corresponding thiophenol salts to enhance its nucleophilicity and facilitate subsequent reactions.
Furthermore, the chlorine atom in this compound is also reactive with the fluorine atom. Chlorine atoms, as a good leaving group, can participate in nucleophilic substitution reactions. Fluorine atoms have high electronegativity, which can affect the density distribution of electron clouds in the benzene ring, and then change the reactivity at other positions on the benzene ring. For example, in electrophilic substitution reactions, the presence of fluorine atoms will reduce the density of electron clouds in the benzene ring, change the reactivity, and its localization effect will affect the position of substituents entering the benzene ring.
In addition, 2-chloro-4-fluorothiophenol may also participate in redox reactions. Thiophenol is easily oxidized to form disulfides. Under the action of appropriate oxidants, sulfur atoms in two 2-chloro-4-fluorothiophenol molecules can form disulfide bonds. This reaction has applications in the study of protein structure and the synthesis of some bioactive molecules, and disulfide bonds are crucial for stabilizing high-level protein structures.
What are 2-chloro-4-fluorobenzenethiol synthesis methods?
The synthesis methods of 2-chloro-4-fluorobenzothiophenol have been around for a long time, and there are various methods. Common ones are as follows.
First, halogenated aromatics are used as the starting material. Take 2-chloro-4-fluorobromobenzene first, which is a common halogenated aromatic hydrocarbon. Mix it with thioreagents, common thioreagents such as sodium hydrosulfide. In an appropriate reaction vessel, add an appropriate amount of solvent, such as dimethyl sulfoxide (DMSO), this solvent can promote the reaction. Control the reaction temperature, usually under the condition of heating and reflux, the nucleophilic substitution reaction occurs between the two. The thiohydrogen ion attacks the carbon atom attached to the halogen atom of the halogenated aromatic hydrocarbon, and the halogen atom leaves to form 2-chloro-4-fluorobenzene thiophenol. This process requires attention to the purity of the reaction system, and impurities may affect the yield and selectivity of the reaction.
Second, phenolic compounds are used as the starting material. Take 2-chloro-4-fluorophenol first and convert it into the corresponding sulfonate. It can react with sulfonyl chloride reagents, such as p-toluenesulfonyl chloride, under basic conditions to form sulfonates. Afterwards, use thioreagents, such as thiourea, to carry out nucleophilic substitution reactions on sulfonates. During the reaction, the sulfur atom in thiourea attacks the carbon atom of the sulfonate, and the sulfonate group leaves. After subsequent steps such as hydrolysis, 2-chloro-4-fluorothiophenol can be obtained. The key to this method lies in the precise control of the reaction conditions of each step, including the amount of base, reaction temperature and time.
Third, the aryl diazonium salt is used as the intermediate. First, the aryl diazonium salt is prepared from 2-chloro-4-fluoroaniline. 2-chloro-4-fluoroaniline reacts with sodium nitrite under acidic conditions to form a diazonium salt at low temperature. Subsequently, thioreagents such as sodium thiosulfate are added, and the diazo group is replaced by sulfur atoms to generate the target product 2-chloro-4-fluorothiophenol. This method requires attention to the stability of the diazo salt, and the reaction should be carried out quickly at low temperature to prevent the decomposition of the diazo salt.
All synthesis methods have their own advantages and disadvantages. It is necessary to carefully select the appropriate method according to the actual situation, such as the availability of raw materials, the difficulty of controlling the reaction conditions, the purity and yield requirements of the target product, etc., in order to efficiently synthesize 2-chloro-4-fluorothiophenol.
First, halogenated aromatics are used as the starting material. Take 2-chloro-4-fluorobromobenzene first, which is a common halogenated aromatic hydrocarbon. Mix it with thioreagents, common thioreagents such as sodium hydrosulfide. In an appropriate reaction vessel, add an appropriate amount of solvent, such as dimethyl sulfoxide (DMSO), this solvent can promote the reaction. Control the reaction temperature, usually under the condition of heating and reflux, the nucleophilic substitution reaction occurs between the two. The thiohydrogen ion attacks the carbon atom attached to the halogen atom of the halogenated aromatic hydrocarbon, and the halogen atom leaves to form 2-chloro-4-fluorobenzene thiophenol. This process requires attention to the purity of the reaction system, and impurities may affect the yield and selectivity of the reaction.
Second, phenolic compounds are used as the starting material. Take 2-chloro-4-fluorophenol first and convert it into the corresponding sulfonate. It can react with sulfonyl chloride reagents, such as p-toluenesulfonyl chloride, under basic conditions to form sulfonates. Afterwards, use thioreagents, such as thiourea, to carry out nucleophilic substitution reactions on sulfonates. During the reaction, the sulfur atom in thiourea attacks the carbon atom of the sulfonate, and the sulfonate group leaves. After subsequent steps such as hydrolysis, 2-chloro-4-fluorothiophenol can be obtained. The key to this method lies in the precise control of the reaction conditions of each step, including the amount of base, reaction temperature and time.
Third, the aryl diazonium salt is used as the intermediate. First, the aryl diazonium salt is prepared from 2-chloro-4-fluoroaniline. 2-chloro-4-fluoroaniline reacts with sodium nitrite under acidic conditions to form a diazonium salt at low temperature. Subsequently, thioreagents such as sodium thiosulfate are added, and the diazo group is replaced by sulfur atoms to generate the target product 2-chloro-4-fluorothiophenol. This method requires attention to the stability of the diazo salt, and the reaction should be carried out quickly at low temperature to prevent the decomposition of the diazo salt.
All synthesis methods have their own advantages and disadvantages. It is necessary to carefully select the appropriate method according to the actual situation, such as the availability of raw materials, the difficulty of controlling the reaction conditions, the purity and yield requirements of the target product, etc., in order to efficiently synthesize 2-chloro-4-fluorothiophenol.
2-chloro-4-fluorobenzenethiol what are the precautions during use
2-Chloro-4-fluorothiophenol is a commonly used chemical raw material in organic synthesis. When using it, many things must be paid attention to.
The first safety protection. This compound is toxic and irritating, or harmful to the human body. When operating, be sure to wear protective clothing, protective gloves and goggles to prevent it from contacting the skin and eyes. It should be operated in a well-ventilated environment. It is best to operate in a fume hood to avoid inhalation of its volatile aerosol. In case of accidental contact, rinse with plenty of water immediately and seek medical treatment according to the specific situation.
The second is the storage condition. Store it in a cool, dry and ventilated place, away from fire and heat sources. Due to its volatility and chemical activity, it should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed to prevent dangerous chemical reactions. Storage containers should also be well sealed to prevent leakage.
Furthermore, the use process requires fine operation. Because of its active chemical nature, the control of reaction conditions is crucial. When participating in chemical reactions, parameters such as temperature, reaction time and proportion of reactants should be precisely controlled according to the reaction requirements. During the reaction process, the reaction situation needs to be closely monitored, and the reaction process should be tracked with the help of appropriate analytical methods, such as thin-layer chromatography and gas chromatography, to ensure that the reaction proceeds in the expected direction and avoid side reactions.
At the same time, waste treatment cannot be ignored. After use, the remaining 2-chloro-4-fluorothiophenol and the waste generated by the reaction should not be discarded at will. It should be properly disposed of in accordance with relevant environmental regulations. Generally, it needs to be sorted and collected and handed over to professional waste treatment institutions for disposal to prevent pollution to the environment.
In short, when using 2-chloro-4-fluorothiophenol, safety, storage, operation and waste disposal should be treated with caution, so as to ensure the smooth progress of experiments or production, while ensuring the safety of personnel and the environment.
The first safety protection. This compound is toxic and irritating, or harmful to the human body. When operating, be sure to wear protective clothing, protective gloves and goggles to prevent it from contacting the skin and eyes. It should be operated in a well-ventilated environment. It is best to operate in a fume hood to avoid inhalation of its volatile aerosol. In case of accidental contact, rinse with plenty of water immediately and seek medical treatment according to the specific situation.
The second is the storage condition. Store it in a cool, dry and ventilated place, away from fire and heat sources. Due to its volatility and chemical activity, it should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed to prevent dangerous chemical reactions. Storage containers should also be well sealed to prevent leakage.
Furthermore, the use process requires fine operation. Because of its active chemical nature, the control of reaction conditions is crucial. When participating in chemical reactions, parameters such as temperature, reaction time and proportion of reactants should be precisely controlled according to the reaction requirements. During the reaction process, the reaction situation needs to be closely monitored, and the reaction process should be tracked with the help of appropriate analytical methods, such as thin-layer chromatography and gas chromatography, to ensure that the reaction proceeds in the expected direction and avoid side reactions.
At the same time, waste treatment cannot be ignored. After use, the remaining 2-chloro-4-fluorothiophenol and the waste generated by the reaction should not be discarded at will. It should be properly disposed of in accordance with relevant environmental regulations. Generally, it needs to be sorted and collected and handed over to professional waste treatment institutions for disposal to prevent pollution to the environment.
In short, when using 2-chloro-4-fluorothiophenol, safety, storage, operation and waste disposal should be treated with caution, so as to ensure the smooth progress of experiments or production, while ensuring the safety of personnel and the environment.
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