Linshang Chemical
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2-Chloro-4-Fluorobenzenethiolate
Linshang Chemical
|
HS Code |
881644 |
| Chemical Formula | C6H3ClFS- |
| Molecular Weight | 162.59 |
| Appearance | Typically a solid (but appearance can vary based on purity and conditions) |
| Odor | May have a characteristic sulfur - containing odor |
| Solubility In Water | Low solubility in water due to non - polar benzene ring |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone, etc. |
| Reactivity | Reactive towards electrophiles, can participate in substitution reactions |
As an accredited 2-Chloro-4-Fluorobenzenethiolate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 4 - fluorobenzenethiolate packaged in a sealed, chemical - resistant bottle. |
| Storage | 2 - Chloro - 4 - fluorobenzenethiolate should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly - sealed container to prevent contact with air and moisture, which could potentially cause decomposition. Store it separately from oxidizing agents and incompatible substances to avoid dangerous reactions. |
| Shipping | 2 - chloro - 4 - fluorobenzenethiolate, a chemical, is shipped in sealed, corrosion - resistant containers. It follows strict hazardous material regulations, ensuring safe transport to prevent leakage and potential environmental or safety risks. |
Competitive 2-Chloro-4-Fluorobenzenethiolate prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemistry of 2-chloro-4-fluorobenzenethiolate?
2-Chloro-4-fluorophenylthiophenol salt, this is an organic compound. Its chemical properties are unique and quite eye-catching.
Let's talk about its nucleophilicity first. The sulfur atom in thiophenol salt has lone pair electrons, which makes it exhibit a certain nucleophilic ability. In many chemical reactions, it can act as a nucleophilic reagent to attack electrophilic substrates. For example, when it encounters halogenated hydrocarbons, the sulfur atom of thiophenol salt will attack the carbon atom of halogenated hydrocarbons by virtue of its nucleophilicity, and the halogen atom will leave to form a new sulfur-containing organic compound, which is a nucleophilic substitution reaction.
Besides its alkalinity, thiophenol can be regarded as a conjugated base obtained after thiophenol loses protons. Due to the relatively small electronegativity of sulfur atoms, its ability to disperse negative charges is limited, making 2-chloro-4-fluorophenol thiophenol salt have a certain alkalinity. In a suitable acid-base environment, it can combine with protons and change back to thiophenol form.
From the perspective of stability, the presence of chlorine and fluorine atoms on the benzene ring will affect the stability of thiophenol salt. Both chlorine and fluorine atoms have an electron-absorbing induction effect, which can reduce the electron cloud density of the benzene ring, and then disperse the negative charge of thiophenol salt, which enhances its stability to a certain extent. However, if there are substances in the environment that can react with it, such as strong oxidizing agents, it may also undergo oxidation and other reactions, thereby changing the structure and properties.
In addition, the solubility of 2-chloro-4-fluorothiophenol salt is also worthy of attention. Generally speaking, its solubility in organic solvents may be better than in water, because of its larger organic groups and stronger interaction with organic solvents, in line with the principle of similar miscibility. However, the specific solubility is also affected by various factors such as temperature and solvent type. In practical applications and research, it is necessary to comprehensively consider these chemical properties in order to better control the related chemical reactions and processes.
Let's talk about its nucleophilicity first. The sulfur atom in thiophenol salt has lone pair electrons, which makes it exhibit a certain nucleophilic ability. In many chemical reactions, it can act as a nucleophilic reagent to attack electrophilic substrates. For example, when it encounters halogenated hydrocarbons, the sulfur atom of thiophenol salt will attack the carbon atom of halogenated hydrocarbons by virtue of its nucleophilicity, and the halogen atom will leave to form a new sulfur-containing organic compound, which is a nucleophilic substitution reaction.
Besides its alkalinity, thiophenol can be regarded as a conjugated base obtained after thiophenol loses protons. Due to the relatively small electronegativity of sulfur atoms, its ability to disperse negative charges is limited, making 2-chloro-4-fluorophenol thiophenol salt have a certain alkalinity. In a suitable acid-base environment, it can combine with protons and change back to thiophenol form.
From the perspective of stability, the presence of chlorine and fluorine atoms on the benzene ring will affect the stability of thiophenol salt. Both chlorine and fluorine atoms have an electron-absorbing induction effect, which can reduce the electron cloud density of the benzene ring, and then disperse the negative charge of thiophenol salt, which enhances its stability to a certain extent. However, if there are substances in the environment that can react with it, such as strong oxidizing agents, it may also undergo oxidation and other reactions, thereby changing the structure and properties.
In addition, the solubility of 2-chloro-4-fluorothiophenol salt is also worthy of attention. Generally speaking, its solubility in organic solvents may be better than in water, because of its larger organic groups and stronger interaction with organic solvents, in line with the principle of similar miscibility. However, the specific solubility is also affected by various factors such as temperature and solvent type. In practical applications and research, it is necessary to comprehensively consider these chemical properties in order to better control the related chemical reactions and processes.
What are the common uses of 2-chloro-4-fluorobenzenethiolate?
2-Chloro-4-fluorophenylthiophenol salts are commonly used as follows. First, in the field of organic synthesis, they are often key intermediates. Due to their unique structure, thiophenol salts are highly reactive and can react with many halogenated hydrocarbons and acyl halides. For example, when they meet halogenated alkanes, thioether products can be generated. This thioether has important uses in various fields such as medicine, pesticides and materials science. In medicine, it may be the structural unit of active pharmaceutical ingredients; in materials, it may endow materials with special properties.
Furthermore, in the field of metal complexation chemistry, 2-chloro-4-fluorobenzene thiophenates are also useful. Its sulfur atoms are rich in electrons and can combine with metal ions by coordination bonds to form metal thiophenate complexes. Such complexes often have specific physical and chemical properties and have emerged in the field of catalysis. For example, some metal thiophenate complexes can be used as catalysts. In organic reactions, such as hydrogenation reactions and oxidation reactions, they exhibit high catalytic activity and good selectivity, which greatly promote the progress of the reaction and reduce the severity of the reaction conditions.
In addition, 2-chloro-4-fluorothiophenol salts can also play a significant role in surface modification of materials. This compound can be modified on the surface of the material by the interaction of sulfur atoms with metal atoms or active check points on the surface of the material. After this modification, the properties of the surface of the material, such as hydrophilicity, surface charge, biocompatibility, etc., can be regulated. In the field of biomedical materials, modified materials may better blend with biological systems, reduce immune responses, and improve the stability and functionality of materials in living organisms.
Due to the presence of chlorine, fluorine and other halogen atoms, 2-chloro-4-fluorophenylthiophenol salts also play an important role in some reactions or material designs that have special needs for halogen atoms. The introduction of fluorine atoms can often enhance the stability and fat solubility of compounds, while chlorine atoms can participate in specific substitution or elimination reactions, providing various possibilities for subsequent chemical transformations.
Furthermore, in the field of metal complexation chemistry, 2-chloro-4-fluorobenzene thiophenates are also useful. Its sulfur atoms are rich in electrons and can combine with metal ions by coordination bonds to form metal thiophenate complexes. Such complexes often have specific physical and chemical properties and have emerged in the field of catalysis. For example, some metal thiophenate complexes can be used as catalysts. In organic reactions, such as hydrogenation reactions and oxidation reactions, they exhibit high catalytic activity and good selectivity, which greatly promote the progress of the reaction and reduce the severity of the reaction conditions.
In addition, 2-chloro-4-fluorothiophenol salts can also play a significant role in surface modification of materials. This compound can be modified on the surface of the material by the interaction of sulfur atoms with metal atoms or active check points on the surface of the material. After this modification, the properties of the surface of the material, such as hydrophilicity, surface charge, biocompatibility, etc., can be regulated. In the field of biomedical materials, modified materials may better blend with biological systems, reduce immune responses, and improve the stability and functionality of materials in living organisms.
Due to the presence of chlorine, fluorine and other halogen atoms, 2-chloro-4-fluorophenylthiophenol salts also play an important role in some reactions or material designs that have special needs for halogen atoms. The introduction of fluorine atoms can often enhance the stability and fat solubility of compounds, while chlorine atoms can participate in specific substitution or elimination reactions, providing various possibilities for subsequent chemical transformations.
What is 2-chloro-4-fluorobenzenethiolate synthesis method?
The synthesis of 2-chloro-4-fluorobenzene thiophenol salt is an important topic in the field of organic synthesis. The synthesis idea needs to follow the basic principles and reaction laws of organic chemistry.
First, it can be started from 2-chloro-4-fluorobromobenzene. In this compound, the bromine atom has good exodus property and can undergo nucleophilic substitution reaction with sulfur-containing nucleophiles. Common nucleophiles such as sodium hydrosulfide (NaHS). In appropriate solvent, such as dimethyl sulfoxide (DMSO) or N, N-dimethylformamide (DMF), under heating conditions, 2-chloro-4-fluorobromobenzene reacts with sodium hydrosulfide, and the bromine atom is replaced by thiohydrogen to generate 2-chloro-4-fluorobenzothiophenol. The reaction formula is roughly as follows:
2-chloro-4-fluorobromobenzene + NaHS → 2-chloro-4-fluorothiophenol + NaBr
After generating 2-chloro-4-fluorothiophenol, it can be reacted with an appropriate base to obtain 2-chloro-4-fluorothiophenol salt. Commonly used bases such as sodium hydroxide (NaOH), in aqueous solution, 2-chloro-4-fluorothiophenol reacts with sodium hydroxide, and the thiophenol hydroxyl hydrogen is replaced by sodium ions to form 2-chloro-4-fluorothiophenol salt. The reaction formula is:
2-chloro-4-fluorothiophenol + NaOH → 2-chloro-4-fluorothiophenol sodium + H 2O O
Another possible way is to use 2-chloro-4-fluoroaniline as a raw material. The amino group is first converted into a diazonium salt through a diazotization reaction. Subsequently, the diazonium salt is reacted with thiocyanate to introduce thiocyanyl group. After that, the thiocyanyl group is converted into thiophenol group through hydrolysis and other steps, and then reacts with the base to form 2-chloro-4-fluorophenylthiophenol salt. This route is relatively complicated, and the reaction conditions of each step need to be strictly controlled to ensure the smooth progress of the reaction and the purity of the product.
During the synthesis process, the control of the reaction conditions is extremely critical. Temperature, reaction time, proportion of reactants, solvent selection, etc., all affect the reaction yield and product purity. Exploration and optimization of appropriate reaction conditions are the keys to successful synthesis. In short, 2-chloro-4-fluorothiophenol salt can be effectively synthesized through rational selection of starting materials and reaction routes, and fine control of reaction conditions.
First, it can be started from 2-chloro-4-fluorobromobenzene. In this compound, the bromine atom has good exodus property and can undergo nucleophilic substitution reaction with sulfur-containing nucleophiles. Common nucleophiles such as sodium hydrosulfide (NaHS). In appropriate solvent, such as dimethyl sulfoxide (DMSO) or N, N-dimethylformamide (DMF), under heating conditions, 2-chloro-4-fluorobromobenzene reacts with sodium hydrosulfide, and the bromine atom is replaced by thiohydrogen to generate 2-chloro-4-fluorobenzothiophenol. The reaction formula is roughly as follows:
2-chloro-4-fluorobromobenzene + NaHS → 2-chloro-4-fluorothiophenol + NaBr
After generating 2-chloro-4-fluorothiophenol, it can be reacted with an appropriate base to obtain 2-chloro-4-fluorothiophenol salt. Commonly used bases such as sodium hydroxide (NaOH), in aqueous solution, 2-chloro-4-fluorothiophenol reacts with sodium hydroxide, and the thiophenol hydroxyl hydrogen is replaced by sodium ions to form 2-chloro-4-fluorothiophenol salt. The reaction formula is:
2-chloro-4-fluorothiophenol + NaOH → 2-chloro-4-fluorothiophenol sodium + H 2O O
Another possible way is to use 2-chloro-4-fluoroaniline as a raw material. The amino group is first converted into a diazonium salt through a diazotization reaction. Subsequently, the diazonium salt is reacted with thiocyanate to introduce thiocyanyl group. After that, the thiocyanyl group is converted into thiophenol group through hydrolysis and other steps, and then reacts with the base to form 2-chloro-4-fluorophenylthiophenol salt. This route is relatively complicated, and the reaction conditions of each step need to be strictly controlled to ensure the smooth progress of the reaction and the purity of the product.
During the synthesis process, the control of the reaction conditions is extremely critical. Temperature, reaction time, proportion of reactants, solvent selection, etc., all affect the reaction yield and product purity. Exploration and optimization of appropriate reaction conditions are the keys to successful synthesis. In short, 2-chloro-4-fluorothiophenol salt can be effectively synthesized through rational selection of starting materials and reaction routes, and fine control of reaction conditions.
What are the precautions in storage and transportation of 2-chloro-4-fluorobenzenethiolate?
2-Chloro-4-fluorothiophenol salt, when storing and transporting, need to pay attention to many matters. This is a chemical substance, which is active or active, and has potential hazards, so it must be handled with caution.
First, store in a cool, dry and well-ventilated place. Due to humid gas, or its deterioration, the temperature is too high, which can also cause chemical reactions, damage its quality, or even cause danger. Avoid direct sunlight, light is often a catalyst for chemical reactions, so that the stability of the substance decreases, or accidental changes occur. The storage place should be isolated from oxidants, acids, etc. When these substances meet with 2-chloro-4-fluorophenylthiophenol salt, they are prone to violent reactions and risk fire and explosion. And the storage place should be prepared with suitable materials to contain leaks in case of leakage, which can be handled in time to prevent pollution from spreading.
As for transportation, it should not be neglected. The transportation equipment must be airtight and firm to prevent it from leaking and scattered. When loading and unloading, the operator needs to wear appropriate protective equipment, such as protective clothing, gloves, goggles, etc., to avoid direct contact with the object and damage to the skin and eyes. During transportation, it should be stable to avoid bumps and vibrations to avoid damage to the packaging. At the same time, transportation vehicles should follow the designated route to avoid densely populated and complicated traffic areas. In case of accidents, hazards can be reduced. Transportation personnel should also be familiar with emergency treatment methods, and in case of leaks, they can be dealt with quickly and properly.
In short, the storage and transportation of 2-chloro-4-fluorophenylthiophenol salts is related to safety and quality. All links must strictly abide by regulations and operate cautiously to ensure safety.
First, store in a cool, dry and well-ventilated place. Due to humid gas, or its deterioration, the temperature is too high, which can also cause chemical reactions, damage its quality, or even cause danger. Avoid direct sunlight, light is often a catalyst for chemical reactions, so that the stability of the substance decreases, or accidental changes occur. The storage place should be isolated from oxidants, acids, etc. When these substances meet with 2-chloro-4-fluorophenylthiophenol salt, they are prone to violent reactions and risk fire and explosion. And the storage place should be prepared with suitable materials to contain leaks in case of leakage, which can be handled in time to prevent pollution from spreading.
As for transportation, it should not be neglected. The transportation equipment must be airtight and firm to prevent it from leaking and scattered. When loading and unloading, the operator needs to wear appropriate protective equipment, such as protective clothing, gloves, goggles, etc., to avoid direct contact with the object and damage to the skin and eyes. During transportation, it should be stable to avoid bumps and vibrations to avoid damage to the packaging. At the same time, transportation vehicles should follow the designated route to avoid densely populated and complicated traffic areas. In case of accidents, hazards can be reduced. Transportation personnel should also be familiar with emergency treatment methods, and in case of leaks, they can be dealt with quickly and properly.
In short, the storage and transportation of 2-chloro-4-fluorophenylthiophenol salts is related to safety and quality. All links must strictly abide by regulations and operate cautiously to ensure safety.
2-chloro-4-fluorobenzenethiolate impact on the environment
2-Chloro-4-fluorothiophenol salt is also a chemical substance. Its impact on the environment cannot be ignored.
When this substance enters the natural environment, it bears the brunt, and the water ecology may be disrupted by it. If it flows into rivers, lakes and marshes, aquatic organisms, such as fish and shrimp, shellfish, and algae, may suffer from it. It may inhibit the development and growth of aquatic organisms, causing obstacles to reproduction. In terms of fish and shrimp, the growth of larvae may be hindered, or even cause aberration, body damage, and the ability to survive is greatly reduced. As a result, shellfish and shellfish may also be affected by their physiological dysregulation, filtering, feeding, and breathing.
In the soil domain, if 2-chloro-4-fluorobenzothiophenol salt accumulates in the soil, it can change the properties of the soil. It may interact with various minerals and organic matter in the soil to change the fertility and structure of the soil. In this way, it is difficult for plants to take root and absorb. Plant roots are in the soil containing this substance, and their development is often poor. The parts on the ground are also sluggish, the leaves are yellow and the branches are withered, and the flowers and fruits are sparse. The business of farming mulberry must be affected by it.
And this substance is in the atmosphere, and it is not inactive. Although its normal state is mostly in water and soil, it may enter the atmosphere due to volatilization, dust, etc. In the atmosphere, it may participate in photochemical reactions, which combine with other pollutants, increasing the harm of air pollution. If people inhale it, the airway and lungs may be damaged, and coughing, asthma, and dyspnea may follow.
Furthermore, the chemical properties of 2-chloro-4-fluorophenylthiophenol salt make it difficult to self-dissolve in the environment. Over the years, the concentration gradually increases. Although the amount may be small at the beginning, it will accumulate less and more over time. In the ecological balance, it will be a disaster. Its impact on the food chain should not be underestimated. Lower organisms are harmed by it, secondary to higher organisms, and the ecological chain will inevitably collapse.
When this substance enters the natural environment, it bears the brunt, and the water ecology may be disrupted by it. If it flows into rivers, lakes and marshes, aquatic organisms, such as fish and shrimp, shellfish, and algae, may suffer from it. It may inhibit the development and growth of aquatic organisms, causing obstacles to reproduction. In terms of fish and shrimp, the growth of larvae may be hindered, or even cause aberration, body damage, and the ability to survive is greatly reduced. As a result, shellfish and shellfish may also be affected by their physiological dysregulation, filtering, feeding, and breathing.
In the soil domain, if 2-chloro-4-fluorobenzothiophenol salt accumulates in the soil, it can change the properties of the soil. It may interact with various minerals and organic matter in the soil to change the fertility and structure of the soil. In this way, it is difficult for plants to take root and absorb. Plant roots are in the soil containing this substance, and their development is often poor. The parts on the ground are also sluggish, the leaves are yellow and the branches are withered, and the flowers and fruits are sparse. The business of farming mulberry must be affected by it.
And this substance is in the atmosphere, and it is not inactive. Although its normal state is mostly in water and soil, it may enter the atmosphere due to volatilization, dust, etc. In the atmosphere, it may participate in photochemical reactions, which combine with other pollutants, increasing the harm of air pollution. If people inhale it, the airway and lungs may be damaged, and coughing, asthma, and dyspnea may follow.
Furthermore, the chemical properties of 2-chloro-4-fluorophenylthiophenol salt make it difficult to self-dissolve in the environment. Over the years, the concentration gradually increases. Although the amount may be small at the beginning, it will accumulate less and more over time. In the ecological balance, it will be a disaster. Its impact on the food chain should not be underestimated. Lower organisms are harmed by it, secondary to higher organisms, and the ecological chain will inevitably collapse.
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